Patrick F. McDermott

Genetic Evidence that InhA of Mycobacterium smegmatis Is a Target for Triclosan

McMurry, Laura M., McDermott, Patrick F., Levy, Stuart B.

Three Mycobacterium smegmatis mutants selected for resistance to triclosan each had a different mutation in InhA, an enoyl reductase involved in fatty acid synthesis. Two expressed some isoniazid...

Identification and Expression of Cephamycinase blaCMY Genes in Escherichia coli and Salmonella Isolates from Food Animals and Ground Meat

Zhao, Shaohua, White, David G., McDermott, Patrick F., Friedman, Sharon, English, Linda, Ayers, Sherry, ...

Twenty-one Salmonella and 54 Escherichia coli isolates, recovered from food animals and retail ground meats, that exhibited decreased susceptibilities to ceftiofur and ceftriaxone were shown to...

Induction of Cytokine Synthesis by Flagella from Gram-Negative Bacteria May Be Dependent on the Activation or Differentiation State of Human Monocytes

Ciacci-Woolwine, Federica, McDermott, Patrick F., Mizel, Steven B.

We have previously demonstrated that salmonellae, but not Escherichia coli or Yersinia enterocolitica, stimulates tumor necrosis factor alpha (TNFα) production in the human promonocytic cell line...

High-Affinity Interaction between Gram-Negative Flagellin and a Cell Surface Polypeptide Results in Human Monocyte Activation

McDermott, Patrick F., Ciacci-Woolwine, Federica, Snipes, James A., Mizel, Steven B.

Flagella from diverse gram-negative bacteria induce tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β) synthesis by human monocytes (F. Ciacci-Woolwine, P. F. McDermott, and S. B....

Multidrug Resistance following Expression of the Escherichia coli marA Gene in Mycobacterium smegmatis

McDermott, Patrick F., White, David G., Podglajen, Isabelle, Alekshun, Michael N., Levy, Stuart B.

Expression of the Escherichia coli multiple antibiotic resistance marA gene cloned in Mycobacterium smegmatis produced increased resistance to multiple antimicrobial agents, including rifampin,...

Antimicrobial Resistance of Escherichia coli O157 Isolated from Humans, Cattle, Swine, and Food

Schroeder, Carl M., Zhao, Cuiwei, DebRoy, Chitrita, Torcolini, Jocelyn, Zhao, Shaohua, White, David G., ...

A total of 361 Escherichia coli O157 isolates, recovered from humans, cattle, swine, and food during the years 1985 to 2000, were examined to better understand the prevalence of antimicrobial...

Class 1 Integron-Associated Tobramycin-Gentamicin Resistance in Campylobacter jejuni Isolated from the Broiler Chicken House Environment

Lee, Margie D., Sanchez, Susan, Zimmer, Martha, Idris, Umelaalim, Berrang, Mark E., McDermott, Patrick F.

Using PCR, we screened 105 isolates of poultry-associated Campylobacter jejuni for the presence of class 1 integrons. Of those isolates, 21% (22 of 105) possessed the integrase gene, but only 5...

Characterization of Chloramphenicol Resistance in Beta-Hemolytic Escherichia coli Associated with Diarrhea in Neonatal Swine

Bischoff, Kenneth M., White, David G., McDermott, Patrick F., Zhao, Shaohua, Gaines, Stuart, Maurer, John J., ...

Ninety beta-hemolytic Escherichia coli isolates associated with diarrhea in neonatal pigs from multiple farms in Oklahoma were investigated for known associated disease serotypes, virulence factors,...

Antimicrobial-Resistant Campylobacter Species from Retail Raw Meats

Ge, Beilei, White, David G., McDermott, Patrick F., Girard, Webb, Zhao, Shaohua, Hubert, Susannan, ...

The antimicrobial susceptibilities of 378 Campylobacter isolates were determined. Resistance to tetracycline was the most common (82%), followed by resistance to doxycycline (77%), erythromycin...

Characterization of integron mediated antimicrobial resistance in Salmonella isolated from diseased swine

White, David G., Zhao, Shaohua, McDermott, Patrick F., Ayers, Sherry, Friedman, Sharon, Sherwood, Julie, ...

Forty-two Salmonella isolates obtained from diseased swine were genetically characterized for the presence of specific antimicrobial resistance mechanisms. Twenty of these isolates were characterized...

Characterization of Multiple-Antimicrobial-Resistant Salmonella Serovars Isolated from Retail Meats

Chen, Sheng, Zhao, Shaohua, White, David G., Schroeder, Carl M., Lu, Ran, Yang, Hanchun, ...

A total of 133 Salmonella isolates recovered from retail meats purchased in the United States and the People's Republic of China were assayed for antimicrobial susceptibility, the presence of...

Role of Efflux Pumps and Topoisomerase Mutations in Fluoroquinolone Resistance in Campylobacter jejuni and Campylobacter coli

Ge, Beilei, McDermott, Patrick F., White, David G., Meng, Jianghong

Point mutations in the topoisomerase (DNA gyrase A) gene are known to be associated with fluoroquinolone resistance in Campylobacter. Recent studies have shown that an efflux pump encoded by cmeABC...

Changes in Antimicrobial Susceptibility of Native Enterococcus faecium in Chickens Fed Virginiamycin

McDermott, Patrick F., Cullen, Patti, Hubert, Susannah K., McDermott, Shawn D., Bartholomew, Mary, Simjee, Shabbir, ...

The extent of transfer of antimicrobial resistance from agricultural environments to humans is controversial. To assess the potential hazard posed by streptogramin use in food animals, this study...

Broth Microdilution Susceptibility Testing of Campylobacter jejuni and the Determination of Quality Control Ranges for Fourteen Antimicrobial Agents

McDermott, Patrick F., Bodeis-Jones, Sonya M., Fritsche, Thomas R., Jones, Ronald N., Walker, Robert D.

Quality control ranges were developed for broth microdilution testing of Campylobacter jejuni ATCC 33560 against 14 antimicrobials. Cation-adjusted Mueller-Hinton broth containing 2.5% laked horse...

Effect of Conventional and Organic Production Practices on the Prevalence and Antimicrobial Resistance of Campylobacter spp. in Poultry

Luangtongkum, Taradon, Morishita, Teresa Y., Ison, Aaron J., Huang, Shouxiong, McDermott, Patrick F., Zhang, Qijing

Intestinal tracts of broilers and turkeys from 10 conventional broiler farms and 10 conventional turkey farms, where antimicrobials were routinely used, and from 5 organic broiler farms and 5 organic...

Genetic Evidence that InhA of Mycobacterium smegmatis Is a Target for Triclosan

McMurry, Laura M., McDermott, Patrick F., Levy, Stuart B.

Three Mycobacterium smegmatis mutants selected for resistance to triclosan each had a different mutation in InhA, an enoyl reductase involved in fatty acid synthesis. Two expressed some isoniazid...

Identification and Expression of Cephamycinase blaCMY Genes in Escherichia coli and Salmonella Isolates from Food Animals and Ground Meat

Zhao, Shaohua, White, David G., McDermott, Patrick F., Friedman, Sharon, English, Linda, Ayers, Sherry, ...

Twenty-one Salmonella and 54 Escherichia coli isolates, recovered from food animals and retail ground meats, that exhibited decreased susceptibilities to ceftiofur and ceftriaxone were shown to...

Induction of Cytokine Synthesis by Flagella from Gram-Negative Bacteria May Be Dependent on the Activation or Differentiation State of Human Monocytes

Ciacci-Woolwine, Federica, McDermott, Patrick F., Mizel, Steven B.

We have previously demonstrated that salmonellae, but not Escherichia coli or Yersinia enterocolitica, stimulates tumor necrosis factor alpha (TNFα) production in the human promonocytic cell line...

High-Affinity Interaction between Gram-Negative Flagellin and a Cell Surface Polypeptide Results in Human Monocyte Activation

McDermott, Patrick F., Ciacci-Woolwine, Federica, Snipes, James A., Mizel, Steven B.

Flagella from diverse gram-negative bacteria induce tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β) synthesis by human monocytes (F. Ciacci-Woolwine, P. F. McDermott, and S. B....

Multidrug Resistance following Expression of the Escherichia coli marA Gene in Mycobacterium smegmatis

McDermott, Patrick F., White, David G., Podglajen, Isabelle, Alekshun, Michael N., Levy, Stuart B.

Expression of the Escherichia coli multiple antibiotic resistance marA gene cloned in Mycobacterium smegmatis produced increased resistance to multiple antimicrobial agents, including rifampin,...

Antimicrobial Resistance of Escherichia coli O157 Isolated from Humans, Cattle, Swine, and Food

Schroeder, Carl M., Zhao, Cuiwei, DebRoy, Chitrita, Torcolini, Jocelyn, Zhao, Shaohua, White, David G., ...

A total of 361 Escherichia coli O157 isolates, recovered from humans, cattle, swine, and food during the years 1985 to 2000, were examined to better understand the prevalence of antimicrobial...

Class 1 Integron-Associated Tobramycin-Gentamicin Resistance in Campylobacter jejuni Isolated from the Broiler Chicken House Environment

Lee, Margie D., Sanchez, Susan, Zimmer, Martha, Idris, Umelaalim, Berrang, Mark E., McDermott, Patrick F.

Using PCR, we screened 105 isolates of poultry-associated Campylobacter jejuni for the presence of class 1 integrons. Of those isolates, 21% (22 of 105) possessed the integrase gene, but only 5...

Characterization of Chloramphenicol Resistance in Beta-Hemolytic Escherichia coli Associated with Diarrhea in Neonatal Swine

Bischoff, Kenneth M., White, David G., McDermott, Patrick F., Zhao, Shaohua, Gaines, Stuart, Maurer, John J., ...

Ninety beta-hemolytic Escherichia coli isolates associated with diarrhea in neonatal pigs from multiple farms in Oklahoma were investigated for known associated disease serotypes, virulence factors,...

Antimicrobial-Resistant Campylobacter Species from Retail Raw Meats

Ge, Beilei, White, David G., McDermott, Patrick F., Girard, Webb, Zhao, Shaohua, Hubert, Susannan, ...

The antimicrobial susceptibilities of 378 Campylobacter isolates were determined. Resistance to tetracycline was the most common (82%), followed by resistance to doxycycline (77%), erythromycin...

Characterization of integron mediated antimicrobial resistance in Salmonella isolated from diseased swine

White, David G., Zhao, Shaohua, McDermott, Patrick F., Ayers, Sherry, Friedman, Sharon, Sherwood, Julie, ...

Forty-two Salmonella isolates obtained from diseased swine were genetically characterized for the presence of specific antimicrobial resistance mechanisms. Twenty of these isolates were characterized...

Characterization of Multiple-Antimicrobial-Resistant Salmonella Serovars Isolated from Retail Meats

Chen, Sheng, Zhao, Shaohua, White, David G., Schroeder, Carl M., Lu, Ran, Yang, Hanchun, ...

A total of 133 Salmonella isolates recovered from retail meats purchased in the United States and the People's Republic of China were assayed for antimicrobial susceptibility, the presence of...

Role of Efflux Pumps and Topoisomerase Mutations in Fluoroquinolone Resistance in Campylobacter jejuni and Campylobacter coli

Ge, Beilei, McDermott, Patrick F., White, David G., Meng, Jianghong

Point mutations in the topoisomerase (DNA gyrase A) gene are known to be associated with fluoroquinolone resistance in Campylobacter. Recent studies have shown that an efflux pump encoded by cmeABC...

Changes in Antimicrobial Susceptibility of Native Enterococcus faecium in Chickens Fed Virginiamycin

McDermott, Patrick F., Cullen, Patti, Hubert, Susannah K., McDermott, Shawn D., Bartholomew, Mary, Simjee, Shabbir, ...

The extent of transfer of antimicrobial resistance from agricultural environments to humans is controversial. To assess the potential hazard posed by streptogramin use in food animals, this study...

Broth Microdilution Susceptibility Testing of Campylobacter jejuni and the Determination of Quality Control Ranges for Fourteen Antimicrobial Agents

McDermott, Patrick F., Bodeis-Jones, Sonya M., Fritsche, Thomas R., Jones, Ronald N., Walker, Robert D.

Quality control ranges were developed for broth microdilution testing of Campylobacter jejuni ATCC 33560 against 14 antimicrobials. Cation-adjusted Mueller-Hinton broth containing 2.5% laked horse...

Effect of Conventional and Organic Production Practices on the Prevalence and Antimicrobial Resistance of Campylobacter spp. in Poultry

Luangtongkum, Taradon, Morishita, Teresa Y., Ison, Aaron J., Huang, Shouxiong, McDermott, Patrick F., Zhang, Qijing

Intestinal tracts of broilers and turkeys from 10 conventional broiler farms and 10 conventional turkey farms, where antimicrobials were routinely used, and from 5 organic broiler farms and 5 organic...

Comparison of Subtyping Methods for Differentiating Salmonella enterica Serovar Typhimurium Isolates Obtained from Food Animal Sources

Foley, Steven L., White, David G., McDermott, Patrick F., Walker, Robert D., Rhodes, Bobbie, Fedorka-Cray, Paula J., ...

Molecular characterization (e.g., DNA-based typing methods) of Salmonella isolates is frequently employed to compare and distinguish clinical isolates recovered from animals and from patients with...

Multiple Antimicrobial Resistance in Plague: An Emerging Public Health Risk

Welch, Timothy J., Fricke, W. Florian, McDermott, Patrick F., White, David G., Rosso, Marie-Laure, Rasko, David A., ...

Antimicrobial resistance in Yersinia pestis is rare, yet constitutes a significant international public health and biodefense threat. In 1995, the first multidrug resistant (MDR) isolate of Y. pestis...

Contribution of Target Gene Mutations and Efflux to Decreased Susceptibility of Salmonella enterica Serovar Typhimurium to Fluoroquinolones and Other Antimicrobials▿

Chen, Sheng, Cui, Shenghui, McDermott, Patrick F., Zhao, Shaohua, White, David G., Paulsen, Ian, ...

The mechanisms involved in fluoroquinolone resistance in Salmonella enterica include target alterations and overexpression of efflux pumps. The present study evaluated the role of known and putative...