Paul D. Straight

Mps1p Regulates Meiotic Spindle Pole Body Duplication in Addition to Having Novel Roles during Sporulation

Straight, Paul D., Giddings, Thomas H., Winey, Mark

Sporulation in yeast requires that a modified form of chromosome segregation be coupled to the development of a specialized cell type, a process akin to gametogenesis. Mps1p is a dual-specificity...

Three-dimensional Ultrastructure of Saccharomyces cerevisiae Meiotic SpindlesD⃞V⃞

Winey, Mark, Morgan, Garry P., Straight, Paul D., Giddings, Thomas H., Mastronarde, David N.

Meiotic chromosome segregation leads to the production of haploid germ cells. During meiosis I (MI), the paired homologous chromosomes are separated. Meiosis II (MII) segregation leads to the...

Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase

Yin, Jun, Straight, Paul D., McLoughlin, Shaun M., Zhou, Zhe, Lin, Alison J., Golan, David E., ...

An 11-residue peptide with the sequence DSLEFIASKLA was identified from a genomic library of Bacillus subtilis by phage display as an efficient substrate for Sfp phosphopantetheinyl...

Interactions between Streptomyces coelicolor and Bacillus subtilis: Role of Surfactants in Raising Aerial Structures

Straight, Paul D., Willey, Joanne M., Kolter, Roberto

Using mixed-species cultures, we have undertaken a study of interactions between two common spore-forming soil bacteria, Bacillus subtilis and Streptomyces coelicolor. Our experiments demonstrate...

Mps1p Regulates Meiotic Spindle Pole Body Duplication in Addition to Having Novel Roles during Sporulation

Straight, Paul D., Giddings, Thomas H., Winey, Mark

Sporulation in yeast requires that a modified form of chromosome segregation be coupled to the development of a specialized cell type, a process akin to gametogenesis. Mps1p is a dual-specificity...

Three-dimensional Ultrastructure of Saccharomyces cerevisiae Meiotic SpindlesD⃞V⃞

Winey, Mark, Morgan, Garry P., Straight, Paul D., Giddings, Thomas H., Mastronarde, David N.

Meiotic chromosome segregation leads to the production of haploid germ cells. During meiosis I (MI), the paired homologous chromosomes are separated. Meiosis II (MII) segregation leads to the...

Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase

Yin, Jun, Straight, Paul D., McLoughlin, Shaun M., Zhou, Zhe, Lin, Alison J., Golan, David E., ...

An 11-residue peptide with the sequence DSLEFIASKLA was identified from a genomic library of Bacillus subtilis by phage display as an efficient substrate for Sfp phosphopantetheinyl...

Interactions between Streptomyces coelicolor and Bacillus subtilis: Role of Surfactants in Raising Aerial Structures

Straight, Paul D., Willey, Joanne M., Kolter, Roberto

Using mixed-species cultures, we have undertaken a study of interactions between two common spore-forming soil bacteria, Bacillus subtilis and Streptomyces coelicolor. Our experiments demonstrate...

A singular enzymatic megacomplex from Bacillus subtilis

Straight, Paul D., Fischbach, Michael A., Walsh, Christopher T., Rudner, David Z., Kolter, Roberto

Nonribosomal peptide synthetases (NRPS), polyketide synthases (PKS), and hybrid NRPS/PKS are of particular interest, because they produce numerous therapeutic agents, have great potential for...

The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis

Butcher, Rebecca A., Schroeder, Frank C., Fischbach, Michael A., Straight, Paul D., Kolter, Roberto, Walsh, Christopher T., ...

The ≈80-kb pksX gene cluster in Bacillus subtilis encodes an unusual hybrid polyketide/nonribosomal peptide synthase that has been linked to the production of the uncharacterized antibiotic...