Patricia A. Spears

Genetic Characterization of Escherichia coli Type 1 Pilus Adhesin Mutants and Identification of a Novel Binding Phenotype

Hamrick, Terri S., Harris, Sandra L., Spears, Patricia A., Havell, Edward A., Horton, John R., Russell, Perry W., ...

Five Escherichia coli type 1 pilus mutants that had point mutations in fimH, the gene encoding the type 1 pilus adhesin FimH, were characterized. FimH is a minor component of type 1 pili that is...

Characterization of Escherichia coli Type 1 Pilus Mutants with Altered Binding Specificities

Harris, Sandra L., Spears, Patricia A., Havell, Edward A., Hamrick, Terri S., Horton, John R., Orndorff, Paul E.

PCR mutagenesis and a unique enrichment scheme were used to obtain two mutants, each with a single lesion in fimH, the chromosomal gene that encodes the adhesin protein (FimH) of Escherichia coli...

Unexpected Similarities between Bordetella avium and Other Pathogenic Bordetellae

Spears, Patricia A., Temple, Louise M., Miyamoto, David M., Maskell, Duncan J., Orndorff, Paul E.

Bordetella avium causes an upper respiratory tract disease (bordetellosis) in avian species. Commercially raised turkeys are particularly susceptible. Like other pathogenic members of the genus...

The Product of the fimI Gene Is Necessary for Escherichia coli Type 1 Pilus Biosynthesis

Valenski, Mary L., Harris, Sandra L., Spears, Patricia A., Horton, John R., Orndorff, Paul E.

Site-directed mutagenesis was employed to create lesions in fimI, a gene of uncertain function located in the chromosomal gene cluster (fim) involved in Escherichia coli type 1 pilus biosynthesis....

Influence of Pregnancy on the Pathogenesis of Listeriosis in Mice Inoculated Intragastrically

Hamrick, Terri S., Horton, John R., Spears, Patricia A., Havell, Edward A., Smoak, Ida W., Orndorff, Paul E.

Pregnancy increases the risk of listeriosis, a systemic disease caused by Listeria monocytogenes. However, there is incomplete agreement on the reasons for this increased risk. We examined two...

Genetic Characterization of Escherichia coli Type 1 Pilus Adhesin Mutants and Identification of a Novel Binding Phenotype

Hamrick, Terri S., Harris, Sandra L., Spears, Patricia A., Havell, Edward A., Horton, John R., Russell, Perry W., ...

Five Escherichia coli type 1 pilus mutants that had point mutations in fimH, the gene encoding the type 1 pilus adhesin FimH, were characterized. FimH is a minor component of type 1 pili that is...

Characterization of Escherichia coli Type 1 Pilus Mutants with Altered Binding Specificities

Harris, Sandra L., Spears, Patricia A., Havell, Edward A., Hamrick, Terri S., Horton, John R., Orndorff, Paul E.

PCR mutagenesis and a unique enrichment scheme were used to obtain two mutants, each with a single lesion in fimH, the chromosomal gene that encodes the adhesin protein (FimH) of Escherichia coli...

Unexpected Similarities between Bordetella avium and Other Pathogenic Bordetellae

Spears, Patricia A., Temple, Louise M., Miyamoto, David M., Maskell, Duncan J., Orndorff, Paul E.

Bordetella avium causes an upper respiratory tract disease (bordetellosis) in avian species. Commercially raised turkeys are particularly susceptible. Like other pathogenic members of the genus...

The Product of the fimI Gene Is Necessary for Escherichia coli Type 1 Pilus Biosynthesis

Valenski, Mary L., Harris, Sandra L., Spears, Patricia A., Horton, John R., Orndorff, Paul E.

Site-directed mutagenesis was employed to create lesions in fimI, a gene of uncertain function located in the chromosomal gene cluster (fim) involved in Escherichia coli type 1 pilus biosynthesis....

Influence of Pregnancy on the Pathogenesis of Listeriosis in Mice Inoculated Intragastrically

Hamrick, Terri S., Horton, John R., Spears, Patricia A., Havell, Edward A., Smoak, Ida W., Orndorff, Paul E.

Pregnancy increases the risk of listeriosis, a systemic disease caused by Listeria monocytogenes. However, there is incomplete agreement on the reasons for this increased risk. We examined two...