Patrick P. Zarrinkar

Elucidation of the kinetic folding pathway of a Group I intron (1996)

Zarrinkar, Patrick P. (Patrick Parvis)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.

Elucidation of the kinetic folding pathway of a Group I intron (1996)

Zarrinkar, Patrick P. (Patrick Parvis)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer

Welsh, John B., Zarrinkar, Patrick P., Sapinoso, Lisa M., Kern, Suzanne G., Behling, Cynthia A., Monk, Bradley J., ...

Epithelial ovarian cancer is the leading cause of death from gynecologic cancer, in part because of the lack of effective early detection methods. Although alterations of several genes, such as...

Arrays of Arrays for High-Throughput Gene Expression Profiling

Zarrinkar, Patrick P., Mainquist, James K., Zamora, Matthew, Stern, David, Welsh, John B., Sapinoso, Lisa M., ...

Gene expression profiling using DNA arrays is rapidly becoming an essential tool for research and drug discovery and may soon play a central role in disease diagnosis. Although it is possible to make...

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

Carter, Todd A., Wodicka, Lisa M., Shah, Neil P., Velasco, Anne Marie, Fabian, Miles A., Treiber, Daniel K., ...

To realize the full potential of targeted protein kinase inhibitors for the treatment of cancer, it is important to address the emergence of drug resistance in treated patients. Mutant forms of...

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer

Welsh, John B., Zarrinkar, Patrick P., Sapinoso, Lisa M., Kern, Suzanne G., Behling, Cynthia A., Monk, Bradley J., ...

Epithelial ovarian cancer is the leading cause of death from gynecologic cancer, in part because of the lack of effective early detection methods. Although alterations of several genes, such as...

Arrays of Arrays for High-Throughput Gene Expression Profiling

Zarrinkar, Patrick P., Mainquist, James K., Zamora, Matthew, Stern, David, Welsh, John B., Sapinoso, Lisa M., ...

Gene expression profiling using DNA arrays is rapidly becoming an essential tool for research and drug discovery and may soon play a central role in disease diagnosis. Although it is possible to make...

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

Carter, Todd A., Wodicka, Lisa M., Shah, Neil P., Velasco, Anne Marie, Fabian, Miles A., Treiber, Daniel K., ...

To realize the full potential of targeted protein kinase inhibitors for the treatment of cancer, it is important to address the emergence of drug resistance in treated patients. Mutant forms of...

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

Zarrinkar, Patrick P., Gunawardane, Ruwanthi N., Cramer, Merryl D., Gardner, Michael F., Brigham, Daniel, Belli, Barbara, ...

Activating mutations in the receptor tyrosine kinase FLT3 are present in up to approximately 30% of acute myeloid leukemia (AML) patients, implicating FLT3 as a driver of the disease and therefore as...