Bahit, M C, Granger, C B, Zoldhelyi, P, Ardissino, D, Brooks, L, ...
AIMS: We compared the effects of hirudin and heparin on thrombin generation and activity among 350 patients with acute coronary syndromes enrolled in the GUSTO-IIb trial. METHODS AND RESULTS: We...
Kottke-Marchant, K., Bahit, M.C., Granger, C.B., Zoldhelyi, P., Ardissino, D., Brooks, L., ...
Aims We compared the effects of hirudin and heparin on thrombin generation and activity among 350 patients with acute coronary syndromes enrolled in the GUSTO-IIb trial. Methods and Results We...
Pislaru, S, Van Pelt, N, Gerard, R D, Zoldhelyi, P, ...
BACKGROUND: Nitric oxide, synthesized from L-arginine by nitric oxide synthase (NOS), is a vasodilator and inhibits vascular smooth muscle cell (SMC) proliferation and migration. The effects of local...
Flaherty, D, Nong, Z, Varenne, O, Van Pelt, N, ...
BACKGROUND: Loss of endothelial NO production after arterial injury may contribute to restenosis, characterized by neointima formation and elastic recoil. Adenovirus-mediated transfer of the gene...
Bloch, K D, Nong, Z, Gerard, R D, Zoldhelyi, P
Nitric oxide (NO), a vasodilator involved in the regulation of pulmonary vascular tone, is synthesized by a family of enzymes, nitric oxide synthases (NOS). To investigate whether adenoviral-mediated...
Hirudin as a molecular probe for thrombin in vitro and during systemic coagulation in the pig.
Zoldhelyi, P, Chesebro, J H, Owen, W G
The amount of thrombin active in vivo in the intravascular space (blood and endothelial surface), both basally and in experimental intravascular coagulation, is measured by way of the accessibility...
Gene therapy for vascular diseases.
Wu, K K, Zoldhelyi, P, Willerson, J T, Xu, X M, Loose-Mitchell, D S, Wang, L H
Gene transfer by virus- and liposome-mediated vectors has potential for treating genetic diseases, cancer, and cardiovascular diseases. In this article, we discuss the general principle and...
Janssens, S P, Bloch, K D, Nong, Z, Gerard, R D, Zoldhelyi, P, Collen, D
Nitric oxide (NO), a vasodilator involved in the regulation of pulmonary vascular tone, is synthesized by a family of enzymes, nitric oxide synthases (NOS). To investigate whether adenoviral-mediated...
Hirudin as a molecular probe for thrombin in vitro and during systemic coagulation in the pig.
Zoldhelyi, P, Chesebro, J H, Owen, W G
The amount of thrombin active in vivo in the intravascular space (blood and endothelial surface), both basally and in experimental intravascular coagulation, is measured by way of the accessibility...
Gene therapy for vascular diseases.
Wu, K K, Zoldhelyi, P, Willerson, J T, Xu, X M, Loose-Mitchell, D S, Wang, L H
Gene transfer by virus- and liposome-mediated vectors has potential for treating genetic diseases, cancer, and cardiovascular diseases. In this article, we discuss the general principle and...
Janssens, S P, Bloch, K D, Nong, Z, Gerard, R D, Zoldhelyi, P, Collen, D
Nitric oxide (NO), a vasodilator involved in the regulation of pulmonary vascular tone, is synthesized by a family of enzymes, nitric oxide synthases (NOS). To investigate whether adenoviral-mediated...
Gene therapy to restore prostacyclin presence to injured endothelium.
Willerson, J. T., Zoldhelyi, P., Meidell, R., McNatt, J., Xu, X. M., Wu, K. K.
These preliminary studies demonstrate the feasibility of restoration of prostacyclin synthesis in mechanically-injured porcine carotid arteries following angioplasty. Our initial data suggest the...