EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer (2008)
Koivunen, Jussi P., Mermel, Craig, Zejnullahu, Kreshnik, Murphy, Carly, Lifshits, Eugene, Holmes, Alison J., ...
Li, Jin, Berbeco, Ross, Distel, Robert J., Jänne, Pasi A., Wang, Lilin, Makrigiorgos, G. Mike
The rapidly growing understanding of human genetic pathways, including those that mediate cancer biology and drug response, leads to an increasing need for extensive and reliable mutation screening...
Thomas, Roman K., Nickerson, Elizabeth, Simons, Jan F., Jänne, Pasi A., Tengs, Torstein, Yuza, Yuki, ...
Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants (2005)
Heidi Greulich, Tzu-Hsiu Chen, Whei Feng, Pasi A. Jänne, James V. Alvarez, Mauro Zappaterra, ...
Different EGFR mutations are associated with lung cancer. All of the classes can transform fibroblasts and lung epithelial cells, most are sensitive to erlotinib and gefininib, but exon 20 mutations...
Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants (2005)
Heidi Greulich, Tzu-Hsiu Chen, Whei Feng, Pasi A. Jänne, James V. Alvarez, Mauro Zappaterra, ...
Background Somatic mutations in the kinase domain of the epidermal growth factor receptor tyrosine kinase gene EGFR are common in lung adenocarcinoma. The presence of mutations correlates with tumor...
Mukohara, Toru, Engelman, Jeffrey A., Hanna, Nasser H., Yeap, Beow Y., Kobayashi, Susumu, Lindeman, Neal, ...
Background: Many patients with non–small-cell lung cancer (NSCLC) who achieve radiographic responses to treatment with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors...
Using Single Nucleotide Polymorphism Arrays (2004)
Xiaojun Zhao, Cheng Li, J. Guillermo Paez, Koei Chin, Pasi A. Jänne, Tzu-hsiu Chen, ...
Changes in DNA copy number contribute to cancer pathogenesis. We now show that high-density single nucleotide polymorphism (SNP) arrays can detect copy number alterations. By hybridizing genomic...
Engelman, Jeffrey A., Jänne, Pasi A., Mermel, Craig, Pearlberg, Joseph, Mukohara, Toru, Fleet, Christina, ...
Therapies that target the EGF receptor (EGFR), such as gefitinib (IRESSA), are effective in a subset of patients with advanced non-small cell lung cancer (NSCLC). The differences in intracellular...
Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants
Greulich, Heidi, Chen, Tzu-Hsiu, Feng, Whei, Jänne, Pasi A, Alvarez, James V, Zappaterra, Mauro, ...
Different EGFR mutations are associated with lung cancer. All of the classes can transform fibroblasts and lung epithelial cells, most are sensitive to erlotinib and gefininib, but exon 20 mutations...
Engelman, Jeffrey A., Mukohara, Toru, Zejnullahu, Kreshnik, Lifshits, Eugene, Borrás, Ana M., Gale, Christopher-Michael, ...
EGFR is frequently mutated and amplified in lung adenocarcinomas sensitive to EGFR inhibitors gefitinib and erlotinib. A secondary mutation, T790M, has been associated with acquired resistance but...
Engelman, Jeffrey A., Jänne, Pasi A., Mermel, Craig, Pearlberg, Joseph, Mukohara, Toru, Fleet, Christina, ...
Therapies that target the EGF receptor (EGFR), such as gefitinib (IRESSA), are effective in a subset of patients with advanced non-small cell lung cancer (NSCLC). The differences in intracellular...
Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants
Greulich, Heidi, Chen, Tzu-Hsiu, Feng, Whei, Jänne, Pasi A, Alvarez, James V, Zappaterra, Mauro, ...
Different EGFR mutations are associated with lung cancer. All of the classes can transform fibroblasts and lung epithelial cells, most are sensitive to erlotinib and gefininib, but exon 20 mutations...
Engelman, Jeffrey A., Mukohara, Toru, Zejnullahu, Kreshnik, Lifshits, Eugene, Borrás, Ana M., Gale, Christopher-Michael, ...
EGFR is frequently mutated and amplified in lung adenocarcinomas sensitive to EGFR inhibitors gefitinib and erlotinib. A secondary mutation, T790M, has been associated with acquired resistance but...
Sattler, Martin, Walz, Christoph, Crowley, Brian J., Lengfelder, Eva, Jänne, Pasi A., Rogers, Andrew M., ...
Li, Jin, Berbeco, Ross, Distel, Robert J., Jänne, Pasi A., Wang, Lilin, Makrigiorgos, G. Mike
The rapidly growing understanding of human genetic pathways, including those that mediate cancer biology and drug response, leads to an increasing need for extensive and reliable mutation screening...