Cancer-associated proteins in effusion fluids.
Booth, S N, Lakin, G, Dykes, P W, Burnett, D, Bradwell, A R
Two cancer-associated proteins, carcinoembryonic antigen (CEA) and pregnancy-associated alpha2 glycoprotein (PAG), together with 13 normal serum proteins were measured in the serum and effusion fluid...
Crawley, J. M., Northam, B. E., King, J. P. G., Leonard, J. C., Booth, S. N., Dykes, P. W.
Carcinoembryonic antigen (CEA) has been measured in parallel with seven serum proteins and seromucoids in the sera of patients with malignant neoplasia and non-neoplastic disease. In the total group...
Optimal timing of operation for bleeding peptic ulcer: prospective randomised trial.
Morris, D L, Hawker, P C, Brearley, S, Simms, M, Dykes, P W, Keighley, M R
From October 1980 to September 1983 all patients with upper gastrointestinal bleeding were admitted to a centralised unit and investigated by early endoscopy. A total of 142 patients with a proved...
Comparison of surgical and medical management of bleeding peptic ulcers
Morris, D L, Hawker, P C, Dykes, P W, Allan, R N, Keighley, M R B
Management of gastrointestinal bleeding
Keighley, M R B, Allan, R N, Alexander-Williams, John, Dykes, P W
Halsall, A K, Fairweather, D S, Bradwell, A R, Blackburn, J C, Dykes, P W, Howell, A, ...
Sheep IgG antibody to alpha-fetoprotein was labelled with 131I and used to identify human germ-cell tumours by emission scanning. Eleven patients were studied after resection of their primary...
Albendazole in hydatid disease.
Morris, D L, Dykes, P W, Dickson, B, Marriner, S E, Bogan, J A, Burrows, F G
Improved tumour localisation using indium-111 labelled antibodies.
Fairweather, D S, Bradwell, A R, Dykes, P W, Vaughan, A T, Watson-James, S F, Chandler, S
Immunoglobulin G (IgG) antibodies to carcinoembryonic antigen (CEA) were labelled with radioactive indium (111In) or iodine (131I) and a comparison made of their value in locating CEA producing...
Dykes, P W, Hine, K R, Bradwell, A R, Blackburn, J C, Reeder, T A, Drolc, Z, ...
Sheep IgG antibody to carcinoembryonic antigen (CEA) was radiolabelled with 131I and used to identify human gastrointestinal tumours by external subtraction imaging. 99Tc-pertechnetate and 99Tc-human...
Carcinoembryonic Antigen in Management of Colorectal Carcinoma
Booth, S. N., Jamieson, G. C., King, J. P. G., Leonard, J., Oates, G. D., Dykes, P. W.
Carcinoembryonic antigen (C.E.A.) estimation has been used in the preoperative assessment of colorectal carcinoma patients and has been shown to give a useful guide to the presence of metastatic...
Mortality in patients with bleeding peptic ulcer when those aged 60 or over are operated on early.
Wheatley, K E, Snyman, J H, Brearley, S, Keighley, M R, Dykes, P W
Cancer-associated proteins in effusion fluids.
Booth, S N, Lakin, G, Dykes, P W, Burnett, D, Bradwell, A R
Two cancer-associated proteins, carcinoembryonic antigen (CEA) and pregnancy-associated alpha2 glycoprotein (PAG), together with 13 normal serum proteins were measured in the serum and effusion fluid...
Crawley, J. M., Northam, B. E., King, J. P. G., Leonard, J. C., Booth, S. N., Dykes, P. W.
Carcinoembryonic antigen (CEA) has been measured in parallel with seven serum proteins and seromucoids in the sera of patients with malignant neoplasia and non-neoplastic disease. In the total group...
Optimal timing of operation for bleeding peptic ulcer: prospective randomised trial.
Morris, D L, Hawker, P C, Brearley, S, Simms, M, Dykes, P W, Keighley, M R
From October 1980 to September 1983 all patients with upper gastrointestinal bleeding were admitted to a centralised unit and investigated by early endoscopy. A total of 142 patients with a proved...
Comparison of surgical and medical management of bleeding peptic ulcers
Morris, D L, Hawker, P C, Dykes, P W, Allan, R N, Keighley, M R B
Management of gastrointestinal bleeding
Keighley, M R B, Allan, R N, Alexander-Williams, John, Dykes, P W
Halsall, A K, Fairweather, D S, Bradwell, A R, Blackburn, J C, Dykes, P W, Howell, A, ...
Sheep IgG antibody to alpha-fetoprotein was labelled with 131I and used to identify human germ-cell tumours by emission scanning. Eleven patients were studied after resection of their primary...
Albendazole in hydatid disease.
Morris, D L, Dykes, P W, Dickson, B, Marriner, S E, Bogan, J A, Burrows, F G
Improved tumour localisation using indium-111 labelled antibodies.
Fairweather, D S, Bradwell, A R, Dykes, P W, Vaughan, A T, Watson-James, S F, Chandler, S
Immunoglobulin G (IgG) antibodies to carcinoembryonic antigen (CEA) were labelled with radioactive indium (111In) or iodine (131I) and a comparison made of their value in locating CEA producing...
Dykes, P W, Hine, K R, Bradwell, A R, Blackburn, J C, Reeder, T A, Drolc, Z, ...
Sheep IgG antibody to carcinoembryonic antigen (CEA) was radiolabelled with 131I and used to identify human gastrointestinal tumours by external subtraction imaging. 99Tc-pertechnetate and 99Tc-human...
Carcinoembryonic Antigen in Management of Colorectal Carcinoma
Booth, S. N., Jamieson, G. C., King, J. P. G., Leonard, J., Oates, G. D., Dykes, P. W.
Carcinoembryonic antigen (C.E.A.) estimation has been used in the preoperative assessment of colorectal carcinoma patients and has been shown to give a useful guide to the presence of metastatic...
Mortality in patients with bleeding peptic ulcer when those aged 60 or over are operated on early.
Wheatley, K E, Snyman, J H, Brearley, S, Keighley, M R, Dykes, P W
Diagnostic Accuracy of Early Radiology in Acute Gastrointestinal Haemorrhage
Allan, R. N., Dykes, P. W., Toye, D. K. M.
The accuracy of early radiology in patients with acute gastrointestinal haemorrhage has been studied by a comparison of the radiological opinion with the established diagnosis. A full examination has...
Auto-allergic reactions following internal irradiation of the liver
Wordsworth, O. J., Dykes, P. W.
Complement fixation tests using crude liver antigen were carried out on rats following the injection of colloidal 198Au calculated to deliver β radiation doses from 5000 to 10,000 rad. Marked...
Growth enhancing property of human monocytes from normal donors and cancer patients.
Trejdosiewicz, L K, Trejdosiewicz, A J, Ling, N R, Dykes, P W
Peripheral blood monocytes, but not other leucocytes, from healthy donors, were shown to enhance the DNA synthesis of three cell lines. The effect was very marked on an epithelial (Chang) and...
Hall, C, Griffin, J, Dykes, P W, Williams, J A, Keighley, M R
Patients who had undergone curative resection for colorectal cancer were studied to compare the efficacy of faecal occult blood detection (Haemoccult test) with colonoscopy in the detection of...
Serum carcinoembryonic antigen in clinical disorders
Booth, S. N., King, J. P. G., Leonard, J. C., Dykes, P. W.
Carcinoembryonic antigen (CEA) levels have been measured in the serum of 490 patients and 93 normal controls using the double antibody radioimmunoassay technique. Levels were elevated in 71 of...
Of 663 patients treated with radical surgery for colorectal cancer, 52 showed a progressive rise in serum carcinoembryonic antigen (CEA) with no other evidence of recurrent disease and were...
The therapeutic dilatation of enteric strictures due to Crohn's disease.
Alexander-Williams, J., Allan, A., Morel, P., Hawker, P. C., Dykes, P. W., O'Connor, H.
The use of dilatation as a treatment of strictures due to Crohn's disease has hitherto received little attention. We report dilatation of small and large bowel strictures in twelve patients with...
The surgical treatment of gastroduodenal Crohn's disease.
Shepherd, A. F., Allan, R. N., Dykes, P. W., Keighley, M. R., Alexander-Williams, J.
Crohn's disease can affect any part of the gastrointestinal tract. Gastroduodenal involvement is uncommon and was not recognised until 1949 (1). Since then approximately 200 cases have been described...
Brearley, S., Hawker, P. C., Dorricott, N. J., Lee, J. R., Ambrose, N. S., Silverman, S. H., ...
Thirty-seven patients who had had either a colonoscopy or a selective mesenteric angiogram while being investigated for severe or persistent gastrointestinal bleeding of obscure origin were reviewed....
Enterovesical fistulas in Crohn's disease.
Heyen, F., Ambrose, N. S., Allan, R. N., Dykes, P. W., Alexander-Williams, J., Keighley, M. R.
A total of 19 enterovesical fistulas were recorded in a series of 799 patients with Crohn's disease (2.4%). The origin of the fistulas was: ileum (9), colon (6) and four were complex involving the...
Intestinal absorption at high altitude.
Chesner, I. M., Small, N. A., Dykes, P. W.
Three tests of small intestinal function were performed at 3100 m and 4846 m to seek evidence of malabsorption of high altitude. Xylose tolerance did not change in 11 subjects but, in three who...
Serum CEA testing in the post-operative surveillance of colorectal carcinoma.
Six hundred and sixty-three patients were followed with serial serum CEA measurements in addition to routine clinical surveillance after radical resection of colorectal carcinoma. Of 626 available...
Theoretical considerations for improving tumour targeting.
Thomas, G. D., Chappell, M. J., Dykes, P. W., Ramsden, D. B., Godfrey, K. R., Ellis, J. R., ...
To determine the relative importance of factors influencing tumour uptake of antibodies, we used a mathematical model to simulate intravenous injection of substances of varying molecular sizes and...