Khadjesari, Z., Murray, E., Kalaitzaki, E., White, I., McCambridge, J., Godfrey, C., ...
Objective This paper reports on the development of a new online measure of beverage-specific past week alcohol consumption (the TOT-AL), its test–retest reliability, and comparability with the...
Methodological challenges in online trials (2009)
Murray, E., Khadjesari, Z., White, I.R., Kalaitzaki, E., Godfrey, C., McCambridge, J., ...
Health care and health care services are increasingly being delivered over the Internet. There is a strong argument that interventions delivered online should also be evaluated online to maximize the...
Linke, S., McCambridge, J., Khadjesari, Z., Wallace, P., Murray, E.
Aims: The content of novel interventions is often not well specified. We provide a detailed account of the rationale for and redevelopment of an Internet resource for hazardous drinkers – Down Your...
Murray, E., McCambridge, J., Kjadjesaris, Z., White, I., Thomson, S., Godfrey, C., ...
BACKGROUND Excessive alcohol consumption is a significant public health problem throughout the world. Although there are a range of effective interventions to help heavy drinkers reduce their alcohol...
Murray, E, McCambridge, J, Khadjesari, Z, White, I. R., Thompson, S. G., Godfrey, C, ...
Background Excessive alcohol consumption is a significant public health problem throughout the world. Although there are a range of effective interventions to help heavy drinkers reduce their alcohol...
Upadhyaya, Meena, Huson, Susan M., Davies, Mark, Thomas, Nicholas Stuart Tudor, Chuzhanova, Nadia, Giovannini, S., ...
Upadhyaya, Meena, Huson, Susan M., Davies, Mark, Thomas, Nicholas Stuart Tudor, Chuzhanova, Nadia, Giovannini, S., ...
Upadyaya, M., Huson, S M., Davies, M., Thomas, N., Chuzhanova, N., Giovannini, S., ...
Copyright © 2007 The American Society of Human Genetics
Upadyaya, M., Huson, S M., Davies, M., Thomas, N., Chuzhanova, N., Giovannini, S., ...
Copyright © 2007 The American Society of Human Genetics
Upadhyaya, M., Huson, S.M., Davies, M., Thomas, N., Chuzhanova, N., Giovannini, S., ...
Neurofibromatosis type 1 (NF1) is characterized by cafe-au-lait spots, skinfold freckling, and cutaneous neurofibromas. No obvious relationships between small mutations (ACG change of codon 990....
Hilton, J. L., Capitaine, N., Chapront, J., Ferrandiz, J. M., Fienga, A., Fukushima, T., ...
The IAU Working Group on Precession and the Equinox looked at several solutions for replacing the precession part of the IAU 2000A precession-nutation model, which is not consistent with dynamical...
Porakishvili, N., Kulikova, N., Jewell, A.P., Youinou, P.Y., Yong, K., Nathwani, A., ...
We have studied the surface expression of the Toll-like receptor family member CD180 on cells from 78 patients with B-chronic lymphocytic leukaemia (B-CLL). B-CLL cells had variable levels of CD180...
Bloom, S. D., Dale, D. A., Cool, R., Dupczak, K., Miller, C., Haugsjaa, A., ...
We present the most recent results of an optical survey of the position error contours ("error boxes") of unidentified high energy gamma-ray sources.
DOWN YOUR DRINK: A WEB-BASED INTERVENTION FOR PEOPLE WITH EXCESSIVE ALCOHOL CONSUMPTION (2004)
Linke, S., Brown, A., Wallace, P.
Aims: To conduct a pilot study of the usefulness of Down Your Drink (DYD), a web-based intervention to encourage excessive drinkers to adopt a healthy pattern of drinking and reduce...
Jacklin, P.B., Roberts, J.A., Wallace, P., Haines, A., Harrison, R., Barber, J.A., ...
Objectives: To test the hypotheses that, compared with conventional outpatient consultations, joint teleconsultation (virtual outreach) would incur no increased costs to the NHS, reduce costs to...
Litterick, Audrey, Harrier, L., Wallace, P., Watson, C. A., Wood, M.
Introduction Composts and manures are of major importance in providing fertility in organic farming systems, since synthetic fertilisers are prohibited. It is understood that composts have radically...
An exploratory study of DMT in support of hornet operations (2003)
Wallace, P., Lenne, M., Miller, R.
This study concerns the potential application of Distributed Mission Training (DMT) concepts to Hornet tactical fighter operations training. The study built on earlier and separate training task...
An exploratory study of DMT in support of hornet operations (2003)
Wallace, P., Lenne, M., Miller, R.
This study concerns the potential application of Distributed Mission Training (DMT) concepts to Hornet tactical fighter operations training. The study built on earlier and separate training task...
An exploratory study of DMT in support of hornet operations (2003)
Wallace, P., Lenne, M., Miller, R.
This study concerns the potential application of Distributed Mission Training (DMT) concepts to Hornet tactical fighter operations training. The study built on earlier and separate training task...
Litterick, Audrey, Harrier, L., Wallace, P., Watson, C. A., Wood, M.
Introduction Composts and manures are of major importance in providing fertility in organic farming systems, since synthetic fertilisers are prohibited. It is understood that composts have radically...
An exploratory study of DMT in support of hornet operations (2003)
Wallace, P., Lenne, M., Miller, R.
This study concerns the potential application of Distributed Mission Training (DMT) concepts to Hornet tactical fighter operations training. The study built on earlier and separate training task...
Wallace, P., Haines, A., Harrison, R., Barber, J.A., Thompson, S., Jacklin, P., ...
Summary: Background: The current model of general practitioner referral of patients to hospital specialists in the UK is sometimes associated with unnecessary duplication of investigations and...
Wallace, P., Haines, A., Harrison, R., Barbour, J., Thompson, S., Jacklin, P., ...
Background: The current model of general practitioner referral of patients to hospital specialists in the UK is sometimes associated with unnecessary duplication of investigations and treatments. We...
SOFA Software Progress Report (1998)
The International Astronomical Union (IAU) set up the Standards of Fundamental Astronomy (SOFA) initiative at the 1994 General Assembly to promulgate an authoritative set of fundamental astronomy...
Direct measurement of in situ methane quantities in a large gas-hydrate reservoir (1997)
Dickens, GR, Paull, CK, Wallace, P
Certain gases can combine with water to form solids-gas hydrates-that are stable at high pressures and low temperatures(1,2), Conditions appropriate for gas-hydrate formation exist in many marine...
Environmental Corporation (1997)
T. Wheeler, E. D. Jensen, A. Kanevsky, J. Maurer, P. Wallace, Bedford Ma, ...
This paper describes a prototype being developed that provides a worked example of a distributed, real-time system that utilizes application level Quality of Service (QoS) metrics to adapt to...
MIGRATION OF THE INTERSTITIAL-IMPURITY MIXED DUMBBELL CONFIGURATION IN Al-Zn (1985)
Wallace, P., Hultman, K., Holder, J., Granato, A.
From measurements of ultrasonic attenuation and velocity in alloys with different atomic Zn concentrations (.01%, 0.1%, and 0.5%), we obtain positive evidence that the Al-Zn dumbbell migrates as a...
MIGRATION OF THE INTERSTITIAL-IMPURITY MIXED DUMBBELL CONFIGURATION IN Al-Zn (1985)
Wallace, P., Hultman, K., Holder, J., Granato, A.
From measurements of ultrasonic attenuation and velocity in alloys with different atomic Zn concentrations (.01%, 0.1%, and 0.5%), we obtain positive evidence that the Al-Zn dumbbell migrates as a...
MIGRATION OF THE INTERSTITIAL-IMPURITY MIXED DUMBBELL CONFIGURATION IN Al-Zn (1985)
Wallace, P., Hultman, K., Holder, J., Granato, A.
From measurements of ultrasonic attenuation and velocity in alloys with different atomic Zn concentrations (.01%, 0.1%, and 0.5%), we obtain positive evidence that the Al-Zn dumbbell migrates as a...
Jacklin, P B, Roberts, J A, Wallace, P, Haines, A, Harrison, R, Barber, J A, ...
Objectives To test the hypotheses that, compared with conventional outpatient consultations, joint teleconsultation (virtual outreach) would incur no increased costs to the NHS, reduce costs to...
Thorburn, A W, Gumbiner, B, Bulacan, F, Wallace, P, Henry, R R
To examine whether reduced rates of oxidative (Gox) and non-oxidative (Nox) glucose metabolism in non-insulin-dependent diabetes mellitus (NIDDM) are due to reduced glucose uptake, intrinsic defects...
Effects of aging on glucose-mediated glucose disposal and glucose transport.
Fink, R I, Wallace, P, Olefsky, J M
To assess the effects of aging on glucose-mediated glucose disposal and glucose transport, glucose disposal rates were measured in 10 nonelderly (32 +/- 4 yr) and 11 elderly (64 +/- 4 yr) subjects at...
Prager, R, Wallace, P, Olefsky, J M
To determine whether abnormal kinetics of insulin's biologic actions contribute to the overall insulin resistance in obesity, we compared the rate of activation and deactivation of insulin's effects...
Bagby, G C, Dinarello, C A, Wallace, P, Wagner, C, Hefeneider, S, McCall, E
Studies designed to characterize monocyte-derived recruiting activity (MRA) a monokine that stimulates endothelial cells to produce granulocyte macrophage-colony-stimulating activity (CSA) by...
Garvey, W T, Maianu, L, Zhu, J H, Brechtel-Hook, G, Wallace, P, Baron, A D
Insulin resistance is instrumental in the pathogenesis of type 2 diabetes mellitus and the Insulin Resistance Syndrome. While insulin resistance involves decreased glucose transport activity in...
Van Marwijk, H W, Wallace, P, De Bock, G H, Hermans, J, Kaptein, A A, Mulder, J D
BACKGROUND. Many scales have been developed to assess depression, but they are often too lengthy to be of practical use in general practice consultations. AIM. A study was undertaken to investigate...
Is participation in research as an investigator an effective form of continuing medical education?
Continuing medical education and research are a daily necessity for general practitioners (GPs). This study investigated the possibility that participation in research is an effective form of...
Chisholm, D, Godfrey, E, Ridsdale, L, Chalder, T, King, M, Seed, P, ...
BACKGROUND: There is a paucity of evidence relating to the cost-effectiveness of alternative treatment responses to chronic fatigue. AIM: To compare the relative costs and outcomes of counselling...
Ridsdale, L, Godfrey, E, Chalder, T, Seed, P, King, M, Wallace, P, ...
BACKGROUND: Fatigue is a common symptom for which patients consult their doctors in primary care. With usual medical management the majority of patients report that their symptoms persist and become...
Wessely, S, Chalder, T, Hirsch, S, Wallace, P, Wright, D
OBJECTIVES: This study examined the prevalence and public health impact of chronic fatigue and chronic fatigue syndrome in primary care patients in England. METHODS: There were 2376 subjects, aged 18...
A self administered questionnaire, the health survey questionnaire, was designed to detect excessive alcohol consumption and mailed to patients who were registered with two general practices. Replies...
Safe limits of drinking: general practitioners' views.
Wallace, P, Cremona, A, Anderson, P
A survey was carried out by questionnaire of general practitioners' views on what the safe upper limits of alcohol consumption are for health education for men and women. The results showed lower...
Long term survival after intensive care.
Ridley, S, Jackson, R, Findlay, J, Wallace, P
OBJECTIVE--To examine the long term survival of critically ill patients admitted to an intensive therapy unit and to ascertain the effects of age, severity of illness, and diagnostic category at...
Jacklin, P B, Roberts, J A, Wallace, P, Haines, A, Harrison, R, Barber, J A, ...
Objectives To test the hypotheses that, compared with conventional outpatient consultations, joint teleconsultation (virtual outreach) would incur no increased costs to the NHS, reduce costs to...
Thorburn, A W, Gumbiner, B, Bulacan, F, Wallace, P, Henry, R R
To examine whether reduced rates of oxidative (Gox) and non-oxidative (Nox) glucose metabolism in non-insulin-dependent diabetes mellitus (NIDDM) are due to reduced glucose uptake, intrinsic defects...
Effects of aging on glucose-mediated glucose disposal and glucose transport.
Fink, R I, Wallace, P, Olefsky, J M
To assess the effects of aging on glucose-mediated glucose disposal and glucose transport, glucose disposal rates were measured in 10 nonelderly (32 +/- 4 yr) and 11 elderly (64 +/- 4 yr) subjects at...
Prager, R, Wallace, P, Olefsky, J M
To determine whether abnormal kinetics of insulin's biologic actions contribute to the overall insulin resistance in obesity, we compared the rate of activation and deactivation of insulin's effects...
Bagby, G C, Dinarello, C A, Wallace, P, Wagner, C, Hefeneider, S, McCall, E
Studies designed to characterize monocyte-derived recruiting activity (MRA) a monokine that stimulates endothelial cells to produce granulocyte macrophage-colony-stimulating activity (CSA) by...
Garvey, W T, Maianu, L, Zhu, J H, Brechtel-Hook, G, Wallace, P, Baron, A D
Insulin resistance is instrumental in the pathogenesis of type 2 diabetes mellitus and the Insulin Resistance Syndrome. While insulin resistance involves decreased glucose transport activity in...
Van Marwijk, H W, Wallace, P, De Bock, G H, Hermans, J, Kaptein, A A, Mulder, J D
BACKGROUND. Many scales have been developed to assess depression, but they are often too lengthy to be of practical use in general practice consultations. AIM. A study was undertaken to investigate...
Is participation in research as an investigator an effective form of continuing medical education?
Continuing medical education and research are a daily necessity for general practitioners (GPs). This study investigated the possibility that participation in research is an effective form of...
Chisholm, D, Godfrey, E, Ridsdale, L, Chalder, T, King, M, Seed, P, ...
BACKGROUND: There is a paucity of evidence relating to the cost-effectiveness of alternative treatment responses to chronic fatigue. AIM: To compare the relative costs and outcomes of counselling...
Ridsdale, L, Godfrey, E, Chalder, T, Seed, P, King, M, Wallace, P, ...
BACKGROUND: Fatigue is a common symptom for which patients consult their doctors in primary care. With usual medical management the majority of patients report that their symptoms persist and become...
Wessely, S, Chalder, T, Hirsch, S, Wallace, P, Wright, D
OBJECTIVES: This study examined the prevalence and public health impact of chronic fatigue and chronic fatigue syndrome in primary care patients in England. METHODS: There were 2376 subjects, aged 18...
A self administered questionnaire, the health survey questionnaire, was designed to detect excessive alcohol consumption and mailed to patients who were registered with two general practices. Replies...
Safe limits of drinking: general practitioners' views.
Wallace, P, Cremona, A, Anderson, P
A survey was carried out by questionnaire of general practitioners' views on what the safe upper limits of alcohol consumption are for health education for men and women. The results showed lower...
Long term survival after intensive care.
Ridley, S, Jackson, R, Findlay, J, Wallace, P
OBJECTIVE--To examine the long term survival of critically ill patients admitted to an intensive therapy unit and to ascertain the effects of age, severity of illness, and diagnostic category at...
Teenagers' health concerns: implications for primary health care professionals.
Epstein, R, Rice, P, Wallace, P
Four hundred and eighty five students, aged 13-15 years, at nine comprehensive schools in the London borough of Brent completed a questionnaire about health-related behaviours and health concerns....
Oncostatin M in the anti-inflammatory response
Oncostatin M (OM) is a pleiotropic cytokine of the interleukin 6 family, whose in vivo properties and physiological function remain in dispute and poorly defined. These in vivo studies strongly...
Wallace, P., Cutler, S., Haines, A.
OBJECTIVE: To determine effectiveness of advice from general practitioners to heavy drinkers to reduce their excessive alcohol consumption (35 U or more a week for men, 21 U or more for women)....
Upadhyaya, M., Huson, S. M., Davies, M., Thomas, N., Chuzhanova, N., Giovannini, S., ...
Neurofibromatosis type 1 (NF1) is characterized by café-au-lait spots, skinfold freckling, and cutaneous neurofibromas. No obvious relationships between small mutations (
Allawi, H S, Wallace, P, Pitcher, A, Gaffen, Z, Bland-Ward, P A, Moore, P K
1. The effect of the nitric oxide synthase (NOS) inhibitor, 7-nitro indazole (7-NI), on sympathetic and purinergic neurotransmission in the rat isolated vas deferens preparation has been studied. 2....
Morgan, C. V., Babbedge, R. C., Gaffen, Z., Wallace, P., Hart, S. L., Moore, P. K.
1. L-NG-nitro arginine methyl ester (L-NAME) administered i.p. produces anti-nociception in the mouse assessed by the formalin-induced paw licking and acetic acid-induced abdominal constriction...
An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus.
Gibson, A., Babbedge, R., Brave, S. R., Hart, S. L., Hobbs, A. J., Tucker, J. F., ...
1. The effect of five S-nitrosothiols, and of the stereoisomers of NG-hydroxy-arginine (HOARG), were investigated on the mouse anococcygeus. 2. All five S-nitrosothiols produced concentration-related...
Moore, P. K., Babbedge, R. C., Wallace, P., Gaffen, Z. A., Hart, S. L.
7-Nitro indazole (7-NI) inhibits mouse cerebellar nitric oxide synthase (NOS) in vitro with an IC50 of 0.47 microM. Following i.p. administration in mice, 7-NI (10-50 mg kg-1) produces dose-related...
Handy, R. L., Wallace, P., Gaffen, Z. A., Whitehead, K. J., Moore, P. K.
1-(2-trifluoromethylphenyl)imidazole (TRIM) is a potent inhibitor of neuronal (mouse cerebellar) and inducible (lung from endotoxin-pretreated rats) isoforms of nitric oxide synthase (NOS) with IC50...
Handy, R. L., Harb, H. L., Wallace, P., Gaffen, Z., Whitehead, K. J., Moore, P. K.
1. The ability of a range of substituted imidazole compounds to inhibit mouse cerebellar neuronal nitric oxide synthase (nNOS), bovine aortic endothelial NOS (eNOS) and inducible NOS (iNOS) from...
L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse.
Moore, P. K., Oluyomi, A. O., Babbedge, R. C., Wallace, P., Hart, S. L.
1. L-NG-nitro arginine methyl ester (L-NAME, 1-75 mg kg-1) administered intraperitoneally (i.p.) elicits dose-related antinociception in the mouse assessed by the formalin-induced paw licking...
Moore, P. K., Wallace, P., Gaffen, Z., Hart, S. L., Babbedge, R. C.
1. 7-Nitro indazole (7-NI, 10-50 mg kg-1), 6-nitro indazole and indazole (25-100 mg kg-1) administered i.p. in the mouse produce dose-related antinociception in the late phase of the formalin-induced...
Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families.
Harper, P S, Youngman, S, Anderson, M A, Sarfarazi, M, Quarrell, O, Tanzi, R, ...
Analysis of the polymorphism shown by the DNA probe G8 in eight South Wales families with Huntington's disease has confirmed close genetic linkage between this marker and the disorder, the most...
Can telemedicine be used to improve communication between primary and secondary care?
Harrison, R., Clayton, W., Wallace, P.
OBJECTIVE: To test feasibility and acceptability of teleconferencing routine outpatient consultations. DESIGN: Exploratory trial of teleconferenced outpatient referrals of general practitioners....
Population based study of fatigue and psychological distress.
Pawlikowska, T., Chalder, T., Hirsch, S. R., Wallace, P., Wright, D. J., Wessely, S. C.
OBJECTIVES--To determine the prevalence of fatigue in the general population and the factors associated with fatigue. DESIGN--Postal survey. SETTING--Six general practices in southern England....
Embedding guidelines into direct physician order entry: simple methods, powerful results.
Kaiser Permanente in the Northwest Region has implemented a comprehensive outpatient computer-based patient record (CPR). Using this system, clinicians electronically order laboratory tests,...