Castellino, Gabriella, Corallini, Federica, Bortoluzzi, Alessandra, Corte, Renato La, Monaco, Andrea Lo, Secchiero, Paola, ...
Objective. To investigate the role of the TNF-related apoptosis-inducing ligand–osteoprotegerin (TRAIL–OPG) system in the pathogenesis of limited SSc (lSSc). Methods. Circulating levels of TRAIL...
Unsung Hero Robert C. Gallo (2009)
Abbadessa, Giovanni, Accolla, Roberto, Aiuti, Fernando, Albini, Adriana, Aldovini, Anna, Alfano, Massimo, ...
Awarding the Nobel prize in physiology or medicine to Francoise Barré-Sinoussi and Luc Montagnier for the discovery of HIV-1, the causative agent of AIDS, is timely given the harm that the virus...
Corallini, Federica, Bossi, Fleur, Gonelli, Arianna, Tripodo, Claudio, Castellino, Gabriella, Mollnes, Tom E., ...
Objective. Complement activation products contribute to a large number of inflammatory diseases, including RA. We have investigated whether osteoprotegerin (OPG) may concur with the soluble terminal...
Samantha S. Soldan, Rossana Berti, Nazi Salem, Paola Secchiero, Louis Flamand, Peter A. Calabresi, ...
Secchiero, Paola, Zella, Davide, Curreli, Sabrina, Mirandola, Prisco, Capitani, Silvano, Gallo, Robert C., ...
We show here that HIV type 1 (HIV-1) Tat protein, in combination with anti-CD3/CD28 mAbs, promotes IL-2 production and proliferation of primary CD4+ T lymphocytes, obtained from HIV-1-seronegative...
Stefan, Alessandra, De Lillo, Margherita, Frascaroli, Giada, Secchiero, Paola, Neipel, Frank, Campadelli-Fiume, Gabriella
Human antibodies raised in response to human herpesvirus 7 (HHV-7) infection are directed predominantly to one or more HHV-7-infected cell proteins with apparent molecular masses of about 85 to 89...
Identification and Analysis of a Novel Heparin-Binding Glycoprotein Encoded by Human Herpesvirus 7
Skrincosky, David, Hocknell, Peter, Whetter, Linda, Secchiero, Paola, Chandran, Bala, Dewhurst, Stephen
Human herpesvirus 6 (HHV-6) and HHV-7 are closely related betaherpesviruses that encode a number of genes with no known counterparts in other herpesviruses. The product of one such gene is the HHV-6...
Rocca, Bianca, Secchiero, Paola, Ciabattoni, Giovanni, Ranelletti, Franco O., Catani, Lucia, Guidotti, Lia, ...
Cyclooxygenase (COX)-1 or -2 and prostaglandin (PG) synthases catalyze the formation of various PGs and thromboxane (TX) A2. We have investigated the expression and activity of COX-1 and -2 during...
Evidence for a Proangiogenic Activity of TNF-Related Apoptosis-Inducing Ligand1
Secchiero, Paola, Gonelli, Arianna, Carnevale, Edvige, Corallini, Federica, Rizzardi, Clara, Zacchigna, Serena, ...
Starting from the observation that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo-2L protein is expressed in both malignant and inflammatory cells in some highly vascularized...
Zauli, Giorgio, Milani, Daniela, Rimondi, Erika, Baldini, Giovanna, Nicolin, Vanessa, Grill, Vittorio, ...
Most neuroblastoma cell lines do not express apical caspases 8 and 10, which play a key role in mediating tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity in a variety of...
Secchiero, Paola, Zella, Davide, Curreli, Sabrina, Mirandola, Prisco, Capitani, Silvano, Gallo, Robert C., ...
We show here that HIV type 1 (HIV-1) Tat protein, in combination with anti-CD3/CD28 mAbs, promotes IL-2 production and proliferation of primary CD4+ T lymphocytes, obtained from HIV-1-seronegative...
Stefan, Alessandra, De Lillo, Margherita, Frascaroli, Giada, Secchiero, Paola, Neipel, Frank, Campadelli-Fiume, Gabriella
Human antibodies raised in response to human herpesvirus 7 (HHV-7) infection are directed predominantly to one or more HHV-7-infected cell proteins with apparent molecular masses of about 85 to 89...
Identification and Analysis of a Novel Heparin-Binding Glycoprotein Encoded by Human Herpesvirus 7
Skrincosky, David, Hocknell, Peter, Whetter, Linda, Secchiero, Paola, Chandran, Bala, Dewhurst, Stephen
Human herpesvirus 6 (HHV-6) and HHV-7 are closely related betaherpesviruses that encode a number of genes with no known counterparts in other herpesviruses. The product of one such gene is the HHV-6...
Rocca, Bianca, Secchiero, Paola, Ciabattoni, Giovanni, Ranelletti, Franco O., Catani, Lucia, Guidotti, Lia, ...
Cyclooxygenase (COX)-1 or -2 and prostaglandin (PG) synthases catalyze the formation of various PGs and thromboxane (TX) A2. We have investigated the expression and activity of COX-1 and -2 during...
Evidence for a Proangiogenic Activity of TNF-Related Apoptosis-Inducing Ligand1
Secchiero, Paola, Gonelli, Arianna, Carnevale, Edvige, Corallini, Federica, Rizzardi, Clara, Zacchigna, Serena, ...
Starting from the observation that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo-2L protein is expressed in both malignant and inflammatory cells in some highly vascularized...
Zauli, Giorgio, Milani, Daniela, Rimondi, Erika, Baldini, Giovanna, Nicolin, Vanessa, Grill, Vittorio, ...
Most neuroblastoma cell lines do not express apical caspases 8 and 10, which play a key role in mediating tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity in a variety of...
Campioni, Diana, Secchiero, Paola, Corallini, Federica, Melloni, Elisabetta, Capitani, Silvano, Lanza, Francesco, ...
Myelodysplastic syndromes (MDS) are characterized by impaired erythropoiesis, possibly caused by proapoptotic cytokines. We focused our study on the cytokine TRAIL (TNF-related apoptosis-inducing...
Secchiero, Paola, Barbarotto, Elisa, Gonelli, Arianna, Tiribelli, Mario, Zerbinati, Carlotta, Celeghini, Claudio, ...
Evidence suggests that cyclooxygenase-2 (COX-2) increases tumorigenic potential by promoting resistance to apoptosis. Because B chronic lymphoid leukemia (B-CLL) cells exhibit a defective apoptotic...
Secchiero, Paola, Corallini, Federica, Pandolfi, Assunta, Consoli, Agostino, Candido, Riccardo, Fabris, Bruno, ...
Serum osteoprotegerin (OPG) is significantly increased in diabetic patients, prompting expanded investigation of the correlation between OPG production/release and glycemic levels. Serum levels of...
The MDM-2 Antagonist Nutlin-3 Promotes the Maturation of Acute Myeloid Leukemic Blasts1
Secchiero, Paola, Zerbinati, Carlotta, Melloni, Elisabetta, Milani, Daniela, Campioni, Diana, Fadda, Roberto, ...
The small-molecule inhibitor of murine double minute (MDM-2), Nutlin-3, induced variable apoptosis in primary acute myeloid leukemia (AML) blasts and promoted myeloid maturation of surviving cells,...