Liver Fluke Induces Cholangiocarcinoma (2007)
Banchob Sripa, Sasithorn Kaewkes, Paiboon Sithithaworn, Eimorn Mairiang, Thewarach Laha, Michael Smout, ...
Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini (2007)
Laha, Thewarach, Pinlaor, Porntip, Mulvenna, Jason, Sripa, Banchob, Sripa, Manop, Smout, Michael J, ...
Abstract Background Cholangiocarcinoma (CCA) – cancer of the bile ducts – is associated with chronic infection with the liver fluke, Opisthorchis viverrini . Despite being the only eukaryote that...
Koehler, Jeffrey W, Morales, Maria E, Shelby, Bryan D, Brindley, Paul J
We examined the efficiency of digestion of hemoglobin from four mammalian species, human, cow, sheep, and horse by acidic extracts of mixed sex adults of Schistosoma japonicum and S. mansoni....
Koehler,Jeffrey W, Morales,Maria E, Shelby,Bryan D, Brindley,Paul J
We examined the efficiency of digestion of hemoglobin from four mammalian species, human, cow, sheep, and horse by acidic extracts of mixed sex adults of Schistosoma japonicum and S. mansoni....
Claudia S Copeland, Fred A Lewis, Paul J Brindley
Schistosomes have a comparatively large genome, estimated for Schistosoma mansoni to be about 270 megabase pairs (haploid genome). Recent findings have shown that mobile genetic elements...
Copeland,Claudia S, Lewis,Fred A, Brindley,Paul J
Schistosomes have a comparatively large genome, estimated for Schistosoma mansoni to be about 270 megabase pairs (haploid genome). Recent findings have shown that mobile genetic elements constitute...
Feng Liu, Jiong Lu, Wei Hu, Sheng-Yue Wang, Shu-Jian Cui, Ming Chi, ...
Schistosomiasis remains a serious public health problem with an estimated 200 million people infected in 76 countries. Here we isolated ~ 8,400 potential protein-encoding cDNA contigs from...
Xiao-Xian Gan, Li-Ying Shen, Yue Wang, Jian-Zu Ding, Hui-Ying Shen, Xiao-Peng Zeng, ...
A polyhistidine-tagged recombinant tegumental protein Schistosoma japonicum very lowdensity lipoprotein binding protein (SVLBP) from adult Schistosoma japonicum was expressed in Escherichia coli...
Gan,Xiao-Xian, Shen,Li-Ying, Wang,Yue, Ding,Jian-Zu, Shen,Hui-Ying, Zeng,Xiao-Peng, ...
A polyhistidine-tagged recombinant tegumental protein Schistosoma japonicum very lowdensity lipoprotein binding protein (SVLBP) from adult Schistosoma japonicum was expressed in Escherichia coli. The...
Wang, Lili, Yang,Zhong, Li, Yuanyuan, Yu,Fudong, Brindley, Paul J., McManus, Donald P., ...
At present, little is known about signal transduction mechanisms in schistosomes, which cause the disease of schistosomiasis. The mitogen-activated protein kinase (MAPK) signaling pathways, which are...
Heyers, Oliver, Walduck, Anna, Brindley, Paul J., Bleiss, Wilfried, Lucius, Richard, Dorbic, Tomislav, ...
Methionine Aminopeptidase 2 Expression in Microsporidia (2003)
ELIZABETH S. DIDIER, AARON D. MARTIN, MARY E. STOVALL, XAVIER ALVAREZ, DEREK MITTLEIDER, LINDA C. GREEN, ...
Heyers, Oliver, Walduck, Anna, Brindley, Paul J., Bleiss, Wilfried, Lucius, Richard, Dorbic, Tomislav, ...
DEREK MITTLEIDER, LINDA C. GREEN, VICTORIA H. MANN, SCOTT F. MICHAEL, ELIZABETH S. DIDIER, PAUL J. BRINDLEY
The microsporidian Vittaforma corneae has been reported as a pathogen of the human stratum corneum, where it can cause keratitis, and is associated with systemic infections. In addition to this...
Burton J. Bogitsh, John P. Dalton, Ciaran P. Brady, Paul J. Brindley
Transcripts encoding discrete, cathepsin L-like cysteine proteases, known as SmCL1 and SmCL2, have been reported from the adult stages of the human blood fluke Schistosoma mansoni. However, the...
Brady, Ciaran P., Dowd, Andrew J., Brindley, Paul J., Ryan, Thecla, Day, Sharon R., Dalton, John P.
Cysteine proteinases expressed by schistosomes appear to play key roles in the digestion of host hemoglobin, the principal source of amino acid nutrients utilized by these parasites. We have shown...
Receptor for Fc on the Surfaces of Schistosomes
Loukas, Alex, Jones, Malcolm K., King, Lynette T., Brindley, Paul J., McManus, Donald P.
Schistosoma mansoni masks its surface with adsorbed host proteins including erythrocyte antigens, immunoglobulins, major histocompatibility complex class I, and β2-microglobulin (β2m), presumably...
Copeland, Claudia S., Brindley, Paul J., Heyers, Oliver, Michael, Scott F., Johnston, David A., Williams, David L., ...
The genome of Schistosoma mansoni contains a proviral form of a retrovirus-like long terminal repeat (LTR) retrotransposon, designated Boudicca. Sequence and structural characterization of the new...
Liu, Feng, Lu, Jiong, Hu, Wei, Wang, Sheng-Yue, Cui, Shu-Jian, Chi, Ming, ...
Schistosomiasis remains a serious public health problem with an estimated 200 million people infected in 76 countries. Here we isolated ~ 8,400 potential protein-encoding cDNA contigs from...
Didier, Peter J., Phillips, Jennifer N., Kuebler, Dorothy J., Nasr, Mohamed, Brindley, Paul J., Stovall, Mary E., ...
Therapies for microsporidiosis in humans are limited, and fumagillin, which appears to be the most broadly effective antimicrosporidial drug, is considered to be moderately toxic. The purpose of this...
Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini
Laha, Thewarach, Pinlaor, Porntip, Mulvenna, Jason, Sripa, Banchob, Sripa, Manop, Smout, Michael J, ...
Liver Fluke Induces Cholangiocarcinoma
Sripa, Banchob, Kaewkes, Sasithorn, Sithithaworn, Paiboon, Mairiang, Eimorn, Laha, Thewarach, Smout, Michael, ...
The authors discuss the molecular pathogenesis of opisthorchiasis and associated cholangiocarcinogenesis, particularly nitrative and oxidative DNA damage and the clinical manifestations of...
Laha, Thewarach, Loukas, Alex, Wattanasatitarpa, Supatra, Somprakhon, Jenjira, Kewgrai, Nonglack, Sithithaworn, Paiboon, ...
Because of its importance to public health, the hookworm parasite has become the focus of increased research over the past decade—research that will ultimately decipher its genetic code. We now...
Helminth infections: the great neglected tropical diseases
Hotez, Peter J., Brindley, Paul J., Bethony, Jeffrey M., King, Charles H., Pearce, Edward J., Jacobson, Julie
Helminths are parasitic worms. They are the most common infectious agents of humans in developing countries and produce a global burden of disease that exceeds better-known conditions, including...
Rinaldi, Gabriel, Morales, Maria E., Cancela, Martín, Castillo, Estela, Brindley, Paul J., Tort, José F.
The growing availability of sequence information from diverse parasites through genomic and transcriptomic projects offer new opportunities for the identification of key mediators in the...