Dianca R. Graham, Paul A. Overbeek, John D. Ash
PURPOSE. Activating ligands of gp130, including leukemia inhibitory factor (LIF), can block differentiation and function of retinal neurons. This study focused on determining whether LIF inhibits...
FGF9 can induce endochondral ossification in cranial mesenchyme (2006)
Govindarajan, Venkatesh, Overbeek, Paul A
Abstract Background The flat bones of the skull (i.e., the frontal and parietal bones) normally form through intramembranous ossification. At these sites cranial mesenchymal cells directly...
Long-range activation of Sox9 in Odd Sex (Ods) mice (2004)
Qin, Yangjun, Kong, Ling-kun, Poirier, Christophe, Truong, Cavatina, Overbeek, Paul A., Bishop, Colin E.
The Odd Sex mouse mutation arose in a transgenic line of mice carring a tyrosinase minigene driven by the dopachrome tautomerase (Dct) promotor region. The minigene integrated 0.98 Mb upstream of...
Yang, Tao, Liang, Dongcai, Koch, Peter J., Hohl, Daniel, Kheradmand, Farrah, Overbeek, Paul A.
Netherton syndrome (NS) is a human autosomal recessive skin disease caused by mutations in the SPINK5 gene, which encodes the putative proteinase inhibitor LEKTI. We have generated a transgenic mouse...
Long-range activation of Sox9 in Odd Sex (Ods) mice (2004)
Qin, Yangjun, Kong, Ling-kun, Poirier, Christophe, Truong, Cavatina, Overbeek, Paul A., Bishop, Colin E.
The Odd Sex mouse mutation arose in a transgenic line of mice carring a tyrosinase minigene driven by the dopachrome tautomerase (Dct) promotor region. The minigene integrated 0.98 Mb upstream of...
CREB-binding Protein/p300 Co-activation of Crystallin Gene Expression (2002)
Qin Chen, Dennis H. Dowhan, Dongcai Liang, David D. Moore, Paul A. Overbeek
In this study, we designed experiments to test whether the co-activators CREB-binding protein (CBP) and/or p300 interact with c-Maf, Prox-1, or Sox-1 to enhance transcription of crystallin genes. Our...
CREB-binding Protein/p300 Co-activation of Crystallin Gene Expression (2002)
Qin Chen, Dennis H. Dowhan, Dongcai Liang, David D. Moore, Paul A. Overbeek
In this study, we designed experiments to test whether the co-activators CREB-binding protein (CBP) and/or p300 interact with c-Maf, Prox-1, or Sox-1 to enhance transcription of crystallin genes. Our...
CREB-binding protein/p300 co-activation of crystallin gene expression (2002)
Chen, Qin, Dowhan, Dennis H., Liang, Dongcai C., Moore, David D. D., Overbeek, Paul A.
Although some of the transcription factors that are required for expression of crystallins during lens development have been identified, the molecular interactions that contribute to enhanced...
CREB-binding protein/p300 co-activation of crystallin gene expression (2002)
Chen, Qin, Dowhan, Dennis H., Liang, Dongcai C., Moore, David D. D., Overbeek, Paul A.
Although some of the transcription factors that are required for expression of crystallins during lens development have been identified, the molecular interactions that contribute to enhanced...
Fei, Yijian, Matragoon, Suraporn, Smith, Sylvia B., Overbeek, Paul A., Chen, Shiming, Zack, Donald J., ...
The essential control elements in the interphotoreceptor retinoid-binding protein gene (IRBP) promoter are located between −156 and +19. The −156/−109 sequence contains a...
Yokoyama, Takahiko, Silversides, David W., Waymire, Katrina G., Kwon, Byoung S., Takeuchi, Takuji, Overbeek, Paul A.
Albinism, due to a lack of melanin pigment, is one of the oldest known mutations in mice. Tyrosinase (monophenol oxygenase, EC 1.14.18.1) is the first enzyme in the pathway for melanin synthesis, and...
Characterization of five members of the actin gene family in the sea urchin (1981)
Overbeek, Paul A., Merlino, Glenn T., Kent Peters, N., Cohn, Vivian H., Moore, Gordon P., Kleinsmith, Lewis J.
Hybridization of an actin cDNA clone (pSA38) to restriction enzyme digests of Strongylocentrotus purpuratus DNA indicates that the sea urchin genome contains at least five different actin genes. A...
Oh, Hidemasa, Taffet, George E., Youker, Keith A., Entman, Mark L., Overbeek, Paul A., Michael, Lloyd H., ...
Cardiac muscle regeneration after injury is limited by “irreversible” cell cycle exit. Telomere shortening is one postulated basis for replicative senescence, via down-regulation of telomerase...
Yang, Tao, Liang, Dongcai, Koch, Peter J., Hohl, Daniel, Kheradmand, Farrah, Overbeek, Paul A.
Netherton syndrome (NS) is a human autosomal recessive skin disease caused by mutations in the SPINK5 gene, which encodes the putative proteinase inhibitor LEKTI. We have generated a transgenic mouse...
Generation of the primary hair follicle pattern
Mou, Chunyan, Jackson, Ben, Schneider, Pascal, Overbeek, Paul A., Headon, Denis J.
Hair follicles are spaced apart from one another at regular intervals through the skin. Although follicles are predominantly epidermal structures, classical tissue recombination experiments indicated...
Oh, Hidemasa, Taffet, George E., Youker, Keith A., Entman, Mark L., Overbeek, Paul A., Michael, Lloyd H., ...
Cardiac muscle regeneration after injury is limited by “irreversible” cell cycle exit. Telomere shortening is one postulated basis for replicative senescence, via down-regulation of telomerase...
Yang, Tao, Liang, Dongcai, Koch, Peter J., Hohl, Daniel, Kheradmand, Farrah, Overbeek, Paul A.
Netherton syndrome (NS) is a human autosomal recessive skin disease caused by mutations in the SPINK5 gene, which encodes the putative proteinase inhibitor LEKTI. We have generated a transgenic mouse...
Generation of the primary hair follicle pattern
Mou, Chunyan, Jackson, Ben, Schneider, Pascal, Overbeek, Paul A., Headon, Denis J.
Hair follicles are spaced apart from one another at regular intervals through the skin. Although follicles are predominantly epidermal structures, classical tissue recombination experiments indicated...
TGFβ induces morphological and molecular changes similar to human anterior subcapsular cataract
Lovicu, Frank J, Schulz, Mark W, Hales, Angela M, Vincent, Lisa N, Overbeek, Paul A, Chamberlain, Coral G, ...
Background: Transforming growth factor β (TGFβ) has been shown to induce subcapsular plaques in cultured rat lenses as well as in lenses of transgenic mice. In the present study the authors have...