Nicolas Cenac, Anne-marie Coelho, Cathy Nguyen, Steven Compton, Patricia Andrade-gordon, Wallace K. Macnaughton, ...
Proteinase-activated receptor (PAR)-2, a G-proteincoupled receptor for trypsin and mast cell tryptase, is highly expressed in the intestine. Luminal trypsin and tryptase are elevated in the colon of...
Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation (2007)
Saban, Ricardo, D'Andrea, Michael R, Andrade-Gordon, Patricia, Derian, Claudia K, Dozmorov, Igor, Ihnat, Michael A, ...
Abstract Background In general, inflammation plays a role in most bladder pathologies and represents a defense reaction to injury that often times is two edged. In particular, bladder neurogenic...
Regulatory network of inflammation downstream of proteinase-activated receptors (2007)
Saban, Ricardo, D'Andrea, Michael R, Andrade-Gordon, Patricia, Derian, Claudia K, Dozmorov, Igor, Ihnat, Michael A, ...
Abstract Background Protease-activated receptors (PAR) are present in the urinary bladder, and their expression is altered in response to inflammation. PARs are a unique class of G protein-coupled...
Development of immobilized fluorogenic substrates to study proteolytic enzymes / (1984)
Thesis (Ph. D.)--State University of New York at Stony Brook, 1984.
Andrade-Gordon, Patricia, Maryanoff, Bruce E., Derian, Claudia K., Zhang, Han-Cheng, Addo, Michael F., Darrow, Andrew L., ...
Protease-activated receptors (PARs) represent a unique family of seven-transmembrane G protein-coupled receptors, which are enzymatically cleaved to expose a truncated extracellular N terminus that...
Lourbakos, Afrodite, Potempa, Jan, Travis, James, D'Andrea, Michael R., Andrade-Gordon, Patricia, Santulli, Rosemary, ...
Periodontitis is a chronic inflammatory disease affecting oral tissues. Oral epithelial cells represent the primary barrier against bacteria causing the disease. We examined the responses of such...
A role for proteinase-activated receptor–1 in inflammatory bowel diseases
Vergnolle, Nathalie, Cellars, Laurie, Mencarelli, Andrea, Rizzo, Giovanni, Swaminathan, Sunita, Beck, Paul, ...
Proteinase-activated receptor–1 (PAR1), a G protein–coupled receptor activated by thrombin, is highly expressed in different cell types of the gastrointestinal tract. The activity of thrombin and...
Hansen, Kristina K., Sherman, Philip M., Cellars, Laurie, Andrade-Gordon, Patricia, Pan, Zhengying, Baruch, Amos, ...
Citrobacter rodentium is a bacterial pathogen that causes a murine infectious colitis equivalent to enterohemorrhagic Escherichia coli infection in humans. Colonic luminal fluid from C....
A novel serine protease predominately expressed in macrophages.
Chen, Cailin, Darrow, Andrew L, Qi, Jian-Shen, D'Andrea, Michael R, Andrade-Gordon, Patricia
We have identified a novel serine protease designated EOS by sequence identity searches. The deduced protein contains 284 amino acids with an active form containing 248 amino acids starting from an...
A role for proteinase-activated receptor-1 in inflammatory bowel diseases
Vergnolle, Nathalie, Cellars, Laurie, Mencarelli, Andrea, Rizzo, Giovanni, Swaminathan, Sunita, Beck, Paul, ...
Andrade-Gordon, Patricia, Maryanoff, Bruce E., Derian, Claudia K., Zhang, Han-Cheng, Addo, Michael F., Darrow, Andrew L., ...
Protease-activated receptors (PARs) represent a unique family of seven-transmembrane G protein-coupled receptors, which are enzymatically cleaved to expose a truncated extracellular N terminus that...
Lourbakos, Afrodite, Potempa, Jan, Travis, James, D'Andrea, Michael R., Andrade-Gordon, Patricia, Santulli, Rosemary, ...
Periodontitis is a chronic inflammatory disease affecting oral tissues. Oral epithelial cells represent the primary barrier against bacteria causing the disease. We examined the responses of such...
A role for proteinase-activated receptor–1 in inflammatory bowel diseases
Vergnolle, Nathalie, Cellars, Laurie, Mencarelli, Andrea, Rizzo, Giovanni, Swaminathan, Sunita, Beck, Paul, ...
Proteinase-activated receptor–1 (PAR1), a G protein–coupled receptor activated by thrombin, is highly expressed in different cell types of the gastrointestinal tract. The activity of thrombin and...
Hansen, Kristina K., Sherman, Philip M., Cellars, Laurie, Andrade-Gordon, Patricia, Pan, Zhengying, Baruch, Amos, ...
Citrobacter rodentium is a bacterial pathogen that causes a murine infectious colitis equivalent to enterohemorrhagic Escherichia coli infection in humans. Colonic luminal fluid from C....
A novel serine protease predominately expressed in macrophages.
Chen, Cailin, Darrow, Andrew L, Qi, Jian-Shen, D'Andrea, Michael R, Andrade-Gordon, Patricia
We have identified a novel serine protease designated EOS by sequence identity searches. The deduced protein contains 284 amino acids with an active form containing 248 amino acids starting from an...
A role for proteinase-activated receptor-1 in inflammatory bowel diseases
Vergnolle, Nathalie, Cellars, Laurie, Mencarelli, Andrea, Rizzo, Giovanni, Swaminathan, Sunita, Beck, Paul, ...
Role for protease activity in visceral pain in irritable bowel syndrome
Cenac, Nicolas, Andrews, Christopher N., Holzhausen, Marinella, Chapman, Kevin, Cottrell, Graeme, Andrade-Gordon, Patricia, ...
Mediators involved in the generation of symptoms in patients with irritable bowel syndrome (IBS) are poorly understood. Here we show that colonic biopsy samples from IBS patients release increased...
Holzhausen, Marinella, Spolidorio, Luis Carlos, Ellen, Richard P., Jobin, Marie-Claude, Steinhoff, Martin, Andrade-Gordon, Patricia, ...
We have investigated the specific contribution of protease-activated receptor-2 (PAR2) to host defense during Porphyromonas gingivalis infection. Culture supernatants from P. gingivalis strains 33277...
Regulatory network of inflammation downstream of proteinase-activated receptors
Saban, Ricardo, D'Andrea, Michael R, Andrade-Gordon, Patricia, Derian, Claudia K, Dozmorov, Igor, Ihnat, Michael A, ...
Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation
Saban, Ricardo, D'Andrea, Michael R, Andrade-Gordon, Patricia, Derian, Claudia K, Dozmorov, Igor, Ihnat, Michael A, ...
Induction of Intestinal Inflammation in Mouse by Activation of Proteinase-Activated Receptor-2
Cenac, Nicolas, Coelho, Anne-Marie, Nguyen, Cathy, Compton, Steven, Andrade-Gordon, Patricia, MacNaughton, Wallace K., ...
Proteinase-activated receptor (PAR)-2, a G-protein-coupled receptor for trypsin and mast cell tryptase, is highly expressed in the intestine. Luminal trypsin and tryptase are elevated in the colon of...
D’Andrea, Michael R., Saban, Marcia R., Nguyen, Ngoc-Bich, Andrade-Gordon, Patricia, Saban, Ricardo
Inflammation underlines all major bladder pathologies and represents a defense reaction to injury involving a mandatory participation of mast cells and sensory nerves. Mast cells are particularly...
D’Andrea, Michael R., Derian, Claudia K., Santulli, Rosemary J., Andrade-Gordon, Patricia
The serine proteases thrombin and trypsin are among many factors that malignant cells secrete into the extracellular space to mediate metastatic processes such as cellular invasion, extracellular...
Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism
Garavilla, Lawrence De, Vergnolle, Nathalie, Young, Steven H, Ennes, Helena, Steinhoff, Martin, Ossovskaya, Valeria S, ...
Thrombin, generated in the circulation during injury, cleaves proteinase-activated receptor 1 (PAR1) to stimulate plasma extravasation and granulocyte infiltration. However, the mechanism of...
McGuire, John J, Hollenberg, Morley D, Andrade-Gordon, Patricia, Triggle, Chris R
Activation of PAR2 in second-order mesenteric arteriole (MA) rings from C57BL/6J, NOS3 (−/−) and PAR2 (−/−) mice was assessed for the contributions of NO, cyclo-oxygenases, guanylyl cyclase,...
Tognetto, Michele, D'Andrea, Michael R, Trevisani, Marcello, Guerrini, Remo, Salvadori, Severo, Spisani, Lorella, ...
The in vitro motor function of protease-activated recepter-1 (PAR-1), PAR-2 and PAR-4 and the presence by immunohistochemistry of PAR-1 in the human renal artery have been investigated.Thrombin and...
Noorbakhsh, Farshid, Tsutsui, Shigeki, Vergnolle, Nathalie, Boven, Leonie A., Shariat, Neda, Vodjgani, Mohammed, ...
The proteinase-activated receptors (PARs) are widely recognized for their modulatory properties of inflammation and neurodegeneration. We investigated the role of PAR2 in the pathogenesis of multiple...