A method for determining the robustness of bio-molecular oscillator models (2009)
Ghaemi, Reza, Sun, Jing, Iglesias, Pablo A, Del Vecchio, Domitilla
Abstract Background Quantifying the robustness of biochemical models is important both for determining the validity of a natural system model and for designing reliable and robust synthetic...
Modeling cellular deformations using the level set formalism (2008)
Yang, Liu, Effler, Janet C, Kutscher, Brett L, Sullivan, Sarah E, Robinson, Douglas N, Iglesias, Pablo A
Abstract Background Many cellular processes involve substantial shape changes. Traditional simulations of these cell shape changes require that grids and boundaries be moved as the cell's shape...
Signal Detection and Approximate Adaptation Implies an Approximate Internal Model (2008)
Burton W. Andrews, Pablo A. Iglesias
Abstract — The proper function of many biological systems requires that external perturbations be detected, allowing the system to adapt to these environmental changes. It is now well established...
Tang, Linnan, Franca-Koh, Jonathan, Xiong, Yuan, Chen, Mei-Yu, Long, Yu, Bickford, Ross M., ...
In a forward genetic screen for chemotaxis mutants in Dictyostelium discoideum, we identified a loss-of-function mutation, designated tsunami, encoding a homolog of the Fused kinase. Cells lacking...
Dynacortin facilitates polarization of chemotaxing cells (2007)
Kabacoff, Cathryn, Xiong, Yuan, Musib, Runa, Reichl, Elizabeth M, Kim, John, Iglesias, Pablo A, ...
Abstract Background Cell shape changes during cytokinesis and chemotaxis require regulation of the actin cytoskeletal network. Dynacortin, an actin cross-linking protein, localizes to the cell cortex...
Pablo A. Iglesias, Marc A. Peters
Characterizations for the induced norms of two types of systems are considered. It is first shown that the induced ` 2 norm of a discrete-time, linear time-varying system may be characterized by the...
An integrative approach to understanding mechanosensation (2007)
Poirier, Christopher C., Iglesias, Pablo A.
The ability for a living organism to sense and respond to its external environment is crucial to its survival. Understanding mechanosensation, the mechanism by which organisms react in response to...
An Information-Theoretic Characterization of the Optimal Gradient Sensing Response of Cells (2007)
Burton W. Andrews, Pablo A. Iglesias
Many cellular systems rely on the ability to interpret spatial heterogeneities in chemoattractant concentration to direct cell migration. The accuracy of this process is limited by stochastic...
An information-theoretic characterization of the optimal gradient sensing response of cells (2007)
Burt W Andrews, Pablo A Iglesias
Many cellular systems rely on the ability to interpret spatial heterogeneities in chemoattractant concentration to direct cell migration. The accuracy of this process is limited by stochastic...
Optimal Noise Filtering in the Chemotactic Response of Escherichia coli (2006)
Burton W. Andrews, Tau-Mu Yi, Pablo A. Iglesias
Information-carrying signals in the real world are often obscured by noise. A challenge for any system is to filter the signal from the corrupting noise. This task is particularly acute for the...
Optimal noise filtering in the chemotactic response of E. coli (2006)
Burt W Andrews, Tau-Mu Yi, Pablo A Iglesias
Information-carrying signals in the real world are often obscured by noise. A challenge for any system is to filter the signal from the corrupting noise. This task is particularly acute for the...
Robustness analysis of biochemical network models (2006)
Jongrae Kim, Declan G. Bates, Ian Postlethwaite, Lan Ma, Pablo A. Iglesias
Biological systems which have been experimentally verified to be robust to significant changes in their environments require mathematical models which are themselves robust. In this context, a...
Dynamic Properties of Network Motifs Contribute to Biological Network Organization (2005)
Robert J. Prill, Pablo A. Iglesias, Andre Levchenko
The authors model how network motifs respond to small-scale perturbations and find a strong correlation between motif stability and abundance in a network, suggesting that dynamic properties of...
Dynamic Properties of Network Motifs Contribute to Biological Network Organization (2005)
Robert J. Prill, Pablo A. Iglesias, Andre Levchenko
Biological networks, such as those describing gene regulation, signal transduction, and neural synapses, are representations of large-scale dynamic systems. Discovery of organizing principles of...
Quantifying robustness of biochemical network models (2002)
Abstract Background Robustness of mathematical models of biochemical networks is important for validation purposes and can be used as a means of selecting between different competing models. Tools...
Models of eukaryotic gradient sensing: Application to chemotaxis of amoebae and neutrophils (2002)
Andre Levchenko, Pablo A. Iglesias
ABSTRACT Eukaryotic cells can detect shallow gradients of chemoattractants with exquisite precision and respond quickly to changes in the gradient steepness and direction. Here, we describe a set of...
Research article Quantifying robustness of biochemical network models (2002)
Bmc Bioinformatics, Lan Ma, Pablo A Iglesias, Lan Ma, Pablo A Iglesias
Background: Robustness of mathematical models of biochemical networks is important for validation purposes and can be used as a means of selecting between different competing models. Tools for...
An Entropy Formula for Time-Varying Discrete-Time Control Systems (1996)
. The results of this paper generalize the formula for the entropy of a transfer function to time-varying systems. This is done through the use of some results on spectral factorizations due to...
An entropy formula for time-varying discrete-time control system (1994)
The results of this paper generalize the formula for the entropy of a transfer function to time-varying systems. This is done through the use of some results on spectral factorizations due to Arveson...
Minimum entropy control for discrete-time time-varying systems: The full information problem (1994)
Marc A. Peters, Pablo A. Iglesias
Discrete-time linear time-varying can be represented using infinite dimensional operators. Using this representation the well-known definition of the entropy for time-invariant systems can be...
Minimum entropy control for discrete-time time-varying systems: The full information problem (1994)
Marc A. Peters, Pablo A. Iglesias
The representation of discrete-time time-varying systems using infinite dimensional operators has shown to be suitable for extending the entropy as it is defined for time-invariant systems. In this...
Input-Output Stability of Sampled-Data Linear Time-Varying Systems (1994)
In this paper we consider the input-ouput stability of feedback systems consisting of a continuous-time, linear, time-varying plant with a discrete-time, linear time-varying controller. These results...
Janetopoulos, Chris, Ma, Lan, Devreotes, Peter N., Iglesias, Pablo A.
Experiments in amoebae and neutrophils have shown that local accumulations of phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] mediate the ability of cells to migrate during gradient sensing....
Dynamic Properties of Network Motifs Contribute to Biological Network Organization
Prill, Robert J, Iglesias, Pablo A, Levchenko, Andre
Biological networks, such as those describing gene regulation, signal transduction, and neural synapses, are representations of large-scale dynamic systems. Discovery of organizing principles of...
Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils.
Levchenko, Andre, Iglesias, Pablo A
Eukaryotic cells can detect shallow gradients of chemoattractants with exquisite precision and respond quickly to changes in the gradient steepness and direction. Here, we describe a set of models...
Ma, Lan, Janetopoulos, Chris, Yang, Liu, Devreotes, Peter N., Iglesias, Pablo A.
Chemotaxing cells, such as Dictyostelium and mammalian neutrophils, sense shallow chemoattractant gradients and respond with highly polarized changes in cell morphology and motility. Uniform...
Optimal Noise Filtering in the Chemotactic Response of Escherichia coli
Andrews, Burton W, Yi, Tau-Mu, Iglesias, Pablo A
Information-carrying signals in the real world are often obscured by noise. A challenge for any system is to filter the signal from the corrupting noise. This task is particularly acute for the...
Janetopoulos, Chris, Ma, Lan, Devreotes, Peter N., Iglesias, Pablo A.
Experiments in amoebae and neutrophils have shown that local accumulations of phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] mediate the ability of cells to migrate during gradient sensing....
Dynamic Properties of Network Motifs Contribute to Biological Network Organization
Prill, Robert J, Iglesias, Pablo A, Levchenko, Andre
Biological networks, such as those describing gene regulation, signal transduction, and neural synapses, are representations of large-scale dynamic systems. Discovery of organizing principles of...
Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils.
Levchenko, Andre, Iglesias, Pablo A
Eukaryotic cells can detect shallow gradients of chemoattractants with exquisite precision and respond quickly to changes in the gradient steepness and direction. Here, we describe a set of models...
Ma, Lan, Janetopoulos, Chris, Yang, Liu, Devreotes, Peter N., Iglesias, Pablo A.
Chemotaxing cells, such as Dictyostelium and mammalian neutrophils, sense shallow chemoattractant gradients and respond with highly polarized changes in cell morphology and motility. Uniform...
Optimal Noise Filtering in the Chemotactic Response of Escherichia coli
Andrews, Burton W, Yi, Tau-Mu, Iglesias, Pablo A
Information-carrying signals in the real world are often obscured by noise. A challenge for any system is to filter the signal from the corrupting noise. This task is particularly acute for the...
An Information-Theoretic Characterization of the Optimal Gradient Sensing Response of Cells
Andrews, Burton W, Iglesias, Pablo A
Many cellular systems rely on the ability to interpret spatial heterogeneities in chemoattractant concentration to direct cell migration. The accuracy of this process is limited by stochastic...
Dynacortin facilitates polarization of chemotaxing cells
Kabacoff, Cathryn, Xiong, Yuan, Musib, Runa, Reichl, Elizabeth M, Kim, John, Iglesias, Pablo A, ...
Modeling cellular deformations using the level set formalism
Yang, Liu, Effler, Janet C, Kutscher, Brett L, Sullivan, Sarah E, Robinson, Douglas N, Iglesias, Pablo A
tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis
Tang, Linnan, Franca-Koh, Jonathan, Xiong, Yuan, Chen, Mei-Yu, Long, Yu, Bickford, Ross M., ...
In a forward genetic screen for chemotaxis mutants in Dictyostelium discoideum, we identified a loss-of-function mutation, designated tsunami, encoding a homolog of the Fused kinase. Cells lacking...
Spatial Regulation Improves Antiparallel Microtubule Overlap during Mitotic Spindle Assembly
Channels, Wilbur E., Nédélec, François J., Zheng, Yixian, Iglesias, Pablo A.
The mitotic spindle plays an essential role in chromosome segregation during cell division. Spindle formation and proper function require that microtubules with opposite polarity overlap and...