Patricia Hartge

Breast cancer epidemiology according to recognized breast cancer risk factors in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial Cohort (2009)

Lacey, James V, Kreimer, Aimee R, Buys, Saundra S, Marcus, Pamela M, Chang, Shih-Chen, Leitzmann, Michael F, ...

Abstract Background Multidisciplinary attempts to understand the etiology of breast cancer are expanding to increasingly include new potential markers of disease risk. Those efforts may have maximal...

ABO Blood Group and the Risk of Pancreatic Cancer (2009)

Wolpin, Brian M., Chan, Andrew T., Hartge, Patricia, Chanock, Stephen J., Kraft, Peter, Hunter, David J., ...

Background Other than several rare, highly penetrant familial syndromes, genetic risk factors for sporadic pancreatic cancer are largely unknown. ABO blood type is an inherited characteristic that in...

Obesity, Lifestyle Factors, and Risk of Myelodysplastic Syndromes in a Large US Cohort (2009)

Ma, Xiaomei, Lim, Unhee, Park, Yikyung, Mayne, Susan T., Wang, Rong, Hartge, Patricia, ...

The etiology of myelodysplastic syndromes (MDS) is not well understood. The authors examined the relations of obesity and lifestyle factors to MDS in a cohort of 471,799 persons aged 50–71 years...

Cigarette Smoking and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort Consortium (2009)

Lynch, Shannon M., Vrieling, Alina, Lubin, Jay H., Kraft, Peter, Mendelsohn, Julie B., Hartge, Patricia, ...

Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association of smoking intensity, smoking duration, and cumulative smoking dose with pancreatic...

A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma (2009)

Purdue, Mark P., Lan, Qing, Wang, Sophia S., Kricker, Anne, Menashe, Idan, Zheng, Tong-Zhang, ...

Toll-like receptors (TLRs) may influence the development of non-Hodgkin lymphoma (NHL) given their important roles in recognizing microbial pathogens and stimulating multiple immune pathways. We...

Personal Use of Hair Dye and the Risk of Certain Subtypes of Non-Hodgkin Lymphoma (2008)

Zhang, Yawei, Sanjose, Silvia De, Bracci, Paige M., Morton, Lindsay M., Wang, Rong, Brennan, Paul, ...

Personal use of hair dye has been inconsistently linked to risk of non-Hodgkin lymphoma (NHL), perhaps because of small samples or a lack of detailed information on personal hair-dye use in previous...

Chromosomal Aberrations in Peripheral Blood Lymphocytes and Risk for Non-Hodgkin Lymphoma (2008)

Wang, Sophia S., Davis, Scott, Hartge, Patricia, Cozen, Wendy, Severson, Richard K., Cerhan, James R., ...

Chromosomal aberrations (CAs) are thought to be integrative biomarkers that reflect exposure to chromosome-damaging carcinogens and host factors. To investigate whether CAs indicate non-Hodgkin...

Alcohol, Smoking, and Body Size in Relation to Incident Hodgkin's and Non-Hodgkin's Lymphoma Risk (2007)

Lim, Unhee, Morton, Lindsay M., Subar, Amy F., Baris, Dalsu, Stolzenberg-Solomon, Rachael, Leitzmann, Michael, ...

Studies associate alcohol consumption, cigarette smoking, and body size with the risk of overall or subtype lymphoma. Current data come mostly from case-control studies or prospective studies with...

Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma (2007)

Morton, Lindsay M., Bernstein, Leslie, Wang, Sophia S., Hein, David W., Rothman, Nathaniel, Colt, Joanne S., ...

Background: Several previous studies have found non-Hodgkin lymphoma (NHL) risk to be associated with hair dye use, particularly use of permanent, dark colors and use before 1980, when hair dye...

Cigarette Smoking and Cancer Risk: Modeling Total Exposure and Intensity (2007)

Lubin, Jay H., Alavanja, Michael C. R., Caporaso, Neil, Brown, Linda M., Brownson, Ross C., Field, R. William, ...

A recent analysis showed that the excess odds ratio (EOR) for lung cancer due to smoking can be modeled by a function which is linear in total pack-years and exponential in the logarithm of smoking...

Reproductive Risk Factors for Cutaneous Melanoma in Women: A Case-Control Study (2007)

Lea, C. Suzanne, Holly, Elizabeth A., Hartge, Patricia, Lee, Jennifer S., Guerry, DuPont, Elder, David E., ...

Reproductive hormonal factors may have a potential role in cutaneous melanoma. This study estimated the risk of melanoma in women related to self-reported changes in nevi during pregnancy, while...

Menopausal Hormone Therapy and Ovarian Cancer Risk in the National Institutes of Health–AARP Diet and Health Study Cohort (2006)

Lacey, James V., Brinton, Louise A., Leitzmann, Michael F., Mouw, Traci, Hollenbeck, Albert, Schatzkin, Arthur, ...

Background: Recent studies offer conflicting data on risks of ovarian cancer in users of menopausal hormone therapy. Some findings of increased risks associated with unopposed estrogen use are based...

Age at Natural Menopause in Women Exposed to Diethylstilbestrol in Utero (2006)

Hatch, Elizabeth E., Troisi, Rebecca, Wise, Lauren A., Hyer, Marianne, Palmer, Julie R., Titus-Ernstoff, Linda, ...

Age at natural menopause is related to several health outcomes, including cardiovascular disease and overall mortality. Age at menopause may be influenced by the number of follicles formed during...

Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma (2006)

Wang, Sophia S., Davis, Scott, Cerhan, James R., Hartge, Patricia, Severson, Richard K., Cozen, Wendy, ...

Evidence supporting the contribution of oxidative stress to key pathways in cancer, such as inflammation and DNA damage, continues to mount. We investigated variations within genes mediating...

Reporting Participation in Epidemiologic Studies: A Survey of Practice (2006)

Morton, Lindsay M., Cahill, Jack, Hartge, Patricia

Self-selection bias may threaten the internal validity of epidemiologic studies. Studies with a low level of participation are particularly vulnerable to this bias, and commentators note apparent...

Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES) (2006)

Titus-Ernstoff, Linda, Troisi, Rebecca, Hatch, Elizabeth E, Wise, Lauren A, Palmer, Julie, Hyer, Marianne, ...

Background In women, prenatal exposure to diethylstilbestrol (DES) is associated with adult reproductive dysfunction. The mouse model, which replicates many DES outcomes, suggests DES causes...

Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES) (2006)

Titus-Ernstoff, Linda, Troisi, Rebecca, Hatch, Elizabeth E., Wise, Lauren A., Palmer, Julie, Hyer, Marianne, ...

Background In women, prenatal exposure to diethylstilbestrol (DES) is associated with adult reproductive dysfunction. The mouse model, which replicates many DES outcomes, suggests DES causes...

Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma (2006)

Wang, Sophia S., Davis, Scott, Cerhan, James R., Hartge, Patricia, Severson, Richard K., Cozen, Wendy, ...

Evidence supporting the contribution of oxidative stress to key pathways in cancer, such as inflammation and DNA damage, continues to mount. We investigated variations within genes mediating...

A Network of Investigator Networks in Human Genome Epidemiology (2005)

Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...

The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...

Immune-Related Conditions and Immune-Modulating Medications as Risk Factors for Non-Hodgkin's Lymphoma: A Case-Control Study (2005)

Engels, Eric A., Cerhan, James R., Linet, Martha S., Cozen, Wendy, Colt, Joanne S., Davis, Scott, ...

In immunosuppressed or autoimmune disease states, disordered immune responses may lead to non-Hodgkin's lymphoma (NHL). In a US population-based case-control study of NHL (1998-2000), the authors...

Reporting Participation in Epidemiologic Studies: A Survey of Practice (2005)

Morton, Lindsay M., Cahill, Jack, Hartge, Patricia

Self-selection bias may threaten the internal validity of epidemiologic studies. Studies with a low level of participation are particularly vulnerable to this bias, and commentators note apparent...

Cancer Risk Prediction Models: A Workshop on Development, Evaluation, and Application (2005)

Freedman, Andrew N., Seminara, Daniela, Gail, Mitchell H., Hartge, Patricia, Colditz, Graham A., Ballard-Barbash, Rachel, ...

Cancer researchers, clinicians, and the public are increasingly interested in statistical models designed to predict the occurrence of cancer. As the number and sophistication of cancer risk...

Meat and meat-mutagen intake and risk of non-hodgkin lymphoma: results from a NCI-SEER case-control study (2005)

Cross, Amanda J., Ward, Mary H., Schenk, MaryJean, Kulldorff, Martin, Cozen, Wendy, Davis, Scott, ...

Non-Hodgkin Lymphoma (NHL) incidence has risen dramatically over past decades, but the reasons for most of this increase are not known. Meat cooked well-done by high temperature cooking techniques...

A Network of Investigator Networks in Human Genome Epidemiology (2005)

Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...

The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...

Immune-Related Conditions and Immune-Modulating Medications as Risk Factors for Non-Hodgkin's Lymphoma: A Case-Control Study (2005)

Engels, Eric A., Cerhan, James R., Linet, Martha S., Cozen, Wendy, Colt, Joanne S., Davis, Scott, ...

In immunosuppressed or autoimmune disease states, disordered immune responses may lead to non-Hodgkin's lymphoma (NHL). In a US population-based case-control study of NHL (1998–2000), the authors...

A Network of Investigator Networks in Human Genome Epidemiology (2005)

Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...

The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...

Immune-Related Conditions and Immune-Modulating Medications as Risk Factors for Non-Hodgkin's Lymphoma: A Case-Control Study (2005)

Engels, Eric A., Cerhan, James R., Linet, Martha S., Cozen, Wendy, Colt, Joanne S., Davis, Scott, ...

In immunosuppressed or autoimmune disease states, disordered immune responses may lead to non-Hodgkin's lymphoma (NHL). In a US population-based case-control study of NHL (1998-2000), the authors...

Reporting Participation in Epidemiologic Studies: A Survey of Practice (2005)

Morton, Lindsay M., Cahill, Jack, Hartge, Patricia

Self-selection bias may threaten the internal validity of epidemiologic studies. Studies with a low level of participation are particularly vulnerable to this bias, and commentators note apparent...

Case–Control Study of Simian Virus 40 and Non-Hodgkin Lymphoma in the United States (2004)

Engels, Eric A., Viscidi, Raphael P., Galloway, Denise A., Carter, Joseph J., Cerhan, James R., Davis, Scott, ...

Background: Recent studies have reported detection of simian virus 40 (SV40) DNA in tumor tissues from 15%–43% of U.S. non-Hodgkin lymphoma (NHL) patients. SV40 accidentally contaminated U.S....

Gynecologic Surgeries and Risk of Ovarian Cancer in Women With BRCA1 and BRCA2 Ashkenazi Founder Mutations: An Israeli Population-Based Case–Control Study (2003)

Rutter, Joni L., Wacholder, Sholom, Chetrit, Angela, Lubin, Flora, Menczer, Joseph, Ebbers, Sarah, ...

Background: In the general population, the risk of developing ovarian cancer is reduced in women who have undergone tubal ligation, hysterectomy, or oophorectomy, although peritoneal cancer can arise...

Recent Trends in Cutaneous Melanoma Incidence Among Whites in the United States (2001)

Jemal, Ahmedin, Devesa, Susan S., Hartge, Patricia, Tucker, Margaret A.

Background: It is not yet clear whether increasing melanoma incidence is real or whether recent incidence trends mainly reflect improved diagnosis. To address this question, we examined the most...

Multiple Births and Risk of Epithelial Ovarian Cancer (2000)

Whiteman, David C., Murphy, Michael F. G., Cook, Linda S., Cramer, Daniel W., Hartge, Patricia, Marchbanks, Polly A., ...

Background and Methods: Prevailing hypotheses about the causes of ovarian carcinogenesis predict that women with a history of multiple births (twins, triplets, etc.) should be at increased risk of...

Cancer Surveillance Series: Changing Patterns of Cutaneous Malignant Melanoma Mortality Rates Among Whites in the United States (2000)

Jemal, Ahmedin, Devesa, Susan S., Fears, Thomas R., Hartge, Patricia

Background: Mortality from melanoma among whites is still increasing in the United States. In this study, we describe the changing patterns of melanoma mortality rates among whites by demographic...

Survival After Breast Cancer in Ashkenazi Jewish BRCA1 and BRCA2 Mutation Carriers (1999)

Lee, Jennifer S., Wacholder, Sholom, Struewing, Jeffery P., McAdams, Mary, Pee, David, Brody, Lawrence C., ...

BACKGROUND: Studies of survival following breast and ovarian cancers in BRCA1 and/or BRCA2 mutation carriers have yielded conflicting results. We undertook an analysis of a community-based study of...

The Kin-Cohort Study for Estimating Penetrance (1998)

Wacholder, Sholom, Hartge, Patricia, Struewing, Jeffery P., Pee, David, McAdams, Mary, Brody, Lawrence, ...

A cross-sectional study may be more feasible than a cohort or case-control study for examining the effect of a genetic mutation on cancer penetrance outside of cancer families. The kin-cohort design...

Epidemiology of Brain Lymphoma Among People With or Without Acquired Immunodeficiency Syndrome (1996)

Coté, Timothy R., Manns, Angela, Hardy, Catherine R., Yellin, Frances J., Hartge, Patricia

Background: In recent years, brain lymphoma incidence has dramatically increased, presumably because of elevated risk of brain lymphoma among persons with acquired immunodeficiency syndrome (AIDS)....

Effect of Human T-Lymphotropic Virus Type I Infection on Non-Hodgkin's Lymphoma Incidence (1995)

Cleghorn, Farley R., Manns, Angela, Falk, Roni, Hartge, Patricia, Hanchard, Barrie, Jack, Noreen, ...

Background: We previously reported from a case—control analysis that T-cell non-Hodgkin's lymphoma (NHL) was strongly associated with human T-lym-photropic virus type I (HTLV-I) infection in...

Attributable Risk: Advantages of a Broad Definition of Exposure (1994)

Wacholder, Sholom, Benichou, Jacques, Heineman, Ellen F., Hartge, Patricia, Hoover, Robert N.

Classification of exposure into two levels—one consisting exclusively of unexposed individuals and the other consisting of exposed and perhaps unexposed ones—yields an unbiased estimate of...

Validation Studies using an Alloyed Gold Standard (1993)

Wacholder, Sholom, Armstrong, Ben, Hartge, Patricia

A key assumption made when using a validation study to correct an estimate of relative risk for bias due to misdassification or measurement error is that the available measure, known to have error...

Unexplained Excess Risk of Bladder Cancer in Men (1990)

Hartge, Patricia, Harvey, Elizabeth B., Linehan, W. Marston, Silverman, Debra T., Sullivan, Jerry W., Hoover, Robert N., ...

In nearly all populations studied, the risk of bladder cancer is two to four times as great in men as in Women.We estimated what the gender-specific incidence rates would be in the absence of...

Occupational Risks of Bladder Cancer in the United States: I. White Men (1989)

Silverman, Debra T., Levin, Lynn I., Hoover, Robert N., Hartge, Patricia

We examined the relationship between occupation and bladder cancer risk using data obtained from interviews conducted with 2,100 white males with bladder cancer and 3,874 population controls during...

MENOPAUSE AND OVARIAN CANCER (1988)

HARTGE, PATRICIA, HOOVER, ROBERT, McGOWAN, LARRY, LESHER, LINDA, NORRIS, HENRY J.

Using data from a study of 296 patients diagnosed in greater Washington, D. C., from 1978 to 1981 with primary epithelial ovarian cancer and 343 patients hospitalized for other conditions, the...

RACIAL DIFFERENCES IN BLADDER CANCER RISK: A CASE-CONTROL STUDY (1988)

SCHAIRER, CATHERINE, HARTGE, PATRICIA, HOOVER, ROBERT N., SILVERMAN, DEBRA T.

To determine why the incidence rate of transitional cell bladder cancer in whites in the United States is approximately twice that in blacks, the authors examined data from a large population-based...

Tuberculosis Chemotherapy and Risk of Bladder Cancer (1985)

KANTOR, ARLENE F, HARTGE, PATRICIA, HOOVER, ROBERT N, FRAUMENI, JOSEPH F

Kantor A F (Environmental Epidemiology Branch, National Cancer Institute, Landow Building, Room 3C07, Bethesda, Maryland 20205, USA), Hartge P, Hoover R N, Fraumeni J F Jr. Tuberculosis chemotherapy...

URINARY TRACT INFECTION AND RISK OF BLADDER CANCER (1984)

KANTOR, ARLENE F., HARTGE, PATRICIA, HOOVER, ROBERT N., NARAYANA, AMBATI S., SULLIVAN, J. W., FRAUMENI, JOSEPH F.

In an epidemiologic study of 2982 bladder carcinoma patients and 5782 population controls from 10 geographic areas of the United States, the role of urinary tract infection and inflammation in the...

RANDOM DIGIT DIALING IN SELECTING A POPULATION-BASED CONTROL GROUP (1984)

HARTGE, PATRICIA, BRINTON, LOUISE A., ROSENTHAL, JEANNE F., CAHILL, JOHN I, HOOVER, ROBERT N., WAKSBERG, JOSEPH

Results are described from four epidemiologic studies in the United States which used random digit dialing in over 30,000 households to identify controls from the general population for use in...

BLADDER CANCER AND ALCOHOLIC BEVERAGE CONSUMPTION (1983)

THOMAS, DAVID B., UHL, CHARLES N., HARTGE, PATRICIA

Thomas, D. B. (The Fred Hutchlnson Cancer Research Center, Seattle, WA 98104), C. N. Uhl and P. Hartge. Bladder cancer and alcoholic beverage consumption. Am J Epidemiol 1983; 118: 720–7. A...

Epidemiologic Evaluation of Measurement Data in the Presence of Detection Limits

Lubin, Jay H., Colt, Joanne S., Camann, David, Davis, Scott, Cerhan, James R., Severson, Richard K., ...

Quantitative measurements of environmental factors greatly improve the quality of epidemiologic studies but can pose challenges because of the presence of upper or lower detection limits or...

Proximity to Crops and Residential Exposure to Agricultural Herbicides in Iowa

Ward, Mary H., Lubin, Jay, Giglierano, James, Colt, Joanne S., Wolter, Calvin, Bekiroglu, Nural, ...

Rural residents can be exposed to agricultural pesticides through the proximity of their homes to crop fields. Previously, we developed a method to create historical crop maps using a geographic...

Epidemiologic Evaluation of Measurement Data in the Presence of Detection Limits

Lubin, Jay H., Colt, Joanne S., Camann, David, Davis, Scott, Cerhan, James R., Severson, Richard K., ...

Quantitative measurements of environmental factors greatly improve the quality of epidemiologic studies but can pose challenges because of the presence of upper or lower detection limits or...

Proximity to Crops and Residential Exposure to Agricultural Herbicides in Iowa

Ward, Mary H., Lubin, Jay, Giglierano, James, Colt, Joanne S., Wolter, Calvin, Bekiroglu, Nural, ...

Rural residents can be exposed to agricultural pesticides through the proximity of their homes to crop fields. Previously, we developed a method to create historical crop maps using a geographic...

Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001

Morton, Lindsay M., Wang, Sophia S., Devesa, Susan S., Hartge, Patricia, Weisenburger, Dennis D., Linet, Martha S.

Because the causes of most lymphoid neoplasms remain unknown, comparison of incidence patterns by disease subtype may provide critical clues for future etiologic investigations. We therefore...

Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes

Hill, Deirdre A., Wang, Sophia S., Cerhan, James R., Davis, Scott, Cozen, Wendy, Severson, Richard K., ...

Chromosomal translocations, insertions, and deletions are common early events in non-Hodgkin lymphoma (NHL) carcinogenesis, and implicated in their formation are endogenous processes involved in...

Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study

Lim, Unhee, Wang, Sophia S., Hartge, Patricia, Cozen, Wendy, Kelemen, Linda E., Chanock, Stephen, ...

We previously reported a lower risk of non-Hodgkin lymphoma (NHL) associated with high consumption of vitamin B6 and methionine, dietary determinants of one-carbon metabolism. Evidence has linked...

Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)

Wang, Sophia S., Slager, Susan L., Brennan, Paul, Holly, Elizabeth A., De Sanjose, Silvia, Bernstein, Leslie, ...

A role for genetic susceptibility in non-Hodgkin lymphoma (NHL) is supported by the accumulating evidence of common genetic variations altering NHL risk. However, the pattern of NHL heritability...

Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival

Cerhan, James R., Wang, Sophia, Maurer, Matthew J., Ansell, Stephen M., Geyer, Susan M., Cozen, Wendy, ...

Recent gene-expression data have suggested that host immune genetic signatures may predict outcomes in patients with follicular lymphoma. We evaluated the hypothesis that germ line common variation...

Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma

Colt, Joanne S., Rothman, Nathaniel, Severson, Richard K., Hartge, Patricia, Cerhan, James R., Chatterjee, Nilanjan, ...

Organochlorine exposure was linked to non-Hodgkin lymphoma (NHL) risk. To determine whether this relation is modified by immune gene variation, we genotyped 61 polymorphisms in 36 immune genes in...

Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era

Habermann, Thomas M., Wang, Sophia S., Maurer, Matthew J., Morton, Lindsay M., Lynch, Charles F., Ansell, Stephen M., ...

To evaluate the hypothesis that host germ line variation in immune genes is associated with overall survival in diffuse large B-cell lymphoma (DLBCL), we genotyped 73 single nucleotide polymorphisms...