Paul A. B. Moretti

Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A (2008)

Barr, Renae Karen, Lynn, Helen Elizabeth, Moretti, Paul A. B., Khew-Goodall, Yeesim, Pitson, Stuart Maxwell

Sphingosine kinase 1 (SK1) is an important regulator of cellular signaling that has been implicated in a broad range of cellular processes. Cell exposure to a wide array of growth factors, cytokines,...

Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A (2008)

Barr, Renae Karen, Lynn, Helen Elizabeth, Moretti, Paul A. B., Khew-Goodall, Yeesim, Pitson, Stuart Maxwell

Sphingosine kinase 1 (SK1) is an important regulator of cellular signaling that has been implicated in a broad range of cellular processes. Cell exposure to a wide array of growth factors, cytokines,...

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

Pitson, Stuart M., Moretti, Paul A.B., Zebol, Julia R., Lynn, Helen E., Xia, Pu, Vadas, Mathew A., ...

Sphingosine kinase 1 is an agonist-activated signalling enzyme that catalyses the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a number of...

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

Pitson, Stuart M., Moretti, Paul A.B., Zebol, Julia R., Lynn, Helen E., Xia, Pu, Vadas, Mathew A., ...

Sphingosine kinase 1 is an agonist-activated signalling enzyme that catalyses the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a number of...

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

Pitson, Stuart M., Xia, Pu, Leclercq, Tamara M., Moretti, Paul A.B., Zebol, Julia R., Lynn, Helen E., ...

Sphingosine kinase (SK) 1 catalyzes the formation of the bioactive lipid sphingosine 1-phosphate, and has been implicated in several biological processes in mammalian cells, including enhanced...

Eukaryotic Elongation Factor 1A Interacts with Sphingosine Kinase and Directly Enhances Its Catalytic Activity*

Leclercq, Tamara M., Moretti, Paul A. B., Vadas, Mathew A., Pitson, Stuart M.

Sphingosine 1-phosphate (S1P) has many important roles in mammalian cells, including contributing to the control of cell survival and proliferation. S1P is generated by sphingosine kinases (SKs), of...