Bestoso, Federica, Ottaggio, Laura, Armirotti, Andrea, Balbi, Alessandro, Damonte, Gianluca, Degan, Paolo, ...
Abstract Background Taxol is an effective antineoplastic agent, originally extracted from the bark of Taxus brevifolia with a low yield. Many attempts have been made to produce Taxol by chemical...
Degan, Paolo, Sancandi, Monica, Zunino, Annalisa, Ottaggio, Laura, Viaggi, Silvia, Cesarone, Carmelo Federico, ...
Exposure of freshly drawn lymphocytes and lymphoblastoid cells (LB and COR3) to simulated microgravity decreased the intracellular ATP concentration to 50%-40% of the value found in normal growth...
Pagano, Giovanni, Degan, Paolo, D'Ischia, Marco, Kelly, Frank J., Pallardó, Federico V., Zatterale, Adriana, ...
Some selected oxidative stress parameters were measured in 56 Fanconi anaemia (FA) patients (42 untransplanted and 14 transplanted), 54 FA heterozygotes (parents) and 173 controls. Untransplanted FA...
Pagano, Giovanni, Degan, Paolo, D'Ischia, Marco, Kelly, Frank J., Pallardó, Federico V., Zatterale, Adriana, ...
Some selected oxidative stress parameters were measured in 56 Fanconi anaemia (FA) patients (42 untransplanted and 14 transplanted), 54 FA heterozygotes (parents) and 173 controls. Untransplanted FA...
Bogliolo, Massimo, Borghini, Silvia, Abbondandolo, Angelo, Degan, Paolo
Deregulation of control of the apoptotic process in Fanconi anaemia (FA) appears to be one of the main features of this disease at the cellular level. We show here that FA cells are resistant to...
Zunino, Annalisa, Degan, Paolo, Vigo, Tiziana, Abbondandolo, Angelo
Fanconi's anemia (FA) is an inherited autosomal recessive syndrome; cells from FA patients are very sensitive to crosslinking agents and to oxygen. Epstein–Barr virus (EBV)-transformed lymphoblasts...
Cappelli, Enrico, Degan, Paolo, Frosina, Guido
The repair of the endogenous lesions 8-oxo-7,8-dihydroguanine (8-oxoG), uracil (U) and natural abasic site (AP site) was investigated using an in vitro base excision repair assay in which a plasmid...
Detection of the `4977 bp' mitochondrial DNA deletion in human atherosclerotic lesions (1999)
Bogliolo, Massimo, Izzotti, Alberto, De Flora, Silvio, Carli, Carla, Abbondandolo, Angelo, Degan, Paolo
The presence of the 4977 bp deletion (`common deletion') in the mitochondrial DNA (mtDNA) is associated with defects in the metabolic machinery acquired during ageing as a hallmark of a degenerative...
Degan, Paolo, Bonassi, Stefano, Caterina, Maurizio De, Korkina, Ludmila G., Pinto, Luciano, Scopacasa, Francesco, ...
The present study was aimed at verifying the occurrence, if any, of in vivo oxidative DNA damage in FA homozygotes, their parents and siblings. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) was measured, by...
Inga, Alberto, Iannone, Raffaella, Degan, Paolo, Campomenosi, Paola, Fronza, Gilberto, Abbondandolo, Angelo, ...
Mutation spectra induced by 4-nitroquinoline 1-oxide (4NQO) at the hprt locus for both normal (AA8) and 4NQO-sensitive (UV5) Chinese hamster ovary cells were determined to investigate the effect of...
Degan, Paolo, Shigenaga, Mark K., Park, Eun-Mi, Alperin, Peter E., Ames, Bruce N.
An immunoaffinity column is described that facilitates the analysis of oxidative DNA adducts excised from DNA are excreted in urine and can assayed as a measure of DNA damage in individuals....
Russo, Maria Teresa, Blasi, Monica Francesca, Chiera, Federica, Fortini, Paola, Degan, Paolo, Macpherson, Peter, ...
Oxidation is a common form of DNA damage to which purines are particularly susceptible. We previously reported that oxidized dGTP is potentially an important source of DNA 8-oxodGMP in mammalian...
Bestoso, Federica, Ottaggio, Laura, Armirotti, Andrea, Balbi, Alessandro, Damonte, Gianluca, Degan, Paolo, ...
Russo, Maria Teresa, Blasi, Monica Francesca, Chiera, Federica, Fortini, Paola, Degan, Paolo, Macpherson, Peter, ...
Oxidation is a common form of DNA damage to which purines are particularly susceptible. We previously reported that oxidized dGTP is potentially an important source of DNA 8-oxodGMP in mammalian...
Bestoso, Federica, Ottaggio, Laura, Armirotti, Andrea, Balbi, Alessandro, Damonte, Gianluca, Degan, Paolo, ...
New functions of XPC in the protection of human skin cells from oxidative damage
D'Errico, Mariarosaria, Parlanti, Eleonora, Teson, Massimo, Degan, Paolo, Calcagnile, Angelo, ...
Xeroderma pigmentosum (XP) C is involved in the recognition of a variety of bulky DNA-distorting lesions in nucleotide excision repair. Here, we show that XPC plays an unexpected and multifaceted...
Narciso, Laura, Fortini, Paola, Pajalunga, Deborah, Franchitto, Annapaola, Liu, Pingfang, Degan, Paolo, ...
The differentiation of skeletal myoblasts is characterized by permanent withdrawal from the cell cycle and fusion into multinucleated myotubes. Muscle cell survival is critically dependent on the...
A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration
De Luca, Gabriele, Russo, Maria Teresa, Degan, Paolo, Tiveron, Cecilia, Zijno, Andrea, Meccia, Ettore, ...
Several human neurodegenerative disorders are characterized by the accumulation of 8-oxo-7,8-dihydroguanine (8-oxodG) in the DNA of affected neurons. This can occur either through direct oxidation of...