Page W. Caufield

Publication List Details

Period

1985 - 1995

Number

28

Co-Authors

Mutacin II, a Bactericidal Lantibiotic from Streptococcus mutans (1995)

Chikindas, Michael L., Novák, Jan, Driessen, Arnold J.M., Konings, Wil N., Schilling, Kurt M., Caufield, Page W.

Mutacin II is a lantibiotic that is produced by group II Streptococcus mutans. It inhibits the growth of other streptococci as well as many other gram-positive microorganisms by a hitherto unknown...

Genotypic Diversity of Mutans Streptococci in Brazilian Nursery Children Suggests Horizontal Transmission

Mattos-Graner, Renata O., Li, Yihong, Caufield, Page W., Duncan, Margaret, Smith, Daniel J.

Streptococcus mutans strains were isolated from cohorts of Brazilian nursery school children and genotyped by arbitrarily primed PCR and restriction fragment length polymorphism analysis. Of 24...

Functional Analyses of the Promoters in the Lantibiotic Mutacin II Biosynthetic Locus in Streptococcus mutans

Qi, Fengxia, Chen, Ping, Caufield, Page W.

The lantibiotic bacteriocin mutacin II is produced by the group II Streptococcus mutans. The mutacin II biosynthetic locus consists of seven genes, mutR, -A, -M, -T, -F, -E, and -G, organized as two...

The Specific Genes for Lantibiotic Mutacin II Biosynthesis in Streptococcus mutans T8 Are Clustered and Can Be Transferred En Bloc

Chen, Ping, Qi, FengXia, Novak, Jan, Caufield, Page W.

Mutacin II is a ribosomally synthesized peptide lantibiotic produced by group II Streptococcus mutans. DNA sequencing has revealed that the mutacin II biosynthetic gene cluster consists of seven...

Purification and Biochemical Characterization of Mutacin I from the Group I Strain of Streptococcus mutans, CH43, and Genetic Analysis of Mutacin I Biosynthesis Genes

Qi, Fengxia, Chen, Ping, Caufield, Page W.

Previously, we reported isolation and characterization of mutacin III and genetic analysis of mutacin III biosynthesis genes from the group III strain of Streptococcus mutans, UA787 (F. Qi, P. Chen,...

The Group I Strain of Streptococcus mutans, UA140, Produces Both the Lantibiotic Mutacin I and a Nonlantibiotic Bacteriocin, Mutacin IV

Qi, Fengxia, Chen, Ping, Caufield, Page W.

Strains of Streptococcus mutans produce at least three mutacins, I, II, and III. Mutacin II is a member of subgroup AII in the lantibiotic family of bacteriocins, and mutacins I and III belong to...

Purification of Mutacin III from Group III Streptococcus mutans UA787 and Genetic Analyses of Mutacin III Biosynthesis Genes

Qi, Fengxia, Chen, Ping, Caufield, Page W.

Previously, members of our group reported the isolation and characterization of mutacin II from Streptococcus mutans T8 and the genetic analyses of the mutacin II biosynthesis genes (J. Novak, P. W....

Natural History of Streptococcus sanguinis in the Oral Cavity of Infants: Evidence for a Discrete Window of Infectivity

Caufield, Page W., Dasanayake, Ananda P., Li, Yihong, Pan, Yaping, Hsu, Jay, Hardin, J. Michael

The heterogeneous group of oral bacteria within the sanguinis (sanguis) streptococci comprise members of the indigenous biota of the human oral cavity. While the association of Streptococcus...

Structure-Activity Study of the Lantibiotic Mutacin II from Streptococcus mutans T8 by a Gene Replacement Strategy

Chen, Ping, Novak, Jan, Kirk, Marion, Barnes, Stephen, Qi, FengXia, Caufield, Page W.

Mutacin II, elaborated by group II Streptococcus mutans, is a ribosomally synthesized and posttranslationally modified polypeptide antibiotic containing unusual thioether and didehydro amino acids....

Diacylglycerol Kinase Is Involved in Regulation of Expression of the Lantibiotic Mutacin II of Streptococcus mutans

Chen, Ping, Novak, Jan, Qi, Fengxia, Caufield, Page W.

Genetic characterization of a Tn916 transposon mutant, Streptococcus mutans T8-1, defective in mutacin II production, revealed that the transposon was inserted into the 3′ region of a...

Identification of Streptococcus sanguinis with a PCR-Generated Species-Specific DNA Probe

Li, Yihong, Pan, Yaping, Qi, Fengxia, Caufield, Page W.

The objective of the present study was to design a PCR-generated DNA probe and determine the specificity of the probe for the identification of clinical isolates of Streptococcus sanguinis. To do...

Identification of Unique Bacterial Gene Segments from Streptococcus mutans with Potential Relevance to Dental Caries by Subtraction DNA Hybridization

Saxena, Deepak, Li, Yihong, Caufield, Page W.

Using DNA subtractive hybridization, 49 unique gene segments were identified from a strain of Streptococcus mutans that was isolated from a patient with severe early childhood caries (S-ECC). Further...

Genotypic Diversity of Mutans Streptococci in Brazilian Nursery Children Suggests Horizontal Transmission

Mattos-Graner, Renata O., Li, Yihong, Caufield, Page W., Duncan, Margaret, Smith, Daniel J.

Streptococcus mutans strains were isolated from cohorts of Brazilian nursery school children and genotyped by arbitrarily primed PCR and restriction fragment length polymorphism analysis. Of 24...

Functional Analyses of the Promoters in the Lantibiotic Mutacin II Biosynthetic Locus in Streptococcus mutans

Qi, Fengxia, Chen, Ping, Caufield, Page W.

The lantibiotic bacteriocin mutacin II is produced by the group II Streptococcus mutans. The mutacin II biosynthetic locus consists of seven genes, mutR, -A, -M, -T, -F, -E, and -G, organized as two...

The Specific Genes for Lantibiotic Mutacin II Biosynthesis in Streptococcus mutans T8 Are Clustered and Can Be Transferred En Bloc

Chen, Ping, Qi, FengXia, Novak, Jan, Caufield, Page W.

Mutacin II is a ribosomally synthesized peptide lantibiotic produced by group II Streptococcus mutans. DNA sequencing has revealed that the mutacin II biosynthetic gene cluster consists of seven...

Purification and Biochemical Characterization of Mutacin I from the Group I Strain of Streptococcus mutans, CH43, and Genetic Analysis of Mutacin I Biosynthesis Genes

Qi, Fengxia, Chen, Ping, Caufield, Page W.

Previously, we reported isolation and characterization of mutacin III and genetic analysis of mutacin III biosynthesis genes from the group III strain of Streptococcus mutans, UA787 (F. Qi, P. Chen,...

The Group I Strain of Streptococcus mutans, UA140, Produces Both the Lantibiotic Mutacin I and a Nonlantibiotic Bacteriocin, Mutacin IV

Qi, Fengxia, Chen, Ping, Caufield, Page W.

Strains of Streptococcus mutans produce at least three mutacins, I, II, and III. Mutacin II is a member of subgroup AII in the lantibiotic family of bacteriocins, and mutacins I and III belong to...

Purification of Mutacin III from Group III Streptococcus mutans UA787 and Genetic Analyses of Mutacin III Biosynthesis Genes

Qi, Fengxia, Chen, Ping, Caufield, Page W.

Previously, members of our group reported the isolation and characterization of mutacin II from Streptococcus mutans T8 and the genetic analyses of the mutacin II biosynthesis genes (J. Novak, P. W....

Natural History of Streptococcus sanguinis in the Oral Cavity of Infants: Evidence for a Discrete Window of Infectivity

Caufield, Page W., Dasanayake, Ananda P., Li, Yihong, Pan, Yaping, Hsu, Jay, Hardin, J. Michael

The heterogeneous group of oral bacteria within the sanguinis (sanguis) streptococci comprise members of the indigenous biota of the human oral cavity. While the association of Streptococcus...

Structure-Activity Study of the Lantibiotic Mutacin II from Streptococcus mutans T8 by a Gene Replacement Strategy

Chen, Ping, Novak, Jan, Kirk, Marion, Barnes, Stephen, Qi, FengXia, Caufield, Page W.

Mutacin II, elaborated by group II Streptococcus mutans, is a ribosomally synthesized and posttranslationally modified polypeptide antibiotic containing unusual thioether and didehydro amino acids....

Diacylglycerol Kinase Is Involved in Regulation of Expression of the Lantibiotic Mutacin II of Streptococcus mutans

Chen, Ping, Novak, Jan, Qi, Fengxia, Caufield, Page W.

Genetic characterization of a Tn916 transposon mutant, Streptococcus mutans T8-1, defective in mutacin II production, revealed that the transposon was inserted into the 3′ region of a...

Identification of Streptococcus sanguinis with a PCR-Generated Species-Specific DNA Probe

Li, Yihong, Pan, Yaping, Qi, Fengxia, Caufield, Page W.

The objective of the present study was to design a PCR-generated DNA probe and determine the specificity of the probe for the identification of clinical isolates of Streptococcus sanguinis. To do...

Identification of Unique Bacterial Gene Segments from Streptococcus mutans with Potential Relevance to Dental Caries by Subtraction DNA Hybridization

Saxena, Deepak, Li, Yihong, Caufield, Page W.

Using DNA subtractive hybridization, 49 unique gene segments were identified from a strain of Streptococcus mutans that was isolated from a patient with severe early childhood caries (S-ECC). Further...

Population Structure of Plasmid-Containing Strains of Streptococcus mutans, a Member of the Human Indigenous Biota▿

Caufield, Page W., Saxena, Deepak, Fitch, David, Li, Yihong

There are suggestions that the phylogeny of Streptococcus mutans, a member of the human indigenous biota that is transmitted mostly mother to child, might parallel the evolutionary history of its...

Genetic Classification of Severe Early Childhood Caries by Use of Subtracted DNA Fragments from Streptococcus mutans▿

Saxena, Deepak, Caufield, Page W., Li, Yihong, Brown, Stuart, Song, Jinmei, Norman, Robert

Streptococcus mutans is one of several members of the oral indigenous biota linked with severe early childhood caries (S-ECC). Because most humans harbor S. mutans, but not all manifest disease, it...