Newport, M, Sirugo, G, Lyons, E, Vannberg, F, Hill, AVS, Bradbury, LA, ...
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis ( AS), autoimmune thyroid disease...
CD14 variants in UK and Finnish ankylosing spondylitis families (2006)
Pointon, J. J., Beynon, O. C., Jaakkola, E., Laiho, K., Kauppi, M., Kaarela, K., ...
Analysis of positional candidate genes in ankylosing spondylitis: A possible role for ENPP1 (2006)
Pointon, JJ, Timms, AE, Bradbury, L, Brown, MA, Wordsworth, P
Hsieh, HJ, Palmer, CGS, Harney, S, Newton, JL, Wordsworth, P, Brown, MA, ...
The MFG test is a family-based association test that detects genetic effects contributing to disease in offspring, including offspring allelic effects, maternal allelic effects and MFG...
MacKay, K., Milicic, A., Lee, D., Tikly, M., Laval, S., Shatford, J., ...
Introduction. IL-10 is an immunoregulatory cytokine which may modulate disease expression in rheumatoid arthritis (RA). The IL-10 gene is highly polymorphic with a number of single nucleotide...
Williams, CJ, Zhan, Y, Timms, A, Bonavita, G, Caeiro, F, Broxholme, J, ...
MacKay, K, Eyre, S, Myerscough, A, Milicic, A, Barton, A, Laval, S, ...
Objective. To undertake a systematic wholegenome screen to identify regions exhibiting genetic linkage to rheumatoid arthritis (RA). Methods. Two hundred fifty-two RA-affected sibling pairs from 182...
Critical role for the Val/Gly86 HLA-DR beta dimorphism in autoantigen presentation to human T cells.
Ong, B, Willcox, N, Wordsworth, P, Beeson, D, Vincent, A, Altmann, D, ...
Helper T lymphocytes recognize fragments of foreign (or self) antigens in the peptide-binding clefts of major histocompatibility complex class II molecules; their activation is a crucial step in the...
HLA heterozygosity contributes to susceptibility to rheumatoid arthritis.
Wordsworth, P, Pile, K D, Buckely, J D, Lanchbury, J S, Ollier, B, Lathrop, M, ...
We have investigated the role of HLA-DR genotypes in 184 patients with severe rheumatoid arthritis (RA) and in 46 patients with Felty syndrome, to establish the relative contribution of the...
Critical role for the Val/Gly86 HLA-DR beta dimorphism in autoantigen presentation to human T cells.
Ong, B, Willcox, N, Wordsworth, P, Beeson, D, Vincent, A, Altmann, D, ...
Helper T lymphocytes recognize fragments of foreign (or self) antigens in the peptide-binding clefts of major histocompatibility complex class II molecules; their activation is a crucial step in the...
HLA heterozygosity contributes to susceptibility to rheumatoid arthritis.
Wordsworth, P, Pile, K D, Buckely, J D, Lanchbury, J S, Ollier, B, Lathrop, M, ...
We have investigated the role of HLA-DR genotypes in 184 patients with severe rheumatoid arthritis (RA) and in 46 patients with Felty syndrome, to establish the relative contribution of the...
Wordsworth, P, Ogilvie, D, Smith, R, Sykes, B
We have used a high frequency site polymorphism within the human pro-alpha 1(II) collagen gene (COL2A1) in order to examine the segregation of this gene within a large pedigree with type II...
Pile, K, Wordsworth, P, Lioté, F, Bardin, T, Bell, J, Cornélis, F
OBJECTIVES--The assessment of allelic polymorphism of the T cell receptor gene segment, TCRBV2S1, in rheumatoid arthritis. METHODS--A total of 136 patients with rheumatoid arthritis (RA) (ACR...
HLA class II antigens associated with systemic lupus erythematosus in black South Africans.
Rudwaleit, M, Tikly, M, Gibson, K, Pile, K, Wordsworth, P
OBJECTIVE--To assess the associations of HLA class II antigens with systemic lupus erythematosus (SLE) in black South Africans. METHODS--HLA-DRB1 genotype frequencies assigned by polymerase chain...
Analysis of T cell receptor V alpha polymorphisms in rheumatoid arthritis
Ibberson, M., Peclat, V., Guerne, P., Tiercy, J., Wordsworth, P., Lanchbury, J., ...
OBJECTIVE—To test for association of T cell receptor (TCR) V alpha polymorphisms and rheumatoid arthritis (RA) in British and Swiss white populations. METHODS—TCRAV polymorphisms were analysed...
Axford, J., Rees, D., Mageed, R., Wordsworth, P., Alavi, A., Steere, A.
OBJECTIVE—To investigate whether autoreactive mechanisms occur in Lyme disease (LD) by determining IgA, IgG and IgM rheumatoid factor (RF) concentrations and RF associated cross reactive idiotype...
Emery, P., Salmon, M., Bradley, H., Wordsworth, P., Tunn, E., Bacon, P. A., ...
OBJECTIVE--To determine whether genetic factors associated with established rheumatoid arthritis could, in combination with rheumatoid factor, predict the development of radiological erosions in...
Wordsworth, P, Ogilvie, D, Akhras, F, Jackson, G, Sykes, B
Three pedigrees were identified in which mitral valve prolapse seemed to be inherited as a mendelian autosomal dominant trait. The segregation of the genes encoding the major fibrillar collagens...
Ogilvie, D, Wordsworth, P, Thompson, E, Sykes, B
The structure of the locus encoding the major cartilage collagen gene (COL2A1) was studied in a total of 19 cases of achondroplasia. No gross rearrangements were seen. The segregation of COL2A1 was...
Wordsworth, P, Ogilvie, D, Priestley, L, Smith, R, Wynne-Davies, R, Sykes, B
Seventy-seven persons with a variety of heritable chondrodysplasias were screened for gross rearrangements of the structural gene encoding the major cartilage collagen, collagen II. None was found....