Paul D. Allen

The Millennium Galaxy Catalogue: the B-band attenuation of bulge and disc light and the implied cosmic dust and stellar mass densities (2007)

Driver, Simon P., Popescu, Cristina C., Tuffs, Richard J., Liske, Jochen, Graham, Alister W., Allen, Paul D., ...

Based on our sample of 10095 galaxies with bulge-disc decompositions we derive the empirical B-band internal attenuation--inclination relation for galaxy discs and their associated central bulges....

The Millennium Galaxy Catalogue: The local supermassive black hole mass function in early- and late-type galaxies (2007)

Graham, Alister W., Driver, Simon P., Allen, Paul D., Liske, Jochen

We provide a new estimate of the local supermassive black hole mass function using (i) the empirical relation between supermassive black hole mass and the Sersic index of the host spheroidal stellar...

The Millennium Galaxy Catalogue: The luminosity functions of bulges and discs and their implied stellar mass densities (2007)

Driver, Simon P., Allen, Paul D., Liske, Jochen, Graham, Alister W.

We derive the luminosity functions of elliptical galaxies, galaxy bulges, galaxy pseudo-bulges and galaxy discs from our structural catalogue of 10,095 galaxies. In addition we compute their...

The Millennium Galaxy Catalogue : the luminosity functions of bulges and disks and their implied stellar mass densities (2007)

Driver, Simon P., Allen, Paul D., Liske, Jochen, Graham, Alister W.

We derive the luminosity functions of elliptical galaxies, galaxy bulges, galaxy pseudobulges, and galaxy disks from our structural catalog of 10,095 galaxies. In addition, we compute their...

The millennium galaxy catalogue : the connection between close pairs and asymmetry : implications for the galaxy merger rate (2007)

De Propris, Roberto, Conselice, Christopher J., Liske, Jochen, Driver, Simon P., Patton, David R., Graham, Alister W., ...

We compare the use of galaxy asymmetry and pair proximity for measuring galaxy merger fractions and rates for a volume limited sample of 3184 galaxies with -21 < MB - 5 log h < - 18 mag. and 0.010 <...

The Millennium Galaxy Catalogue: the connection between close pairs and asymmetry: implications for the galaxy merger rate (2007)

De Propris, Roberto, Conselice, Christopher J., Liske, Jochen, Driver, Simon P., Patton, David R., Graham, Alister W., ...

We compare the use of galaxy asymmetry and pair proximity for measuring galaxy merger fractions and rates for a volume limited sample of 3184 galaxies with -21 < MB - 5 log h < - 18 mag. and 0.010 <...

The Millennium Galaxy Catalogue: the luminosity functions of bulges and disks and their implied stellar mass densities (2007)

Driver, Simon P., Allen, Paul D., Liske, Jochen, Graham, Alister W.

We derive the luminosity functions of elliptical galaxies, galaxy bulges, galaxy pseudobulges, and galaxy disks from our structural catalog of 10,095 galaxies. In addition, we compute their...

The millennium galaxy catalogue : the connection between close pairs and asymmetry : implications for the galaxy merger rate (2007)

De Propris, Roberto, Conselice, Christopher J., Liske, Jochen, Driver, Simon P., Patton, David R., Graham, Alister W., ...

We compare the use of galaxy asymmetry and pair proximity for measuring galaxy merger fractions and rates for a volume limited sample of 3184 galaxies with -21 < MB - 5 log h < - 18 mag. and 0.010 <...

The Millennium Galaxy Catalogue : the luminosity functions of bulges and disks and their implied stellar mass densities (2007)

Driver, Simon P., Allen, Paul D., Liske, Jochen, Graham, Alister W.

We derive the luminosity functions of elliptical galaxies, galaxy bulges, galaxy pseudobulges, and galaxy disks from our structural catalog of 10,095 galaxies. In addition, we compute their...

Measuring Structural Properties of Galaxies in the Local Universe (2007)

Allen, Paul D., Driver, Simon P., Liske, Jochen, Graham, Alister W.

The Millennium Galaxy Catalogue provides a representative and complete sample of nearby galaxies for structural analysis. GIM2D is used to model the light profiles for over 10,000 resolved galaxies,...

Measuring structural properties of galaxies in the local universe (2007)

Allen, Paul D., Driver, Simon P., Liske, Jochen, Graham, Alister W.

The Millennium Galaxy Catalogue provides a representative and complete sample of nearby galaxies for structural analysis. GIM2D is used to model the light profiles for over 10,000 resolved galaxies,...

The Millennium Galaxy Catalogue : the luminosity functions of bulges and disks and their implied stellar mass densities (2007)

Driver, Simon P., Allen, Paul D., Liske, Jochen, Graham, Alister W.

We derive the luminosity functions of elliptical galaxies, galaxy bulges, galaxy pseudobulges, and galaxy disks from our structural catalog of 10,095 galaxies. In addition, we compute their...

The millennium galaxy catalogue : the connection between close pairs and asymmetry : implications for the galaxy merger rate (2007)

De Propris, Roberto, Conselice, Christopher J., Liske, Jochen, Driver, Simon P., Patton, David R., Graham, Alister W., ...

We compare the use of galaxy asymmetry and pair proximity for measuring galaxy merger fractions and rates for a volume limited sample of 3184 galaxies with -21 < MB - 5 log h < - 18 mag. and 0.010 <...

Measuring Structural Properties of Galaxies in the Local Universe (2007)

Allen, Paul D., Driver, Simon P., Liske, Jochen, Graham, Alister W.

The Millennium Galaxy Catalogue provides a representative and complete sample of nearby galaxies for structural analysis. GIM2D is used to model the light profiles for over 10,000 resolved galaxies,...

The Millennium Galaxy Catalogue: the local supermassive black hole mass function in early- and late-type galaxies (2007)

Graham, Alister W., Driver, Simon P., Allen, Paul D., Liske, Jochen

We provide a new estimate of the local supermassive black hole mass function using (i) the empirical relation between supermassive black hole mass and the Sérsic index of the host spheroidal...

The Millennium Galaxy Catalogue: the luminosity functions of bulges and disks and their implied stellar mass densities (2007)

Driver, Simon P., Allen, Paul D., Liske, Jochen, Graham, Alister W.

We derive the luminosity functions of elliptical galaxies, galaxy bulges, galaxy pseudobulges, and galaxy disks from our structural catalog of 10,095 galaxies. In addition, we compute their...

The Millennium Galaxy Catalogue: the connection between close pairs and asymmetry: implications for the galaxy merger rate (2007)

De Propris, Roberto, Conselice, Christopher J., Liske, Jochen, Driver, Simon P., Patton, David R., Graham, Alister W., ...

We compare the use of galaxy asymmetry and pair proximity for measuring galaxy merger fractions and rates for a volume limited sample of 3184 galaxies with -21 < MB - 5 log h < - 18 mag. and 0.010 <...

Measuring structural properties of galaxies in the local universe (2007)

Allen, Paul D., Driver, Simon P., Liske, Jochen, Graham, Alister W.

The Millennium Galaxy Catalogue provides a representative and complete sample of nearby galaxies for structural analysis. GIM2D is used to model the light profiles for over 10,000 resolved galaxies,...

The Millennium Galaxy Catalogue: the local supermassive black hole mass function in early- and late-type galaxies (2007)

Graham, Alister W., Driver, Simon P., Allen, Paul D., Liske, Jochen

We provide a new estimate of the local supermassive black hole mass function using (i) the empirical relation between supermassive black hole mass and the Sérsic index of the host spheroidal...

The Millennium Galaxy Catalogue: Bulge/Disc Decomposition of 10095 Nearby Galaxies (2006)

Allen, Paul D., Driver, Simon P., Graham, Alister W., Cameron, Ewan, Liske, Jochen, De Propris, Roberto

We have modelled the light distribution in 10095 galaxies from the Millennium Galaxy Catalogue (MGC), providing publically available structural catalogues for a large, representative sample of...

The Millennium Galaxy Catalogue: morphological classification and bimodality in the colour-concentration plane (2006)

Driver, Simon P., Allen, Paul D., Graham, Alister W., Cameron, Ewan, Liske, Jochen, Ellis, Simon C., ...

Using 10 095 galaxies (B < 20 mag) from the Millennium Galaxy Catalogue, we derive B-band luminosity distributions and selected bivariate brightness distributions for the galaxy population. All...

The Millennium Galaxy Catalogue : bulge-disc decomposition of 10 095 nearby galaxies (2006)

Allen, Paul D., Driver, Simon P., Graham, Alister W., Cameron, Ewan, Liske, Jochen, De Propris, Roberto

We have modelled the light distribution in 10 095 galaxies from the Millennium Galaxy Catalogue (MGC), providing publicly available structural catalogues for a large, representative sample of...

The Millennium Galaxy Catalogue : bulge-disc decomposition of 10 095 nearby galaxies (2006)

Allen, Paul D., Driver, Simon P., Graham, Alister W., Cameron, Ewan, Liske, Jochen, De Propris, Roberto

We have modelled the light distribution in 10 095 galaxies from the Millennium Galaxy Catalogue (MGC), providing publicly available structural catalogues for a large, representative sample of...

The Millennium Galaxy Catalogue : bulge-disc decomposition of 10 095 nearby galaxies (2006)

Allen, Paul D., Driver, Simon P., Graham, Alister W., Cameron, Ewan, Liske, Jochen, De Propris, Roberto

We have modelled the light distribution in 10 095 galaxies from the Millennium Galaxy Catalogue (MGC), providing publicly available structural catalogues for a large, representative sample of...

The Millennium Galaxy Catalogue : bulge-disc decomposition of 10 095 nearby galaxies (2006)

Allen, Paul D., Driver, Simon P., Graham, Alister W., Cameron, Ewan, Liske, Jochen, De Propris, Roberto

We have modelled the light distribution in 10 095 galaxies from the Millennium Galaxy Catalogue (MGC), providing publicly available structural catalogues for a large, representative sample of...

The Millennium Galaxy Catalogue: the nearby supermassive black hole mass function (2006)

Driver, Simon P., Graham, Alister W., Allen, Paul D., Liske, Jochen

We highlight the correlation between a galaxy's supermassive black hole mass and the Sersic-index of the host spheroid or bulge component. From our bulge-disk decompositions of 10 095 galaxies, drawn...

The local supermassive black hole mass function from 10,000 galaxies and the Mbh-concentration relation (2006)

Graham, Alister W., Driver, Simon P., Allen, Paul D., Liske, Jochen

We present an updated linear, and a new quadratic, relation between supermassive black hole mass and bulge concentration, that can be used to predict black hole masses in other galaxies. Using the...

The Millennium Galaxy Catalogue: morphological classification and bimodality in the colour-concentration plane (2006)

Driver, Simon P., Allen, Paul D., Graham, Alister W., Cameron, Ewan, Liske, Jochen, Ellis, S. C., ...

Using 10 095 galaxies (B < 20 mag) from the Millennium Galaxy Catalogue, we derive B-band luminosity distributions and selected bivariate brightness distributions for the galaxy population subdivided...

The Millennium Galaxy Catalogue : bulge-disc decomposition of 10 095 nearby galaxies (2006)

Allen, Paul D., Driver, Simon P., Graham, Alister W., Cameron, Ewan, Liske, Jochen, De Propris, Roberto

We have modelled the light distribution in 10 095 galaxies from the Millennium Galaxy Catalogue (MGC), providing publicly available structural catalogues for a large, representative sample of...

The Millennium Galaxy Catalogue: the nearby supermassive black hole mass function (2006)

Driver, Simon P., Graham, Alister W., Allen, Paul D., Liske, Jochen

We highlight the correlation between a galaxy's supermassive black hole mass and the Sersic-index of the host spheroid or bulge component. From our bulge-disk decompositions of 10 095 galaxies, drawn...

The local supermassive black hole mass function from 10,000 galaxies and the Mbh-concentration relation (2006)

Graham, Alister W., Driver, Simon P., Allen, Paul D., Liske, Jochen

We present an updated linear, and a new quadratic, relation between supermassive black hole mass and bulge concentration, that can be used to predict black hole masses in other galaxies. Using the...

The Millennium Galaxy Catalogue: morphological classification and bimodality in the colour-concentration plane (2006)

Driver, Simon P., Allen, Paul D., Graham, Alister W., Cameron, Ewan, Liske, Jochen, Ellis, S. C., ...

Using 10 095 galaxies (B < 20 mag) from the Millennium Galaxy Catalogue, we derive B-band luminosity distributions and selected bivariate brightness distributions for the galaxy population subdivided...

The Millennium Galaxy Catalogue: The nearby supermassive black hole mass function (2005)

Driver, Simon P., Graham, Alister W., Allen, Paul D., Liske, Jochen

We highlight the correlation between a galaxy's supermassive black hole mass and the Sersic-index of the host spheroid or bulge component. From our bulge-disk decompositions of 10 095 galaxies, drawn...

The Oxford-Dartmouth Thirty Degree Survey II: Clustering of Bright Lyman Break Galaxies - Strong Luminosity Dependent Bias at z=4 (2005)

Allen, Paul D., Moustakas, Leonidas A., Dalton, Gavin, MacDonald, Emily, Blake, Chris, Clewley, Lee, ...

We present measurements of the clustering properties of bright ($L>L_{*}$) z$\sim$4 Lyman Break Galaxies (LBGs) selected from the Oxford-Dartmouth Thirty Degree Survey (ODT). We describe techniques...

The Millennium Galaxy Catalogue: the space density and surface brightness distribution(s) of galaxies (2005)

Driver, Simon P, Liske, Jochen, Cross, Nicholas J. G., De Propris, Roberto, Allen, Paul D.

We recover the joint and individual space density and surface brightness distribution(s) of galaxies from the Millennium Galaxy Catalogue. The MGC is a local survey spanning 30.9 sq deg and probing...

The Oxford-Dartmouth Thirty Degree Survey - II. Clustering of bright Lyman break galaxies: Strong luminosity-dependent bias at z=4 (2005)

Allen, Paul D., Moustakas, Leonidas A., Dalton, Gavin, MacDonald, Emily, Blake, Chris, Clewley, Lee, ...

We present measurements of the clustering properties of bright (L > L*) z~ 4 Lyman break galaxies (LBGs) selected from the Oxford- Dartmouth Thirty Degree Survey (ODT). We describe techniques used to...

The Oxford-Dartmouth Thirty Degree Survey II: clustering of bright Lyman break galaxies: strong luminosity-dependent bias at z = 4 (2005)

Allen, Paul D., Moustakas, Leonidas A., Dalton, Gavin, MacDonald, Emily, Blake, Chris, Clewley, Lee, ...

We present measurements of the clustering properties of bright (L > L*) z∼ 4 Lyman break galaxies (LBGs) selected from the Oxford–Dartmouth Thirty Degree Survey (ODT). We describe...

The Oxford-Dartmouth Thirty Degree Survey II: clustering of bright Lyman break galaxies: strong luminosity-dependent bias at z = 4 (2005)

Allen, Paul D., Moustakas, Leonidas A., Dalton, Gavin, MacDonald, Emily, Blake, Chris, Clewley, Lee, ...

We present measurements of the clustering properties of bright (L > L*) z∼ 4 Lyman break galaxies (LBGs) selected from the Oxford–Dartmouth Thirty Degree Survey (ODT). We describe...

Electromyographic Assessment during Isokinetic Exercise in Women 1, 2, 3. (2002)

Lloyd,Andree J., Allen,Paul D., Cote,Marc G.

Electromyographic (EMG) recordings were made during the assessment of arm strength and endurance of an isokinetic exercise in 25 high school women participating in a study designed to evaluate the...

The Effects of Metallicity on the Cepheid P-L Relation and the Consequences for the Extragalactic Distance Scale (2001)

Allen, Paul D., Shanks, Tom

Using published HST Cepheid data from 25 galaxies, we have found a correlation between the P-L dispersion and host galaxy metallicity which is significant at the ~3sigma level in the V band. This...

Divergent Functional Properties of Ryanodine Receptor Types 1 and 3 Expressed in a Myogenic Cell Line (2000)

James D. Fessenden, Yaming Wang, Rennee A. Moore, Paul D. Allen, Isaac N. Pessah

ABSTRACT Of the three known ryanodine receptor (RyR) isoforms expressed in muscle, RyR1 and RyR2 have well-defined roles in contraction. However, studies on mammalian RyR3 have been difficult because...

Negative inotropic and relaxant effects of cocaine on myopathic human ventricular myocardium and epicardial coronary arteries in vitro (1993)

Perreault, Cynthia L, Hague, Nancy L, Morgan, Kathleen G, Allen, Paul D, Morgan, James P

Objective: Cocaine produces both vascular and myocardial effects that can lead to serious cardiovascular complications in man. Tissue catecholamine stores are known to be depleted in the advanced...

Ryanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodine

Fessenden, James D., Chen, Lili, Wang, Yaming, Paolini, Cecilia, Franzini-Armstrong, Clara, Allen, Paul D., ...

The ryanodine receptor (RyR) family of proteins constitutes a unique type of calcium channel that mediates Ca2+ release from endoplasmic reticulum/sarcoplasmic reticulum stores. Ryanodine has been...

The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development

Yang, Huang-Tian, Tweedie, David, Wang, Su, Guia, Antonio, Vinogradova, Tatiana, Bogdanov, Konstantin, ...

In adult myocardium, the heartbeat originates from the sequential activation of ionic currents in pacemaker cells of the sinoatrial node. Ca2+ release via the ryanodine receptor (RyR) modulates the...

Conformational activation of Ca2+ entry by depolarization of skeletal myotubes

Cherednichenko, Gennady, Hurne, Alanna M., Fessenden, James D., Lee, Eun Hui, Allen, Paul D., Beam, Kurt G., ...

Store-operated Ca2+ entry (SOCE) occurs in diverse cell types in response to depletion of Ca2+ within the endoplasmic/sarcoplasmic reticulum and functions both to refill these stores and to shape...

Ca2+ activation of RyR1 is not necessary for the initiation of skeletal-type excitation-contraction coupling.

O'Brien, Jennifer J, Feng, Wei, Allen, Paul D, Chen, S R Wayne, Pessah, Isaac N, Beam, Kurt G

Although an elevation in myoplasmic Ca2+ can activate the skeletal muscle ryanodine receptor (RyR1), the function of this Ca2+ activation is unclear because extracellular Ca2+ influx is unnecessary...

Morphology and molecular composition of sarcoplasmic reticulum surface junctions in the absence of DHPR and RyR in mouse skeletal muscle.

Felder, Edward, Protasi, Feliciano, Hirsch, Ronit, Franzini-Armstrong, Clara, Allen, Paul D

Calcium release during excitation-contraction coupling of skeletal muscle cells is initiated by the functional interaction of the exterior membrane and the sarcoplasmic reticulum (SR), mediated by...

Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscle.

Protasi, Feliciano, Paolini, Cecilia, Nakai, Junichi, Beam, Kurt G, Franzini-Armstrong, Clara, Allen, Paul D

Excitation-contraction (e-c) coupling in muscle relies on the interaction between dihydropyridine receptors (DHPRs) and RyRs within Ca(2+) release units (CRUs). In skeletal muscle this interaction is...

RyR1/RyR3 Chimeras Reveal that Multiple Domains of RyR1 Are Involved in Skeletal-Type E-C Coupling

Perez, Claudio F., Voss, Andrew, Pessah, Isaac N., Allen, Paul D.

Skeletal-type E-C coupling is thought to require a direct interaction between RyR1 and the α1S-DHPR. Most available evidence suggests that the cytoplasmic II–III loop of the dihydropyridine...

Ryanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodine

Fessenden, James D., Chen, Lili, Wang, Yaming, Paolini, Cecilia, Franzini-Armstrong, Clara, Allen, Paul D., ...

The ryanodine receptor (RyR) family of proteins constitutes a unique type of calcium channel that mediates Ca2+ release from endoplasmic reticulum/sarcoplasmic reticulum stores. Ryanodine has been...

The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development

Yang, Huang-Tian, Tweedie, David, Wang, Su, Guia, Antonio, Vinogradova, Tatiana, Bogdanov, Konstantin, ...

In adult myocardium, the heartbeat originates from the sequential activation of ionic currents in pacemaker cells of the sinoatrial node. Ca2+ release via the ryanodine receptor (RyR) modulates the...

Conformational activation of Ca2+ entry by depolarization of skeletal myotubes

Cherednichenko, Gennady, Hurne, Alanna M., Fessenden, James D., Lee, Eun Hui, Allen, Paul D., Beam, Kurt G., ...

Store-operated Ca2+ entry (SOCE) occurs in diverse cell types in response to depletion of Ca2+ within the endoplasmic/sarcoplasmic reticulum and functions both to refill these stores and to shape...

Ca2+ activation of RyR1 is not necessary for the initiation of skeletal-type excitation-contraction coupling.

O'Brien, Jennifer J, Feng, Wei, Allen, Paul D, Chen, S R Wayne, Pessah, Isaac N, Beam, Kurt G

Although an elevation in myoplasmic Ca2+ can activate the skeletal muscle ryanodine receptor (RyR1), the function of this Ca2+ activation is unclear because extracellular Ca2+ influx is unnecessary...

Morphology and molecular composition of sarcoplasmic reticulum surface junctions in the absence of DHPR and RyR in mouse skeletal muscle.

Felder, Edward, Protasi, Feliciano, Hirsch, Ronit, Franzini-Armstrong, Clara, Allen, Paul D

Calcium release during excitation-contraction coupling of skeletal muscle cells is initiated by the functional interaction of the exterior membrane and the sarcoplasmic reticulum (SR), mediated by...

Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscle.

Protasi, Feliciano, Paolini, Cecilia, Nakai, Junichi, Beam, Kurt G, Franzini-Armstrong, Clara, Allen, Paul D

Excitation-contraction (e-c) coupling in muscle relies on the interaction between dihydropyridine receptors (DHPRs) and RyRs within Ca(2+) release units (CRUs). In skeletal muscle this interaction is...

RyR1/RyR3 Chimeras Reveal that Multiple Domains of RyR1 Are Involved in Skeletal-Type E-C Coupling

Perez, Claudio F., Voss, Andrew, Pessah, Isaac N., Allen, Paul D.

Skeletal-type E-C coupling is thought to require a direct interaction between RyR1 and the α1S-DHPR. Most available evidence suggests that the cytoplasmic II–III loop of the dihydropyridine...

Cardiac Gene Expression Profiling Provides Evidence for Cytokinopathy as a Molecular Mechanism in Chagas’ Disease Cardiomyopathy

Cunha-Neto, Edecio, Dzau, Victor J., Allen, Paul D., Stamatiou, Dimitri, Benvenutti, Luiz, Higuchi, M. Lourdes, ...

Chronic Chagas’ disease cardiomyopathy is a leading cause of congestive heart failure in Latin America, affecting more than 3 million people. Chagas’ cardiomyopathy is more aggressive than other...

Global Gene Expression Profiling of End-Stage Dilated Cardiomyopathy Using a Human Cardiovascular-Based cDNA Microarray

Barrans, J. David, Allen, Paul D., Stamatiou, Dimitrios, Dzau, Victor J., Liew, Choong-Chin

To obtain a genomic portrait of heart failure derived from end-stage dilated cardiomyopathy (DCM), we explored expression analysis using the CardioChip, a nonredundant 10,848-element human...

Bidirectional signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions

Sheridan, David C., Takekura, Hiroaki, Franzini-Armstrong, Clara, Beam, Kurt G., Allen, Paul D., Perez, Claudio F.

We have defined regions of the skeletal muscle ryanodine receptor (RyR1) essential for bidirectional signaling with dihydropyridine receptors (DHPRs) and for the organization of DHPR into tetrad...

Expression of ryanodine receptor RyR3 produces Ca2+ sparks in dyspedic myotubes

Ward, Christopher W, Schneider, Martin F, Castillo, Daniel, Protasi, Feliciano, Wang, Yaming, Wayne Chen, S R, ...

Discrete, localized elevations of myoplasmic [Ca2+], Ca2+‘sparks’, were readily detected using the fluorescent Ca2+ indicator fluo-3 and laser scanning confocal microscopy in ‘dyspedic’ 1B5...

Role of Ryanodine Receptors in the Assembly of Calcium Release Units in Skeletal Muscle

Protasi, Feliciano, Franzini-Armstrong, Clara, Allen, Paul D.

Abstract. In muscle cells, excitation–contraction (e–c) coupling is mediated by “calcium release units,” junctions between the sarcoplasmic reticulum (SR) and exterior membranes. Two...

Reorganized stores and impaired calcium handling in skeletal muscle of mice lacking calsequestrin-1

Paolini, Cecilia, Quarta, Marco, Nori, Alessandra, Boncompagni, Simona, Canato, Marta, Volpe, Pompeo, ...

Calsequestrin (CS), the major Ca2+-binding protein in the sarcoplasmic reticulum (SR), is thought to play a dual role in excitation–contraction coupling: buffering free Ca2+ increasing SR capacity,...

Age-Related Hearing Loss in C57BL/6J Mice has both Frequency-Specific and Non-Frequency-Specific Components that Produce a Hyperacusis-Like Exaggeration of the Acoustic Startle Reflex

Ison, James R., Allen, Paul D., O’Neill, William E.

Auditory brainstem-evoked response (ABR) thresholds were obtained in a longitudinal study of C57BL/6J mice between 10 and 53 weeks old, with repeated testing every 2 weeks. On alternate weeks,...

α2δ1 Dihydropyridine Receptor Subunit Is a Critical Element for Excitation-Coupled Calcium Entry but Not for Formation of Tetrads in Skeletal Myotubes

Gach, Marcin P., Cherednichenko, Gennady, Haarmann, Claudia, Lopez, Jose R., Beam, Kurt G., Pessah, Isaac N., ...

It has been shown that small interfering RNA (siRNA) partial knockdown of the α2δ1 dihydropyridine receptor subunits cause a significant increase in the rate of activation of the L-type Ca2+...

Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation–contraction coupling, and cardiac arrhythmias

Chopra, Nagesh, Yang, Tao, Asghari, Parisa, Moore, Edwin D., Huke, Sabine, Akin, Brandy, ...

Heart muscle excitation–contraction (E-C) coupling is governed by Ca2+ release units (CRUs) whereby Ca2+ influx via L-type Ca2+ channels (Cav1.2) triggers Ca2+ release from juxtaposed Ca2+ release...