Patrick M. Bossuyt

Where is the supporting evidence for treating mild to moderate chronic obstructive pulmonary disease exacerbations with antibiotics? A systematic review (2008)

Puhan, Milo A, Vollenweider, Daniela, Steurer, Johann, Bossuyt, Patrick M, Ter Riet, Gerben

Abstract Background Randomised trials comparing different drugs head-to-head are extremely valuable for clinical decision-making. However, it is scientifically and ethically sensible to demand strong...

Pivotal Evaluation of the Accuracy of a Biomarker Used for Classification or Prediction: Standards for Study Design (2008)

Pepe, Margaret S., Feng, Ziding, Janes, Holly, Bossuyt, Patrick M., Potter, John D.

Research methods for biomarker evaluation lag behind those for evaluating therapeutic treatments. Although a phased approach to development of biomarkers exists and guidelines are available for...

No beneficial effect of preimplantation genetic screening in women of advanced maternal age with a high risk for embryonic aneuploidy (2008)

Twisk, Moniek, Mastenbroek, Sebastiaan, Hoek, Annemieke, Heineman, Maas-Jan, Van Der Veen, Fulco, Bossuyt, Patrick M., ...

BACKGROUND Human preimplantation embryos generated through in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatments show a variable rate of numerical chromosome...

Statistical models for quantifying diagnostic accuracy with multiple lesions per patient (2008)

Zwinderman, Aeilko H., Glas, Afina S., Bossuyt, Patrick M., Florie, Jasper, Bipat, Shandra, Stoker, Jaap

We propose random-effects models to summarize and quantify the accuracy of the diagnosis of multiple lesions on a single image without assuming independence between lesions. The number of...

Disturbed mineral metabolism is associated with muscle and skin complaints in a prospective cohort of dialysis patients (2007)

Noordzij, Marlies, Boeschoten, Elisabeth W., Bos, Willem J., Dekker, Friedo W., Bossuyt, Patrick M., Krediet, Raymond T., ...

Background. Disturbed mineral metabolism is associated with increased morbidity and mortality, however, its influence on physical symptoms is less clear. We explored the effects of disordered plasma...

Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort (2007)

Painter, Rebecca C., De Rooij, Susanne R., Bossuyt, Patrick M., De Groot, Eric, Stok, Wim J., Osmond, Clive, ...

OBJECTIVE: Experimental evidence indicates that maternal undernutrition during gestation may program hypertension in the offspring. We investigated whether maternal undernutrition leads to increased...

Reproducibility of the STARD checklist: an instrument to assess the quality of reporting of diagnostic accuracy studies (2006)

Smidt, Nynke, Rutjes, Anne WS, Van Der Windt, Daniëlle AWM, Ostelo, Raymond WJG, Bossuyt, Patrick M, Reitsma, Johannes B, ...

Abstract Background In January 2003, STAndards for the Reporting of Diagnostic accuracy studies (STARD) were published in a number of journals, to improve the quality of reporting in diagnostic...

Hypothalamic-pituitary-adrenal axis activity in adults who were prenatally exposed to the Dutch famine (2006)

De Rooij, Susanne R., Painter, Rebecca C., Phillips, David I., Osmond, Clive, Michels, Robert P., Bossuyt, Patrick M., ...

OBJECTIVE: The hypothalamic-pituitary-adrenal (HPA) axis has been proposed to be susceptible to fetal programming, the process by which an adverse fetal environment elicits permanent physiological...

Mineral metabolism and cardiovascular morbidity and mortality risk--peritoneal dialysis patients compared with haemodialysis patients (2006)

Noordzij, Marlies, Korevaar, Johanna C., Bos, Willem J., Boeschoten, Elisabeth W., Dekker, Friedo W., Bossuyt, Patrick M., ...

Background. The K/DOQI guideline for bone metabolism and disease in chronic kidney disease is predominantly based on studies in haemodialysis (HD) patients. However, in clinical practice, this...

Mineral metabolism and cardiovascular morbidity and mortality risk: peritoneal dialysis patients compared with haemodialysis patients (2006)

Noordzij, Marlies, Korevaar, Johanna C., Bos, Willem J., Boeschoten, Elisabeth W., Dekker, Friedo W., Bossuyt, Patrick M., ...

Background. The K/DOQI guideline for bone metabolism and disease in chronic kidney disease is predominantly based on studies in haemodialysis (HD) patients. However, in clinical practice, this...

Mineral metabolism and cardiovascular morbidity and mortality risk: peritoneal dialysis patients compared with haemodialysis patients (2006)

Noordzij, Marlies, Korevaar, Johanna C., Bos, Willem J., Boeschoten, Elisabeth W., Dekker, Friedo W., Bossuyt, Patrick M., ...

Background. The K/DOQI guideline for bone metabolism and disease in chronic kidney disease is predominantly based on studies in haemodialysis (HD) patients. However, in clinical practice, this...

Mineral metabolism and cardiovascular morbidity and mortality risk: peritoneal dialysis patients compared with haemodialysis patients (2006)

Noordzij, Marlies, Korevaar, Johanna C., Bos, Willem J., Boeschoten, Elisabeth W., Dekker, Friedo W., Bossuyt, Patrick M., ...

Background. The K/DOQI guideline for bone metabolism and disease in chronic kidney disease is predominantly based on studies in haemodialysis (HD) patients. However, in clinical practice, this...

Mineral metabolism and cardiovascular morbidity and mortality risk--peritoneal dialysis patients compared with haemodialysis patients (2006)

Noordzij, Marlies, Korevaar, Johanna C., Bos, Willem J., Boeschoten, Elisabeth W., Dekker, Friedo W., Bossuyt, Patrick M., ...

Background. The K/DOQI guideline for bone metabolism and disease in chronic kidney disease is predominantly based on studies in haemodialysis (HD) patients. However, in clinical practice, this...

Mineral metabolism and cardiovascular morbidity and mortality risk: peritoneal dialysis patients compared with haemodialysis patients (2006)

Noordzij, Marlies, Korevaar, Johanna C., Bos, Willem J., Boeschoten, Elisabeth W., Dekker, Friedo W., Bossuyt, Patrick M., ...

Background. The K/DOQI guideline for bone metabolism and disease in chronic kidney disease is predominantly based on studies in haemodialysis (HD) patients. However, in clinical practice, this...

Mineral metabolism and cardiovascular morbidity and mortality risk: peritoneal dialysis patients compared with haemodialysis patients (2006)

Noordzij, Marlies, Korevaar, Johanna C., Bos, Willem J., Boeschoten, Elisabeth W., Dekker, Friedo W., Bossuyt, Patrick M., ...

Background. The K/DOQI guideline for bone metabolism and disease in chronic kidney disease is predominantly based on studies in haemodialysis (HD) patients. However, in clinical practice, this...

BMC Medical Research Methodology (2006)

Biomed Central, Nynke Smidt, Anne Ws Rutjes, Raymond Wjg Ostelo, Patrick M Bossuyt, ...

Research article Reproducibility of the STARD checklist: an instrument to assess the quality of reporting of diagnostic accuracy studies

Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative (2004)

Bossuyt, Patrick M, Reitsma, Johannes B, Bruns, David E, Gatsonis, Constantine A, Glasziou, Paul P, Irwig, Les M, ...

Objective. Our aim was to improve the accuracy and completeness of reporting of studies of diagnostic accuracy in order to allow readers to assess the potential for bias in a study and to evaluate...

Early switch from intravenous to oral antibiotics: guidelines and implementation in a large teaching hospital (1999)

Sevinç, Fatma, Prins, Jan M., Koopmans, Richard P., Langendijk, Pim N. J., Bossuyt, Patrick M., Dankert, Jaap, ...

In recent years ‘switch therapy’ has been advocated: short intravenous antibiotic therapy, for 2- 3 days, followed by oral treatment for the remainder of the course. Little is known about the...

Sample sizes of studies on diagnostic accuracy: literature survey

Bachmann, Lucas M, Puhan, Milo A, Ter Riet, Gerben, Bossuyt, Patrick M

Objectives To determine sample sizes in studies on diagnostic accuracy and the proportion of studies that report calculations of sample size.

Comparative accuracy: assessing new tests against existing diagnostic pathways

Bossuyt, Patrick M, Irwig, Les, Craig, Jonathan, Glasziou, Paul

Most studies of diagnostic accuracy only compare a test with the reference standard. Is this helpful?

Comparative accuracy: assessing new tests against existing diagnostic pathways

Bossuyt, Patrick M, Irwig, Les, Craig, Jonathan, Glasziou, Paul

Most studies of diagnostic accuracy only compare a test with the reference standard. Is this helpful?

Sample sizes of studies on diagnostic accuracy: literature survey

Bachmann, Lucas M, Puhan, Milo A, Ter Riet, Gerben, Bossuyt, Patrick M

Objectives To determine sample sizes in studies on diagnostic accuracy and the proportion of studies that report calculations of sample size.

Statistical models for quantifying diagnostic accuracy with multiple lesions per patient

Zwinderman, Aeilko H., Glas, Afina S., Bossuyt, Patrick M., Florie, Jasper, Bipat, Shandra, Stoker, Jaap

We propose random-effects models to summarize and quantify the accuracy of the diagnosis of multiple lesions on a single image without assuming independence between lesions. The number of...

Pivotal Evaluation of the Accuracy of a Biomarker Used for Classification or Prediction: Standards for Study Design

Pepe, Margaret S., Feng, Ziding, Janes, Holly, Bossuyt, Patrick M., Potter, John D.

Research methods for biomarker evaluation lag behind those for evaluating therapeutic treatments. Although a phased approach to development of biomarkers exists and guidelines are available for...