Ney, Paul A., Sorrentino, Brian P., Lowrey, Chris H., Nienhuis, Arthur W.
An erythroid specific, inducible enhancer associated with hypersensitive site II (HS II) plays a central role in the function of the human β globin dominant control region. The HS II enhancer...
Li, You-Jun, Higgins, Rachel R., Pak, Brian J., Shivdasani, Ramesh A., Ney, Paul A., Archer, Michael, ...
In previous studies, we identified a common site of retroviral integration designated Fli-2 in Friend murine leukemia virus (F-MuLV)-induced erythroleukemia cell lines. Insertion of F-MuLV at the...
Zang, Heesuk, Sato, Ken, Nakajima, Hideaki, McKay, Catriona, Ney, Paul A., Ihle, James N.
The erythropoietin receptor (EpoR) is required for the proliferation and survival of committed erythroid lineage cells. Previous studies have utilized receptor mutations to show the requirement for...
Li, You-Jun, Higgins, Rachel R., Pak, Brian J., Shivdasani, Ramesh A., Ney, Paul A., Archer, Michael, ...
In previous studies, we identified a common site of retroviral integration designated Fli-2 in Friend murine leukemia virus (F-MuLV)-induced erythroleukemia cell lines. Insertion of F-MuLV at the...
Zang, Heesuk, Sato, Ken, Nakajima, Hideaki, McKay, Catriona, Ney, Paul A., Ihle, James N.
The erythropoietin receptor (EpoR) is required for the proliferation and survival of committed erythroid lineage cells. Previous studies have utilized receptor mutations to show the requirement for...
Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia
Zhang, Ji, Randall, Mindy S., Loyd, Melanie R., Li, Weimin, Schweers, Rachel L., Persons, Derek A., ...
Friend virus is an acutely oncogenic retrovirus that causes erythroblastosis and polycythemia in mice. Previous studies suggested that the Friend virus oncoprotein, gp55, constitutively activates the...
Xu, Wu, Fukuyama, Tomofusa, Ney, Paul A., Wang, Demin, Rehg, Jerold, Boyd, Kelli, ...
CREB-binding protein (CBP) and its para-log p300 are transcriptional coactivators that physically or functionally interact with over 320 mammalian and viral proteins, including 36 that are essential...
NIX is required for programmed mitochondrial clearance during reticulocyte maturation
Schweers, Rachel L., Zhang, Ji, Randall, Mindy S., Loyd, Melanie R., Li, Weimin, Dorsey, Frank C., ...
The regulated clearance of mitochondria is a well recognized but poorly understood aspect of cellular homeostasis, and defects in this process have been linked to aging, degenerative diseases, and...
GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synuclein
Scherzer, Clemens R., Grass, Jeffrey A., Liao, Zhixiang, Pepivani, Imelda, Zheng, Bin, Eklund, Aron C., ...
Increased α-synuclein gene (SNCA) dosage due to locus multiplication causes autosomal dominant Parkinson's disease (PD). Variation in SNCA expression may be critical in common, genetically complex...
Kundu, Mondira, Lindsten, Tullia, Yang, Chia-Ying, Wu, Junmin, Zhao, Fangping, Zhang, Ji, ...
Production of a red blood cell's hemoglobin depends on mitochondrial heme synthesis. However, mature red blood cells are devoid of mitochondria and rely on glycolysis for ATP production. The...