Scientific Commons: Paul A. Barrow

Prevention of Salmonella infection by contact using intestinal flora of adult birds and/or a mixture of organic acids (2000)

Oliveira,Gláucia Helaine De, Berchieri Junior,Angelo, Barrow,Paul A.

This study was carried out to assess the ability of competitive exclusion and a mixture of organic acids to prevent Salmonella infection by contact between newly hatched chicks. A bird infected with...

Experimental Salmonella Gallinarum infection in light laying hen lines (2000)

Berchieri Júnior,Angelo, Oliveira,Gláucia Helaine De, Pinheiro,Lucas Augusto Soeiro, Barrow,Paul A.

Although the epidemiology of fowl typhoid in chickens supposedly involves a vertical transmission stage, a previous work run by the authors has suggested that this did not happen in a commercial line...

Salmonella enterica Serovar Gallinarum Requires the Salmonella Pathogenicity Island 2 Type III Secretion System but Not the Salmonella Pathogenicity Island 1 Type III Secretion System for Virulence in Chickens

Jones, Michael A., Wigley, Paul, Page, Kerrie L., Hulme, Scott D., Barrow, Paul A.

Salmonella enterica serovar Gallinarum is a host-specific serotype that causes the severe systemic disease fowl typhoid in domestic poultry and a narrow range of other avian species but rarely causes...

Identification of Salmonella typhimurium Genes Required for Colonization of the Chicken Alimentary Tract and for Virulence in Newly Hatched Chicks

Turner, Arthur K., Lovell, Margaret A., Hulme, Scott D., Zhang-Barber, Li, Barrow, Paul A.

From a collection of 2,800 Tn5-TC1 transposon mutants of Salmonella typhimurium F98, 18 that showed reduced intestinal colonization of 3-week-old chicks were identified. The sites of transposon...

Induction of Proinflammatory Responses in the Human Monocytic Cell Line THP-1 by Campylobacter jejuni

Jones, Michael A., Tötemeyer, Sabine, Maskell, Duncan J., Bryant, Clare E., Barrow, Paul A.

Campylobacter jejuni can cause an enteritis that is associated with an acute inflammatory response at the gut epithelial surface. The signals inducing inflammation are unknown. C. jejuni can...

l-Serine Catabolism via an Oxygen-Labile l-Serine Dehydratase Is Essential for Colonization of the Avian Gut by Campylobacter jejuni

Velayudhan, Jyoti, Jones, Michael A., Barrow, Paul A., Kelly, David J.

Campylobacter jejuni is a microaerophilic, asaccharolytic bacterium. The identity of the carbon and energy sources used by C. jejuni in vivo is unknown, but the genome sequence of strain NCTC11168...

Adaptation of Campylobacter jejuni NCTC11168 to High-Level Colonization of the Avian Gastrointestinal Tract

Jones, Michael A., Marston, Kerrie L., Woodall, Claire A., Maskell, Duncan J., Linton, Dennis, Karlyshev, Andrey V., ...

The genome sequence of the human pathogen Campylobacter jejuni NCTC11168 has been determined recently, but studies on colonization and persistence in chickens have been limited due to reports that...

Campylobacter jejuni-Induced Cytokine Responses in Avian Cells

Smith, Chris K., Kaiser, Pete, Rothwell, Lisa, Humphrey, Tom, Barrow, Paul A., Jones, Michael A.

Campylobacter jejuni is a major cause of human inflammatory enteritis. During the course of human disease numerous proinflammatory cytokines are produced. Little is known, however, about the cytokine...

A Strong Antigen-Specific T-Cell Response Is Associated with Age and Genetically Dependent Resistance to Avian Enteric Salmonellosis

Beal, Richard K., Powers, Claire, Wigley, Paul, Barrow, Paul A., Kaiser, Pete, Smith, Adrian L.

Chicken genetics and age affect resistance to enteric infection with Salmonella enterica serovar Typhimurium and were used to identify the immune responses that may contribute to rapid clearance....

Signature-Tagged Transposon Mutagenesis Studies Demonstrate the Dynamic Nature of Cecal Colonization of 2-Week-Old Chickens by Campylobacter jejuni†

Grant, Andrew J., Coward, Christopher, Jones, Michael A., Woodall, Claire A., Barrow, Paul A., Maskell, Duncan J.

We have constructed plasmids to be used for in vitro signature-tagged mutagenesis (STM) of Campylobacter jejuni and used these to generate STM libraries in three different strains. Statistical...

Virulence of Broad- and Narrow-Host-Range Salmonella enterica Serovars in the Streptomycin-Pretreated Mouse Model

Suar, Mrutyunjay, Jantsch, Jonathan, Hapfelmeier, Siegfried, Kremer, Marcus, Stallmach, Thomas, Barrow, Paul A., ...

Salmonella enterica subspecies I serovars are common bacterial pathogens causing diseases ranging from enterocolitis to systemic infections. Some serovars are adapted to specific hosts, whereas...

Clearance of Enteric Salmonella enterica Serovar Typhimurium in Chickens Is Independent of B-Cell Function

Beal, Richard K., Powers, Claire, Davison, T. Fred, Barrow, Paul A., Smith, Adrian L.

Salmonella enterica serovar Typhimurium colonizes the gut of chickens and is cleared from the intestine within about 3 weeks. Infection induces high levels of specific antibody, but B cells do not...