Patrick T. F. Kennedy

Modulation of the CD8+-T-Cell Response by CD4+ CD25+ Regulatory T Cells in Patients with Hepatitis B Virus Infection

Franzese, Ornella, Kennedy, Patrick T. F., Gehring, Adam J., Gotto, Jim, Williams, Roger, Maini, Mala K., ...

CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell...

Modulation of the CD8+-T-Cell Response by CD4+ CD25+ Regulatory T Cells in Patients with Hepatitis B Virus Infection

Franzese, Ornella, Kennedy, Patrick T. F., Gehring, Adam J., Gotto, Jim, Williams, Roger, Maini, Mala K., ...

CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell...

The Level of Viral Antigen Presented by Hepatocytes Influences CD8 T-Cell Function▿

Gehring, Adam J., Sun, Dianxing, Kennedy, Patrick T. F., Lim, Seng Gee, Wasser, Shanthi, ...

CD8 T cells exert their antiviral function through cytokines and lysis of infected cells. Because hepatocytes are susceptible to noncytolytic mechanisms of viral clearance, CD8 T-cell antiviral...

Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection

Das, Abhishek, Hoare, Matthew, Davies, Nathan, Lopes, A. Ross, Dunn, Claire, Kennedy, Patrick T.F., ...

The inflamed liver in chronic hepatitis B virus (HBV) infection (CHB) is characterized by a large influx of non–virus-specific CD8 T cells. Little is known about the functional capacity of these...