Paul Clapham

Characterization of a Late Entry Event in the Replication Cycle of Human Immunodeficiency Virus Type 2

McKnight, Áine, Griffiths, David J., Dittmar, Matthias, Clapham, Paul, Thomas, Elaine

Certain human cell lines and primary macrophage cultures are restricted to infection by some primary isolates of human immunodeficiency virus type 2 (HIV-2), although early steps of the viral life...

Repression of the HIV-1 5′ LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors

Reynolds, Lindsey, Ullman, Christopher, Moore, Michael, Isalan, Mark, West, Michelle J., Clapham, Paul, ...

Zinc finger domains are small DNA-binding modules that can be engineered to bind desired target sequences. Functional transcription factors can be made from these DNA-binding modules, by fusion with...

Envelope Conformational Changes Induced by Human Immunodeficiency Virus Type 1 Attachment Inhibitors Prevent CD4 Binding and Downstream Entry Events

Ho, Hsu-Tso, Fan, Li, Nowicka-Sans, Beata, McAuliffe, Brian, Li, Chang-Ben, Yamanaka, Gregory, ...

BMS-488043 is a small-molecule human immunodeficiency virus type 1 (HIV-1) CD4 attachment inhibitor with demonstrated clinical efficacy. The compound inhibits soluble CD4 (sCD4) binding to the 11...

Characterization of a Late Entry Event in the Replication Cycle of Human Immunodeficiency Virus Type 2

McKnight, Áine, Griffiths, David J., Dittmar, Matthias, Clapham, Paul, Thomas, Elaine

Certain human cell lines and primary macrophage cultures are restricted to infection by some primary isolates of human immunodeficiency virus type 2 (HIV-2), although early steps of the viral life...

Repression of the HIV-1 5′ LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors

Reynolds, Lindsey, Ullman, Christopher, Moore, Michael, Isalan, Mark, West, Michelle J., Clapham, Paul, ...

Zinc finger domains are small DNA-binding modules that can be engineered to bind desired target sequences. Functional transcription factors can be made from these DNA-binding modules, by fusion with...

Envelope Conformational Changes Induced by Human Immunodeficiency Virus Type 1 Attachment Inhibitors Prevent CD4 Binding and Downstream Entry Events

Ho, Hsu-Tso, Fan, Li, Nowicka-Sans, Beata, McAuliffe, Brian, Li, Chang-Ben, Yamanaka, Gregory, ...

BMS-488043 is a small-molecule human immunodeficiency virus type 1 (HIV-1) CD4 attachment inhibitor with demonstrated clinical efficacy. The compound inhibits soluble CD4 (sCD4) binding to the 11...