Black, Antony P.B., Ardern-Jones, Michael R., Kasprowicz, Victoria, Bowness, Paul, Jones, Louise, Bailey, Abigail S., ...
The ability of human keratinocytes to present antigen to T cells is controversial and, indeed, it has been suggested that keratinocytes may promote T cell hyporesponsiveness. Furthermore, it is...
Ondondo, Beatrice, Yang, Hongbing, Dong, Tao, Gleria, Kati De, Suttill, Annie, Conlon, Christopher, ...
No abstract available.
Raine, Tim, Brown, Damien, Bowness, Paul, Hill Gaston, J.S., Moffett, Ashley, Trowsdale, John, ...
Objectives. Major histocompatibility complex class I (MHC-I) proteins exist at the cell surface in antigen presenting forms and as β 2m-independent free heavy chains (FHCs). FHCs have been...
Raine, Tim, Brown, Damien, Bowness, Paul, Hill Gaston, J.S., Moffett, Ashley, Trowsdale, John, ...
Objectives. Major histocompatibility complex class I (MHC-I) proteins exist at the cell surface in antigen presenting forms and as β 2m-independent free heavy chains (FHCs). FHCs have been...
Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection (2005)
Adiba Isa, Victoria Kasprowicz, Oscar Norbeck, Andrew Loughry, Katie Jeffery, Kristina Broliden, ...
Although parvovirus B19 apparently causes an acute viral infection, it appears to induce a persistent activated CD8 + T cell response.
Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection (2005)
Adiba Isa, Victoria Kasprowicz, Oscar Norbeck, Andrew Loughry, Katie Jeffery, Kristina Broliden, ...
Background Human parvovirus B19 (B19) is a ubiquitous and clinically significant pathogen, causing erythema infectiosum, arthropathy, transient aplastic crisis, and intrauterine fetal death. The...
Appel, Heiner, Kuon, Wolfgang, Kuhne, Maren, Wu, Peihua, Kuhlmann, Stefanie, Kollnberger, Simon, ...
Abstract Reports of the use of HLA-B27/peptide tetrameric complexes to study peptide-specific CD8 + T cells in HLA-B27 + -related diseases are rare. To establish HLA-B27 tetramers we first compared...
Bird, Lucy A., Peh, Chen Au, Kollnberger, Simon, Elliott, Tim, McMichael, Andrew J., Bowness, Paul
The MHC class I allele HLA-B27 is very strongly associated with development of autoimmune spondyloarthritis, although the disease mechanism remains unknown. Class I molecules classically associate in...
HLA-B27: natural function and pathogenic role in spondyloarthritis (2002)
McMichael, Andrew, Bowness, Paul
Chapter summary The human leukocyte antigen HLA-B27 is strongly associated with development of a group of inflammatory arthritides collectively known as the spondyloarthritides. We have set out to...
Abstract T lymphocytes play a key role in the immune response to both foreign and self peptide antigens, which they recognize in combination with MHC molecules. In the past it has been difficult to...
Recognition of antigen and superantigen by cytotoxic T lymphocytes. (1993)
Thesis (Ph. D.)--University of Oxford, 1993.
T lymphocytes play a key role in the immune response to both foreign and self peptide antigens, which they recognize in combination with MHC molecules. In the past it has been difficult to analyse...
Appel, Heiner, Kuon, Wolfgang, Kuhne, Maren, Wu, Peihua, Kuhlmann, Stefanie, Kollnberger, Simon, ...
Reports of the use of HLA-B27/peptide tetrameric complexes to study peptide-specific CD8+ T cells in HLA-B27+-related diseases are rare. To establish HLA-B27 tetramers we first compared the function...
Sustained CD8+ T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans
Norbeck, Oscar, Isa, Adiba, Pöhlmann, Christoph, Broliden, Kristina, Kasprowicz, Victoria, Bowness, Paul, ...
Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally...
Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection
Isa, Adiba, Kasprowicz, Victoria, Norbeck, Oscar, Loughry, Andrew, Jeffery, Katie, Broliden, Kristina, ...
Although parvovirus B19 apparently causes an acute viral infection, it appears to induce a persistent activated CD8 + T cell response.
Dorrell, Lucy, Yang, Hongbing, Ondondo, Beatrice, Dong, Tao, Di Gleria, Kati, Suttill, Annie, ...
Affordable therapeutic strategies that induce sustained control of human immunodeficiency virus type 1 (HIV-1) replication and are tailored to the developing world are urgently needed. Since CD8+ and...
T lymphocytes play a key role in the immune response to both foreign and self peptide antigens, which they recognize in combination with MHC molecules. In the past it has been difficult to analyse...
Appel, Heiner, Kuon, Wolfgang, Kuhne, Maren, Wu, Peihua, Kuhlmann, Stefanie, Kollnberger, Simon, ...
Reports of the use of HLA-B27/peptide tetrameric complexes to study peptide-specific CD8+ T cells in HLA-B27+-related diseases are rare. To establish HLA-B27 tetramers we first compared the function...
Sustained CD8+ T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans
Norbeck, Oscar, Isa, Adiba, Pöhlmann, Christoph, Broliden, Kristina, Kasprowicz, Victoria, Bowness, Paul, ...
Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally...
Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection
Isa, Adiba, Kasprowicz, Victoria, Norbeck, Oscar, Loughry, Andrew, Jeffery, Katie, Broliden, Kristina, ...
Although parvovirus B19 apparently causes an acute viral infection, it appears to induce a persistent activated CD8 + T cell response.
Dorrell, Lucy, Yang, Hongbing, Ondondo, Beatrice, Dong, Tao, Di Gleria, Kati, Suttill, Annie, ...
Affordable therapeutic strategies that induce sustained control of human immunodeficiency virus type 1 (HIV-1) replication and are tailored to the developing world are urgently needed. Since CD8+ and...
Ondondo, Beatrice, Yang, Hongbing, Dong, Tao, Gleria, Kati De, Suttill, Annie, Conlon, Christopher, ...
Kasprowicz, Victoria, Isa, Adiba, Tolfvenstam, Thomas, Jeffery, Katie, Bowness, Paul, Klenerman, Paul
The evolution of peptide-specific CD4+ T-cell responses to acute viral infections of humans is poorly understood. We analyzed the response to parvovirus B19 (B19), a ubiquitous and clinically...