Patricia R. Watson

Flagellar phase variation of Salmonella enterica serovar typhimurium contributes to virulence in the murine typhoid infection model but does not influence Salmonella-induced enteropathogenesis (2001)

Ikeda, Jack S., Schmitt, Clare K., Darnell, Stephen C., Watson, Patricia R., Bispham, Jennifer, Wallis, Timothy S., ...

Although Salmonella enterica serovar Typhimurium can undergo phase variation to alternately express two different types of flagellin subunit proteins, FljB or FliC, no biological function for this...

Differential Regulation of Enteric and Systemic Salmonellosis by slyA

Watson, Patricia R., Paulin, Sue M., Bland, A. Patricia, Libby, Stephen J., Jones, Philip W., Wallis, Tim S.

Mutation of slyA, which reduces Salmonella typhimurium virulence in mice, caused only minor attenuation of S. typhimurium virulence in orally inoculated calves. This correlated with modest reductions...

Salmonella enterica Serovars Typhimurium and Dublin Can Lyse Macrophages by a Mechanism Distinct from Apoptosis

Watson, Patricia R., Gautier, Anne V., Paulin, Sue M., Bland, A. Patricia, Jones, Philip W., Wallis, Timothy S.

Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA...

Mutation of waaN Reduces Salmonella enterica Serovar Typhimurium-Induced Enteritis and Net Secretion of Type III Secretion System 1-Dependent Proteins

Watson, Patricia R., Benmore, Annette, Khan, Shahid A., Jones, Philip W., Maskell, Duncan J., Wallis, Timothy S.

Mutation of waaN, a gene involved in lipid A biosynthesis, reduced enteropathogenic responses induced by Salmonella enterica serovar Typhimurium in bovine ligated ileal loops. However, the secretion...

Flagellar Phase Variation of Salmonella enterica Serovar Typhimurium Contributes to Virulence in the Murine Typhoid Infection Model but Does Not Influence Salmonella-Induced Enteropathogenesis

Ikeda, Jack S., Schmitt, Clare K., Darnell, Stephen C., Watson, Patricia R., Bispham, Jennifer, Wallis, Timothy S., ...

Although Salmonella enterica serovar Typhimurium can undergo phase variation to alternately express two different types of flagellin subunit proteins, FljB or FliC, no biological function for this...

Salmonella enterica Serovar-Host Specificity Does Not Correlate with the Magnitude of Intestinal Invasion in Sheep

Uzzau, Sergio, Leori, Guido S., Petruzzi, Valentino, Watson, Patricia R., Schianchi, Giuseppe, Bacciu, Donatella, ...

The colonization of intestinal and systemic tissues by Salmonella enterica serovars with different host specificities was determined 7 days after inoculation of 1 to 2-month-old lambs. Following oral...

Absence of All Components of the Flagellar Export and Synthesis Machinery Differentially Alters Virulence of Salmonella enterica Serovar Typhimurium in Models of Typhoid Fever, Survival in Macrophages, Tissue Culture Invasiveness, and Calf Enterocolitis

Schmitt, Clare K., Ikeda, Jack S., Darnell, Stephen C., Watson, Patricia R., Bispham, Jennifer, Wallis, Timothy S., ...

In this study, we constructed an flhD (the master flagellar regulator gene) mutant of Salmonella enterica serovar Typhimurium and compared the virulence of the strain to that of the wild-type strain...

Mutation of invH, but Not stn, Reduces Salmonella-Induced Enteritis in Cattle

Watson, Patricia R., Galyov, Edouard E., Paulin, Sue M., Jones, Philip W., Wallis, Tim S.

The induction of secretory and inflammatory responses in calves by Salmonella typhimurium and Salmonella dublin strains was compared, and the effects of mutations in the invH and stn genes were...

Secreted Effector Proteins of Salmonella dublin Act in Concert To Induce Enteritis

Jones, Michael A., Wood, Michael W., Mullan, Paul B., Watson, Patricia R., Wallis, Tim S., Galyov, Edouard E.

The ability of enteropathogenic salmonellae to recruit inflammatory cells and induce secretory responses in the infected ileum is considered to be a main feature in Salmonella-induced enteritis....

Analysis of Salmonella enterica Serotype-Host Specificity in Calves: Avirulence of S. enterica Serotype Gallinarum Correlates with Bacterial Dissemination from Mesenteric Lymph Nodes and Persistence In Vivo

Paulin, Susan M., Watson, Patricia R., Benmore, Annette R., Stevens, Mark P., Jones, Philip W., Villarreal-Ramos, Bernardo, ...

Host and bacterial factors that determine whether Salmonella serotypes remain restricted to the gastrointestinal tract or penetrate beyond the mucosa and cause systemic disease remain largely...

Differential Regulation of Enteric and Systemic Salmonellosis by slyA

Watson, Patricia R., Paulin, Sue M., Bland, A. Patricia, Libby, Stephen J., Jones, Philip W., Wallis, Tim S.

Mutation of slyA, which reduces Salmonella typhimurium virulence in mice, caused only minor attenuation of S. typhimurium virulence in orally inoculated calves. This correlated with modest reductions...

Salmonella enterica Serovars Typhimurium and Dublin Can Lyse Macrophages by a Mechanism Distinct from Apoptosis

Watson, Patricia R., Gautier, Anne V., Paulin, Sue M., Bland, A. Patricia, Jones, Philip W., Wallis, Timothy S.

Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA...

Mutation of waaN Reduces Salmonella enterica Serovar Typhimurium-Induced Enteritis and Net Secretion of Type III Secretion System 1-Dependent Proteins

Watson, Patricia R., Benmore, Annette, Khan, Shahid A., Jones, Philip W., Maskell, Duncan J., Wallis, Timothy S.

Mutation of waaN, a gene involved in lipid A biosynthesis, reduced enteropathogenic responses induced by Salmonella enterica serovar Typhimurium in bovine ligated ileal loops. However, the secretion...

Flagellar Phase Variation of Salmonella enterica Serovar Typhimurium Contributes to Virulence in the Murine Typhoid Infection Model but Does Not Influence Salmonella-Induced Enteropathogenesis

Ikeda, Jack S., Schmitt, Clare K., Darnell, Stephen C., Watson, Patricia R., Bispham, Jennifer, Wallis, Timothy S., ...

Although Salmonella enterica serovar Typhimurium can undergo phase variation to alternately express two different types of flagellin subunit proteins, FljB or FliC, no biological function for this...

Salmonella enterica Serovar-Host Specificity Does Not Correlate with the Magnitude of Intestinal Invasion in Sheep

Uzzau, Sergio, Leori, Guido S., Petruzzi, Valentino, Watson, Patricia R., Schianchi, Giuseppe, Bacciu, Donatella, ...

The colonization of intestinal and systemic tissues by Salmonella enterica serovars with different host specificities was determined 7 days after inoculation of 1 to 2-month-old lambs. Following oral...

Absence of All Components of the Flagellar Export and Synthesis Machinery Differentially Alters Virulence of Salmonella enterica Serovar Typhimurium in Models of Typhoid Fever, Survival in Macrophages, Tissue Culture Invasiveness, and Calf Enterocolitis

Schmitt, Clare K., Ikeda, Jack S., Darnell, Stephen C., Watson, Patricia R., Bispham, Jennifer, Wallis, Timothy S., ...

In this study, we constructed an flhD (the master flagellar regulator gene) mutant of Salmonella enterica serovar Typhimurium and compared the virulence of the strain to that of the wild-type strain...

Mutation of invH, but Not stn, Reduces Salmonella-Induced Enteritis in Cattle

Watson, Patricia R., Galyov, Edouard E., Paulin, Sue M., Jones, Philip W., Wallis, Tim S.

The induction of secretory and inflammatory responses in calves by Salmonella typhimurium and Salmonella dublin strains was compared, and the effects of mutations in the invH and stn genes were...

Secreted Effector Proteins of Salmonella dublin Act in Concert To Induce Enteritis

Jones, Michael A., Wood, Michael W., Mullan, Paul B., Watson, Patricia R., Wallis, Tim S., Galyov, Edouard E.

The ability of enteropathogenic salmonellae to recruit inflammatory cells and induce secretory responses in the infected ileum is considered to be a main feature in Salmonella-induced enteritis....

Analysis of Salmonella enterica Serotype-Host Specificity in Calves: Avirulence of S. enterica Serotype Gallinarum Correlates with Bacterial Dissemination from Mesenteric Lymph Nodes and Persistence In Vivo

Paulin, Susan M., Watson, Patricia R., Benmore, Annette R., Stevens, Mark P., Jones, Philip W., Villarreal-Ramos, Bernardo, ...

Host and bacterial factors that determine whether Salmonella serotypes remain restricted to the gastrointestinal tract or penetrate beyond the mucosa and cause systemic disease remain largely...

Systemic Translocation of Salmonella enterica Serovar Dublin in Cattle Occurs Predominantly via Efferent Lymphatics in a Cell-Free Niche and Requires Type III Secretion System 1 (T3SS-1) but Not T3SS-2▿

Pullinger, Gillian D., Paulin, Susan M., Charleston, Bryan, Watson, Patricia R., Bowen, Alison J., Dziva, Francis, ...

Salmonella enterica is an important diarrheal pathogen, and infections may involve severe systemic sequelae depending on serovar- and host-specific factors. The molecular mechanisms underlying...