Arp3 is required during preimplantation development of the mouse embryo (2007)
Vauti, Franz, Prochnow, Blair Raymond, Freese, Elke, Ramasamy, Suresh Kumar, Ruiz, Patricia, Arnold, Hans-Henning
The role of Arp3 in mouse development was investigated utilizing a gene trap mutation in the Arp3 gene. Heterozygous Arp3WT/GT mice are normal, however, homozygous Arp3GT/GT embryos die at blastocyst...
High-throughput trapping of secretory pathway genes in mouse embryonic stem cells (2006)
De-Zolt, Silke, Schnütgen, Frank, Seisenberger, Claudia, Hansen, Jens, Hollatz, Melanie, Floss, Thomas, ...
High-throughput gene trapping is a random approach for inducing insertional mutations across the mouse genome. This approach uses gene trap vectors that simultaneously inactivate and report the...
The Hsp90 cochaperone p23 is essential for perinatal survival (triangledown) (2006)
Grad, Iwona, McKee, Thomas A., Ludwig, Sara M., Hoyle, Gary W., Ruiz, Patricia, Wurst, Wolfgang, ...
The functions of molecular chaperones have been extensively investigated biochemically in vitro and genetically in bacteria and yeast. We have embarked on a functional genomic analysis of the Hsp90...
Kirchhof, Paulus, Fabritz, Larissa, Zwiener, Melanie, Witt, Henning, Schäfers, Michael, Zellerhoff, Stephan, ...
Background— Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disorder that causes sudden death and right ventricular heart failure in the young. Clinical data suggest that...
Nord, Alex S., Chang, Patricia J., Conklin, Bruce R., Cox, Antony V., Harper, Courtney A., Hicks, Geoffrey G., ...
Gene trapping is a method of generating murine embryonic stem (ES) cell lines containing insertional mutations in known and novel genes. A number of international groups have used this approach to...
Pfab, Thiemo, Thöne-Reineke, Christa, Theilig, Franziska, Lange, Ines, Witt, Henning, Maser-Gluth, Christiane, ...
The endothelin (ET) system has been implicated in the pathogenesis of diabetic nephropathy. The role of the ET-B receptor (ETBR) is still unclear. The effect of ETBR deficiency on the progression of...
Schefe, Jan H., Menk, Mario, Reinemund, Jana, Effertz, Karin, Hobbs, Robin M., Pandolfi, Pier Paolo, ...
A human renin/prorenin receptor (RER) has recently been cloned. To gain insight into the molecular function of the RER, we studied its signal transduction mechanisms. Initially, we found a ubiquitous...
Centro de rehabilitación Comenzar de Nuevo / (2006)
Castaño, Laura., Trad Marcos, Juan Pablo., Rodríguez, Inés Sofía., Ruiz, Patricia., Treviño, Ana Catalina, Galván Salinas, Jorge E.
Tesis (Arquitectura)--UDEM
Hitz, Christiane, Vogt-Weisenhorn, Daniela, Ruiz, Patricia, Wurst, Wolfgang, Floss, Thomas
We have generated a mouse line with a mutant allele of the mouse Bruce/Birc6 gene induced by gene trap mutagenesis. Based on its structural features, Bruce is a member of the family of apoptosis...
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome (2005)
Schnütgen, Frank, De-Zolt, Silke, Van Sloun, Petra, Hollatz, Melanie, Floss, Thomas, Hansen, Jens, ...
A type of retroviral gene trap vectors has been developed that can induce conditional mutations in most genes expressed in mouse embryonic stem (ES) cells. The vectors rely on directional...
Schupp, Michael, Clemenz, Markus, Gineste, Romain, Witt, Henning, Janke, Jürgen, Helleboid, Stephane, ...
Selective peroxisome proliferator–activated receptor (PPAR) {gamma} modulation is a new pharmacological approach that, based on selective receptor-cofactor interactions and target gene regulation,...
A public gene trap resource for mouse functional genomics (2004)
Skarnes,William C., Von Melchner,Harald, Wurst,Wolfgang, Hicks,Geoff, Nord,Alex S., Cox,Tony, ...
A public gene trap resource for mouse functional genomics (2004)
Skarnes, William C., Von Melchner, Harald, Wurst, Wolfgang, Hicks, Geoff, Nord, Alex S., Cox, Tony, ...
Most,Patrick, Remppis,Andrew, Pleger,Sven T., Loffler,Eva, Ehlermann,Philipp, Bernotat,Juliane, ...
S100A1, a Ca2+-sensing protein of the EF-hand family, is most highly expressed in myocardial tissue, and cardiac S100A1 overexpression in vitro has been shown to enhance myocyte contractile...
Hansen,Jens, Floss,Thomas, Van Sloun,Petra, Fuchtbauer,Ernst-Martin, Vauti,Franz, Arnold,Hans-Hennig, ...
A major challenge of the postgenomic era is the functional characterization of every single gene within the mammalian genome. In an effort to address this challenge, we assembled a collection of...
Expression profiling of human idiopathic dilated cardiomyopathy (2003)
Grzeskowiak,Rafal, Witt,Henning, Drungowski,Mario, Thermann,Rolf, Hennig,Steffen, Perrot,Andreas, ...
Objective: To investigate the global changes accompanying human dilated cardiomyopathy (DCM) we performed a large-scale expression screen using myocardial biopsies from a group of DCM patients with...
RA-specific expression profiles and new candidate genes (2003)
Ungethuem,U., Haeupl,T., Koczan,D., Huber,H., Von Helversen,T., Ruiz,Patricia, ...
Objective: To identify rheumatoid arthritis- (RA)-specific profiles of differentially expressed genes. Methods: Synovial tissues from RA and osteoarthritis (OA) patients and from normal joints were...
Hansen, Jens, Floss, Thomas, Van Sloun, Petra, Fuchtbauer, Ernst-Martin, Vauti, Franz, Arnold, Hans-Hennig, ...
A major challenge of the postgenomic era is the functional characterization of every single gene within the mammalian genome. In an effort to address this challenge, we assembled a collection of...
Most, Patrick, Remppis, Andrew, Pleger, Sven T., Loffler, Eva, Ehlermann, Philipp, Bernotat, Juliane, ...
S100A1, a Ca2+-sensing protein of the EF-hand family, is most highly expressed in myocardial tissue, and cardiac S100A1 overexpression in vitro has been shown to enhance myocyte contractile...
Expression profiling of human idiopathic dilated cardiomyopathy (2003)
Grzeskowiak, Rafal, Witt, Henning, Drungowski, Mario, Thermann, Rolf, Hennig, Steffen, Perrot, Andreas, ...
Objective: To investigate the global changes accompanying human dilated cardiomyopathy (DCM) we performed a large-scale expression screen using myocardial biopsies from a group of DCM patients with...
RA-specific expression profiles and new candidate genes (2003)
Ungethuem, U., Haeupl, T., Koczan, D., Huber, H., Von Helversen, T., Ruiz, Patricia, ...
Objective: To identify rheumatoid arthritis- (RA)-specific profiles of differentially expressed genes. Methods: Synovial tissues from RA and osteoarthritis (OA) patients and from normal joints were...
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome
Hansen, Jens, Floss, Thomas, Van Sloun, Petra, Füchtbauer, Ernst-Martin, Vauti, Franz, Arnold, Hans-Hennig, ...
A major challenge of the postgenomic era is the functional characterization of every single gene within the mammalian genome. In an effort to address this challenge, we assembled a collection of...
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome
Schnütgen, Frank, De-Zolt, Silke, Van Sloun, Petra, Hollatz, Melanie, Floss, Thomas, Hansen, Jens, ...
A type of retroviral gene trap vectors has been developed that can induce conditional mutations in most genes expressed in mouse embryonic stem (ES) cells. The vectors rely on directional...
Nord, Alex S., Chang, Patricia J., Conklin, Bruce R., Cox, Antony V., Harper, Courtney A., Hicks, Geoffrey G., ...
Gene trapping is a method of generating murine embryonic stem (ES) cell lines containing insertional mutations in known and novel genes. A number of international groups have used this approach to...
High-throughput trapping of secretory pathway genes in mouse embryonic stem cells
De-Zolt, Silke, Schnütgen, Frank, Seisenberger, Claudia, Hansen, Jens, Hollatz, Melanie, Floss, Thomas, ...
High-throughput gene trapping is a random approach for inducing insertional mutations across the mouse genome. This approach uses gene trap vectors that simultaneously inactivate and report the...
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome
Hansen, Jens, Floss, Thomas, Van Sloun, Petra, Füchtbauer, Ernst-Martin, Vauti, Franz, Arnold, Hans-Hennig, ...
A major challenge of the postgenomic era is the functional characterization of every single gene within the mammalian genome. In an effort to address this challenge, we assembled a collection of...
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome
Schnütgen, Frank, De-Zolt, Silke, Van Sloun, Petra, Hollatz, Melanie, Floss, Thomas, Hansen, Jens, ...
A type of retroviral gene trap vectors has been developed that can induce conditional mutations in most genes expressed in mouse embryonic stem (ES) cells. The vectors rely on directional...
Nord, Alex S., Chang, Patricia J., Conklin, Bruce R., Cox, Antony V., Harper, Courtney A., Hicks, Geoffrey G., ...
Gene trapping is a method of generating murine embryonic stem (ES) cell lines containing insertional mutations in known and novel genes. A number of international groups have used this approach to...
High-throughput trapping of secretory pathway genes in mouse embryonic stem cells
De-Zolt, Silke, Schnütgen, Frank, Seisenberger, Claudia, Hansen, Jens, Hollatz, Melanie, Floss, Thomas, ...
High-throughput gene trapping is a random approach for inducing insertional mutations across the mouse genome. This approach uses gene trap vectors that simultaneously inactivate and report the...
The Hsp90 Cochaperone p23 Is Essential for Perinatal Survival▿
Grad, Iwona, McKee, Thomas A., Ludwig, Sara M., Hoyle, Gary W., Ruiz, Patricia, Wurst, Wolfgang, ...
The functions of molecular chaperones have been extensively investigated biochemically in vitro and genetically in bacteria and yeast. We have embarked on a functional genomic analysis of the Hsp90...