Blood donation, body iron status and carotid intima-media thickness (2008)
Engberink, M.F., Geleijnse, J.M., Durga, J., Swinkels, D.W., Schouten, E.G., ...
Iron could promote free radical formation, which may lead to injury of the arterial wall and atherosclerosis. Blood donation may reduce cardiovascular risk by lowering body iron status. We collected...
N-3 Fatty acid proportions in plasma and cognitive performance in older adults 1-3 (2007)
Dullemeijer, C., Durga, J., Brouwer, I.A., Kok, F.J., Brummer, R.J., ...
Background: Very-long-chain n¿3 polyunsaturated fatty acids (n¿3 PUFAs) are suggested to be related to cognitive performance in older adults. However, limited data exist on the association between...
Validation of a food frequency questionnaire to assess folate intake of Dutch elderly people (2007)
Durga, J., Verhoef, P., Melse-Boonstra, A., Brants, H.A.M.
Folate is required for 1-carbon metabolism and deficiency in folate leads to megaloblastic anemia. Low levels of folate have been associated with increased risk of vascular disease. To investigate...
Bioavailability of Food Folates is 80% of that of folic acid 1-3 (2007)
Winkels, R.M., Brouwer, I.A., Siebelink, E., Katan, M.B., Verhoef, P.
Background: The bioavailability of natural food folates is lower than that of synthetic folic acid, but no agreement exists as to the extent of the difference. Objective: In a 4-wk dietary...
Very long-chain n-3 fatty acids an cognitive function in older adults (2007)
Dullemeijer, C., Durga, J., Brouwer, I.A., Kok, F.J., Brummer, R.J., ...
What can we learn from the FACIT trial: A randomized, double blind, controlled trial (2007)
Durga, J., Schouten, E.G., Kok, F.J., Jolles, J., Katan, M.B., ...
Durga, J., Anteunis, L.J.C., Schouten, E.G., Bots, M.L., Kok, F.J., Verhoef, P.
Vascular disease and its risk factors have been associated with the age-related hearing loss. We examined the association of elevated plasma homocysteine and its determinants with hearing levels....
Durga, J., Schouten, E.G., Bots, M.L., Kok, F.J., Verhoef, P.
Low folate status has been associated with cognitive decline. We investigated the association of folate status and the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C ¿ T polymorphism with...
Durga, J., Anteunis, L.J.C., Schouten, E.G., Bots, M.L., Kok, F.J., Verhoef, P.
Vascular disease and its risk factors have been associated with the age-related hearing loss. We examined the association of elevated plasma homocysteine and its determinants with hearing levels....
Olthof, M.R., Bots, M.L., Katan, M.B., Verhoef, P.
Objectives: We investigated whether lowering of fasting homocysteine concentrations, either with folic acid or with betaine supplementation, differentially affects vascular function, a surrogate...
Onzekere effecten van foliumzuur op andere aandoeningen dan neuraalbuisdefecten (2006)
Suppletie met foliumzuur rondom de bevruchting reduceert de kans op het krijgen van een baby met een neuraalbuisdefect. 1 Observationele epidemiologische studies wekten hoop dat een hoge inname van...
Olthof, M.R., Verhoef, P., Zock, P.L., Katan, M.B.
Background Betaine (trimethylglycine) lowers plasma homocysteine, a possible risk factor for cardiovascular disease. However, studies in renal patients and in obese individuals who are on a...
Effects of Betaine Intake on Plasma Homocysteine Concentrations and Consequences for Health (2005)
High plasma concentrations of homocysteine may increase risk of cardiovascular disease. Folic acid lowers plasma homocysteine by 25% maximally, because 5-methyltetrahydrofolate is a methyl donor in...
Olthof, M.R., Brink, E.J., Katan, M.B., Verhoef, P.
Background: A high homocysteine concentration is a potential risk factor for cardiovascular disease that can be reduced through betaine supplementation. Choline is the precursor for betaine, but the...
Verhoef, P., Olthof, M.R., Katan, M.B.
Background: A high plasma concentration of total homocysteine (tHcy) is associated with increased risk of cardiovascular disease. A high protein intake and hence a high intake of methionine¿the sole...
Melse-Boonstra, A., Holm, P.I., Ueland, P.M., Olthof, M.R., Clarke, R., Verhoef, P.
Background: Remethylation of homocysteine to methionine can occur through either the folate-dependent methionine synthase pathway or the betaine-dependent betaine-homocysteine methyltransferase...
Durga, J., Schouten, E.G., Kok, F.J., Verhoef, P.
Elevated concentrations of homocysteine and low concentrations of folate may lead to a proinflammatory state that could explain their relation to vascular disease risk. We investigated the effect of...
Durga, J., Bots, M.L., Schouten, E.G., Kok, F.J., Verhoef, P.
Aim: We examined whether total homocysteine, B vitamins and the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C ¿ T polymorphism are related to common carotid intima-media thickness, a marker...
The effect of 3-year folic acid supplementation on hearing (2005)
Durga, J., Verhoef, P., Schouten, E.G., Anteunis, L.J.C., Lucien, J.C., Kok, F.J.
Homocysteine and carotid intima-media thickness: a critical appraisal of the evidence (2004)
Durga, J., Verhoef, P., Bots, M.L., Schouten, E.G.
This review examines the relationship between hyperhomocysteinemia, a risk factor for vascular disease, and carotid intima-media thickness (CIMT), a valid marker of generalized atherosclerosis and...
Bioavailability of heptaglutamyl relative to monoglutamyl folic acid in healthy adults. (2004)
Melse-Boonstra, A., West, C.E., Katan, M.B., Kok, F.J., Verhoef, P.
Development of a new method to study bioavailability of folate from total diets in health (2004)
Winkels, R.M., Melse-Boonstra, A., West, C.E., Katan, M.B., Verhoef, P.
The relationship between inflammation and carotid atherosclerosis (2004)
Durga, J., Bots, M.L., Schouten, E.G., Kok, F.J., Verhoef, P.
Homocysteine is not associated with hearing loss (2004)
Durga, J., Anteunis, L.J.C., Kok, F.J., Schouten, E.G., Verhoef, P.
Homocysteine not associated with intima-media thickness (2004)
Durga, J., Bots, M.L., Schouten, E.G., Kok, F.J., Verhoef, P.
Low Relative Bioavailability of Heptaglutamul Folic Acid (2003)
Boonstra, A., West, C.E., Katan, M.B., Kok, F.J., Verhoef, P.
Betaine supplementation lowers plasma homocysteine levels in healthy men and women (2003)
Steenge, G.R.S., Verhoef, P., Katan, M.B.
Elevated levels of plasma total homocysteine are associated with a higher risk of cardiovascular disease. Betaine and 5-methyltetrahydrofolate can remethylate homocysteine into methionine via...
No effect of folic acid supplementation on hemostasis markers in healthy elderly (2003)
Verhoef, P., Klerk, M., Durga, J., Kluft, C., Kok, F.J., Schouten, E.G.
Homocysteine not associated with intima-media thickness (2003)
Durga, J., Bots, M.L., Schouten, E.G., Grobbee, D.E., Kok, F.J., Verhoef, P.
No effect of folic acid supplementation on hemostasis markers in healthy elderly (2003)
Klerk, M., Durga, J., Schouten, E.G., Kluft, C., Kok, F.J., Verhoef, P.
Blood donation, iron status, and carotid intima-media thickness (2003)
Engberink, M.F., Geleijnse, J.M., Durga, J., Swinkels, D.W., Schouten, E.G., ...
Dietary serine and cystine diminish the homocysteine raising effect of methionine in humans (2003)
Verhoef, P., Steenge, G.R.S., Boelsma, E., Olthof, M.R., Katan, M.B.
Cystathionine beta-synthase polymorphisms and hyperhomocysteinaemia: an association study (2003)
Lievers, K.J.A., Kluijtmans, L.A.J., Heil, S.G., Boers, G.H., Verhoef, P., Den Heijer, M., ...
MTHFR 677C-T polymorphism and risk of coronary heart disease : a meta-analysis (2002)
Klerk, M., Verhoef, P., Clarke, R., Blom, H.J., Kok, F.J., Schouten, E.G.
Melse-Boonstra, A., Verhoef, P., Bjorke-Monsen, A.L., Verschuren, W.M.M.
Dietary folate consists of monoglutamate and polyglutamate folate species. In the small intestine, folate polyglutamate is deconjugated to the monoglutamate form before absorption takes place. This...
Melse-Boonstra, A., Verhoef, P., Konings, E.J., Matser, A., Hollman, P.C., ...
Bioavailability of dietary folate might be impaired by the polyglutamate chain to which ~70␘f dietary folates are bound. This chain must be removed enzymatically in the intestine before folate is...
Lievers, K.J.A., Kluijtmans, L.A.J., Boers, G.H.J., Verhoef, P., Trijbels, F.J.M., ...
Elevated levels of total homocysteine and low folate in blood are independent and graded risk factors for arterial occlusive disease. An impairment of folate distribution can be an important cause of...
Effect of B-vitamin supplementation on activation markers of coagulation (2001)
Klerk, M., Verhoef, P., Schouten, E.G., Verbruggen, B., Bos, G., Den-Heijer, M.
A pooled analysis of studies on MTHFR C677T polymorphism and risk of coronary heart disease (2001)
Klerk, M., Schouten, E.G., Blom, H.J., Kok, F.J., Verhoef, P.
Lievers, K.J., Kluijtmans, L.A., Heil, S.G., Boers, G.H.J., Verhoef, P., ...
Molecular defects in genes encoding enzymes involved in homocysteine metabolism may account for mild hyperhomocysteinaemia, an independent and graded risk factor for cardiovascular disease (CVD)....