Pouwer, R. H., Harper, J. B., Vyakaranam, K., Michl, J., Williams, C. M., Jessen, C. H., ...
Silver(I) acetylides facilitate direct carbon-carbon bond formation at the bridgehead position of adamantane, and in some instances related systems such as carborate anions and bicyclo...
Badrick, A. C., Hamilton, A. J., Bernhardt, P. V., Jones, C. E., Kappler, U., Jennings, M. P., ...
PrrC is a Sco homologue in Rhodobacter sphaeroides that is associated with PrrBA, a two-component signal transduction system that induces photosynthesis gene expression in response to a decrease in...
The NT-26 cytochrome c552 and its role in arsenite oxidation (2007)
Santini, J. M., Kappler, U., Ward, S. A., Honeychurch, M. J., Vanden Hoven, R. N., Bernhardt, P. V.
Arsenite oxidation by the facultative chemolithoautotroph NT-26 involves a periplasmic arsenite oxidase. This enzyme is the first component of an electron transport chain which leads to reduction of...
Direct electrochemistry of human and rat NADPH cytochrome P450 reductase (2006)
Shukla, A., Gillam, E. M. J., Bernhardt, P. V.
The diflavo-protein NADPH cytochrome P450 reductase (CPR) is the key electron transfer partner for all drug metabolizing cytochrome P450 enzymes in humans. The protein delivers, consecutively, two...
Bernhardt, P. V., Bozoglian, F., Gonzalez, G., Martinez, M., Macpherson, B. P., Sienra, B.
The preparation and characterization of a series of trinuclear mixed-valence cyano-bridged Co-III-Fe-II-Co-III compounds derived from known dinuclear [{LnCoIII(mu-NC)}Fe-II(CN)(5)](-) complexes (L-n...
Enzyme Electrochemistry - Biocatalysis on an electrode (2006)
Oxidoreductase enzymes catalyze single- or multi-electron reduction/oxidation reactions of small molecule inorganic or organic substrates, and they are integral to a wide variety of biological...
Richardson, D. R., Sharpe, P. C., Lovejoy, D. B., Senaratne, D., Kalinowski, D. S., Islam, M., ...
There has been much interest in the development of iron (Fe) chelators for the treatment of cancer. We developed a series of di-2-pyridyl ketone thiosemicarbazone (HDpT) ligands which show marked and...
Moore, E. G., Bernhardt, P. V., Riley, M. J., Smith, T. A.
The rate of electronic energy transfer (EET) between a naphthalene donor and an anthracene acceptor in [ZnL3]-(ClO4)(2) and [ZnL4](ClO4)(2) was determined by time-resolved fluorescence measurements,...
Aullon, G., Bernhardt, P. V., Bozoglian, F., Font-Bardia, M., Macpherson, B. P., Martinez, M., ...
We have investigated the isomeric distribution and rearrangement of complexes of the type [CoXLn](2+,3+) (where X = Cl-, OH-, H2O, and L-n represents a pentadentate 13-, 14-, and 15-membered tetraaza...
Polyamines from polyols - Pathways to azamacrocycles with hydroxymethyl pendent groups (2006)
Bernhardt, P. V., Cho, J. H., Harrowfield, J. M., Kim, J. Y., Kim, Y., ...
Several pathways to macromonocylic polyamine ligands with pendent hydroxymethyl substituents have been explored. The new ligands have all been characterised by single-crystal, X-ray structure...
Cobalt complexes of tripodal hexadentate ligands: Electrochemically driven rearrangements (2006)
The Co-III complexes of the hexadentate tripodal ligands HOsen (3-(2'-aminoethylamino)-2,2-bis((2 ''-aminoethylamino) methyl) propan-1-ol) and HOten (3-(2'-aminoethylthia)-2,2-bis((2...
Ali, M. A., Mirza, A. H., Bujan, F. H., Bernhardt, P. V.
Complexes of general formulae, [Cu(qaldsme)(X)(CH3OH)(n)] and [Ni(qaldsme)(2)] (.) 0.5CH(3)CN (qaldsme = anionic form of the 2-quinoline carboxaldehyde Schiff base of S-methyldithiocarbazate; X =...
Ali, M. A., Mirza, A. H., Ejau, W. B., Bernhardt, P. V.
A new pentadentate thiosemicarbazone has been synthesized and structurally characterized by spectroscopic and X-ray diffraction techniques. It reacts with zinc(II) and cadmium(II) nitrate producing...
Singhal, A., Mishra, R., Kulshreshtha, S. K., Bernhardt, P. V., Tiekink, E. R. T.
The synthesis, characterization and thermal behaviour of some new dimeric allylpalladium (II) complexes bridged by pyrazolate ligands are reported. The complexes [Pd(mu-3,...
Azedaralide: total synthesis, relative and absolute stereochemical assignment (2006)
Baker, L. A., Williams, C. M., Bernhardt, P. V., Yanik, G. W.
Azedaralide, a potentially advanced intermediate for the total synthesis of various tetranortriterpenes, was constructed utilising the Fernandez-Mateos protocol and assigned both relative and...
Bernhardt, P. V., Mattsson, J., Richardson, D. R.
In an effort to better understand the antiproliferative effects of the tridentate hydrazone chelators di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) and di-2-pyridyl ketone benzoyl hydrazone...
Determination of the anomeric configurations of 2,3,4,6-tetra-O-acetyl-D-mannopyranosyl azide (2006)
Cosgrove, K. L., Bernhardt, P. V., Ross, B. P., McGeary, R. P.
The structures of 2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl azide and 2,3,4,6-tetra-O-acetyl-beta-D-mannopyranosyl azide were determined using X-ray crystallographic and one-dimensional NOESY...
Direct electrochemically driven catalysis of bovine milk xanthine oxidase (2006)
Bernhardt, P. V., Honeychurch, M. J., McEwan, A. G.
The complex molybdoenzyme xanthine oxidase (XO) catalyses the oxidation of xanthine to uric acid. Here we report the first direct (unmediated) catalytic electrochemistry of the enzyme in the presence...
Kappler, U., Bailey, S., Feng, C., Honeychurch, M. J., Hanson, G. R., Bernhardt, P. V., ...
The sulfite dehydrogenase from Starkeya novella is the only known sulfite-oxidizing enzyme that forms a permanent heterodimeric complex between a molybdenum and a heme c-containing subunit and can be...
PCTH: A novel orally active chelator for the treatment of iron overload disease (2006)
Lovejoy, D. B., Kalinowski, D., Bernhardt, P. V., Richardson, D. R.
Our laboratories have prepared a novel class of iron (Fe) chelators of the 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH) class. This article will review the iron chelation efficacy of this...
Bernhardt, P. V., Santini, J. M.
The chemolithoautotrophic bacterium NT-26 (isolated from a gold mine in the Northern Territory of Australia) is unusual in that it acquires energy by oxidizing arsenite to arsenate while most other...
Schwartz, B. D., Tilly, D. P., Heim, R., Wiedemann, S., Williams, C. M., Bernhardt, P. V.
Studies detailing synthetic approaches to a variety of biosynthetically related vibsanin-type diterpenes (i.e. vibsanin E, 15-O-methylcyclovibsanin B, 3-hydroxy-vibsanin E, furano-vibsanin A, and...
Transition metal complexes as mediator-titrants in protein redox potentiometry (2006)
Bernhardt, P. V., Chen, K. I., Sharpe, P. C.
A selection of nine macrocyclic Fe-III/II and Co-III/II transition metal complexes has been chosen to serve as a universal set of mediator-titrants in redox potentiometry of protein samples. The...
Panthong, K., Garson, M. J., Bernhardt, P. V.
The structure of 1,3-dimethylisoguanine [ or 6-amino-1,3-dimethyl-1H-purin- 2(3H)- one], C7H9N5O, has been redetermined and the correct assignment of H atoms on the heterocycle is now reported....
2-Methoxy-6-methyl-3-nitro-4-(2-nitroprop-1-enyl)phenyl acetate (2005)
Moore, E. G., Meredith, P., Bernhardt, P. V.
In the title compound, C13H14N2O7, steric crowding around the aromatic ring results in significant out-of-plane twisting of the nitro, methoxy, acetoxy and 2-nitropropenyl functional groups. These...
Immobilisation of electroactive macrocyclic complexes within titania films (2005)
Bernhardt, P. V., Kilah, N. L., Meacham, A., Meredith, P., Vogel, R.
The 4-carboxyphenyl-appended macrocyclic ligand trans-6,13-dimethyl-6-((4-carboxybenzyl)amino)-1,4,8,11-tetraazacyclotetradecane-6-amine (HL10) has been synthesised and complexed with Co-III. The...
Molecular mixed-valence cyanide bridged Co-III-Fe-II complexes (2005)
Bernhardt, P. V., Bozoglian, F., Macpherson, B. P., Martinez, M.
Cyano-bridged mixed-valence compounds have been known for a long time, i.e., Prussian Blue polymeric solids. Nevertheless, the interest in discrete complexes having a well-defined molecular...
Macpherson, B. P., Bernhardt, P. V., Hauser, A., Pages, S., Vauthey, E.
Visible pump-probe spectroscopy has been used to identify and characterize short-lived metal-to-metal charge transfer (MMCT) excited states in a group of cyano-bridged mixed-valence complexes of the...
Sheibani, H., Bernhardt, P. V., Wentrup, C.
Metastable but isolable mesoionic 1,3-oxazinium 4-olates 9d-f undergo ring opening to acylketenes 10 at or near room temperature. The ketenes undergo intramolecular criss-cross [2 + 2] cycloaddition...
The 1,3-diaxial dibromo interaction (2005)
Bernhardt, P. V., Carman, R. M., Le, T. T.
The non-bonding interaction between two bromine atoms sited 1,3-diaxially on a simple cyclohexane ring is explored by X-ray crystallography. The ring is distorted to allow the bromine atoms an...
Moore, E. G., Bernhardt, P. V., Furstenberg, A., Riley, M. J., Smith, T., Vauthey, E.
The emission from two photoactive 14-membered macrocyclic ligands, 6-((naphthalen-1-ylmethyl)-amino)trans-6,13-dimethyl- 13-amino- 1,4,8,11 -tetraaza-cyclotetradecane (L-1) and...
Macpherson, B. P., Alzoubi, B. M., Bernhardt, P. V., Martinez, M., Tregloan, P. A., Van Eldik, R.
The effects of pressure and temperature on the energy (E-op) of the metal-to-metal charge transfer (MMCT, Fe-II --> Co-III) transition of the cyano-bridged complexes trans -...
Ali, M. A., Mirza, A. H., Bernhardt, P. V.
New organometallic tin(IV) complexes of the empirical formula Sn(NNS)Ph2Cl (NNS = anionic forms of the 2-quinolinecarboxaldehyde Schiff bases of S-methyl- and S-benzyldithiocarbazate) have been...
Expedient construction of the vibsanin E core without the use of protecting groups (2005)
Heim, R., Wiedemann, S., Williams, C. M., Bernhardt, P. V.
The tricyclic core of vibsanin E was constructed without the use of a protecting group in six steps. The El Gaied Baylis-Hillman variant was key to allowing the Bronsted acid induced tandem...
Williams, C. M., Heim, R., Bernhardt, P. V.
Specific 3-azabicyclo[3.3.1]nonane derivatives undergo skeletal cleavage when subjected to light or Lewis acidic conditions affording novel heteratricycles, which is in stark contrast to...
Moore, E. G., Bernhardt, P. V., Furstenberg, A., Riley, M. J., Vauthey, E.
The synthesis, structural characterization, and photophysical behavior of a 14-membered tetraazamacrocycle with pendant 4-dimethylaminobenzyl (DMAB) and 9-anthracenylmethyl groups is reported (L-3,...
Honeychurch, M. J., Bernhardt, P. V.
Rotating disk voltammetry is routinely used to study electrochemically driven enzyme catalysis because of the assumption that the method produces a steady-state system. This assumption is based on...
Williams, C. M., Mander, L. N., Bernhardt, P. V., Willis, A. C.
Rapid access to the ABCE ring system of the C-20 diterpene alkaloids was achieved by silver (I) promoted intramolecular Friedel-Crafts arylation of a functional group specific...
Ali, M. A., Mirza, A. H., Nazimuddin, M., Karim, F., Bernhardt, P. V.
A binucleating potentially hexadentate chelating agent containing oxygen, nitrogen and sulfur as potential donor atoms (H2ONNO) has been synthesized by condensing...
Ali, M. A., Mirza, A., Bujang, F., Bernhardt, P. V.
New tin(IV) complexes of empirical formula, Sn(NNS)I-3 (NNS = anionic forms of the 2-quinolinecarboxaldehyde Schiff bases of S-methyl- and S-benzyldithiocarbazate) have been prepared and...
Ali, M. A., Mirza, A. H., Tan, A. L., Wei, L. K., Bernhardt, P. V.
New tin(IV) complexes of empirical formula, Sn(SNNNS)I-2 (SNNNS = anionic form of the 2,6-diacetylpyridine Schiff bases of S-methyl- or S-benzyldithiocarbazate) have been prepared and characterized...
Ali, M. A., Mirza, A. H., Bernhardt, P. V.
New mixed-ligand copper(II) complexes of empirical formulas [Cu(pysme)(sac) (CH3OH)] and [Cu(6mptsc)(sac)](2) have been synthesized and characterized by conductance, magnetic, IR and electronic...
Stereocontrol in complexes of cyclam-like macrocycles - influences of chirality (2004)
Bernhardt, P. V., Dyahningtyas, T. E., Han, S. C., Harrowfield, J. M., Kim, I. C., Kim, Y., ...
Enforcement of chirality upon a macrocyclic tetramine ligand structure by the introduction of an asymmetric pendent arm which does not significantly modify the macrocycle conformation has no...
Bernhardt, P. V., Bozoglian, F., Macpherson, B. P., Martinez, M., Merbach, A. E., Gonzalez, G., ...
The outer-sphere oxidation of Fell in the mixed-valence complex trans-[(LCoNCFeII)-Co-14S-N-III(CN)(6)](-), being L-14S an N3S2 macrocylic donor set on the cobalt(III) center, has been studied. The...
Bernhardt, P. V., Harrowfield, J. M., Kim, Y., Koutsantonis, G. A., Lee, Y. H., Thuery, P.
Reaction between ethane-1,2-diamine and 3,3'-dichloropivalic acid results in different, isomeric tetra-amine derivatives, one a tetraamino carboxylic acid and the other a carboxamidotriamino alcohol,...
Iron catalysed assembly of an asymmetric mixed-ligand triple helicate (2004)
Bernhardt, P. V., Chin, P., Richardson, D. R.
The 2-pyridinecarbaldehyde isonicotinoyl hydrazone (HPCIH) family of ligands are typically tridentate N,N,O chelators that exhibit very high in vitro activity in mobilizing intracellular Fe and are...
Tuning the metal-to-metal charge transfer energy of cyano-bridged dinuclear complexes (2004)
Bernhardt, P. V., Bozoglian, F., Macpherson, B. P., Martinez, M.
The metal-to-metal charge transfer (MMCT) transitions of a series of Class II mixed valence dinuclear complexes bearing cyano bridging ligands may be varied systematically by variations to either the...
Electrochemical anion recognition with ferrocene functionalized macrocycles (2004)
Bernhardt, P. V., Creevey, N. L.
The syntheses and characterization of two new redox active cyclam ligands ferrocenylmethyl-(6-methyl-1,4,8,11-tetraazacyclotetradec-6-yl)-amine(L-3) and 1,...
Lonnon, D. G., Craig, D. C., Colbran, S. B., Bernhardt, P. V.
Copper(II) bromide and chloride complexes of the new heptadentate ligand 2,6-bis(bis(2-pyridylmethyl)amino)methylpyridine (L) have been prepared. For the bromide complexes, chains of novel,...
Ridge, J. P., Aguey, F. K., Bernhardt, P. V., Hanson, G. R., McEwan, A. G.
In dimethylsulfoxide reductase of Rhodobacter capsulatus tryptophan-116 forms a hydrogen bond with a single oxo ligand bound to the molybdenum ion. Mutation of this residue to phenylalanine affected...
A numerical approach to modeling the catalytic voltammetry of surface-confined redox enzymes (2004)
Honeychurch, M. J., Bernhardt, P. V.
A finite difference method for simulating voltammograms of electrochemically driven enzyme catalysis is presented. The method enables any enzyme mechanism to be simulated. The finite difference...
Self-assembly of a charge-neutral molecular square (2004)
Ali, M. A., Bernhardt, P. V., Kiem, C. L., Mirza, A. H.
Complexation of cadmium(II) by the ditopic (bis-tridentate) thiocarbazone ligand 1,5-bis(6-methyl-2-pyridylmethylene) thiocarbonohydrazide, H2L1, results in the self-assembly of a charge-neutral 2 x...
The reaction of 8-amino-p-menthene derivatives with electrophiles (2004)
Bernhardt, P. V., Carman, R. M., Derbyshire, R. P. C.
Attempts to ring-close the nitrogen atom of 8-amino-p-menth-1-ene and of N-substituted 8-amino-p-menth-1-enes onto the C1 - C2 double-bond carbons has led to a range of bicyclo[2.2.2] and...
Direct electrochemistry of porcine purple acid phosphatase (uteroferrin) (2004)
Bernhardt, P. V., Schenk, G., Wilson, G. J.
Cyclic voltammetry of the non-heme diiron enzyme porcine purple acid phosphatase (uteroferrin, Uf) has been reported for the first time. Totally reversible one-electron oxidation responses...
1H-1,3-Diazepines, 5H-1,3-diazepines, 1,3-diazepinones, and 2,4-diazabicyclo[3.2.0]heptenes (2004)
Reisinger, A., Koch, R., Bernhardt, P. V., Wentrup, C.
Tetrazolo[1,5-a] pyridines/ 2-azidopyridines 1 undergo photochemical nitrogen elimination and ring expansion to 1,3-diazacyclohepta-1,2,4,6-tetraenes 3, which react with alcohols to afford...
Imidoylketene dimerization and rearrangement (2004)
George, L., Bernhardt, P. V., Netsch, K. P., Wentrup, C.
FVT of pyrroledione 10 affords the NH-imidoylketene 11, which is characterized by its matrix isolation IR spectrum ( 2117 cm 1). On warming above 170 K, 11 dimerizes to the oxazinone 13, the X-ray...
Kappler, U., Aguey, F. K., Hanson, G. R., Bernhardt, P. V., McEwan, A. G.
Cytochromes from the SoxAX family have a major role in thiosulfate oxidation via the thiosulfate-oxidizing multi-enzyme system (TOMES). Previously characterized SoxAX proteins from Rhodovulum...
The synthesis and X-ray crystal structure of 6-bromo-2,4,4-trimethyl-cyclohex-2-enone (2003)
Williams, C. M., Bernhardt, P. V.
Regiospecific bromination of 2,4,4-trimethyl-cyclohex-2-enone was achieved and the X-ray crystal structure of 6-bromo-2,4,4-trimethyl-cyclohex-2-enone is presented.
Williams, C. M., Bernhardt, P. V., Wiedemann, S., Barden, M. C.
9-Carboxyhexahydro-7-methoxy-4a,7-ethano-benzopyran-5-en-1-one (1) was prepared and examined by X-ray crystallography to probe its potential as a new peptide scaffold/template. The crystal structure...
Intramolecular PET & EET - ricepaper screens and masthead lanterns (2003)
Moore, E. G., Bernhardt, P. V., Fuerstenberg, A., Pigliucci, A., Riley, M. J., Smith, T., ...
Direct electrochemistry of a bacterial sulfite dehydrogenase (2003)
Aguey-Zinsou, K. F., Bernhardt, P. V., Kappler, U., McEwan, A. G.
Sulfite dehydrogenase from Starkeya novella is an alphabeta heterodimer comprising a 40.6 kDa subunit (containing the Mo cofactor) and a smaller 8.8 kDa heme c subunit. The enzyme catalyses the...
Ebner, S., Wallfisch, B., Andraos, J., Aitbaev, I., Kiselewsky, M., Bernhardt, P. V., ...
Flash vacuum thermolysis (FVT) of 1-(dimethylamino)pyrrole-2,3-diones 5 causes extrusion of CO with formation of transient hydrazonoketenes 7. The transient ketenes 7 are observable in the form of...