Crystal structure of TNFα complexed with a poxvirus MHC-related TNF binding protein (2009)
Yang, Zhiru, Bjorkman, Pamela J.
The poxvirus 2L protein binds tumor necrosis factor-α (TNFα) to inhibit host antiviral and immune responses. The 2.8-Å 2L–TNFα structure reveals three symmetrically arranged 2L molecules per...
Galimidi, Rachel P., Foglesong, Christopher P., Gnanapragasam, Priyanthi N. P., Klein, Joshua S., Bjorkman, Pamela J.
The envelope glycoprotein of Human Immunodeficiency Virus-1 (HIV-1) has several adaptations that allow the virus to evade antibody neutralization. Nevertheless, a few broadly cross reactive...
Nanogold as a specific marker for electron cryotomography (2009)
He, Yongning, Jensen, Grant J., Bjorkman, Pamela J.
While electron cryotomography (ECT) provides “molecular” resolution, three-dimensional images of unique biological specimens, sample crowdedness, and/or resolution limitations can make it...
He, Yongning, Jensen, Grant J., Bjorkman, Pamela J.
The neural cell adhesion molecule L1 participates in homophilic interactions important for axon guidance and neuronal development. The structural details of homophilic adhesion mediated by L1 and...
Galimidi, Rachel P., Foglesong, Christopher P., Gnanapragasam, Priyanthi N. P., Huey-Tubman, Kathryn E., Klein, Joshua S., ...
The antigen-binding fragment of the broadly neutralizing human immunodeficiency virus type 1 (HIV-1) antibody 2G12 has an unusual three-dimensional (3D) domain-swapped structure with two aligned...
The Crystal Structure of CHIR-AB1: A Primordial Avian Classical Fc Receptor (2008)
Arnon, Tal I., Kaiser, Jens T., Olson, Rich, Diskin, Ron, Viertlboeck, Birgit C., ...
CHIR-AB1 is a newly identified avian immunoglobulin (Ig) receptor that includes both activating and inhibitory motifs and was therefore classified as a potentially bifunctional receptor. Recently,...
Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptor (2008)
Yang, Zhiru, Bjorkman, Pamela J.
UL18 is a human cytomegalovirus class I MHC (MHCI) homolog that binds the host inhibitory receptor LIR-1 and the only known viral MHC homolog that presents peptides. The 2.2-Å structure of a...
Zhang, An-Sheng, Yang, Fan, Meyer, Kathrin, Hernandez, Catalina, Chapman-Arvedson, Tara, Bjorkman, Pamela J., ...
Hemochromatosis type 2 gene (HFE2) is highly expressed in skeletal muscle and liver hepatocytes. Its encoded protein, hemojuvelin (HJV), is a co-receptor for the bone morphogenetic proteins 2 and 4...
The Human Cytomegalovirus Fc Receptor gp68 Binds the Fc CH2-CH3 Interface of Immunoglobulin G (2008)
Sprague, Elizabeth R., Reinhard, Henrike, Cheung, Evelyn J., Farley, Alexander H., Deis Trujillo, Robin, Hengel, Helmut, ...
Recognition of immunoglobulin G (IgG) by surface receptors for the Fc domain of immunoglobulin G (Fc{gamma}), Fc{gamma}Rs, can trigger both humoral and cellular immune responses. Two human...
Tesar, Devin B., Cheung, Evelyn J., Bjorkman, Pamela J.
In mammals the transfer of passive immunity from mother to young is mediated by the MHC-related receptor FcRn, which transports maternal IgG across epithelial cell barriers. In birds, maternal IgY in...
Galimidi, Rachel P., Foglesong, Christopher P., Gnanapragasam, Priyanthi N. P., Huey-Tubman, Kathryn E., Klein, Joshua S., ...
The antigen-binding fragment of the broadly neutralizing Human Immunodeficiency Virus Type 1 (HIV-1) antibody 2G12 has an unusual 3D domain-swapped structure with two aligned combining sites that...
Tesar, Devin B., Tiangco, Noreen E., Bjorkman, Pamela J.
The neonatal Fc receptor (FcRn) transports IgG across epithelial cell barriers to provide maternal antibodies to offspring and serves as a protection receptor by rescuing endocytosed IgG and albumin...
Sprague, Elizabeth R., Wang, Chu, Baker, David, Bjorkman, Pamela J.
Herpes simplex virus type-1 expresses a heterodimeric Fc receptor, gE-gI, on the surfaces of virions and infected cells that binds the Fc region of host immunoglobulin G and is implicated in the...
Elizabeth R. Sprague, Chu Wang, David Baker, Pamela J. Bjorkman
The structure of the C-terminal domain of Herpes simplex virus type-1 Fc receptor identifies interface regions implicated in cell-to-cell spread of virus.
Elizabeth R. Sprague, Chu Wang, David Baker, Pamela J. Bjorkman
Herpes simplex virus type-1 expresses a heterodimeric Fc receptor, gE-gI, on the surfaces of virions and infected cells that binds the Fc region of host immunoglobulin G and is implicated in the...
FcRn mediates elongated serum half-life of human IgG in cattle (2006)
Kacskovics, Imre, Kis, Zsuzsanna, Mayer, Balázs, West, Anthony P., Tiangco, Noreen E., Tilahun, Mulualem, ...
IgG has the longest survival time in the circulation of the Ig classes and the lowest fractional catabolic rate. The neonatal Fc receptor (FcRn) plays an important role in regulating these processes....
FcRn mediates elongated serum half-life of human IgG in cattle (2006)
Kacskovics, Imre, Kis, Zsuzsanna, Mayer, Balázs, West, Anthony P., Tiangco, Noreen E., Tilahun, Mulualem, ...
IgG has the longest survival time in the circulation of the Ig classes and the lowest fractional catabolic rate. The neonatal Fc receptor (FcRn) plays an important role in regulating these processes....
Zhang, An-Sheng, Wyman, Anne E., Bjorkman, Pamela J., Enns, Caroline A.
Type 2 hereditary hemochromatosis (HH) or juvenile hemochromatosis is an early onset, genetically heterogeneous, autosomal recessive disorder of iron overload. Type 2A HH is caused by mutations in...
Structure of a Pheromone Receptor-Associated MHC Molecule with an Open and Empty Groove (2005)
Olson, Rich, Huey-Tubman, Kathryn E., Dulac, Catherine, Bjorkman, Pamela J.
Neurons in the murine vomeronasal organ (VNO) express a family of class Ib major histocompatibility complex (MHC) proteins (M10s) that interact with the V2R class of VNO receptors. This interaction...
Structure of a Pheromone Receptor-Associated MHC Molecule with an Open and Empty Groove (2005)
Rich Olson, Catherine Dulac, Pamela J. Bjorkman
MHC-like protein M10.5 is expressed in the vomeronasal organ. The structure does not bind endogenous class I-binding peptides, but is thought to interact with a larger V2R pheromone receptor.
Structure of a Pheromone Receptor-Associated MHC Molecule with an Open and Empty Groove (2005)
Rich Olson, Catherine Dulac, Pamela J. Bjorkman
Neurons in the murine vomeronasal organ (VNO) express a family of class Ib major histocompatibility complex (MHC) proteins (M10s) that interact with the V2R class of VNO receptors. This interaction...
Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase (2005)
Davis, Mindy I., Bennett, Melanie J., Thomas, Leonard M., Bjorkman, Pamela J.
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer cells and nonprostatic solid tumor neovasculature and is a target for anticancer imaging and therapeutic agents. PSMA...
Giannetti, Anthony M., Bjorkman, Pamela J.
Transferrin receptor (TfR) is a dimeric cell surface protein that binds both the serum iron transport protein transferrin (Fe-Tf) and HFE, the protein mutated in patients with the iron overload...
Sprague, Elizabeth R., Martin, W. Lance, Bjorkman, Pamela J.
Herpes simplex virus type 1 encodes two glycoproteins, gE and gI, that form a heterodimer on the surface of virions and infected cells. The gE-gI heterodimer has been implicated in cell-to-cell...
Willcox, Benjamin E., Thomas, Leonard M., Chapman, Tara L., Heikema, Astrid P., Bjorkman, Pamela J.
Background: Leukocyte Immunoglobulin-like Receptor-1 (LIR-1) and LIR-2 (also known as ILT2 and ILT4 respectively) are highly related cell surface receptors that bind a broad range of class I MHC...
Willcox, Benjamin E, Thomas, Leonard M, Chapman, Tara L, Heikema, Astrid P, West, Anthony P, Bjorkman, Pamela J
Abstract Background Leukocyte Immunoglobulin-like Receptor-1 (LIR-1) and LIR-2 (also known as ILT2 and ILT4 respectively) are highly related cell surface receptors that bind a broad range of class I...
Kennedy, Malcolm W., Heikema, Astrid P., Cooper, Alan, Bjorkman, Pamela J., Sanchez, Luis M.
Zn-alpha2-glycoprotein (ZAG) is a member of the major histocompatibility complex (MHC) class I family of proteins and is identical in amino acid sequence to a tumor-derived lipid-mobilizing factor...
Bennett, Melanie J., Sellers, Vera M., Andrews, Nancy C., Enns, Caroline A., Bjorkman, Pamela J.
The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis. A second receptor for Tf, TfR2,...
Chapman, Tara L., You, Il, Joseph, Ian M., Bjorkman, Pamela J., Morrison, Sherie L., Raghavan, Malini
Herpes simplex virus type I (HSV-1) virions and HSV-1-infected cells bind to human immunoglobulin G (hIgG) via its Fc region. A complex of two surface glycoproteins encoded by HSV-1, gE and gI, is...
Sanchez, Luis, Bjorkman, Pamela J.
Zn-alpha- 2-glycoprotein (ZAG) is a soluble protein that is present in serum and other body fluids. In addition, ZAG accumulates in breast cysts as well as in 40% of breast carcinomas. ZAG stimulates...
Chapman, Tara L., Bjorkman, Pamela J.
Both human and murine cytomegaloviruses (HCMV and MCMV) down-regulate expression of conventional class I major histocompatibility complex (MHC) molecules at the surfaces of infected cells. This...
Bjorkman, Pamela J., Dougherty, Dennis A., Lester, Henry A.
To provide material suitable for structural studies of the nicotinic acetylcholine receptor, we have expressed and purified the NH2-terminal extracellular domain of the mouse muscle alpha subunit....
Expression and Circular Dichroism Studies of the Extracellular Domain of the (1997)
Subunit Of The, Anthony P. West, Pamela J. Bjorkman, Dennis A. Dougherty, Henry A. Lester
this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertise- ment" in accordance with 18 U.S.C. Section 1734 solely to...
Fc receptors and their interactions with immunoglobulins (1996)
Raghavan, Malini, Bjorkman, Pamela J.
Receptors for the Fc domain of immunoglobulins play an important role in immune defense. There are two well-defined functional classes of mammalian receptors. One class of receptors transports...
Fahnestock, Margaret L., Dadgari, Joseph M., McMillan, Minnie, Bjorkman, Pamela J.
A gene encoding a phosphatidyl inosltoHlnked form of the murine class I MHC molecule H-2Kd was constructed and the protein expressed in Chinese hamster ovary cells together with murine or human...
Structure, Function, and Diversity of Class I Major Histocompatibility Complex Molecules (1990)
Bjorkman, Pamela J., Parham, Peter
Lymphocytes are the agents of antigenic specificity in the immune response. They divide into two groups: B cells that make immunoglobulins (Igs), and cells that perform a heterogenous set of...
Feder, John N., Penny, David M., Irrinki, Alivelu, Lee, Vince K., Lebrón, José A., Watson, Nicole, ...
We recently reported the positional cloning of a candidate gene for hereditary hemochromatosis called HFE. The gene product, a member of the major histocompatibility complex class I-like family, was...
Sánchez, Luis M., López-Otín, Carlos, Bjorkman, Pamela J.
Zn-α2-glycoprotein (ZAG) is a 41-kDa soluble protein that is present in most bodily fluids. In addition, ZAG accumulates in fluids from breast cysts and in 40% of breast carcinomas, which suggests...
West, Anthony P., Llamas, Lynda L., Snow, Peter M., Benzer, Seymour, Bjorkman, Pamela J.
The Drosophila mutant methuselah (mth) was identified from a screen for single gene mutations that extended average lifespan. Mth mutants have a 35% increase in average lifespan and increased...
Chapman, Tara L., Bjorkman, Pamela J.
Both human and murine cytomegaloviruses (HCMV and MCMV) down-regulate expression of conventional class I major histocompatibility complex (MHC) molecules at the surfaces of infected cells. This...
IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution
Ramalingam, T.S., Detmer, Scott A., Martin, W.Lance, Bjorkman, Pamela J.
The neonatal Fc receptor (FcRn) transports IgG across epithelial cells and recycles serum IgG. FcRn binds IgG at the acidic pH of endosomes and releases IgG at the basic pH of blood. We expressed rat...
A linear lattice model for polyglutamine in CAG-expansion diseases
Bennett, Melanie J., Huey-Tubman, Kathryn E., Herr, Andrew B., West, Anthony P., Ross, Scott A., Bjorkman, Pamela J.
Huntington's disease and several other neurological diseases are caused by expanded polyglutamine [poly(Gln)] tracts in different proteins. Mechanisms for expanded (>36 Gln residues) poly(Gln)...
Willcox, Benjamin E, Thomas, Leonard M, Chapman, Tara L, Heikema, Astrid P, West, Anthony P, Bjorkman, Pamela J
Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae
Luo, Rensheng, Mann, Beth, Lewis, William S, Rowe, Arthur, Heath, Richard, Stewart, Michael L, ...
Streptococcus pneumoniae (pneumococcus) remains a significant health threat worldwide, especially to the young and old. While some of the biomolecules involved in pneumococcal pathogenesis are known...
Structure of a Pheromone Receptor-Associated MHC Molecule with an Open and Empty Groove
Olson, Rich, Huey-Tubman, Kathryn E, Dulac, Catherine, Bjorkman, Pamela J
Neurons in the murine vomeronasal organ (VNO) express a family of class Ib major histocompatibility complex (MHC) proteins (M10s) that interact with the V2R class of VNO receptors. This interaction...
Sprague, Elizabeth R, Wang, Chu, Baker, David, Bjorkman, Pamela J
Herpes simplex virus type-1 expresses a heterodimeric Fc receptor, gE-gI, on the surfaces of virions and infected cells that binds the Fc region of host immunoglobulin G and is implicated in the...
Tesar, Devin B, Tiangco, Noreen E, Bjorkman, Pamela J
The neonatal Fc receptor (FcRn) transports IgG across epithelial cell barriers to provide maternal antibodies to offspring and serves as a protection receptor by rescuing endocytosed IgG and albumin...
Feder, John N., Penny, David M., Irrinki, Alivelu, Lee, Vince K., Lebrón, José A., Watson, Nicole, ...
We recently reported the positional cloning of a candidate gene for hereditary hemochromatosis called HFE. The gene product, a member of the major histocompatibility complex class I-like family, was...
Sánchez, Luis M., López-Otín, Carlos, Bjorkman, Pamela J.
Zn-α2-glycoprotein (ZAG) is a 41-kDa soluble protein that is present in most bodily fluids. In addition, ZAG accumulates in fluids from breast cysts and in 40% of breast carcinomas, which suggests...
West, Anthony P., Llamas, Lynda L., Snow, Peter M., Benzer, Seymour, Bjorkman, Pamela J.
The Drosophila mutant methuselah (mth) was identified from a screen for single gene mutations that extended average lifespan. Mth mutants have a 35% increase in average lifespan and increased...
Chapman, Tara L., Bjorkman, Pamela J.
Both human and murine cytomegaloviruses (HCMV and MCMV) down-regulate expression of conventional class I major histocompatibility complex (MHC) molecules at the surfaces of infected cells. This...
IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution
Ramalingam, T.S., Detmer, Scott A., Martin, W.Lance, Bjorkman, Pamela J.
The neonatal Fc receptor (FcRn) transports IgG across epithelial cells and recycles serum IgG. FcRn binds IgG at the acidic pH of endosomes and releases IgG at the basic pH of blood. We expressed rat...
A linear lattice model for polyglutamine in CAG-expansion diseases
Bennett, Melanie J., Huey-Tubman, Kathryn E., Herr, Andrew B., West, Anthony P., Ross, Scott A., Bjorkman, Pamela J.
Huntington's disease and several other neurological diseases are caused by expanded polyglutamine [poly(Gln)] tracts in different proteins. Mechanisms for expanded (>36 Gln residues) poly(Gln)...
Willcox, Benjamin E, Thomas, Leonard M, Chapman, Tara L, Heikema, Astrid P, West, Anthony P, Bjorkman, Pamela J
Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae
Luo, Rensheng, Mann, Beth, Lewis, William S, Rowe, Arthur, Heath, Richard, Stewart, Michael L, ...
Streptococcus pneumoniae (pneumococcus) remains a significant health threat worldwide, especially to the young and old. While some of the biomolecules involved in pneumococcal pathogenesis are known...
Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase
Davis, Mindy I., Bennett, Melanie J., Thomas, Leonard M., Bjorkman, Pamela J.
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer cells and nonprostatic solid tumor neovasculature and is a target for anticancer imaging and therapeutic agents. PSMA...
Structure of a Pheromone Receptor-Associated MHC Molecule with an Open and Empty Groove
Olson, Rich, Huey-Tubman, Kathryn E, Dulac, Catherine, Bjorkman, Pamela J
Neurons in the murine vomeronasal organ (VNO) express a family of class Ib major histocompatibility complex (MHC) proteins (M10s) that interact with the V2R class of VNO receptors. This interaction...
Sprague, Elizabeth R, Wang, Chu, Baker, David, Bjorkman, Pamela J
Herpes simplex virus type-1 expresses a heterodimeric Fc receptor, gE-gI, on the surfaces of virions and infected cells that binds the Fc region of host immunoglobulin G and is implicated in the...
Tesar, Devin B, Tiangco, Noreen E, Bjorkman, Pamela J
The neonatal Fc receptor (FcRn) transports IgG across epithelial cell barriers to provide maternal antibodies to offspring and serves as a protection receptor by rescuing endocytosed IgG and albumin...
Liu, Yang, Chirino, Arthur J., Misulovin, Ziva, Leteux, Christine, Feizi, Ten, Nussenzweig, Michel C., ...
The macrophage and epithelial cell mannose receptor (MR) binds carbohydrates on foreign and host molecules. Two portions of MR recognize carbohydrates: tandemly arranged C-type lectin domains...
Leong, Clement C., Chapman, Tara L., Bjorkman, Pamela J., Formankova, Danuska, Mocarski, Edward S., Phillips, Joseph H., ...
Natural killer (NK) cells have been implicated in early immune responses against certain viruses, including cytomegalovirus (CMV). CMV causes downregulation of class I major histocompatibility...
Tesar, Devin B., Cheung, Evelyn J., Bjorkman, Pamela J.
In mammals the transfer of passive immunity from mother to young is mediated by the MHC-related receptor FcRn, which transports maternal IgG across epithelial cell barriers. In birds, maternal IgY in...
The Human Cytomegalovirus Fc Receptor gp68 Binds the Fc CH2-CH3 Interface of Immunoglobulin G▿
Sprague, Elizabeth R., Reinhard, Henrike, Cheung, Evelyn J., Farley, Alexander H., Trujillo, Robin Deis, Hengel, Hartmut, ...
Recognition of immunoglobulin G (IgG) by surface receptors for the Fc domain of immunoglobulin G (Fcγ), FcγRs, can trigger both humoral and cellular immune responses. Two human cytomegalovirus...
Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptor
Yang, Zhiru, Bjorkman, Pamela J.
UL18 is a human cytomegalovirus class I MHC (MHCI) homolog that binds the host inhibitory receptor LIR-1 and the only known viral MHC homolog that presents peptides. The 2.2-Å structure of a...
Neogenin-mediated Hemojuvelin Shedding Occurs after Hemojuvelin Traffics to the Plasma Membrane*
Zhang, An-Sheng, Yang, Fan, Meyer, Kathrin, Hernandez, Catalina, Chapman-Arvedson, Tara, Bjorkman, Pamela J., ...
HFE2 (hemochromatosis type 2 gene) is highly expressed in skeletal muscle and liver hepatocytes. Its encoded protein, hemojuvelin (HJV), is a co-receptor for the bone morphogenetic proteins 2 and 4...
West, Anthony P., Galimidi, Rachel P., Foglesong, Christopher P., Gnanapragasam, Priyanthi N. P., Huey-Tubman, Kathryn E., Klein, Joshua S., ...
The antigen-binding fragment of the broadly neutralizing human immunodeficiency virus type 1 (HIV-1) antibody 2G12 has an unusual three-dimensional (3D) domain-swapped structure with two aligned...
Klein, Joshua S., Gnanapragasam, Priyanthi N. P., Galimidi, Rachel P., Foglesong, Christopher P., West, Anthony P., Bjorkman, Pamela J.
Monoclonal antibodies b12 and 4E10 are broadly neutralizing against a variety of strains of the human immunodeficiency virus type 1 (HIV-1). The epitope for b12 maps to the CD4-binding site in the...