Smith, Ruben, Bacos, Karl, Fedele, Valentina, Soulet, Denis, Walz, Helena A., Obermüller, Stefanie, ...
Huntington's disease is a severe progressive neurodegenerative disorder caused by a CAG expansion in the IT15 gene, which encodes huntingtin. The disease primarily affects the neostriatum and...
Leist, Marcel, Bremer, Susanne, Brundin, Patrik, Hescheler, Jürgen, Kirkeby, Agnete, Krause, Karl-Heinz, ...
Human embryonic stem cells (hESC) are now routinely cultured in many laboratories, and differentiation protocols are available to generate a large variety of cell types. In an ongoing ethical debate...
Anisimov, Sergey V, Christophersen, Nicolaj S, Correia, Ana S, Li, Jia-Yi, Brundin, Patrik
Abstract Background Human stem cells are viewed as a possible source of neurons for a cell-based therapy of neurodegenerative disorders, such as Parkinson's disease. Several protocols that generate...
Christophersen, Nicolaj S, Gronborg, Mette, Petersen, Thomas N, Fjord-Larsen, Lone, Jorgensen, Jesper R, Juliusson, Bengt, ...
Abstract is not available
Large stem cell grafts could lead to erroneous interpretations of behavioral results? (2007)
Christophersen, Nicolaj Stroyer, Brundin, Patrik
Abstract is not available
Anisimov, Sergey V, Christophersen, Nicolaj S, Correia, Ana S, Li, Jia-Yi, Brundin, Patrik
Abstract is not available
Cocaine- and amphetamine-regulated transcript is increased in Huntington disease. (2007)
Björkqvist, Maria, Leavitt, Blair R, Nielsen, Jörgen E, Landwehrmeyer, Bernhard, Ecker, Daniel, Mulder, Hindrik, ...
Abstract is not available
Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease. (2007)
Smith, Ruben, Klein, Pontus, Koc-Schmitz, Yeliz, Waldvogel, Henry J, Faull, Richard L M, Brundin, Patrik, ...
Abstract is not available
Restorative cell therapy for Parkinson's disease: A quest for the perfect cell. (2007)
Hall, Vanessa J, Li, Jia-Yi, Brundin, Patrik
Abstract is not available
Increased metabolism in the R6/2 mouse model of Huntington's disease. (2007)
Bacos, Karl, Wood, Nigel I, Lindqvist, Andreas, Wierup, Nils, Woodman, Ben, ...
Abstract is not available
From bench to bed: the potential of stem cells for the treatment of Parkinson's disease. (2007)
Morizane, Asuka, Li, Jia-Yi, Brundin, Patrik
Abstract is not available
Failure of transdifferentiation of adult hematopoietic stem cells into neurons. (2006)
Roybon, Laurent, Ma, Zhi, Asztely, Fredrik, Fosum, Anna, Jacobsen, Sten Eirik W, Brundin, Patrik, ...
Abstract is not available
On the move to stimulate cell plasticity in the substantia nigra in Parkinson's disease. (2006)
Brundin, Patrik, Angela Cenci, M, Wieloch, Tadeusz
Abstract is not available.
Cholinergic neuronal defect without cell loss in Huntington's disease. (2006)
Smith, Ruben, Chung, Hinfan, Rundquist, Sara, Colgan, Lesley, Englund, Elisabet, ...
Abstract is not available
Westin, Jenny E, Lindgren, Hanna S, Gardi, Jonathan, Nyengaard, Jens Randel, Brundin, Patrik, Mohapel, Paul, ...
Abstract is not available
Transplantation in Parkinson's disease: The future looks bright. (2006)
Paul, Gesine, Ahn, Young Hwan, Li, Jia-Yi, Brundin, Patrik
Abstract is not available.
Nygren, Josefine, Wieloch, Tadeusz, Pesic, Jelena, Brundin, Patrik, Deierborg, Tomas
Abstract is not available
Christophersen, Nicolaj S, Meijer, Xia, Jørgensen, Jesper R, Englund, Ulrica, Grønborg, Mette, Seiger, Ake, ...
Abstract is not available
High-fat diet impairs hippocampal neurogenesis in male rats. (2006)
Lindqvist, A, Mohapel, P, Bouter, B, Frielingsdorf, Helena, Pizzo, D, Brundin, Patrik, ...
Abstract is not available
Van Der Borght, Karin, Brundin, Patrik
Abstract is not available
Cholinergic neuronal defect without cell loss in Huntington's disease (2006)
Smith, Ruben, Chung, Hinfan, Rundquist, Sara, Colgan, Lesley, Englund, Elisabet, ...
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG-repeat expansion in the huntingtin (IT15) gene. The striatum is one of the regions most affected by neurodegeneration,...
Björkqvist, Maria, Petersén, Åsa, Bacos, Karl, Isaacs, Jeremy, Norlén, Per, Gil, Joana, ...
Huntington's disease (HD) is characterised by a triad of motor, psychiatric, and cognitive symptoms. While many of these symptoms are likely to be related to central nervous system pathology, others...
Cholinergic neuronal defect without cell loss in Huntington's disease (2006)
Smith, Ruben, Chung, Hinfan, Rundquist, Sara, Colgan, Lesley, Englund, Elisabet, ...
Huntington's Disease (HD) is a neurodegenerative disorder caused by a CAG-repeat expansion in the huntingtin (IT15) gene. The striatum is one of the regions most affected by neurodegeneration,...
Björkqvist, Maria, Petersén, Åsa, Bacos, Karl, Isaacs, Jeremy, Norlén, Per, Gil, Joana, ...
Huntington's disease (HD) is characterized by a triad of motor, psychiatric and cognitive symptoms. Although many of these symptoms are likely to be related to central nervous system pathology,...
Björkqvist, Maria, Fex, Malin, Renström, Erik, Wierup, Nils, Petersén, Asa, Gil, Joana, ...
Abstract is not available
Proteolysis of NR2B by calpain in the hippocampus of epileptic rats. (2005)
Araújo, Inês, Xapelli, Sara, Gil, Joana, Mohapel, Paul, Petersén, Asa, Pinheiro, Paulo, ...
Abstract is not available
Popovic, Natalija, Maingay, Matthew, Kirik, Deniz, Brundin, Patrik
Abstract is not available
Smith, Ruben, Petersén, Asa, Bates, Gillian P, Brundin, Patrik, Li, Jia-Yi
Abstract is not available
Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice. (2005)
Mohapel, Paul, Araújo, Inês M, Popovic, Natalija, Li, Jia-Yi, Brundin, Patrik, ...
Abstract is not available
Iancu, Ruxandra, Mohapel, Paul, Brundin, Patrik, Paul, Gesine
Abstract is not available
Ahn, Young-Hwan, Bensadoun, Jean-Charles, Aebischer, Patrick, Zurn, Anne D, Seiger, Ake, Björklund, Anders, ...
Abstract is not available
Karlsson, Jenny, Petersén, Asa, Gidö, Gunilla, Wieloch, Tadeusz, Brundin, Patrik
Abstract is not available
Roybon, Laurent, Brundin, Patrik, Li, Jia-Yi
Abstract is not available
Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease. (2005)
Papalexi, Eugenia, Persson, Anna, Bjorkqvist, Maria, Petersén, Asa, Woodman, Ben, Bates, Gillian P, ...
Abstract is not available
Stem cell-based therapy for Parkinson's disease. (2005)
Correia, Ana Sofia, Anisimov, Sergey V, Li, Jia-Yi, Brundin, Patrik
Abstract is not available
Puschban, Zoe, Stefanova, Nadia, Petersén, Asa, Winkler, Christian, Brundin, Patrik, Poewe, Werner, ...
Abstract is not available
Li, Jia Yi, Popovic, Natalija, Brundin, Patrik
Abstract is not available
Lotharius, Julie, Falsig, Jeppe, Beek, Johan Van, Payne, Sarah, Dringen, Ralf, Brundin, Patrik, ...
Models of Parkinson's disease (PD) based on selective neuronal death have been used to study pathogenic mechanisms underlying nigral cell death and in some instances to develop symptomatic therapies....
Björkqvist, Maria, Fex, Malin, Renström, Erik, Wierup, Nils, Petersén, Åsa, Gil, Joana, ...
Diabetes frequently develops in Huntington's disease (HD) patients and in transgenic mouse models of HD such as the R6/2 mouse. The underlying mechanisms have not been clarified. Elucidating the...
Orexin loss in Huntington's disease (2005)
Petersén, Åsa, Gil, Joana, Björkqvist, Maria, Tanila, Heikki, Araújo, Inês M., ...
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin, a protein of unknown function. Mutant huntingtin forms...
Asialoerythropoetin is not effective in the R6/2 line of Huntington's disease mice (2004)
Gil, Joana MAC, Leist, Marcel, Popovic, Natalija, Brundin, Patrik, Petersén, Åsa
Abstract Background Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expanded CAG repeat in the HD gene. Both excitotoxicity and oxidative stress have been proposed...
No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. (2004)
Frielingsdorf, Helena, Schwarz, Katherine, Brundin, Patrik, Mohapel, Paul
Abstract is not available
Harnessing endogenous stem cells to treat neurodegenerative disorders of the basal ganglia. (2004)
Mohapel, Paul, Brundin, Patrik
Abstract is not available
Stem cell therapy for Parkinson's disease: where do we stand? (2004)
Roybon, Laurent, Christophersen, Nicolaj S., Brundin, Patrik, Li, Jia-Yi
Abstract is not available
Orexin loss in Huntington's disease. (2004)
Petersén, Asa, Gil, Joana, Maat-Schieman, Marion Lc, Björkqvist, Maria, Tanila, Heikki, Araújo, Ines M, ...
Abstract is not available
Asialoerythropoetin is not effective in the R6/2 line of Huntington's disease mice (2004)
Gil, Joana MAC, Leist, Marcel, Popovic, Natalija, Brundin, Patrik, Petersén, Åsa
Background: Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expanded CAG repeat in the HD gene. Both excitotoxicity and oxidative stress have been proposed to play...
Orexin loss in Huntington's disease (2004)
Petersén, Åsa, Gil, Joana, Maat-Schieman, Marion LC, Björkqvist, Maria, Tanila, Heikki, Araújo, Ines M, ...
Huntington's disease is a devastating neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin, a protein of unknown function. Mutant huntingtin forms intracellular...
Orexin loss in Huntington's disease (2004)
Petersén, Åsa, Gil, Joana, Maat-Schieman, Marion LC, Björkqvist, Maria, Tanila, Heikki, Araújo, Ines M, ...
Huntington's disease is a devastating neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin, a protein of unknown function. Mutant huntingtin forms intracellular...
Hansson, Oskar, Nylandsted, Jesper, Castilho, Roger F, Leist, Marcel, Jäättelä, Marja, Brundin, Patrik
Abstract is not available
Smith, Ruben, Lotharius, Julie, Brundin, Patrik
Abstract is not available
Ahn, Young Hwan, Emgård, Mia, Brundin, Patrik
Abstract is not available
Neural transplantation for the treatment of Parkinson's disease. (2003)
Björklund, Anders, Dunnett, Stephen B, Brundin, Patrik, Stoessl, A Jon, Freed, Curt R, Breeze, Robert E, ...
Abstract is not available
Huntington's disease: a synaptopathy? (2003)
Li, Jia Yi, Plomann, Markus, Brundin, Patrik
Abstract is not available
Hansson, Oskar, Nylandsted, Jesper, Castilho, Roger F., Leist, Marcel, Jäätela, Marja, Brundin, Patrik
Huntingtons disease (HD) is a neurodegenerative disorder caused by expansion of a polyglutamine tract in a protein called huntingtin. The inducible form of heat shock protein 70 (Hsp70) has been...
Zeron, Melinda M, Hansson, Oskar, Chen, Nansheng, Wellington, Cheryl L, Leavitt, Blair R, Brundin, Patrik, ...
Previous work suggests N-methyl-D-aspartate receptor (NMDAR) activation may be involved in degeneration of medium-sized spiny striatal neurons in Huntington's disease (HD). Here we show that these...
Stem cells: hype or hope? (2002)
Paul, Gesine, Li, Jia, Brundin, Patrik
Stem cells undergo self-renewal and differentiate into multiple lineages of mature cells. The identification of stem cells in diverse adult tissues and the findings that human embryonic stem cells...
Funding embryonic stem-cell research: will commerce counteract collaboration? (2002)
Abstract not available
Dyskinesias following neural transplantation in Parkinson's disease. (2002)
Hagell, Peter, Piccini, Paola, Björklund, Anders, Brundin, Patrik, Rehncrona, Stig, Widner, Håkan, ...
Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic...
Lotharius, Julie, Barg, Sebastian, Wiekop, Pia, Lundberg, Cecilia, Raymon, Heather K., Brundin, Patrik
Mutations in alpha-synuclein have been linked to rare, autosomal dominant forms of Parkinsons disease. Despite its ubiquitous expression, mutant alpha-synuclein primarily leads to the loss of...
Lotharius, Julie, Brundin, Patrik
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the inability to initiate, execute and control movement. Neuropathologically, there is a striking loss of...
Karlsson, Jenny, Emgård, Mia, Brundin, Patrik
Abstract is not available
Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. (2002)
Lotharius, Julie, Brundin, Patrik
Abstract is not available
Huntington's disease: the mystery unfolds? (2002)
Petersén, Asa, Brundin, Patrik
Abstract not available.
Lotharius, Julie, Brundin, Patrik
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the inability to initiate, execute and control movement. Neuropathologically, there is a striking loss of...
Petersén, Åsa, Larsen, Kristin E., Behr, Gerald G., Romero, Norma, Przedborski, Serge, Brundin, Patrik, ...
Huntington’s disease (HD) is caused by an expanded CAG repeat in exon 1 of the gene coding for the huntingtin protein. The cellular pathway by which this mutation induces HD remains unknown,...
Brundin, Patrik, Pogarell, Oliver, Hagell, Peter, Piccini, Paola, Widner, Håkan, Schrag, Anette, ...
Five parkinsonian patients were transplanted bilaterally into the putamen and caudate nucleus with human embryonic mesencephalic tissue from between seven and nine donors. To increase graft survival,...
Hansson, Oskar, Petersén, Åsa, Leist, Marcel, Nicotera, Pierluigi, Castilho, Roger F., Brundin, Patrik
Huntingtons disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant...
Developing Human Embryonic Stem Cells for Grafting in Parkinson's Disease (1998)
The project aims to differentiate human embryonic stem cells (hESCs) into dopaminergic neurons for use in neural grafting in Parkinson's disease (PD). During the first year we studied the survival...
Hansson, Oskar, Petersén, Åsa, Leist, Marcel, Nicotera, Pierluigi, Castilho, Roger F., Brundin, Patrik
Huntington’s disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant...
Asialoerythropoetin is not effective in the R6/2 line of Huntington's disease mice
Gil, Joana MAC, Leist, Marcel, Popovic, Natalija, Brundin, Patrik, Petersén, Åsa
No evidence for new dopaminergic neurons in the adult mammalian substantia nigra
Frielingsdorf, Helena, Schwarz, Katherine, Brundin, Patrik, Mohapel, Paul
A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci....
Li, Jia Yi, Popovic, Natalija, Brundin, Patrik
Summary: Huntington's disease (HD) is a genetic neurodegenerative disorder. Since identification of the disease-causing gene in 1993, a number of genetically modified animal models of HD have been...
Hansson, Oskar, Petersén, Åsa, Leist, Marcel, Nicotera, Pierluigi, Castilho, Roger F., Brundin, Patrik
Huntington’s disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant...
Asialoerythropoetin is not effective in the R6/2 line of Huntington's disease mice
Gil, Joana MAC, Leist, Marcel, Popovic, Natalija, Brundin, Patrik, Petersén, Åsa
No evidence for new dopaminergic neurons in the adult mammalian substantia nigra
Frielingsdorf, Helena, Schwarz, Katherine, Brundin, Patrik, Mohapel, Paul
A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci....
Li, Jia Yi, Popovic, Natalija, Brundin, Patrik
Summary: Huntington's disease (HD) is a genetic neurodegenerative disorder. Since identification of the disease-causing gene in 1993, a number of genetically modified animal models of HD have been...
Correia, Ana Sofia, Anisimov, Sergey V., Roybon, Laurent, Li, Jia-Yi, Brundin, Patrik
In the central nervous system, fibroblast growth factor (FGF)-20 has been reported to act preferentially on midbrain dopaminergic neurons. It also promotes the dopaminergic differentiation of stem...
Correia, Ana Sofia, Anisimov, Sergey V., Li, Jia-Yi, Brundin, Patrik
Human embryonic stem cells (hESCs) are a potential source of dopaminergic neurons for treatment of patients with Parkinson's disease (PD). Dopaminergic neurons can be derived from hESCs and display a...
Björkqvist, Maria, Wild, Edward J., Thiele, Jenny, Silvestroni, Aurelio, Andre, Ralph, Lahiri, Nayana, ...
Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. We examined the peripheral immune system and found widespread...
Roybon, Laurent, Hjalt, Tord, Stott, Simon, Guillemot, Francois, Li, Jia-Yi, Brundin, Patrik
The specification and differentiation of dentate gyrus granule neurons in the hippocampus require temporally and spatially coordinated actions of both intrinsic and extrinsic molecules. The basic...