Patrick M. Winter

Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics

Tran, Trung D, Caruthers, Shelton D, Hughes, Michael, Marsh, John N, Cyrus, Tillmann, Winter, Patrick M, ...

Molecular imaging is a novel tool that has allowed non-invasive diagnostic imaging to transition from gross anatomical description to identification of specific tissue epitopes and observation of...

Minute dosages of ανβ3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits

Winter, Patrick M., Schmieder, Anne H., Caruthers, Shelton D., Keene, Jeffery L., Zhang, Huiying, Wickline, Samuel A., ...

Fumagillin suppresses angiogenesis in cancer models and clinical trials, but it is associated with neurotoxicity at systemic doses. In this study, ανβ3-targeted fumagillin nanoparticles were used...