McCleland, Mark L., Gardner, Richard D., Kallio, Marko J., Daum, John R., Gorbsky, Gary J., Burke, Daniel J., ...
Mitotic inactivation of a human SWI/SNF chromatin remodeling complex (1998)
Sif, Saïd, Stukenberg, P. Todd, Kirschner, Marc W., Kingston, Robert E.
Bolton, Margaret A., Lan, Weijie, Powers, Shannon E., McCleland, Mark L., Kuang, Jian, Stukenberg, P. Todd
Aurora B regulates chromosome segregation and cytokinesis and is the first protein to be implicated as a regulator of bipolar attachment of spindle microtubules to kinetochores. Evidence from several...
McCleland, Mark L., Gardner, Richard D., Kallio, Marko J., Daum, John R., Gorbsky, Gary J., Burke, Daniel J., ...
We show that the Xenopus homologs of Ndc80/Tid3/HEC1 (xNdc80) and Nuf2/MPP1/Him-10 (xNuf2) proteins physically interact in a 190-kD complex that associates with the outer kinetochore from...
Shen, Minhui, Stukenberg, P. Todd, Kirschner, Marc W., Lu, Kun Ping
Phosphorylation of mitotic proteins on the Ser/Thr-Pro motifs has been shown to play an important role in regulating mitotic progression. Pin1 is a novel essential peptidyl–prolyl isomerase...
Mitotic inactivation of a human SWI/SNF chromatin remodeling complex
Sif, Saïd, Stukenberg, P. Todd, Kirschner, Marc W., Kingston, Robert E.
During mitosis, chromatin is condensed into mitotic chromosomes and transcription is inhibited, processes that might be opposed by the chromatin remodeling activity of the SWI/SNF complexes. Brg1 and...
Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein
Satinover, David L., Leach, Craig A., Stukenberg, P. Todd, Brautigan, David L.
Aurora-A kinase is necessary for centrosome maturation, for assembly and maintenance of a bipolar spindle, and for proper chromosome segregation during cell division. Aurora-A is an oncogene that is...
Poddar, Atasi, Stukenberg, P. Todd, Burke, Daniel J.
Favored models of spindle checkpoint signaling propose that two inhibitory complexes (Mad2-Cdc20 and Mad2-Mad3-Bub3-Cdc20) must be assembled at kinetochores in order to inhibit mitosis. We have...
Emanuele, Michael J., McCleland, Mark L., Satinover, David L., Stukenberg, P. Todd
Vertebrate kinetochores contain over 50 different proteins organized into three distinct regions: the inner plate, outer plate, and fibrous corona. The present study characterizes numerous precursors...
Bolton, Margaret A., Lan, Weijie, Powers, Shannon E., McCleland, Mark L., Kuang, Jian, Stukenberg, P. Todd
Aurora B regulates chromosome segregation and cytokinesis and is the first protein to be implicated as a regulator of bipolar attachment of spindle microtubules to kinetochores. Evidence from several...
McCleland, Mark L., Gardner, Richard D., Kallio, Marko J., Daum, John R., Gorbsky, Gary J., Burke, Daniel J., ...
We show that the Xenopus homologs of Ndc80/Tid3/HEC1 (xNdc80) and Nuf2/MPP1/Him-10 (xNuf2) proteins physically interact in a 190-kD complex that associates with the outer kinetochore from...
Shen, Minhui, Stukenberg, P. Todd, Kirschner, Marc W., Lu, Kun Ping
Phosphorylation of mitotic proteins on the Ser/Thr-Pro motifs has been shown to play an important role in regulating mitotic progression. Pin1 is a novel essential peptidyl–prolyl isomerase...
Mitotic inactivation of a human SWI/SNF chromatin remodeling complex
Sif, Saïd, Stukenberg, P. Todd, Kirschner, Marc W., Kingston, Robert E.
During mitosis, chromatin is condensed into mitotic chromosomes and transcription is inhibited, processes that might be opposed by the chromatin remodeling activity of the SWI/SNF complexes. Brg1 and...
Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein
Satinover, David L., Leach, Craig A., Stukenberg, P. Todd, Brautigan, David L.
Aurora-A kinase is necessary for centrosome maturation, for assembly and maintenance of a bipolar spindle, and for proper chromosome segregation during cell division. Aurora-A is an oncogene that is...
Poddar, Atasi, Stukenberg, P. Todd, Burke, Daniel J.
Favored models of spindle checkpoint signaling propose that two inhibitory complexes (Mad2-Cdc20 and Mad2-Mad3-Bub3-Cdc20) must be assembled at kinetochores in order to inhibit mitosis. We have...
Emanuele, Michael J., McCleland, Mark L., Satinover, David L., Stukenberg, P. Todd
Vertebrate kinetochores contain over 50 different proteins organized into three distinct regions: the inner plate, outer plate, and fibrous corona. The present study characterizes numerous precursors...
Zhang, Xin, Lan, Weijie, Ems-McClung, Stephanie C., Stukenberg, P. Todd, Walczak, Claire E.
Chromosome congression and segregation require the proper attachment of microtubules to the two sister kinetochores. Disruption of either Aurora B kinase or the Kinesin-13 mitotic...
Triggering p53 after cytokinesis failure
Cells that fail to divide during cytokinesis often arrest in the next G1 phase by a mysterious mechanism that depends upon p53. What triggers this arrest is unclear. New studies, including a report...
Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly
Emanuele, Michael J., Lan, Weijie, Jwa, Miri, Miller, Stephanie A., Chan, Clarence S.M., Stukenberg, P. Todd
The outer kinetochore binds microtubules to control chromosome movement. Outer kinetochore assembly is restricted to mitosis, whereas the inner kinetochore remains tethered to centromeres throughout...
Phosphorylation Regulates SIRT1 Function
Sasaki, Tsutomu, Maier, Bernhard, Koclega, Katarzyna D., Chruszcz, Maksymilian, Gluba, Wendy, Stukenberg, P. Todd, ...
Wang, Weiping, Stukenberg, P. Todd, Brautigan, David L.
Mitosis in Saccharomyces cerevisiae depends on IPL1 kinase, which genetically interacts with GLC8. The metazoan homologue of GLC8 is inhibitor-2 (I-2), but its function is not understood. We found...
Vorozhko, Valeriya V., Emanuele, Michael J., Kallio, Marko J., Stukenberg, P. Todd, Gorbsky, Gary J.
Kinetochores bind microtubules laterally in a transient fashion and stably, by insertion of plus ends. These pathways may exist to carry out distinct tasks during different stages of mitosis and...