Use of Multiple Biomarkers to Improve the Prediction of Death from Cardiovascular Causes (2008)
Zethelius, B, Berglund, L, Sundström, J, Ingelsson, E, Basu, S, Larsson, A, ...
Background The incremental usefulness of adding multiple biomarkers from different disease pathways for predicting the risk of death from cardiovascular causes has not, to our knowledge, been...
Eosinophil cationic protein alters pulmonary surfactant structure and function in asthma (2004)
Hohlfeld, J.M., Schmiedl, A., Erpenbeck, V.J., Venge, P., Krug, N.
BACKGROUND: Impaired surfactant function has been demonstrated in patients with asthma. Inhibitory proteins originating from plasma or inflammatory mediators are good candidates to contribute to this...
Amin, K, Ekberg-Jansson, A, Löfdahl, C-G, Venge, P
Abstract is not available
James, S.K., Armstrong, P., Barnathan, E., Califf, R., Lindahl, B., Siegbahn, A., ...
OBJECTIVES: We sought to evaluate C-reactive protein (CRP) and troponin T (TnT) as predictors of risk of the individual end points of mortality and myocardial infarction (MI) in a large cohort of...
Effects of rhinovirus-induced common colds on granulocyte activity in allergic rhinitis. (2002)
Greiff, L, Venge, P, Andersson, M, Ener, I, Linden, M, Myint, S, ...
Abstract is not available
C5a receptor expression on leukocytes from patients with severe sepsis or septic shock (2001)
Furebring, M, Håkansson, L, Venge, P, Siegbahn, A, Nilsson, B, Sjölin, J
No abstract available.
Håkansson, L, Hällgren, R, Venge, P
Hyaluronic acid (HA) stimulated the function of polymorphonucler leukocytes (PMN) both in vitro and in vivo. Stimulation in vitro was achieved by the incubation of PMN and HA in heparinized whole...
Trulson, A, Nilsson, S, Venge, P
AIMS: To investigate the kinetics of normalisation of monocyte oxidative activity following tumour eradication. METHODS: Whole blood lucigenin enhanced chemiluminescence was studied in patients with...
Interaction and complex-formation between the eosinophil cationic protein and alpha 2-macroglobulin.
The interaction between the highly basic and cytotoxic eosinophil cationic protein (ECP) and human plasma proteins is described. The major plasma protein responsible for complex-formation with ECP...
Håkansson, L, Hällgren, R, Venge, P
Hyaluronic acid (HA) stimulated the function of polymorphonucler leukocytes (PMN) both in vitro and in vivo. Stimulation in vitro was achieved by the incubation of PMN and HA in heparinized whole...
Trulson, A, Nilsson, S, Venge, P
AIMS: To investigate the kinetics of normalisation of monocyte oxidative activity following tumour eradication. METHODS: Whole blood lucigenin enhanced chemiluminescence was studied in patients with...
Interaction and complex-formation between the eosinophil cationic protein and alpha 2-macroglobulin.
The interaction between the highly basic and cytotoxic eosinophil cationic protein (ECP) and human plasma proteins is described. The major plasma protein responsible for complex-formation with ECP...
The isolation and characterization of a new eosinophil-derived protein, eosinophil protein X (EPX) is here described. The purified EPX is a highly basic glycoprotein and shows one band on sodium...
Venge, P., Boberg, Merike, Håkansson, Lena, Peterson, C.
A granulocyte release-promoting activity (RPA) has been identified in serum from a patient with chronic pruritus. Secretion from granulocytes of both primary granule components (myeloperoxidase) and...
Håkansson, L, Hällgren, R, Venge, P
The influence of serum on phagocytosis related to the complement system was examined by means of a kinetic phagocytosis method using IgG-coated particles, isolated polymorphonuclear neutrophil...
The co-operation between the Fc and C3b receptors of PMNs (neutrophil granulocytes) during phagocytosis has been studied by the effect of interference with either of the receptors. The significance...
Hällgren, R, Bjelle, A, Venge, P
Eosinophils are seldom noted in inflammatory synovial fluids but are reported to infiltrate the synovial tissue in inflammatory arthritides. To elucidate a possible role for eosinophils in...
Feltelius, N, Lindh, U, Venge, P, Hällgren, R
The cellular stores of iron in granulocytes and platelets isolated from 29 patients with ankylosing spondylitis were measured by the nuclear microprobe technique. The mean iron content in...
Feltelius, N, Hällgren, R, Venge, P
The possibility of eosinophil involvement in ankylosing spondylitis (AS) was investigated by measuring serum levels of eosinophil cationic protein (ECP), a specific granule constituent of...
Neutrophil function in patients with primary Sjögren's syndrome: relation to infection propensity.
Gudbjörnsson, B, Feltelius, N, Hällgren, R, Venge, P
The function of neutrophils was studied in 23 consecutive patients with primary Sjögren's syndrome and in 35 healthy controls. Nineteen patients (83%) had extraglandular symptoms and nine patients...
Neutrophil and eosinophil involvement of the small bowel affected by chronic alcoholism.
Colombel, J F, Hällgren, R, Venge, P, Mesnard, B, Rambaud, J C
Excessive ethanol intake may affect the intestinal mucosa functionally and morphologically. The ethanol effect could partly be the result of inflammatory mechanisms, possibly reflected by an enhanced...
Carlson, M, Raab, Y, Sevéus, L, Xu, S, Hällgren, R, Venge, P
Background and aim: Accumulation and infiltration by neutrophil granulocytes is a prominent feature in the local inflammatory process in ulcerative colitis (UC). The present study was performed to...
Hällgren, R., Håkansson, Lena, Schmekel, Birgitta, Stålenheim, G., Venge, P.
Kinetic measurements of the serum-independent uptake of IgG-coated or complement-opsonized latex particles have been performed in 58 patients with sarcoidosis. The mean rate for phagocytic uptake of...
Hällgren, R, Feltelius, N, Svenson, K, Venge, P
Circulating levels of eosinophil cationic protein (ECP), an eosinophil specific granule protein, and numbers of peripheral eosinophils were determined in 42 patients with rheumatoid arthritis. At the...
Schmekel, B, Håkansson, L, Hällgren, R, Nou, E, Stålenheim, G, Venge, P
The phagocytic and complement receptor function of polymorphonuclear neutrophils (PMN) from patients with sarcoidosis was studied using a kinetic assay which allows the distinction to be made between...
Bondestam, M, Funa, K, Venge, P, Alm, G V
The ability of neutrophil granulocytes (PMN) from 15 infection prone children to produce luminol enhanced chemiluminescence (CL) was disturbed to varying extents in eight patients, two of whom were...
The effect of eosinophils on collagen gel contraction and implications for tissue remodelling
ZAGAI, U, SKÖLD, C M, TRULSON, A, VENGE, P, LUNDAHL, J
Asthma is characterized by an eosinophilic inflammation and a subepithelial fibrosis in the airways. Eosinophils contain several cytotoxic substances, such as eosinophil cationic protein (ECP), which...
Kristjánsson, G, Venge, P, Wanders, A, Lööf, L, Hällgren, R
Background and aims: There is a clear need for a rapid, simple, safe, and sensitive method of determining the type and intensity of inflammation in the gut mucosa in clinical practice. In this study,...
Mucosal reactivity to cow's milk protein in coeliac disease
Kristjánsson, G, Venge, P, Hällgren, R
Patients with coeliac disease (CD) on a gluten-free diet may still have gastrointestinal symptoms. On clinical grounds cow's milk (CM) protein sensitivity may be suspected. Here, using rectal protein...
Schmekel, B, Wollmer, P, Venge, P, Linden, M, Blom-Bülow, B
An investigation was performed to determine whether symptom free patients with previously diagnosed extrinsic allergic alveolitis had signs of inflammation in the lung. Pulmonary clearance of inhaled...
Radioimmunoassay of serum myoglobin in neuromuscular diseases.
Askmark, H, Osterman, P O, Roxin, L E, Venge, P
Radioimmunoassay of serum myoglobin was performed in 85 patients with muscular symptoms. Elevated levels were found in 93% of patients with myogenic myopathy, in 54% with myasthenia gravis and in 50%...
Metso, T, Venge, P, Haahtela, T, Peterson, C, Seveus, L
Methods: Induced sputum and bronchoalveolar lavage fluid samples from 14 patients with respiratory conditions and four healthy individuals were studied. Antigens were detected at their intracellular...
Amin, K, Ekberg-Jansson, A, Lofdahl, C, Venge, P
Methods: Bronchial biopsy specimens were taken from 29 smokers and 16 never smokers and stained with monoclonal antibodies HNL, EPO, AA1, CD68 in order to identify neutrophils, eosinophils, mast...
Neutrophil function in infection-prone children.
Håkansson, L, Foucard, T, Hällgren, R, Venge, P
Seven variables connected with the function of the neutrophil granulocyte were studied in 24 children who had undue susceptibilities to infections. The phagocytosis rate of IgG-coated latex particles...
Kristjánsson, G, Högman, M, Venge, P, Hällgren, R
Background and aims: To elucidate the dynamics of nitric oxide (NO) production induced by rectal gluten challenge and the relation between NO production and mucosal granulocyte activation.
Lagerqvist, B, Diderholm, E, Lindahl, B, Husted, S, Kontny, F, Ståhle, E, ...
Objective: To develop a scoring system for risk stratification and evaluation of the effect of an early invasive strategy for treatment of unstable coronary artery disease (CAD).