Boffetta, Paolo, McLaughlin, Joseph K., Lavecchia, Carlo, Tarone, Robert E., Lipworth, Loren, Blot, William J.
The Role of Smoking and Diet in Explaining Educational Inequalities in Lung Cancer Incidence (2009)
Menvielle, Gwenn, Boshuizen, Hendriek, Kunst, Anton E., Dalton, Susanne O., Vineis, Paolo, Bergmann, Manuela M., ...
Background Studies in many countries have reported higher lung cancer incidence and mortality in individuals with lower socioeconomic status. Methods To investigate the role of smoking in these...
Khoury, Muin J., Bertram, Lars, Boffetta, Paolo, Butterworth, Adam S., Chanock, Stephen J., Dolan, Siobhan M., ...
Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new loci associated with susceptibility to...
Purdue, Mark P., Hashibe, Mia, Berthiller, Julien, La Vecchia, Carlo, Maso, Luigino Dal, Herrero, Rolando, ...
The authors pooled data from 15 case-control studies of head and neck cancer (9,107 cases, 14,219 controls) to investigate the independent associations with consumption of beer, wine, and liquor. In...
Zaridze, David, Maximovitch, Dimitri, Lazarev, Alexander, Igitov, Vladimir, Boroda, Alex, Boreham, Jillian, ...
Background The changes in Russian mortality rates during the last two decades are unprecedented in a modern industrialized country. Although these fluctuations have attracted much interest, trends...
Leukaemia and occupation: a New Zealand Cancer Registry-based case-control Study (2009)
McLean, David, Mannetje, Andrea 't, Dryson, Evan, Walls, Chris, McKenzie, Fiona, Maule, Milena, ...
Background To examine the association between occupation and leukaemia. Methods We interviewed 225 cases (aged 20–75 years) notified to the New Zealand Cancer Registry during 2003–04, and 471...
Lynch, Shannon M., Vrieling, Alina, Lubin, Jay H., Kraft, Peter, Mendelsohn, Julie B., Hartge, Patricia, ...
Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association of smoking intensity, smoking duration, and cumulative smoking dose with pancreatic...
Boffetta, Paolo, McLaughlin, Joseph K, La Vecchia, Carlo, Tarone, Robert E, Lipworth, Loren, Blot, William J
Islami, Farhad, Kamangar, Farin, Nasrollahzadeh, Dariush, Aghcheli, Karim, Sotoudeh, Masoud, Abedi-Ardekani, Behnoush, ...
Background Cancer registries in the 1970s showed that parts of Golestan Province in Iran had the highest rate of oesophageal squamous cell carcinoma (OSCC) in the world. More recent studies have...
Lubin, Jay H., Purdue, Mark, Kelsey, Karl, Zhang, Zuo-Feng, Winn, Debbie, Wei, Qingyi, ...
Although cigarette smoking and alcohol consumption increase risk for head and neck cancers, there have been few attempts to model risks quantitatively and to formally evaluate cancer site-specific...
Menvielle, Gwenn, Boshuizen, Hendriek, Kunst, Anton, Vineis, Paolo, Dalton, Susanne, Bergmann, Manuela, ...
The aim of this study is to investigate to what extent occupational exposures may explain socioeconomic inequalities in lung cancer incidence after adjusting for smoking and dietary factors. Analyses...
Menvielle, Gwenn, Boshuizen, Hendriek, Kunst, Anton, Vineis, Paolo, Dalton, Susanne, Bergmann, Manuela, ...
The aim of this study is to investigate to what extent occupational exposures may explain socioeconomic inequalities in lung cancer incidence after adjusting for smoking and dietary factors. Analyses...
Menvielle, Gwenn, Boshuizen, Hendriek, Kunst, Anton, Vineis, Paolo, Dalton, Susanne, Bergmann, Manuela, ...
The aim of this study is to investigate to what extent occupational exposures may explain socioeconomic inequalities in lung cancer incidence after adjusting for smoking and dietary factors. Analyses...
Kyle Steenl, Isabelle Bray, Er Greenl, Paolo Boffetta
Traditional methods of adjustment for multiple comparisons (e.g., Bonferroni adjustments) have fallen into disuse in epidemiological studies. However, alternative kinds of adjustment for data with...
Michael J. Thun, Lindsay M. Hannan, Paolo Boffetta, Julie E. Buring, Diane Feskanich, ...
BackgroundBetter information on lung cancer occurrence in lifelong nonsmokers is needed to understand gender and racial disparities and to examine how factors other than active smoking influence risk...
Smoking and Lymphoma Risk in the European Prospective Investigation into Cancer and Nutrition (2008)
Nieters, Alexandra, Rohrmann, Sabine, Becker, Nikolaus, Linseisen, Jakob, Ruediger, Thomas, Overvad, Kim, ...
Lymphomas are one of the few cancers that have been increasing in incidence over the past decades. So far, only a few established risk factors have been identified, including immunosuppression and...
Assessment of cumulative evidence on genetic associations: interim guidelines (2008)
Ioannidis, John PA, Boffetta, Paolo, Little, Julian, OBrien, Thomas R, Uitterlinden, Andre G, Vineis, Paolo, ...
Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing...
Bonassi, Stefano, Norppa, Hannu, Ceppi, Marcello, Strömberg, Ulf, Vermeulen, Roel, Znaor, Ariana, ...
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies that associated CA frequency in peripheral...
Boccia, Stefania, Hung, Rayjean, Ricciardi, Gualtiero, Gianfagna, Francesco, Ebert, Matthias P. A., Fang, Jing-Yuan, ...
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, whose role in gastric carcinogenesis is controversial. The authors performed a meta-analysis and individual...
False-Positive Results in Cancer Epidemiology: A Plea for Epistemological Modesty (2008)
Boffetta, Paolo, McLaughlin, Joseph K., La Vecchia, Carlo, Tarone, Robert E., Lipworth, Loren, Blot, William J.
False-positive results are inherent in the scientific process of testing hypotheses concerning the determinants of cancer and other human illnesses. Although much of what is known about the etiology...
Boffetta, Paolo, Van Der Hel, Olga, Kricker, Anne, Nieters, Alexandra, De Sanjosé, Silvia, Maynadié, Marc, ...
Background Three recent studies have reported a decreased risk of non-Hodgkin lymphoma (NHL) for high ultraviolet (UV) radiation exposure. Methods We conducted a multicentre case–control study...
Personal Use of Hair Dye and the Risk of Certain Subtypes of Non-Hodgkin Lymphoma (2008)
Zhang, Yawei, Sanjose, Silvia De, Bracci, Paige M., Morton, Lindsay M., Wang, Rong, Brennan, Paul, ...
Personal use of hair dye has been inconsistently linked to risk of non-Hodgkin lymphoma (NHL), perhaps because of small samples or a lack of detailed information on personal hair-dye use in previous...
Sapkota, Amir, Gajalakshmi, Vendhan, Jetly, Dhaval H, Roychowdhury, Soma, Dikshit, Rajesh P, Brennan, Paul, ...
Background A recent monograph by the International Agency for Research on Cancer (IARC) has identified indoor air pollution from coal usage as a known human carcinogen, while that from biomass as a...
Guha, Neela, Boffetta, Paolo, Wünsch Filho, Victor, Eluf Neto, Jose, Shangina, Oxana, Zaridze, David, ...
Poor oral health has been reported as a risk factor in the etiology of head and neck cancer. Data on oral health were ascertained as part of two multicenter case-control studies comprising 924 cases...
Brennan, Paul, McKay, James, Moore, Lee, Zaridze, David, Mukeria, Anush, Szeszenia-Dabrowska, Neonilia, ...
CHEK2 is a key cell cycle control gene encoding a pluripotent kinase that can cause arrest or apoptosis in response to unrepaired DNA damage. We report a large case-control study of a non-functional...
Alcohol accounts for a high proportion of premature mortality in central and eastern Europe (2007)
Rehm, Jürgen, Sulkowska, Urszula, Manczuk, Marta, Boffetta, Paolo, Powles, John, Popova, Svetlana, ...
Background There is a west–east mortality gradient in Europe, more pronounced in men. The objective of this article was to quantify the contribution of alcohol use to the gap in premature adult...
Dietary Risk Factors for Kidney Cancer in Eastern and Central Europe (2007)
Hsu, Charles C., Chow, Wong-Ho, Boffetta, Paolo, Moore, Lee, Zaridze, David, Moukeria, Anush, ...
The authors examined the role of diet in the high-risk population of Central Europe among 1,065 incident kidney cancer cases and 1,509 controls in Russia, Romania, Poland, and the Czech Republic....
Riscos ocupacionais para o câncer de laringe: um estudo caso-controle (2007)
Sartor,Sergio Guerra, Eluf-Neto,José, Travier,Noemie, Wünsch Filho,Victor, Arcuri,Arline Sydneia Abel, Kowalski,Luís Paulo, ...
O tabagismo e o consumo de álcool são os fatores de risco mais bem estabelecidos para o câncer de laringe. Com relação aos fatores ocupacionais, o único carcinógeno estabelecido é a...
Hashibe, Mia, Brennan, Paul, Benhamou, Simone, Castellsague, Xavier, Chen, Chu, Curado, Maria Paula, ...
Background At least 75% of head and neck cancers are attributable to a combination of cigarette smoking and alcohol drinking. A precise understanding of the independent association of each of these...
Maule, Milena, Scélo, Ghislaine, Pastore, Guido, Brennan, Paul, Hemminki, Kari, Tracey, Elizabeth, ...
Background Survivors of childhood leukemia and lymphoma experience high risks of second malignant neoplasms. We quantified such risk using a large dataset from 13 population-based cancer registries. ...
'Environment' in cancer causation and etiological fraction: limitations and ambiguities (2007)
Boffetta, Paolo, McLaughlin, Joseph K., La Vecchia, Carlo, Autier, Philippe, Boyle, Peter
Non-alcoholic beverages and risk of bladder cancer in Uruguay (2007)
De Stefani, Eduardo, Boffetta, Paolo, Deneo-Pellegrini, Hugo, Correa, Pelayo, Ronco, Alvaro L, Brennan, Paul, ...
Abstract Background Bladder cancer is the fourth most frequent malignancy among Uruguayan men. A previous study from Uruguay suggested a high risk of bladder cancer associated with maté drinking. We...
Hall, Janet, Hashibe, Mia, Boffetta, Paolo, Gaborieau, Valerie, Moullan, Norman, Chabrier, Amelie, ...
Cancers of the upper aerodigestive tract (UADT), comprising the oral cavity, pharynx, larynx and oesophagus, account for 5.2% of all cancers cases worldwide. The major risk factors, tobacco and...
Chromosomal Aberrations and Cancer Risk: Results of a Cohort Study from Central Europe (2007)
Boffetta, Paolo, Van Der Hel, Olga, Norppa, Hannu, Fabianova, Eleonora, Fucic, Aleksandra, Gundy, Sarolta, ...
A high level of chromosomal aberrations in peripheral blood lymphocytes may be an early marker of cancer risk, but data on risk of specific cancers and types of chromosomal aberrations (chromosome...
Exposure to Diesel and Gasoline Engine Emissions and the Risk of Lung Cancer (2007)
Parent, Marie-Élise, Rousseau, Marie-Claude, Boffetta, Paolo, Cohen, Aaron, Siemiatycki, Jack
Pollution from motor vehicles constitutes a major environmental health problem. The present paper describes associations between diesel and gasoline engine emissions and lung cancer, as evidenced in...
Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma (2007)
Hayden, Patrick J., Tewari, Prerna, Morris, Derek W., Staines, Anthony, Crowley, Dominique, Nieters, Alexandra, ...
Cytogenetic analysis in myeloma reveals marked chromosomal instability. Both widespread genomic alterations and evidence of aberrant class switch recombination, the physiological process that...
Hashibe, Mia, Boffetta, Paolo, Zaridze, David, Shangina, Oxana, Szeszenia-Dabrowska, Neonila, Mates, Dana, ...
Incidence rates for laryngeal cancer in Central Europe are among the highest in the world. The authors recruited cases and controls between 2000 and 2002 for the Central and Eastern Europe...
Development of lung cancer before the age of 50: the role of xenobiotic metabolism genes (2007)
Gemignani, Federica, Landi, Stefano, Szeszenia-Dabrowska, Neonilia, Zaridze, David, Lissowska, Jolanta, Rudnai, Peter, ...
Objectives The role of genes coding for xenobiotic metabolism enzymes (XME) and the risk of lung cancer is unclear. Under the assumption that these genes may be more important among people having a...
"Environment" in cancer causation and aetiological fraction: Limitations and ambiguities (2007)
Boffetta, Paolo, McLaughlin, Joseph K., La Vecchia, Carlo, Autier, Philippe, Boyle, Peter
Hashibe, Mia, Boffetta, Paolo, Zaridze, David, Shangina, Oxana, Szeszenia-Dabrowska, Neonila, Mates, Dana, ...
Incidence rates for laryngeal cancer in Central Europe are among the highest in the world. The authors recruited cases and controls between 2000 and 2002 for the Central and Eastern Europe...
Bahrami, Hossein, Sadatsafavi, Mohsen, Pourshams, Akram, Kamangar, Farin, Nouraei, Mehdi, Semnani, Shahriar, ...
Abstract Background Once considered as the main public health problem in developed countries, obesity has become a major problem throughout the world and developing countries, like Iran, are joining...
Rohrmann, Sabine, Linseisen, Jakob, Boshuizen, Hendriek C., Whittaker, John, Agudo, Antonio, Vineis, Paolo, ...
Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake...
Brennan, Paul, Crispo, Anna, Zaridze, David, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, Lissowska, Jolanta, ...
The authors have calculated cumulative risks of lung cancer from a case-control study conducted between 1998 and 2002 involving 2,633 lung cancer cases and 2,884 controls in Hungary, Poland, the...
Hall, Janet, Hashibe, Mia, Boffetta, Paolo, Gaborieau, Valerie, Moullan, Norman, Chabrier, Amelie, ...
Cancers of the upper aerodigestive tract (UADT), comprising the oral cavity, pharynx, larynx and esophagus, account for 5.2% of all cancers cases worldwide. The major risk factors, tobacco and...
Association between Personal Use of Hair Dyes and Lymphoid Neoplasms in Europe (2006)
De Sanjosé, Silvia, Benavente, Yolanda, Nieters, Alexandra, Foretova, Lenka, Maynadié, Marc, Cocco, Pier Luigi, ...
Hair dyes have been evaluated as possibly being mutagenic and carcinogenic in animals. Studies of the association between human cancer risk and use of hair dyes have yielded inconsistent results. The...
Shangina, Oxana, Brennan, Paul, Szeszenia-Dabrowska, Neonila, Mates, Dana, Fabiánová, Eleonóra, Fletcher, Tony, ...
A multicenter case-control study was conducted during 1999–2002 in four European countries (Poland, Romania, Russia, and Slovakia) to evaluate the role of occupational exposures in risk of...
A Pooled Analysis of Second Primary Pancreatic Cancer (2006)
Shen, Min, Boffetta, Paolo, Olsen, Jørgen H., Andersen, Aage, Hemminki, Kari, Pukkala, Eero, ...
Studies of pancreatic cancer in the setting of second primary malignant neoplasms can provide etiologic clues. An international multicenter study was carried out using data from 13 cancer registries...
Exposure to Diesel and Gasoline Engine Emissions and the Risk of Lung Cancer (2005)
Marie-élise Parent, Marie-claude Rousseau, Paolo Boffetta, Aaron Cohen
Pollution from motor vehicles constitutes a major environmental health problem. The present paper describes associations between diesel and gasoline engine emissions and lung cancer, as evidenced in...
A Network of Investigator Networks in Human Genome Epidemiology (2005)
Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...
Lung Cancer and Indoor Pollution from Heating and Cooking with Solid Fuels (2005)
Lissowska, Jolanta, Bardin-Mikolajczak, Alicja, Fletcher, Tony, Zaridze, David, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, ...
Exposure to fuel from cooking and heating has not been studied in Europe, where lung cancer rates are high and many residents have had a long tradition of burning coal and unprocessed biomass. Study...
Is the Risk of Lung Cancer Reduced among Eczema Patients? (2005)
Castaing, Marine, Youngson, Judith, Zaridze, David, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, Lissowska, Jolanta, ...
Persons with a history of eczema have been shown to have a reduced risk of lung cancer, but the evidence has been inconclusive because of the small size of previous studies and their limited ability...
Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review (2005)
Hung, Rayjean J., Hall, Janet, Brennan, Paul, Boffetta, Paolo
Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to cancer risk. However, epidemiologic findings have been inconsistent. The authors...
Is the Risk of Lung Cancer Reduced among Eczema Patients? (2005)
Castaing, Marine, Youngson, Judith, Zaridze, David, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, Lissowska, Jolanta, ...
Persons with a history of eczema have been shown to have a reduced risk of lung cancer, but the evidence has been inconclusive because of the small size of previous studies and their limited ability...
Hung, Rayjean J., Brennan, Paul, Canzian, Federico, Szeszenia-Dabrowska, Neonila, Zaridze, David, Lissowska, Jolanta, ...
Background: Base excision repair (BER) is a highly conserved essential mechanism for maintaining genome integrity. We examined associations among four well-characterized polymorphisms of BER genes...
Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review (2005)
Hung, Rayjean J., Hall, Janet, Brennan, Paul, Boffetta, Paolo
Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to cancer risk. However, epidemiologic findings have been inconsistent. The authors...
A Network of Investigator Networks in Human Genome Epidemiology (2005)
Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...
Lissowska, Jolanta, Bardin-Mikolajczak, Alicja, Fletcher, Tony, Zaridze, David, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, ...
Exposure to fuel from cooking and heating has not been studied in Europe, where lung cancer rates are high and many residents have had a long tradition of burning coal and unprocessed biomass. Study...
A Network of Investigator Networks in Human Genome Epidemiology (2005)
Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...
Lung Cancer and Indoor Pollution from Heating and Cooking with Solid Fuels (2005)
Lissowska, Jolanta, Bardin-Mikolajczak, Alicja, Fletcher, Tony, Zaridze, David, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, ...
Exposure to fuel from cooking and heating has not been studied in Europe, where lung cancer rates are high and many residents have had a long tradition of burning coal and unprocessed biomass. Study...
Is the Risk of Lung Cancer Reduced among Eczema Patients? (2005)
Castaing, Marine, Youngson, Judith, Zaridze, David, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, Lissowska, Jolanta, ...
Persons with a history of eczema have been shown to have a reduced risk of lung cancer, but the evidence has been inconclusive because of the small size of previous studies and their limited ability...
Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review (2005)
Hung, Rayjean J., Hall, Janet, Brennan, Paul, Boffetta, Paolo
Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to cancer risk. However, epidemiologic findings have been inconsistent. The authors...
Pooled Analysis of Alcohol Dehydrogenase Genotypes and Head and Neck Cancer: A HuGE Review (2004)
Brennan, Paul, Lewis, Sarah, Hashibe, Mia, Bell, Douglas A., Boffetta, Paolo, Bouchardy, Christine, ...
Possession of the fast metabolizing alleles for alcohol dehydrogenase (ADH), ADH1B*2 and ADH1C*1, and the null allele for aldehyde dehydrogenase (ALDH), ALDH2*2, results in increased acetylaldehyde...
Hung, Rayjean J., Boffetta, Paolo, Brennan, Paul, Malaveille, Christian, Gelatti, Umberto, Placidi, Donatella, ...
Tobacco smoking and occupational exposure are major risk factors of bladder cancer via exposure to polycyclic aromatic hydrocarbons (PAHs) and aromatic amines, which lead to oxidative stress and DNA...
Hung, Rayjean J., Boffetta, Paolo, Brennan, Paul, Malaveille, Christian, Gelatti, Umberto, Placidi, Donatella, ...
Tobacco smoking and occupational exposure are major risk factors of bladder cancer via exposure to polycyclic aromatic hydrocarbons (PAHs) and aromatic amines, which lead to oxidative stress and DNA...
Hung, Rayjean J., Boffetta, Paolo, Brockmöller, Jürgen, Butkiewicz, Dorota, Cascorbi, Ingolf, Clapper, Margie L., ...
Polymorphism for genes encoding the metabolic enzymes, cytochrome P450 (CYP) 1A1 and glutathione S-transferase M1 (GSTM1) might contribute to the variability in individual susceptibility to lung...
Contribution of environmental factors to cancer risk (2003)
Boffetta, Paolo, Nyberg, Fredrik
Environmental carcinogens, in a strict sense, include outdoor and indoor air pollutants, as well as soil and drinking water contaminants. An increased risk of mesothelioma has consistently been...
Hung, Rayjean J., Boffetta, Paolo, Brockmöller, Jürgen, Butkiewicz, Dorota, Cascorbi, Ingolf, Clapper, Margie L., ...
Polymorphisms for genes encoding the metabolic enzymes cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) might contribute to the variability in individual susceptibility to lung...
Burstyn, Igor, Boffetta, Paolo, Heederik, Dick, Partanen, Timo, Kromhout, Hans, Svane, Ole, ...
Work in the asphalt industry has been associated with nonmalignant respiratory morbidity and mortality, but the evidence is not consistent. A historical cohort of asphalt workers included 58,862 men...
Hung, Rayjean J., Boffetta, Paolo, Brockmöller, Jürgen, Butkiewicz, Dorota, Cascorbi, Ingolf, Clapper, Margie L., ...
Polymorphism for genes encoding the metabolic enzymes, cytochrome P450 (CYP) 1A1 and glutathione S-transferase M1 (GSTM1) might contribute to the variability in individual susceptibility to lung...
Familial cancer aggregation and the risk of lung cancer (2002)
Wünsch-Filho,Victor, Boffetta,Paolo, Colin,Didier, Moncau,José Eduardo
CONTEXT: Around 90% of lung cancer worldwide is attributable to cigarette smoking, although less than 20% of cigarette smokers develop lung cancer. Other factors such as diet, chronic lung diseases,...
Benhamou, Simone, Lee, Won Jin, Alexandrie, Anna-Karin, Boffetta, Paolo, Bouchardy, Christine, Butkiewicz, Dorota, ...
Susceptibility to lung cancer may in part be attributable to inter-individual variability in metabolic activation or detoxification of tobacco carcinogens. The glutathione S-transferase M1 (GSTM1)...
Engel, Lawrence S., Taioli, Emanuela, Pfeiffer, Ruth, Garcia-Closas, Montserrat, Marcus, Pamela M., Lan, Qing, ...
Smoking is a known risk factor for bladder cancer. The product of the GSTM1 gene, glutathione S-transferase M1 (GSTM1), is involved in the detoxification of polycyclic aromatic hydrocarbons found in...
Korte, Jeffrey E., Brennan, Paul, Henley, S. Jane, Boffetta, Paolo
Alcohol drinking increases the risk of several types of cancer, but studies of the relation between alcohol and lung cancer risk are complicated by smoking. The authors carried out meta-analyses for...
Ojajärvi, Anneli, Partanen, Timo, Ahlbom, Anders, Boffetta, Paolo, Hakulinen, Timo, Jourenkova, Nadejda, ...
This is a meta-analysis of occupational exposures to chlorinated hydrocarbon (CHC) solvents and pancreatic cancer, based primarily on studies that addressed exposure directly (agent studies) and...
Burstyn, Igor, Kromhout, Hans, Kauppinen, Timo, Heikkilä, Pirjo, Boffetta, Paolo
Introduction: An industrial hygiene database has been constructed for the exposure assessment in a study of cancer risk among asphalt workers. Aim: To create models of bitumen and polycyclic aromatic...
Joint Effect of Diet and Environmental Tobacco Smoke on Risk of Lung Cancer Among Nonsmokers (2000)
Brennan, Paul, Butler, Joel, Agudo, Antonio, Benhamou, Simone, Darby, Sarah, Fortes, Cristina, ...
Gender Differences in the Healthy Worker Effect among Synthetic Vitreous Fiber Workers (1999)
Lea, C. Suzanne, Hertz-Picciotto, Irva, Andersen, Aage, Chang-Claude, Jenny, Olsen, Jørgen H., Pesatori, Angela C., ...
The aim of this study was to determine whether the healthy worker effect and its component parts operate similarly for women and men. A cohort of workers from 14 synthetic vitreous fiber factories in...
Cigar and Pipe Smoking and Lung Cancer Risk: a Multicenter Study From Europe (1999)
Boffetta, Paolo, Pershagen, Göran, Jöckel, Karl-Heinz, Forastiere, Francesco, Gaborieau, Valerie, Heinrich, Joachim, ...
BACKGROUND: Because limited information is available on the quantitative association between consumption of tobacco products other than cigarettes and lung cancer risk, we undertook a case-control...
Environmental and occupational cancer in Argentina: a case-control lung cancer study (1998)
Matos,Elena, Vilensky,Marta, Boffetta,Paolo
The main objective of this study was to analyze the risks for lung cancer associated with occupational exposures in a developing country where lung cancer is the first cause of mortality from cancer...
Historical Exposure to Inorganic Mercury at the smelter works of Abbadia San Salvatore, Italy (1998)
BELLANDER, TOM, MERLER, ENZO, CECCARELLI, FRANCO, BOFFETTA, PAOLO
Metallic mercury production from cinnabar ore may result in high exposures to inorganic mercury, that are difficult to assess separately from the exposures originating from underground extraction,...
Hooived, Mariëtte, Heederik, Dick J. J., Kogevinas, Marnolis, Boffetta, Paolo, Needham, Lamy L., Patterson, Donald G., ...
A retrospective cohort study of workers exposed to phenoxy herbicides, chlorophenols, and contaminants (2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other polychlorinated dioxins and furans) has...
Cancer Mortality in Workers Exposed to Phenoxy Herbicides, Chlorophenols, and Dioxins (1997)
Kogevinas, Manolis, Becher, Heiko, Benn, Trevor, Bertazzi, Pier Alberto, Boffetta, Paolo, ...
The authors examined cancer mortality in a historical cohort study of 21,863 male and female workers in 36 cohorts exposed to phenoxy herbicides, chlorophenols, and dioxins in 12 countries. Subjects...
Risk of Cancer and Exposure to Gasoline Vapors (1997)
Lynge, Elsebeth, Andersen, Aage, Nilsson, Ralph, Barlow, Lotti, Pukkala, Eero, Nordlinder, Rotf, ...
Until the introduction of self-service around 1970, service station workers in the Nordic countries were exposed to gasoline vapors. Based on measurements reported in the literature, the 8-hour...
Kogevinas, Manolis, Becher, Heiko, Benn, Trevor, Bertazzi, Pier Alberto, Boffetta, Paolo, ...
The authors examined cancer mortality in a historical cohort study of 21,863 male and female workers in 36 cohorts exposed to phenoxy herbicides, chlorophenols, and dioxins in 12 countries. Subjects...
Boffetta, Paolo, Merletti, Franco, Faggiano, Fabrizio, Migliaretti, Giuseppe, Ferro, Gilles, Zanetti, Roberto, ...
Little information is available on the role of risk factors for cancer of the larynx in survival. This study analyzed survival through the end of 1994 for 355 cases of laryngeal cancer diagnosed...
Exposure to Styrene and Mortality from Nervous System Diseases and Mental Disorders (1996)
Welp, Esther, Kogevinas, Manolis, Andersen, Aage, Bellander, Tom, Biocca, Marco, Coggon, David, ...
Chronic low-dose exposure to solvents has been associated in epidemiologic studies with chronic neurotoxicity, but the evidence is not consistent. Styrene causes acute disturbances in the central and...
BOFFETTA, PAOLO, LA VECCHIA, CARLO, LEVI, FABIO, LUCCHINI, FRANCA
Mortality from cancers of the oral cavity and pharynx, oesphagus, larynx and lung between 1955 and 1989 has been analysed for USA, Canada and 14 countries in Latin America. Among males, Uruguay,...
Risk Factors for Fatal Colon Cancer in a Large Prospective Study (1992)
Thun, Michael J., Calle, Eugenia E., Namboodiri, Mohan M., Flanders, W. Dana, Coates, Ralph J., Byers, Tim, ...
Background: Diet, physical activity, obesity, aspirin use, and family history may all modify the risk of colon cancer, but few epidemiologic studies are large enough to examine these factors...
Perspectives on Comparing Risks of Environmental Carcinogens (1988)
Perera, Frederica, Boffetta, Paolo
In 1987, investigators (Ames et al.) concluded that the risks of man-made industrial carcinogens and pesticides (outside of the workplace) are trivial compared with the risks of naturally occurring...
Russian mortality trends for 1991-2001: analysis by cause and region
Men, Tamara, Brennan, Paul, Boffetta, Paolo, Zaridze, David
Objectives To investigate trends in Russian mortality for 1991-2001 with particular reference to trends since the Russian economic crisis in 1998 and to geographical differences within Russia.
Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study
Trichopoulou, Antonia, Orfanos, Philippos, Norat, Teresa, Ocké, Marga C, Peeters, Petra HM, ...
Objective To examine whether adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, is associated with longer life expectancy among elderly Europeans.
Mortality from lung cancer in workers exposed to sulfur dioxide in the pulp and paper industry.
Lee, Won Jin, Teschke, Kay, Kauppinen, Timo, Andersen, Aage, Jäppinen, Paavo, Szadkowska-Stanczyk, Irena, ...
Our objective in this study was to evaluate the mortality of workers exposed to sulfur dioxide in the pulp and paper industry. The cohort included 57,613 workers employed for at least 1 year in the...
Applying new biotechnologies to the study of occupational cancer--a workshop summary.
Toraason, Mark, Albertini, Richard, Bayard, Steven, Bigbee, William, Blair, Aaron, Boffetta, Paolo, ...
As high-throughput technologies in genomics, transcriptomics, and proteomics evolve, questions arise about their use in the assessment of occupational cancers. To address these questions, the...
Toxicogenomics of subchronic hexachlorobenzene exposure in Brown Norway rats.
Ezendam, Janine, Staedtler, Frank, Pennings, Jeroen, Vandebriel, Rob J, Pieters, Raymond, Boffetta, Paolo, ...
Hexachlorobenzene (HCB) is a persistent environmental pollutant with toxic effects in man and rat. Reported adverse effects are hepatic porphyria, neurotoxicity, and adverse effects on the...
Listing Occupational Carcinogens
Siemiatycki, Jack, Richardson, Lesley, Straif, Kurt, Latreille, Benoit, Lakhani, Ramzan, Campbell, Sally, ...
The occupational environment has been a most fruitful one for investigating the etiology of human cancer. Many recognized human carcinogens are occupational carcinogens. There is a large volume of...
Chromosomal Aberrations in Lymphocytes of Healthy Subjects and Risk of Cancer
Rossner, Pavel, Boffetta, Paolo, Ceppi, Marcello, Bonassi, Stefano, Smerhovsky, Zdenek, Landa, Karel, ...
There is evidence that increased frequency of chromosomal aberration (CA) in peripheral blood lymphocytes is a predictor of cancer, but further data are needed to better characterize CA as marker of...
ELF MFs: Straif et al. Respond
Straif, Kurt, Cardis, Elisabeth, Boffetta, Paolo, Rousseau, Marie-Claude, Siemiatycki, Jack
McLean, David, Pearce, Neil, Langseth, Hilde, Jäppinen, Paavo, Szadkowska-Stanczyk, Irena, Persson, Bodil, ...
The objective of this study was to evaluate cancer mortality in pulp and paper industry workers exposed to chlorinated organic compounds. We assembled a multinational cohort of workers employed...
Bahrami, Hossein, Sadatsafavi, Mohsen, Pourshams, Akram, Kamangar, Farin, Nouraei, Mehdi, Semnani, Shahriar, ...
Russian mortality trends for 1991-2001: analysis by cause and region
Men, Tamara, Brennan, Paul, Boffetta, Paolo, Zaridze, David
Objectives To investigate trends in Russian mortality for 1991-2001 with particular reference to trends since the Russian economic crisis in 1998 and to geographical differences within Russia.
Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study
Trichopoulou, Antonia, Orfanos, Philippos, Norat, Teresa, Ocké, Marga C, Peeters, Petra HM, ...
Objective To examine whether adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, is associated with longer life expectancy among elderly Europeans.
Mortality from lung cancer in workers exposed to sulfur dioxide in the pulp and paper industry.
Lee, Won Jin, Teschke, Kay, Kauppinen, Timo, Andersen, Aage, Jäppinen, Paavo, Szadkowska-Stanczyk, Irena, ...
Our objective in this study was to evaluate the mortality of workers exposed to sulfur dioxide in the pulp and paper industry. The cohort included 57,613 workers employed for at least 1 year in the...
Applying new biotechnologies to the study of occupational cancer--a workshop summary.
Toraason, Mark, Albertini, Richard, Bayard, Steven, Bigbee, William, Blair, Aaron, Boffetta, Paolo, ...
As high-throughput technologies in genomics, transcriptomics, and proteomics evolve, questions arise about their use in the assessment of occupational cancers. To address these questions, the...
Toxicogenomics of subchronic hexachlorobenzene exposure in Brown Norway rats.
Ezendam, Janine, Staedtler, Frank, Pennings, Jeroen, Vandebriel, Rob J, Pieters, Raymond, Boffetta, Paolo, ...
Hexachlorobenzene (HCB) is a persistent environmental pollutant with toxic effects in man and rat. Reported adverse effects are hepatic porphyria, neurotoxicity, and adverse effects on the...
Listing Occupational Carcinogens
Siemiatycki, Jack, Richardson, Lesley, Straif, Kurt, Latreille, Benoit, Lakhani, Ramzan, Campbell, Sally, ...
The occupational environment has been a most fruitful one for investigating the etiology of human cancer. Many recognized human carcinogens are occupational carcinogens. There is a large volume of...
Chromosomal Aberrations in Lymphocytes of Healthy Subjects and Risk of Cancer
Rossner, Pavel, Boffetta, Paolo, Ceppi, Marcello, Bonassi, Stefano, Smerhovsky, Zdenek, Landa, Karel, ...
There is evidence that increased frequency of chromosomal aberration (CA) in peripheral blood lymphocytes is a predictor of cancer, but further data are needed to better characterize CA as marker of...
ELF MFs: Straif et al. Respond
Straif, Kurt, Cardis, Elisabeth, Boffetta, Paolo, Rousseau, Marie-Claude, Siemiatycki, Jack
McLean, David, Pearce, Neil, Langseth, Hilde, Jäppinen, Paavo, Szadkowska-Stanczyk, Irena, Persson, Bodil, ...
The objective of this study was to evaluate cancer mortality in pulp and paper industry workers exposed to chlorinated organic compounds. We assembled a multinational cohort of workers employed...
Bahrami, Hossein, Sadatsafavi, Mohsen, Pourshams, Akram, Kamangar, Farin, Nouraei, Mehdi, Semnani, Shahriar, ...
Non-alcoholic beverages and risk of bladder cancer in Uruguay
De Stefani, Eduardo, Boffetta, Paolo, Deneo-Pellegrini, Hugo, Correa, Pelayo, Ronco, Alvaro L, Brennan, Paul, ...
Occupational exposure to meat and risk of lymphoma: A multicenter case-control study from Europe
Moore, Tina, Brennan, Paul, Becker, Nikolaus, De SanjosÉ, Silvia, MaynadiÉ, Marc, Foretova, Lenka, ...
Several studies have suggested an increased risk of lymphoma among workers exposed to meat, without conclusive evidence. We conducted a multicenter case-control study during 1998–2004 in the Czech...
Wang, Sophia S., Slager, Susan L., Brennan, Paul, Holly, Elizabeth A., De Sanjose, Silvia, Bernstein, Leslie, ...
A role for genetic susceptibility in non-Hodgkin lymphoma (NHL) is supported by the accumulating evidence of common genetic variations altering NHL risk. However, the pattern of NHL heritability...
False-Positive Results in Cancer Epidemiology: A Plea for Epistemological Modesty
Boffetta, Paolo, McLaughlin, Joseph K., La Vecchia, Carlo, Tarone, Robert E., Lipworth, Loren, Blot, William J.
False-positive results are inherent in the scientific process of testing hypotheses concerning the determinants of cancer and other human illnesses. Although much of what is known about the etiology...
Lung Cancer Occurrence in Never-Smokers: An Analysis of 13 Cohorts and 22 Cancer Registry Studies
Thun, Michael J, Hannan, Lindsay M, Adams-Campbell, Lucile L, Boffetta, Paolo, Buring, Julie E, Feskanich, Diane, ...
Michael Thun and colleagues pooled and analyzed comprehensive data on lung cancer incidence and death rates among never-smokers to examine what factors other than active smoking affect lung cancer...
Bonassi, Stefano, Norppa, Hannu, Ceppi, Marcello, Strömberg, Ulf, Vermeulen, Roel, Znaor, Ariana, ...
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies that associated CA frequency in peripheral...
An Analysis of Growth, Differentiation and Apoptosis Genes with Risk of Renal Cancer
Dong, Linda M., Brennan, Paul, Karami, Sara, Hung, Rayjean J., Menashe, Idan, Berndt, Sonja I., ...
We conducted a case-control study of renal cancer (987 cases and 1298 controls) in Central and Eastern Europe and analyzed genomic DNA for 319 tagging single-nucleotide polymorphisms (SNPs) in 21...
Khoury, Muin J., Bertram, Lars, Boffetta, Paolo, Butterworth, Adam S., Chanock, Stephen J., Dolan, Siobhan M., ...
Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new loci associated with susceptibility to...
Zaridze, David, Brennan, Paul, Boreham, Jillian, Boroda, Alex, Karpov, Rostislav, Lazarev, Alexander, ...
Analysis of SNPs and Haplotypes in Vitamin D Pathway Genes and Renal Cancer Risk
Karami, Sara, Brennan, Paul, Rosenberg, Philip S., Navratilova, Marie, Mates, Dana, Zaridze, David, ...
In the kidney vitamin D is converted to its active form. Since vitamin D exerts its activity through binding to the nuclear vitamin D receptor (VDR), most genetic studies have primarily focused on...