Ines K. Goerendt, Cristina Messa, Andrew D. Lawrence, Paul M. Grasby, Paola Piccini, David J. Brooks, ...
Parkinson's disease is associated with slowness, especially of sequential movements, and is characterized pathologically by degeneration of dopaminergic neurons, particularly targeting...
Hypothalamic involvement in Huntington's disease: an in vivo PET study (2008)
Politis, Marios, Pavese, Nicola, Tai, Yen F., Tabrizi, Sarah J., Barker, Roger A., Piccini, Paola
Recent studies have shown alterations in metabolism, sleep and circadian rhythms as well as in several neuropeptides derived from the hypothalamic–pituitary axis in Huntington's disease patients;...
Cognitive deficits and striato-frontal dopamine release in Parkinson's disease (2008)
Sawamoto, Nobukatsu, Piccini, Paola, Hotton, Gary, Pavese, Nicola, Thielemans, Kris, Brooks, David J.
Idiopathic Parkinson's disease (PD) is often accompanied by a pattern of executive deficits similar to those found in patients with frontal lobe lesions. We investigated whether such cognitive...
Microglial activation in presymptomatic Huntington's disease gene carriers (2007)
Tai, Yen F., Pavese, Nicola, Gerhard, Alexander, Tabrizi, Sarah J., Barker, Roger A., Brooks, David J., ...
Microglial activation may play a role in the pathogenesis of Huntington's disease (HD). Using 11C-(R)-PK11195 (PK) positron emission tomography (PET), we investigated microglial activation in HD...
Khan, Naheed L., Jain, Shushant, Lynch, John M., Pavese, Nicola, Abou-Sleiman, Patrick, Holton, Janice L., ...
We have established that the frequency of LRRK2 mutations in a series of 118 cases of familial Parkinson's disease is 5.1%. In the largest family with autosomal dominant, late-onset Parkinson's...
Factors affecting the clinical outcome after neural transplantation in Parkinson's disease (2005)
Piccini, Paola, Pavese, Nicola, Hagell, Peter, Reimer, Jan, Björklund, Anders, Oertel, Wolfgang H., ...
Intrastriatal grafts of embryonic mesencephalic tissue can survive in the brains of patients with Parkinson's disease, but the degree of symptomatic relief is highly variable and some cases develop...
Goerendt, Ines K., Messa, Cristina, Lawrence, Andrew D., Grasby, Paul M., Piccini, Paola, Brooks, David J.
Parkinson’s disease is associated with slowness, especially of sequential movements, and is characterized pathologically by degeneration of dopaminergic neurons, particularly targeting...
Pavese, Nicola, Andrews, Thomasin C., Brooks, David J., Ho, Aileen K., Rosser, Anne E., Barker, Roger A., ...
We have studied the progression of striatal and extrastriatal post‐synaptic dopaminergic changes in a group of 12 patients with Huntington’s disease using serial 11C‐raclopride PET, a...
Dyskinesias following neural transplantation in Parkinson's disease. (2002)
Hagell, Peter, Piccini, Paola, Björklund, Anders, Brundin, Patrik, Rehncrona, Stig, Widner, Håkan, ...
Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic...
Khan, Naheed L., Brooks, David J., Pavese, Nicola, Sweeney, Mary G., Wood, Nicholas W., Lees, Andrew J., ...
Molecular and clinical characterization of parkin‐associated parkinsonism is well described; however, there are no data available on progression of dopamine terminal dysfunction in...
Brundin, Patrik, Pogarell, Oliver, Hagell, Peter, Piccini, Paola, Widner, Håkan, Schrag, Anette, ...
Five parkinsonian patients were transplanted bilaterally into the putamen and caudate nucleus with human embryonic mesencephalic tissue from between seven and nine donors. To increase graft survival,...