Gómez-Rodríguez, Julio, Washington, Valance, Cheng, Jun, Dutra, Amalia, Pak, Evgenia, Liu, Pentao, ...
We evaluate here the use of real-time quantitative PCR (q-PCR) as a method for screening for homologous recombinants generated in mammalian cells from either conventional gene-targeting constructs or...
Konno, Akihiro, Kirby, Martha, Anderson, Stacie A., Schwartzberg, Pamela L., Candotti, Fabio
The Wiskott–Aldrich syndrome protein (WASP) is a key molecule for transduction of extracellular signals that induce a variety of critical biological events involving actin cytoskeleton...
Konno, Akihiro, Kirby, Martha, Anderson, Stacie A., Schwartzberg, Pamela L., Candotti, Fabio
The Wiskott–Aldrich syndrome protein (WASP) is a key molecule for transduction of extracellular signals that induce a variety of critical biological events involving actin cytoskeleton...
Konno, Akihiro, Kirby, Martha, Anderson, Stacie A., Schwartzberg, Pamela L., Candotti, Fabio
The Wiskott–Aldrich syndrome protein (WASP) is a key molecule for transduction of extracellular signals that induce a variety of critical biological events involving actin cytoskeleton...
Acinar Cell Apoptosis in Serpini2-Deficient Mice Models Pancreatic Insufficiency (2005)
Stacie K. Loftus, Jennifer L. Cannons, Arturo Incao, Evgenia Pak, Amy Chen, Patricia M. Zerfas, ...
Pancreatic insufficiency (PI) when left untreated results in a state of malnutrition due to an inability to absorb nutrients. Frequently, PI is diagnosed as part of a larger clinical presentation in...
Tec family kinases in T lymphocyte development and function (2005)
Berg, Leslie J., Finkelstein, Lisa D., Lucas, Julie Ann, Schwartzberg, Pamela L.
The Tec family tyrosine kinases are now recognized as important mediators of antigen receptor signaling in lymphocytes. Three members of this family, Itk, Rlk, and Tec, are expressed in T cells and...
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk (2001)
Chamorro, Mario, Czar, Michael J, Debnath, Jayanta, Cheng, Genhong, Lenardo, Michael J, Varmus, Harold E, ...
Abstract Background The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases. For most Tec kinases, this...
Xing, Lianping, Venegas, Ana M., Chen, Amy, Garrett-Beal, Lisa, Boyce, Brendan F., Varmus, Harold E., ...
Schwartzberg, Pamela L., Xing, Lianping, Hoffmann, Oskar, Lowell, Clifford A., Garrett, Lisa, Boyce, Brendan F., ...
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk
Chamorro, Mario, Czar, Michael J, Debnath, Jayanta, Cheng, Genhong, Lenardo, Michael J, Varmus, Harold E, ...
Czar, Michael J., Kersh, Ellen N., Mijares, Lilia A., Lanier, Gibson, Lewis, Jennifer, Yap, George, ...
We have introduced a targeted mutation in SH2D1A/DSHP/SAP, the gene responsible for the human genetic disorder X-linked lymphoproliferative disease (XLP). SLAM-associated protein (SAP)-deficient mice...
Shan, Xiaochuan, Czar, Michael J., Bunnell, Stephen C., Liu, Pinghu, Liu, Yusen, Schwartzberg, Pamela L., ...
Pleckstrin homology (PH) domain binding to D3-phosphorylated phosphatidylinositides (PI) provides a reversible means of recruiting proteins to the plasma membrane, with the resultant change in...
rlk/TXK Encodes Two Forms of a Novel Cysteine String Tyrosine Kinase Activated by Src Family Kinases
Debnath, Jayantha, Chamorro, Mario, Czar, Michael J., Schaeffer, Edward M., Lenardo, Michael J., Varmus, Harold E., ...
Rlk/Txk is a member of the BTK/Tec family of tyrosine kinases and is primarily expressed in T lymphocytes. Unlike other members of this kinase family, Rlk lacks a pleckstrin homology (PH) domain near...
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src−/− mutant mice
Schwartzberg, Pamela L., Xing, Lianping, Hoffmann, Oskar, Lowell, Clifford A., Garrett, Lisa, Boyce, Brendan F., ...
The Src tyrosine kinase has been implicated in a wide variety of signal transduction pathways, yet despite the nearly ubiquitous expression of c-src, src−/− mice show only one major...
Horai, Reiko, Nakajima, Akiko, Habiro, Katsuyoshi, Kotani, Motoko, Nakae, Susumu, Matsuki, Taizo, ...
IL-1 receptor antagonist–deficient (IL-1Ra–/–) mice spontaneously develop autoimmune arthritis. We demonstrate here that T cells are required for the induction of arthritis; T cell–deficient...
Acinar Cell Apoptosis in Serpini2-Deficient Mice Models Pancreatic Insufficiency
Loftus, Stacie K, Cannons, Jennifer L, Incao, Arturo, Pak, Evgenia, Chen, Amy, Zerfas, Patricia M, ...
Pancreatic insufficiency (PI) when left untreated results in a state of malnutrition due to an inability to absorb nutrients. Frequently, PI is diagnosed as part of a larger clinical presentation in...
Xing, Lianping, Venegas, Ana M., Chen, Amy, Garrett-Beal, Lisa, Boyce, Brendan F., Varmus, Harold E., ...
Mutant src−/− mice have osteopetrosis resulting from defective osteoclasts, the cells that resorb bone. However, signaling pathways involving Src family members in osteoclasts remain unclear. We...
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk
Chamorro, Mario, Czar, Michael J, Debnath, Jayanta, Cheng, Genhong, Lenardo, Michael J, Varmus, Harold E, ...
Czar, Michael J., Kersh, Ellen N., Mijares, Lilia A., Lanier, Gibson, Lewis, Jennifer, Yap, George, ...
We have introduced a targeted mutation in SH2D1A/DSHP/SAP, the gene responsible for the human genetic disorder X-linked lymphoproliferative disease (XLP). SLAM-associated protein (SAP)-deficient mice...
Shan, Xiaochuan, Czar, Michael J., Bunnell, Stephen C., Liu, Pinghu, Liu, Yusen, Schwartzberg, Pamela L., ...
Pleckstrin homology (PH) domain binding to D3-phosphorylated phosphatidylinositides (PI) provides a reversible means of recruiting proteins to the plasma membrane, with the resultant change in...
rlk/TXK Encodes Two Forms of a Novel Cysteine String Tyrosine Kinase Activated by Src Family Kinases
Debnath, Jayantha, Chamorro, Mario, Czar, Michael J., Schaeffer, Edward M., Lenardo, Michael J., Varmus, Harold E., ...
Rlk/Txk is a member of the BTK/Tec family of tyrosine kinases and is primarily expressed in T lymphocytes. Unlike other members of this kinase family, Rlk lacks a pleckstrin homology (PH) domain near...
Xing, Lianping, Venegas, Ana M., Chen, Amy, Garrett-Beal, Lisa, Boyce, Brendan F., Varmus, Harold E., ...
Mutant src−/− mice have osteopetrosis resulting from defective osteoclasts, the cells that resorb bone. However, signaling pathways involving Src family members in osteoclasts remain unclear. We...
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src−/− mutant mice
Schwartzberg, Pamela L., Xing, Lianping, Hoffmann, Oskar, Lowell, Clifford A., Garrett, Lisa, Boyce, Brendan F., ...
The Src tyrosine kinase has been implicated in a wide variety of signal transduction pathways, yet despite the nearly ubiquitous expression of c-src, src−/− mice show only one major...
Horai, Reiko, Nakajima, Akiko, Habiro, Katsuyoshi, Kotani, Motoko, Nakae, Susumu, Matsuki, Taizo, ...
IL-1 receptor antagonist–deficient (IL-1Ra–/–) mice spontaneously develop autoimmune arthritis. We demonstrate here that T cells are required for the induction of arthritis; T cell–deficient...
Acinar Cell Apoptosis in Serpini2-Deficient Mice Models Pancreatic Insufficiency
Loftus, Stacie K, Cannons, Jennifer L, Incao, Arturo, Pak, Evgenia, Chen, Amy, Zerfas, Patricia M, ...
Pancreatic insufficiency (PI) when left untreated results in a state of malnutrition due to an inability to absorb nutrients. Frequently, PI is diagnosed as part of a larger clinical presentation in...
Lindhurst, Marjorie J., Fiermonte, Giuseppe, Song, Shiwei, Struys, Eduard, De Leonardis, Francesco, Schwartzberg, Pamela L., ...
SLC25A19 mutations cause Amish lethal microcephaly (MCPHA), which markedly retards brain development and leads to α-ketoglutaric aciduria. Previous data suggested that SLC25A19, also called DNC, is...
Cannons, Jennifer L., Yu, Li J., Jankovic, Dragana, Crotty, Shane, Horai, Reiko, Kirby, Martha, ...
X-linked lymphoproliferative disease is caused by mutations affecting SH2D1A/SAP, an adaptor that recruits Fyn to signal lymphocyte activation molecule (SLAM)-related receptors. After infection,...
SH2D1A Regulates T-dependent Humoral Autoimmunity
Hron, Jonathan D., Caplan, Liron, Gerth, Andrea J., Schwartzberg, Pamela L., Peng, Stanford L.
The signaling lymphocytic activation molecule (SLAM)/CD150 family includes a family of chromosome 1–encoded cell surface molecules with costimulatory functions mediated in part by the adaptor...
A Role for Thymic Stromal Lymphopoietin in CD4+ T Cell Development
Al-Shami, Amin, Spolski, Rosanne, Kelly, John, Fry, Terry, Schwartzberg, Pamela L., Pandey, Akhilesh, ...
Thymic stromal lymphopoietin (TSLP) signals via a receptor comprising the interleukin (IL)-7 receptor α chain and a distinctive subunit, TSLP receptor (TSLPR), which is most related to the common...
CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus
Zhao, Ling, Cannons, Jennifer L., Anderson, Stacie, Kirby, Martha, Xu, Liping, Castilla, Lucio H., ...
Recent studies suggest that the chromosome 16 inversion, associated with acute myeloid leukemia M4Eo, takes place in hematopoietic stem cells. If this is the case, it is of interest to know the...
Tec Family Kinases Modulate Thresholds for Thymocyte Development and Selection
Schaeffer, Edward M., Broussard, Christine, Debnath, Jayanta, Anderson, Stacie, McVicar, Daniel W., Schwartzberg, Pamela L.
Tec family kinases are implicated in T cell receptor (TCR) signaling, and combined mutation of inducible T cell kinase (Itk) and resting lymphocyte kinase (Rlk)/Txk in mice dramatically impairs...
Gómez-Rodríguez, Julio, Washington, Valance, Cheng, Jun, Dutra, Amalia, Pak, Evgenia, Liu, Pentao, ...
We evaluate here the use of real-time quantitative PCR (q-PCR) as a method for screening for homologous recombinants generated in mammalian cells from either conventional gene-targeting constructs or...
Selective targeting of ITK blocks multiple steps of HIV replication
Readinger, Julie A., Schiralli, Gillian M., Jiang, Jian-Kang, Thomas, Craig J., August, Avery, Henderson, Andrew J., ...
Treatment for HIV has relied on the use of antiretroviral agents that can be subject to the development of resistant viruses. The study of inhibitors directed against cellular proteins required for...
Cbl Enforces an SLP76-dependent Signaling Pathway for T Cell Differentiation*S⃞
Chiang, Y. Jeffrey, Jordan, Martha S., Horai, Reiko, Schwartzberg, Pamela L., Koretzky, Gary A., Hodes, Richard J.
A signaling pathway involving ZAP-70, LAT, and SLP76 has been regarded as essential for receptor-driven T cell development and activation. Consistent with this model, mice deficient in SLP76 have a...
Washington, A. Valance, Gibot, Sébastien, Acevedo, Ismael, Gattis, James, Quigley, Laura, Feltz, Robert, ...
Triggering receptor expressed on myeloid cells–like (TREM-like) transcript-1 (TLT-1), a type 1 single Ig domain orphan receptor specific to platelet and megakaryocyte α-granules, relocates to the...
Follicular helper T cells are required for systemic autoimmunity
Linterman, Michelle A., Rigby, Robert J., Wong, Raphael. K., Yu, Di, Brink, Robert, Cannons, Jennifer L., ...
Production of high-affinity pathogenic autoantibodies appears to be central to the pathogenesis of lupus. Because normal high-affinity antibodies arise from germinal centers (GCs), aberrant selection...