Search Techniques for Rational Drug Design (2007)
P. W. Finn, L.E. Kavraki, J. C. Latombe, R. Motwani, S. Venkatasubramanian
Pharmaceutical drug design is a long and expensive process. Early selection of promising molecules can dramatically improve this process, but this selection is often similar to searching for a needle...
ized Pharmacophore Identification for Drug Design (2007)
P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, A. Yao
This paper describes a randomized approach for finding invariants in a set of flexible ligands (drug molecules) that underlies an integrated software system called RAPID currently under development....
Computational approaches to drug design (1999)
The rational approach to pharmaceutical drug design begins with an investigation of the relationship between chemical structure and biological activity. Information gained from this analysis is used...
Rapid: Randomized pharmacophore identification for drug design (1997)
P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, ...
This paper describes a randomized approach for finding invariants in a set of flexible ligands (drug molecules) that underlies an integrated software system called RAPID currently under development....
Rapid: randomized pharmacophore identi cation for drug design (1997)
P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, ...
This paper describes a randomized approach for nding invariants in a set of exible and chemically distinct ligands (drug molecules) that underlies an integrated software system called RAPID currently...
RAPID: Randomized Pharmacophore Identification for Drug Design (1997)
Kavraki Latombe, P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, ...
This paper describes a randomized approach for finding invariants in a set of flexible ligands (drug molecules) that underlies an integrated software system called RAPID currently under development....
RAPID: Randomized Pharmacophore Identification for Drug Design (1997)
Finn Kavraki Latombe, P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, ...
This paper describes a randomized approach for finding invariants in a set of flexible and chemically distinct ligands (drug molecules) that underlies an integrated software system called RAPID...
RAPID: Randomized Pharmacophore Identification for Drug Design (1997)
Kavraki Latombe, P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, ...
This paper describes a randomized approach for finding invariants in a set of flexible ligands (drug molecules) that underlies an integrated software system called RAPID currently under development....
RAPID: Randomized Pharmacophore Identification for Drug Design (1997)
P. W. Finn, L.E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, ...
This paper describes a randomized approach for finding invariants in a set of flexible ligands (drug molecules) that underlies an integrated software system called RAPID currently under development....
RAPID: Randomized Pharmacophore Identification for Drug Design (1997)
P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, ...
This paper describes a randomized approach for finding invariants in a set of flexible and chemically distinct ligands (drug molecules) that underlies an integrated software system called RAPID...
Interferon gamma regulates binding of two nuclear protein complexes in a macrophage cell line.
Finn, P W, Kara, C J, Douhan, J, Van, T T, Folsom, V, Glimcher, L H
Interferon gamma (IFN-gamma) is a potent inducer of major histocompatibility complex (MHC) antigens during normal immune responses and in abnormal responses in autoimmune disease. In this report we...
Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model.
Krinzman, S J, De Sanctis, G T, Cernadas, M, Mark, D, Wang, Y, Listman, J, ...
Activation of naive T cells requires at least two signals. In addition to the well characterized interaction of the T cell antigen receptor with the antigen/MHC expressed on an antigen-presenting...
In, K H, Asano, K, Beier, D, Grobholz, J, Finn, P W, Silverman, E K, ...
Five lipoxygenase (5-LO) is the first committed enzyme in the metabolic pathway leading to the synthesis of the leukotrienes. We examined genomic DNA isolated from 25 normal subjects and 31 patients...
The presence of a DNA binding complex correlates with E beta class II MHC gene expression.
Finn, P W, Kara, C J, Van, T T, Douhan, J, Boothby, M R, Glimcher, L H
The class II major histocompatibility complex (MHC, Ia) antigens are a family of membrane proteins whose expression is strictly regulated. They have a limited tissue distribution and their expression...
Interferon gamma regulates binding of two nuclear protein complexes in a macrophage cell line.
Finn, P W, Kara, C J, Douhan, J, Van, T T, Folsom, V, Glimcher, L H
Interferon gamma (IFN-gamma) is a potent inducer of major histocompatibility complex (MHC) antigens during normal immune responses and in abnormal responses in autoimmune disease. In this report we...
Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model.
Krinzman, S J, De Sanctis, G T, Cernadas, M, Mark, D, Wang, Y, Listman, J, ...
Activation of naive T cells requires at least two signals. In addition to the well characterized interaction of the T cell antigen receptor with the antigen/MHC expressed on an antigen-presenting...
In, K H, Asano, K, Beier, D, Grobholz, J, Finn, P W, Silverman, E K, ...
Five lipoxygenase (5-LO) is the first committed enzyme in the metabolic pathway leading to the synthesis of the leukotrienes. We examined genomic DNA isolated from 25 normal subjects and 31 patients...
The presence of a DNA binding complex correlates with E beta class II MHC gene expression.
Finn, P W, Kara, C J, Van, T T, Douhan, J, Boothby, M R, Glimcher, L H
The class II major histocompatibility complex (MHC, Ia) antigens are a family of membrane proteins whose expression is strictly regulated. They have a limited tissue distribution and their expression...