Sharp, Adam, Crabb, Simon J., Johnson, Peter W.M., Hague, Angela, Cutress, Ramsey, Townsend, Paul A., ...
The C-terminal BAG domain is thought to play a key role in BAG-1-induced survival and proliferation by mediating protein-protein interactions, for example, with heat shock proteins HSC70 and HSP70,...
STAT3 deletion sensitizes cells to oxidative stress (2009)
Barry, Seán P., Townsend, Paul A., McCormick, James, Knight, Richard A., Scarabelli, Tiziano M., Latchman, David S., ...
The transcription factor STAT1 plays a role in promoting apoptotic cell death, whereas the related STAT3 transcription factor protects cardiac myocytes from ischemia/reperfusion (I/R) injury or...
Davidson, Sean M., Rybka, Aneta E., Townsend, Paul A.
The urocortins are members of the corticotropin releasing hormone (CRH) family of peptide hormones. The archetypal member of this family, CRH, plays an important role in regulating thermogenesis and...
Zeidan, Bashar A, Townsend, Paul A
Abstract Expression profiling and biomarker(s) discovery aim to provide means for tumour diagnosis, classification, therapy response and prognosis. The identification of novel markers could...
ERK and the F-box protein betaTRCP target STAT1 for degradation (2008)
Soond, Surinder M., Townsend, Paul A., Barry, Sean P., Knight, Richard A., Latchman, David S., Stephanou, Anastasis
The transcription factor STAT1 has roles in development, homeostasis, cellular differentiation, and apoptosis and has been postulated to function as a tumor suppressor. STAT1 is activated by tyrosine...
Zeidan, Bashar A., Townsend, Paul A.
ABSTRACT: Expression profiling and biomarker(s) discovery aim to provide means for tumour diagnosis, classification, therapy response and prognosis. The identification of novel markers could...
Scarabelli, Tiziano M., Townsend, Paul A., Chen Scarabelli, Carol, Yuan, Zhaokan, McCauley, Roy B., Di Rezze, Justin, ...
We have previously demonstrated that the transcription factor STAT1 plays a critical role in promoting apoptotic cell death, whereas the related STAT3 family member may antagonize STAT1 and protect...
Tare, Rahul S., Townsend, Paul A., Packham, Graham K., Inglis, Stefanie, Oreffo, Richard O. C.
BAG-1, an anti-apoptotic protein, was identified by its ability to bind to BCL-2, HSP70-family molecular chaperones and nuclear hormone receptor family members. Two BAG-1 isoforms, BAG-1L (50 kDa)...
Molecular regulation of cardiac hypertrophy (2008)
Barry, Sean P., Davidson, Sean M., Townsend, Paul A.
Heart failure is one of the leading causes of mortality in the western world and encompasses a wide spectrum of cardiac pathologies. When the heart experiences extended periods of elevated workload,...
Townsend, Paul A., Davidson, Sean M., Clarke, Samantha J., Khaliulin, Igor, Carroll, Christopher J., Scarabelli, Tiziano M., ...
Urocortin (UCN) protects hearts against ischemia and reperfusion injury whether given before ischemia or at reperfusion. Here we investigate the roles of PKC, reactive oxygen species, and the...
STAT1 regulates p73-mediated Bax gene expression (2007)
Soond, Surinder M., Carroll, Christopher, Townsend, Paul A., Sayan, Emre, Melino, Gerry, Behrmann, Iris, ...
Although signal transducer and activator of transcription 1 (STAT1) mediated regulation of p53 transcription and apoptosis has been previously reported, modulation of other members of the p53 family...
Role of the JAK-STAT pathway in myocardial injury (2007)
Barry, Seán P., Townsend, Paul A., Latchman, David S., Stephanou, Anastasis
Cardiovascular pathologies are an enormous burden in human health and despite the vast amount of research; the molecular mechanisms and pathways that control the underlying pathologies are still not...
Valentim, Lauren, Laurence, Kevin M., Townsend, Paul A., Carroll, Christopher J., Soond, Surinder, Scarabelli, Tiziano M., ...
Autophagy is known to be a feature of cardiomyopathies and chronic ischaemia. Here we demonstrate that autophagy is also induced by a single cycle of ischaemia/reperfusion (I/R in neonatal and adult...
McCormick, James, Barry, Sean P., Sivarajah, Ahila, Stefanutti, Giorgio, Townsend, Paul A., Lawrence, Kevin M., ...
The signal transducer and activator of transcription (STAT) family are latent transcription factors involved in a variety of signal transduction pathways, including cell death cascades. STAT1 has...
Davidson, Sean M., Townsend, Paul A., Carroll, Chris, Yurek-George, Alexander, Balasubramanyam, Karanam, Kundu, Tapas K., ...
Anacardic acid is an alkylsalicylic acid obtained from cashew-nut-shell liquid, and is a potent inhibitor of p300 histone acetyl-transferase (HAT) activity. We have used anacardic acid to prevent the...
Chanalaris, Anastasios, Lawrence, Kevin M., Townsend, Paul A., Davidson, Sean, Jamshidi, Yalada, Stephanou, Anastasis, ...
The UCN homologues SCP and SRP bind specifically to the CRFR2 receptor, whereas UCN binds to both CRFR1 and CRFR2. We have previously demonstrated that all three peptides are cardioprotective, and...
Davidson, Sean M., Townsend, Paul A., Carroll, Chris, Yurek-George, Alexander, Balasubramanyam, Karanam, Kundu, Tapas K., ...
Anacardic acid is an alkylsalicylic acid obtained from cashew-nut-shell liquid, and is a potent inhibitor of p300 histone acetyl-transferase (HAT) activity. We have used anacardic acid to prevent the...
Cardioprotection mediated by urocortin is dependent on PKCepsilon activation (2005)
Lawrence, Kevin M., Kabir, Alamgir M.N., Bellahcene, Mohammed, Davidson, Sean, Mesquita, Rue S., Cao, Xuebin, ...
Urocortin (Ucn) is an endogenous cardioprotective agent that protects against the damaging effects of ischemia and reperfusion injury in vitro and in vivo. We have found that the mechanism of action...
BAG-1: a multi-functional pro-survival molecule (2005)
Townsend, Paul A., Stephanou, Anastasis, Packham, Graham, Latchman, David S.
BAG-1 is a multi-functional protein that exists as three functionally distinct and differentially localized isoforms which originate from a single mRNA and interact with a wide range of cellular...
STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage (2005)
Townsend, Paul A., Cragg, Mark S., Davidson, Sean M., McCormick, James, Barry, Sean, Lawrence, Kevin M., ...
STAT-1 plays a role in mediating stress responses to various stimuli and has also been implied to be a tumour suppressor. Here, we report that STAT-1-deficient cells have defects both in...
Townsend, Paul A., Cutress, Ramsey I., Carroll, Christopher J., Lawrence, Kevin M., Scarabelli, Tiziano M., Packham, Graham, ...
BAG-1 (Bcl-2-associated athanogene-1) proteins interact with the HSC70 and HSP70 heat shock proteins and have been proposed to promote cell survival by coordinating the function of these chaperones...
STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis (2004)
Townsend, Paul A., Scarabelli, Tiziano M., Davidson, Sean M., Knight, Richard A., Latchman, David S., Stephanou, Anastasis
The STAT-1 transcription factor has been implicated as a tumor suppressor by virtue of its ability to inhibit cell growth and promoting apoptosis. However, the mechanisms by which STAT-1 mediates...
Lawrence, Kevin M., Townsend, Paul A., Davidson, Sean M., Carroll, Christopher J., Eaton, Simon, Hubank, Mike, ...
We have previously shown, using Affymetrix gene chip technology, that urocortin induces the expression of several diverse genes in cardiac myocytes. An ATP sensitive inwardly rectifying potassium...
PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73 (2004)
Munarriz, Eliana, Barcaroli, Daniela, Stephanou, Anastasis, Townsend, Paul A., Maisse, Carine, Terrinoni, Alessandro, ...
p73 is a recently described member of the p53 family, and, like p53, it undergoes a number of posttranslational modifications. Here we show, by yeast two-hybrid screening, pull-down assays, and...
BAG-1 in carcinogenesis (2004)
Sharp, Adam, Crabb, Simon J., Cutress, Ramsey I., Brimmell, Matthew, Wang, Xiu-hong, Packham, Graham, ...
BAG-1 is a multifunctional protein that exists as several differentially localised and functionally distinct isoforms. BAG-1 isoforms interact with a diverse array of molecular targets and regulate a...
Arhel, Nathalie J., Packham, Graham, Townsend, Paul A., Collard, Tracey J., H-Zadeh, Akram M., Sharp, Adam, ...
Although the retinoblastoma susceptibility gene RB1 is inactivated in a wide range of human tumours, overexpression in colonic carcinomas has been linked to the antiapoptotic function of the protein....
Townsend, Paul A., Cutress, Ramsey I., Sharp, Adam, Brimmell, Matthew, Packham, Graham
BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets. There is accumulating evidence that overexpression of BAG-1 may play an important role in breast cancer;...
Arhel, Nathalie J., Packham, Graham, Townsend, Paul A., Collard, Tracey J., H-Zadeh, Akram M., Sharp, Adam, ...
Although the retinoblastoma susceptibility gene RB1 is inactivated in a wide range of human tumours, overexpression in colonic carcinomas has been linked to the antiapoptotic function of the protein....
Townsend, Paul A., Cutress, Ramsey I., Sharp, Adam, Brimmell, Matthew, Packham, Graham
BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets. There is accumulating evidence that overexpression of BAG-1 may play an important role in breast cancer;...
BAG-1: a multifunctional regulator of cell growth and survival (2003)
Townsend, Paul A., Cutress, Ramsey I., Sharp, Adam, Brimmell, Matthew, Packham, Graham
BAG-1 is multifunctional protein which interacts with a wide range of cellular targets to regulate growth control pathways important for normal and malignant cells, including apoptosis, signaling,...
The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription (2003)
Cutress, Ramsey I., Townsend, Paul A., Sharp, Adam, Maison, Anna, Wood, Lynn, Lee, Ron, ...
BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets including heat-shock proteins and some nuclear hormone receptors. BAG-1 exists as three major isoforms, BAG-1L,...
The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription (2003)
Cutress, Ramsey I., Townsend, Paul A., Sharp, Adam, Maison, Anna, Wood, Lynn, Lee, Ron, ...
BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets including heat-shock proteins and some nuclear hormone receptors. BAG-1 exists as three major isoforms, BAG-1L,...
Stephanou, Anastasis, Scarabelli, Tiziano M., Townsend, Paul A., Bell, Robert, Yellon, Derek, Knight, Richard A., ...
We have demonstrated previously that the STAT-1 transcription factor plays a key role in ischemia/reperfusion (I/R)-induced apoptosis in cardiac myocytes. In the present study we assessed which...
Lewis, Charlotte A., Townsend, Paul A., Isacke, Clare M.
CD44 is the principal cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan, and binding to this ligand underlies CD44-mediated cell attachment and migration. As would be...
Margaret Aylward, 1810-1889: Lady of Charity, Sister of Faith (review) (2000)
The Catholic Historical Review - Volume 86, Number 3, July 2000
PIAS-1 Is a Checkpoint Regulator Which Affects Exit from G1 and G2 by Sumoylation of p73
Munarriz, Eliana, Barcaroli, Daniela, Stephanou, Anastasis, Townsend, Paul A., Maisse, Carine, Terrinoni, Alessandro, ...
p73 is a recently described member of the p53 family, and, like p53, it undergoes a number of posttranslational modifications. Here we show, by yeast two-hybrid screening, pull-down assays, and...
PIAS-1 Is a Checkpoint Regulator Which Affects Exit from G1 and G2 by Sumoylation of p73
Munarriz, Eliana, Barcaroli, Daniela, Stephanou, Anastasis, Townsend, Paul A., Maisse, Carine, Terrinoni, Alessandro, ...
p73 is a recently described member of the p53 family, and, like p53, it undergoes a number of posttranslational modifications. Here we show, by yeast two-hybrid screening, pull-down assays, and...
Zeidan, Bashar A, Townsend, Paul A
Expression profiling and biomarker(s) discovery aim to provide means for tumour diagnosis, classification, therapy response and prognosis. The identification of novel markers could potentially lead...
STAT3 deletion sensitizes cells to oxidative stress
Barry, Seán P., Townsend, Paul A., McCormick, James, Knight, Richard A., Scarabelli, Tiziano M., Latchman, David S., ...
The transcription factor STAT1 plays a role in promoting apoptotic cell death, whereas the related STAT3 transcription factor protects cardiac myocytes from ischemia/reperfusion (I/R) injury or...