Baba, Y., Yokota, T., Spits, H., Garrett, K.P., Hayashi, S.I., Kincade, P.W.
This study was designed to investigate one component of the Wnt/beta-catenin signaling pathway that has been implicated in stem cell self-renewal. Retroviral-mediated introduction of stable...
Pregnancy-related steroids are potential negative regulators of B lymphopoiesis.
B lymphopoiesis is selectively suppressed in normal pregnant mice, suggesting that fluctuations in systemic hormone levels might influence local events within bone marrow. This has now been tested by...
B29 gene products complex with immunoglobulins on B lymphocytes.
Ishihara, K, Wood, W J, Damore, M, Hermanson, G G, Wall, R, Kincade, P W
B29 is a B-lineage-specific gene predicted from sequence information to be a transmembrane member of the immunoglobulin (Ig) superfamily, with a single extracellular Ig-like domain. Its presumptive...
Inoculation candidiasis in a murine model of severe combined immunodeficiency syndrome.
Mahanty, S, Greenfield, R A, Joyce, W A, Kincade, P W
To further elucidate the importance of T- and B-lymphocyte-mediated responses in host defense against systemic infection with Candida albicans, we studied this infection in a murine model of severe...
Waneck, G L, Sherman, D H, Kincade, P W, Low, M G, Flavell, R A
Proteins anchored in the membrane by covalent linkage to phosphatidylinositol (PtdIns) can be released by treatment with purified PtdIns-specific phospholipase C (Ptd-Ins-PLC). A recent survey of...
B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells.
Hermanson, G G, Eisenberg, D, Kincade, P W, Wall, R
A number of the glycoproteins identified on the surfaces of cells of the immune response belong to the immunoglobulin superfamily. We have isolated and characterized cDNA clones and the complete...
Enrichment of human marrow lymphocytes with monoclonal antibodies to murine antigens.
Landreth, K S, Kincade, P W, Lee, G, Gathings, W E, Fu, S M
Two monoclonal antibodies, prepared against a murine B lymphoma and characterized as binding to a cell surface antigen represented primarily on cells of the B lineage, were found to bind to human...
Lipopolysaccharide-unresponsive mutant pre-B-cell lines blocked in NF-kappa B activation.
Briskin, M, Damore, M, Law, R, Lee, G, Kincade, P W, Sibley, C H, ...
NF-kappa B activation is a crucial late step in the induction of immunoglobulin kappa light-chain gene expression in pre-B cells by lipopolysaccharide (LPS). We have analyzed NF-kappa B activation in...
Response of bone marrow stromal cells to adipogenic antagonists.
Gimble, J M, Dorheim, M A, Cheng, Q, Pekala, P, Enerback, S, Ellingsworth, L, ...
Adipocytes constitute a major part of the bone marrow stroma in vivo and may play an active role in lymphohematopoiesis. Earlier studies had shown that the bone marrow stromal cell clone BMS2 was...
Abnormalities in clonable B lymphocytes and myeloid progenitors in autoimmune NZB mice.
Kincade, P W, Lee, G, Fernandes, G, Moore, M A, Williams, N, Good, R A
Cloning procedures were used to study B lymphocytes and progenitors of granulocytes and macrophages in NZB mice. Numbers of B cells that were detected in sheep erythrocyte-containing semisolid...
Cycling of peripheral blood and marrow lymphocytes in cyclic neutropenia.
Engelhard, D, Landreth, K S, Kapoor, N, Kincade, P W, De Bault, L E, Theodore, A, ...
A 16-month-old male patient with cyclic neutropenia was found to have cyclic fluctuations of monocytes, lymphocytes, platelets, and eosinophils in the peripheral blood. Changes in lymphocyte counts...
Zheng, Z, Cummings, R D, Pummill, P E, Kincade, P W
The density, molecular isoform, and posttranslational modifications of CD44 can markedly influence growth and metastatic behavior of tumors. Many CD44 functions, including some involving tumors, have...
Pregnancy-related steroids are potential negative regulators of B lymphopoiesis.
B lymphopoiesis is selectively suppressed in normal pregnant mice, suggesting that fluctuations in systemic hormone levels might influence local events within bone marrow. This has now been tested by...
B29 gene products complex with immunoglobulins on B lymphocytes.
Ishihara, K, Wood, W J, Damore, M, Hermanson, G G, Wall, R, Kincade, P W
B29 is a B-lineage-specific gene predicted from sequence information to be a transmembrane member of the immunoglobulin (Ig) superfamily, with a single extracellular Ig-like domain. Its presumptive...
Inoculation candidiasis in a murine model of severe combined immunodeficiency syndrome.
Mahanty, S, Greenfield, R A, Joyce, W A, Kincade, P W
To further elucidate the importance of T- and B-lymphocyte-mediated responses in host defense against systemic infection with Candida albicans, we studied this infection in a murine model of severe...
Waneck, G L, Sherman, D H, Kincade, P W, Low, M G, Flavell, R A
Proteins anchored in the membrane by covalent linkage to phosphatidylinositol (PtdIns) can be released by treatment with purified PtdIns-specific phospholipase C (Ptd-Ins-PLC). A recent survey of...
B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells.
Hermanson, G G, Eisenberg, D, Kincade, P W, Wall, R
A number of the glycoproteins identified on the surfaces of cells of the immune response belong to the immunoglobulin superfamily. We have isolated and characterized cDNA clones and the complete...
Enrichment of human marrow lymphocytes with monoclonal antibodies to murine antigens.
Landreth, K S, Kincade, P W, Lee, G, Gathings, W E, Fu, S M
Two monoclonal antibodies, prepared against a murine B lymphoma and characterized as binding to a cell surface antigen represented primarily on cells of the B lineage, were found to bind to human...
Lipopolysaccharide-unresponsive mutant pre-B-cell lines blocked in NF-kappa B activation.
Briskin, M, Damore, M, Law, R, Lee, G, Kincade, P W, Sibley, C H, ...
NF-kappa B activation is a crucial late step in the induction of immunoglobulin kappa light-chain gene expression in pre-B cells by lipopolysaccharide (LPS). We have analyzed NF-kappa B activation in...
Response of bone marrow stromal cells to adipogenic antagonists.
Gimble, J M, Dorheim, M A, Cheng, Q, Pekala, P, Enerback, S, Ellingsworth, L, ...
Adipocytes constitute a major part of the bone marrow stroma in vivo and may play an active role in lymphohematopoiesis. Earlier studies had shown that the bone marrow stromal cell clone BMS2 was...
Abnormalities in clonable B lymphocytes and myeloid progenitors in autoimmune NZB mice.
Kincade, P W, Lee, G, Fernandes, G, Moore, M A, Williams, N, Good, R A
Cloning procedures were used to study B lymphocytes and progenitors of granulocytes and macrophages in NZB mice. Numbers of B cells that were detected in sheep erythrocyte-containing semisolid...
Cycling of peripheral blood and marrow lymphocytes in cyclic neutropenia.
Engelhard, D, Landreth, K S, Kapoor, N, Kincade, P W, De Bault, L E, Theodore, A, ...
A 16-month-old male patient with cyclic neutropenia was found to have cyclic fluctuations of monocytes, lymphocytes, platelets, and eosinophils in the peripheral blood. Changes in lymphocyte counts...
Zheng, Z, Cummings, R D, Pummill, P E, Kincade, P W
The density, molecular isoform, and posttranslational modifications of CD44 can markedly influence growth and metastatic behavior of tumors. Many CD44 functions, including some involving tumors, have...
Wostmann, B. S., Pleasants, J. R., Bealmear, Patricia, Kincade, P. W.
Germ-free CFW mice reared on practical type steam sterilized solid diets showed lower than conventional levels of all serum immunoglobulins. Reared on water soluble, low molecular weight, chemically...
CD44-stimulated dendrite formation ('spreading') in activated B cells.
Santos-Argumedo, L, Kincade, P W, Partida-Sánchez, S, Parkhouse, R M
A rat monoclonal antibody (mAb) (NIM-R8), insolubilized by binding to plastic plates, induced a rapid and extensive formation of dendrite processes ('spreading') in B lymphocytes activated by...
A two-stage model for development of antibody-producing cells
Cooper, M. D., Lawton, A. R., Kincade, P. W.
This model divides plasma cell differentiation into two developmental stages within the framework of the clonal selection theory. The first stage occurs within specific induction micro-environments,...