Genetic History of Hepatitis C Virus in East Asia (2009)
Barnes, Eleanor, Taggart, Rachel, Markov, Peter V, Rasachak, Bouachan, ...
The hepatitis C virus (HCV), which currently infects an estimated 3% of people worldwide, has been present in some human populations for several centuries, notably HCV genotypes 1 and 2 in West...
Komatsu, Haruki, Inui, Ayano, Sogo, Tsuyoshi, Fujisawa, Tomoo, Nagasaka, Hironori, Nonoyama, Shigeaki, ...
Abstract Background Cellular immunity plays a crucial role in cytomegalovirus (CMV) infection and substantial populations of CMV-specific T cells accumulate throughout life. However, although CMV...
Leah C. Solberg, William Valdar, Dominique Gauguier, Graciela Nunez, Amy Taylor, Stephanie Burnett, ...
in mice
Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection (2005)
Adiba Isa, Victoria Kasprowicz, Oscar Norbeck, Andrew Loughry, Katie Jeffery, Kristina Broliden, ...
Although parvovirus B19 apparently causes an acute viral infection, it appears to induce a persistent activated CD8 + T cell response.
Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection (2005)
Adiba Isa, Victoria Kasprowicz, Oscar Norbeck, Andrew Loughry, Katie Jeffery, Kristina Broliden, ...
Background Human parvovirus B19 (B19) is a ubiquitous and clinically significant pathogen, causing erythema infectiosum, arthropathy, transient aplastic crisis, and intrauterine fetal death. The...
Antagonist HIV-1 Gag peptides induce structural changes in HLA B8 (1996)
W. Reid, Steve Mcadam, Kathrine J. Smith, Paul Klenerman, Chris A. O’callaghan, Karl Harlos, ...
In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend,
Cytotoxic T cell antagonism in HIV infection /--Paul Klederman. (1995)
Thesis (D.Phil.)--University of Oxford, 1995.
Viral persistence in vivo through selection of neutralizing antibody-escape variants
Ciurea, Adrian, Klenerman, Paul, Hunziker, Lukas, Horvath, Edit, Senn, Beatrice M., Ochsenbein, Adrian F., ...
Despite initial virus control by CD8+ cytotoxic T lymphocytes (CTLs), noncytopathic or variably cytopathic viruses (e.g., hepatitis B and C viruses, HIV) are able to establish persistent infections....
Ochsenbein, Adrian F., Karrer, Urs, Klenerman, Paul, Althage, Alana, Ciurea, Adrian, Shen, Hao, ...
Cytotoxic T cell (CTL) memory was analyzed after infection with lymphocytic choriomeningitis virus (LCMV) and recombinant Listeria monocytogenes (rLM) expressing the complete nucleoprotein of LCMV...
Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice
Ciurea, Adrian, Klenerman, Paul, Hunziker, Lukas, Horvath, Edit, Odermatt, Bernhard, Ochsenbein, Adrian F., ...
Lymphocytic choriomeningitis virus (LCMV), strain WE, is a non-cytopathic RNA virus that is highly adapted to its natural host, the mouse. Acute infection of adult mice leads to generalized virus...
Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection
Price, David A., Goulder, Philip J. R., Klenerman, Paul, Sewell, Andrew K., Easterbrook, Philippa J., Troop, Maxine, ...
Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate...
Purbhoo, Marco A., Sewell, Andrew K., Klenerman, Paul, Goulder, Philip J. R., Hilyard, Katherine L., Bell, John I., ...
It is not known how human immunodeficiency virus type 1 (HIV-1)-derived antagonist peptides interfere with intracellular activation of cytotoxic T lymphocytes (CTL). We identified Gag epitope...
André, Patrice, Groettrup, Marcus, Klenerman, Paul, De Giuli, Rita, Booth, Bruce L., Cerundolo, Vincenzo, ...
Inhibitors of the protease of HIV-1 have been used successfully for the treatment of HIV-1-infected patients and AIDS disease. We tested whether these protease inhibitory drugs exerted effects in...
Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection
Klenerman, Paul, Phillips, Rodney E., Rinaldo, Charles R., Wahl, Linda M., Ogg, Graham, May, Robert M., ...
To understand the role of the immune system in limiting HIV type 1 replication, it is critical to know to what extent the rapid turnover of productively infected cells is caused by viral...
Immune surveillance against a solid tumor fails because of immunological ignorance
Ochsenbein, Adrian F., Klenerman, Paul, Karrer, Urs, Ludewig, Burkhard, Pericin, Marcus, Hengartner, Hans, ...
Many peripheral solid tumors such as sarcomas and carcinomas express tumor-specific antigens that can serve as targets for immune effector T cells. Nevertheless, overall immune surveillance against...
Human CD1d–glycolipid tetramers generated by in vitro oxidative refolding chromatography
Karadimitris, Anastasios, Gadola, Stephan, Altamirano, Myriam, Brown, Dave, Woolfson, Adrian, Klenerman, Paul, ...
CD1 molecules are specialized in presenting lipids to T lymphocytes, but identification and isolation of CD1-restricted lipidspecific T cells has been hampered by the lack of reliable and sensitive...
Oxenius, Annette, Martinic, Marianne M. A., Hengartner, Hans, Klenerman, Paul
Synthetic nonmethylated oligonucleotides containing CpG dinucleotides (CpG-ODNs) have been shown to exhibit immunostimulatory activity. CpG-ODNs have the capacity to directly activate B cells,...
Seiler, Peter, Senn, Beatrice M., Klenerman, Paul, Kalinke, Ulrich, Hengartner, Hans, Zinkernagel, Rolf M.
Poorly cytopathic or noncytopathic viruses can escape immune surveillance and establish a chronic infection. Here we exploited the strategy of combining antiviral drug treatment with the induction of...
Goulder, Philip J. R., Lechner, Franziska, Klenerman, Paul, McIntosh, Kenneth, Walker, Bruce D.
Respiratory syncytial virus (RSV) infection is a major cause of morbidity in childhood worldwide. The first human RSV-specific cytotoxic T-lymphocyte epitope to be defined is described. This HLA...
Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus
Gruener, Norbert H., Lechner, Franziska, Jung, Maria-Christina, Diepolder, Helmut, Gerlach, Tilman, Lauer, Georg, ...
Hepatitis C virus (HCV) sets up persistent infection in the majority of those exposed. It is likely that, as with other persistent viral infections, the efficacy of T-lymphocyte responses influences...
Lauer, Georg M., Nguyen, Tam N., Day, Cheryl L., Robbins, Gregory K., Flynn, Theresa, McGowan, Katherine, ...
Both human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) lead to chronic infection in a high percentage of persons, and an expanding epidemic of HIV-1-HCV coinfection has recently...
Effects of Promyelocytic Leukemia Protein on Virus-Host Balance
Bonilla, Weldy V., Pinschewer, Daniel D., Klenerman, Paul, Rousson, Valentin, Gaboli, Mirella, Pandolfi, Pier P., ...
The cellular promyelocytic leukemia protein (PML) associates with the proteins of several viruses and in some cases reduces viral propagation in cell culture. To examine the role of PML in vivo, we...
Lauer, Georg M., Ouchi, Kei, Chung, Raymond T., Nguyen, Tam N., Day, Cheryl L., Purkis, Deborah R., ...
The hepatitis C virus (HCV)-specific CD8+-T-cell response is thought to play a critical role in HCV infection. Studies of these responses have largely relied on the analysis of a small number of...
Lucas, Michaela, Gadola, Stephan, Meier, Ute, Young, Neil T., Harcourt, Gillian, Karadimitris, Anastasios, ...
Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Vα24/Vβ11 double positive, in hepatitis C virus (HCV)...
Komarova, Natalia L., Barnes, Eleanor, Klenerman, Paul, Wodarz, Dominik
Drug therapies against persistent human infections such as hepatitis C virus, hepatitis B virus, and HIV fail to consistently eradicate the infection from the host. Hence, recent emphasis has shifted...
Day, Cheryl L., Seth, Nilufer P., Lucas, Michaela, Appel, Heiner, Gauthier, Laurent, Lauer, Georg M., ...
Containment of hepatitis C virus (HCV) and other chronic human viral infections is associated with persistence of virus-specific CD4 T cells, but ex vivo characterization of circulating CD4 T cells...
Expansion of Protective CD8+ T-Cell Responses Driven by Recombinant Cytomegaloviruses
Karrer, Urs, Wagner, Markus, Sierro, Sophie, Oxenius, Annette, Hengel, Hartmut, Dumrese, Tilman, ...
CD8+ T cells are critical for the control of many persistent viral infections, such as human immunodeficiency virus, hepatitis C virus, Epstein-Barr virus, and cytomegalovirus (CMV). In most...
Underwhelming the Immune Response: Effect of Slow Virus Growth on CD8+-T-Lymphocyte Responses
Bocharov, Gennady, Ludewig, Burkhard, Bertoletti, Antonio, Klenerman, Paul, Junt, Tobias, Krebs, Philippe, ...
The speed of virus replication has typically been seen as an advantage for a virus in overcoming the ability of the immune system to control its population growth. Under some circumstances, the...
Sheridan, Isabelle, Pybus, Oliver G., Holmes, Edward C., Klenerman, Paul
Hepatitis C virus (HCV) persists in the majority of those infected despite host immune responses. Evidence has accrued that selectively fixed mutations in the envelope genes (E1 and E2) are...
Underwhelming the Immune Response: Effect of Slow Virus Growth on CD8+-T-Lymphocyte Responses
Bocharov, Gennady, Ludewig, Burkhard, Bertoletti, Antonio, Klenerman, Paul, Junt, Tobias, Krebs, Philippe, ...
Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells
Lucas, Michaela, Day, Cheryl L., Wyer, Jessica R., Cunliffe, Sharon L., Loughry, Andrew, McMichael, Andrew J., ...
Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a...
Impact of Alpha Interferon and Ribavirin on the Function of Maturing Dendritic Cells
Barnes, Eleanor, Salio, Mariolina, Cerundolo, Vincenzo, Medlin, Joanne, Murphy, Shona, Dusheiko, Geoffrey, ...
Alpha interferon and ribavirin are required in combination to achieve a sustained virological response in the treatment of hepatitis C virus (HCV) infection. Alpha interferon has direct antiviral...
HIV-1–specific CD4+ T lymphocyte turnover and activation increase upon viral rebound
Scriba, Thomas J., Zhang, Hua-Tang, Brown, Helen L., Oxenius, Annette, Tamm, Norbert, Fidler, Sarah, ...
HIV-specific CD4+ T helper lymphocytes are preferred targets for infection. Although complete interruption of combination antiretroviral therapy (ART) can form part of therapeutic manipulations,...
Rushbrook, Simon M., Ward, Scott M., Unitt, Esther, Vowler, Sarah L., Lucas, Michaela, Klenerman, Paul, ...
The basis of chronic infection following exposure to hepatitis C virus (HCV) infection is unexplained. One factor may be the low frequency and immature phenotype of virus-specific CD8+ T cells. The...
Meier, Ute-Christiane, Owen, Rachel E., Taylor, Elizabeth, Worth, Andrew, Naoumov, Nikolai, Willberg, Christian, ...
Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) cause clinically important persistent infections. The effects of virus persistence on innate immunity, including NK cell responses, and...
Pillay, Thillagavathie, Zhang, Hua-Tang, Drijfhout, Jan W., Robinson, Nicola, Brown, Helen, Khan, Munira, ...
The role of cytotoxic T-lymphocyte (CTL) escape in rapidly progressive infant human immunodeficiency virus type 1 (HIV-1) infection is undefined. The data presented here demonstrate that infant...
Sustained CD8+ T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans
Norbeck, Oscar, Isa, Adiba, Pöhlmann, Christoph, Broliden, Kristina, Kasprowicz, Victoria, Bowness, Paul, ...
Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally...
Lauer, Georg M., Lucas, Michaela, Timm, Joerg, Ouchi, Kei, Kim, Arthur Y., Day, Cheryl L., ...
Multispecific CD8+ T-cell responses are thought to be important for the control of acute hepatitis C virus (HCV) infection, but to date little information is actually available on the breadth of...
Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection
Isa, Adiba, Kasprowicz, Victoria, Norbeck, Oscar, Loughry, Andrew, Jeffery, Katie, Broliden, Kristina, ...
Although parvovirus B19 apparently causes an acute viral infection, it appears to induce a persistent activated CD8 + T cell response.
Viral persistence in vivo through selection of neutralizing antibody-escape variants
Ciurea, Adrian, Klenerman, Paul, Hunziker, Lukas, Horvath, Edit, Senn, Beatrice M., Ochsenbein, Adrian F., ...
Despite initial virus control by CD8+ cytotoxic T lymphocytes (CTLs), noncytopathic or variably cytopathic viruses (e.g., hepatitis B and C viruses, HIV) are able to establish persistent infections....
Ochsenbein, Adrian F., Karrer, Urs, Klenerman, Paul, Althage, Alana, Ciurea, Adrian, Shen, Hao, ...
Cytotoxic T cell (CTL) memory was analyzed after infection with lymphocytic choriomeningitis virus (LCMV) and recombinant Listeria monocytogenes (rLM) expressing the complete nucleoprotein of LCMV...
Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice
Ciurea, Adrian, Klenerman, Paul, Hunziker, Lukas, Horvath, Edit, Odermatt, Bernhard, Ochsenbein, Adrian F., ...
Lymphocytic choriomeningitis virus (LCMV), strain WE, is a non-cytopathic RNA virus that is highly adapted to its natural host, the mouse. Acute infection of adult mice leads to generalized virus...
Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection
Price, David A., Goulder, Philip J. R., Klenerman, Paul, Sewell, Andrew K., Easterbrook, Philippa J., Troop, Maxine, ...
Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate...
Purbhoo, Marco A., Sewell, Andrew K., Klenerman, Paul, Goulder, Philip J. R., Hilyard, Katherine L., Bell, John I., ...
It is not known how human immunodeficiency virus type 1 (HIV-1)-derived antagonist peptides interfere with intracellular activation of cytotoxic T lymphocytes (CTL). We identified Gag epitope...
André, Patrice, Groettrup, Marcus, Klenerman, Paul, De Giuli, Rita, Booth, Bruce L., Cerundolo, Vincenzo, ...
Inhibitors of the protease of HIV-1 have been used successfully for the treatment of HIV-1-infected patients and AIDS disease. We tested whether these protease inhibitory drugs exerted effects in...
Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection
Klenerman, Paul, Phillips, Rodney E., Rinaldo, Charles R., Wahl, Linda M., Ogg, Graham, May, Robert M., ...
To understand the role of the immune system in limiting HIV type 1 replication, it is critical to know to what extent the rapid turnover of productively infected cells is caused by viral...
Immune surveillance against a solid tumor fails because of immunological ignorance
Ochsenbein, Adrian F., Klenerman, Paul, Karrer, Urs, Ludewig, Burkhard, Pericin, Marcus, Hengartner, Hans, ...
Many peripheral solid tumors such as sarcomas and carcinomas express tumor-specific antigens that can serve as targets for immune effector T cells. Nevertheless, overall immune surveillance against...
Human CD1d–glycolipid tetramers generated by in vitro oxidative refolding chromatography
Karadimitris, Anastasios, Gadola, Stephan, Altamirano, Myriam, Brown, Dave, Woolfson, Adrian, Klenerman, Paul, ...
CD1 molecules are specialized in presenting lipids to T lymphocytes, but identification and isolation of CD1-restricted lipidspecific T cells has been hampered by the lack of reliable and sensitive...
Oxenius, Annette, Martinic, Marianne M. A., Hengartner, Hans, Klenerman, Paul
Synthetic nonmethylated oligonucleotides containing CpG dinucleotides (CpG-ODNs) have been shown to exhibit immunostimulatory activity. CpG-ODNs have the capacity to directly activate B cells,...
Seiler, Peter, Senn, Beatrice M., Klenerman, Paul, Kalinke, Ulrich, Hengartner, Hans, Zinkernagel, Rolf M.
Poorly cytopathic or noncytopathic viruses can escape immune surveillance and establish a chronic infection. Here we exploited the strategy of combining antiviral drug treatment with the induction of...
Goulder, Philip J. R., Lechner, Franziska, Klenerman, Paul, McIntosh, Kenneth, Walker, Bruce D.
Respiratory syncytial virus (RSV) infection is a major cause of morbidity in childhood worldwide. The first human RSV-specific cytotoxic T-lymphocyte epitope to be defined is described. This HLA...
Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus
Gruener, Norbert H., Lechner, Franziska, Jung, Maria-Christina, Diepolder, Helmut, Gerlach, Tilman, Lauer, Georg, ...
Hepatitis C virus (HCV) sets up persistent infection in the majority of those exposed. It is likely that, as with other persistent viral infections, the efficacy of T-lymphocyte responses influences...
Lauer, Georg M., Nguyen, Tam N., Day, Cheryl L., Robbins, Gregory K., Flynn, Theresa, McGowan, Katherine, ...
Both human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) lead to chronic infection in a high percentage of persons, and an expanding epidemic of HIV-1-HCV coinfection has recently...
Effects of Promyelocytic Leukemia Protein on Virus-Host Balance
Bonilla, Weldy V., Pinschewer, Daniel D., Klenerman, Paul, Rousson, Valentin, Gaboli, Mirella, Pandolfi, Pier P., ...
The cellular promyelocytic leukemia protein (PML) associates with the proteins of several viruses and in some cases reduces viral propagation in cell culture. To examine the role of PML in vivo, we...
Lauer, Georg M., Ouchi, Kei, Chung, Raymond T., Nguyen, Tam N., Day, Cheryl L., Purkis, Deborah R., ...
The hepatitis C virus (HCV)-specific CD8+-T-cell response is thought to play a critical role in HCV infection. Studies of these responses have largely relied on the analysis of a small number of...
Lucas, Michaela, Gadola, Stephan, Meier, Ute, Young, Neil T., Harcourt, Gillian, Karadimitris, Anastasios, ...
Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Vα24/Vβ11 double positive, in hepatitis C virus (HCV)...
Komarova, Natalia L., Barnes, Eleanor, Klenerman, Paul, Wodarz, Dominik
Drug therapies against persistent human infections such as hepatitis C virus, hepatitis B virus, and HIV fail to consistently eradicate the infection from the host. Hence, recent emphasis has shifted...
Day, Cheryl L., Seth, Nilufer P., Lucas, Michaela, Appel, Heiner, Gauthier, Laurent, Lauer, Georg M., ...
Containment of hepatitis C virus (HCV) and other chronic human viral infections is associated with persistence of virus-specific CD4 T cells, but ex vivo characterization of circulating CD4 T cells...
Expansion of Protective CD8+ T-Cell Responses Driven by Recombinant Cytomegaloviruses
Karrer, Urs, Wagner, Markus, Sierro, Sophie, Oxenius, Annette, Hengel, Hartmut, Dumrese, Tilman, ...
CD8+ T cells are critical for the control of many persistent viral infections, such as human immunodeficiency virus, hepatitis C virus, Epstein-Barr virus, and cytomegalovirus (CMV). In most...
Underwhelming the Immune Response: Effect of Slow Virus Growth on CD8+-T-Lymphocyte Responses
Bocharov, Gennady, Ludewig, Burkhard, Bertoletti, Antonio, Klenerman, Paul, Junt, Tobias, Krebs, Philippe, ...
The speed of virus replication has typically been seen as an advantage for a virus in overcoming the ability of the immune system to control its population growth. Under some circumstances, the...
Sheridan, Isabelle, Pybus, Oliver G., Holmes, Edward C., Klenerman, Paul
Hepatitis C virus (HCV) persists in the majority of those infected despite host immune responses. Evidence has accrued that selectively fixed mutations in the envelope genes (E1 and E2) are...
Underwhelming the Immune Response: Effect of Slow Virus Growth on CD8+-T-Lymphocyte Responses
Bocharov, Gennady, Ludewig, Burkhard, Bertoletti, Antonio, Klenerman, Paul, Junt, Tobias, Krebs, Philippe, ...
Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells
Lucas, Michaela, Day, Cheryl L., Wyer, Jessica R., Cunliffe, Sharon L., Loughry, Andrew, McMichael, Andrew J., ...
Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a...
Impact of Alpha Interferon and Ribavirin on the Function of Maturing Dendritic Cells
Barnes, Eleanor, Salio, Mariolina, Cerundolo, Vincenzo, Medlin, Joanne, Murphy, Shona, Dusheiko, Geoffrey, ...
Alpha interferon and ribavirin are required in combination to achieve a sustained virological response in the treatment of hepatitis C virus (HCV) infection. Alpha interferon has direct antiviral...
HIV-1–specific CD4+ T lymphocyte turnover and activation increase upon viral rebound
Scriba, Thomas J., Zhang, Hua-Tang, Brown, Helen L., Oxenius, Annette, Tamm, Norbert, Fidler, Sarah, ...
HIV-specific CD4+ T helper lymphocytes are preferred targets for infection. Although complete interruption of combination antiretroviral therapy (ART) can form part of therapeutic manipulations,...
Rushbrook, Simon M., Ward, Scott M., Unitt, Esther, Vowler, Sarah L., Lucas, Michaela, Klenerman, Paul, ...
The basis of chronic infection following exposure to hepatitis C virus (HCV) infection is unexplained. One factor may be the low frequency and immature phenotype of virus-specific CD8+ T cells. The...
Meier, Ute-Christiane, Owen, Rachel E., Taylor, Elizabeth, Worth, Andrew, Naoumov, Nikolai, Willberg, Christian, ...
Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) cause clinically important persistent infections. The effects of virus persistence on innate immunity, including NK cell responses, and...
Pillay, Thillagavathie, Zhang, Hua-Tang, Drijfhout, Jan W., Robinson, Nicola, Brown, Helen, Khan, Munira, ...
The role of cytotoxic T-lymphocyte (CTL) escape in rapidly progressive infant human immunodeficiency virus type 1 (HIV-1) infection is undefined. The data presented here demonstrate that infant...
Sustained CD8+ T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans
Norbeck, Oscar, Isa, Adiba, Pöhlmann, Christoph, Broliden, Kristina, Kasprowicz, Victoria, Bowness, Paul, ...
Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally...
Lauer, Georg M., Lucas, Michaela, Timm, Joerg, Ouchi, Kei, Kim, Arthur Y., Day, Cheryl L., ...
Multispecific CD8+ T-cell responses are thought to be important for the control of acute hepatitis C virus (HCV) infection, but to date little information is actually available on the breadth of...
Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection
Isa, Adiba, Kasprowicz, Victoria, Norbeck, Oscar, Loughry, Andrew, Jeffery, Katie, Broliden, Kristina, ...
Although parvovirus B19 apparently causes an acute viral infection, it appears to induce a persistent activated CD8 + T cell response.
Komatsu, Haruki, Inui, Ayano, Sogo, Tsuyoshi, Fujisawa, Tomoo, Nagasaka, Hironori, Nonoyama, Shigeaki, ...
Jones, Emma, Price, David A, Dahm-Vicker, Michaela, Cerundolo, Vincenzo, Klenerman, Paul, Gallimore, Awen
Macrophage inflammatory protein 1α (MIP-1α), a member of the CC-chemokine subfamily, is known to induce chemotaxis of a variety of cell types in vivo. Although the role of MIP-1α in inflammatory...
Kasprowicz, Victoria, Isa, Adiba, Tolfvenstam, Thomas, Jeffery, Katie, Bowness, Paul, Klenerman, Paul
The evolution of peptide-specific CD4+ T-cell responses to acute viral infections of humans is poorly understood. We analyzed the response to parvovirus B19 (B19), a ubiquitous and clinically...
Analysis of 'driver' and 'passenger' CD8+ T-cell responses against variable viruses.
Zafiropoulos, Andreas, Barnes, Eleanor, Piggott, Clive, Klenerman, Paul
Variable viruses, such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV), persist despite host immune responses directed against them. Numerous lines of evidence have suggested that...
Day, Cheryl L., Kiepiela, Photini, Leslie, Alasdair J., Van Der Stok, Mary, Nair, Kriebashne, Ismail, Nasreen, ...
The relationship between the function of human immunodeficiency virus (HIV)-specific CD8 T-cell responses and viral load has not been defined. In this study, we used a panel of major...
Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection
Lucas, Michaela, Ulsenheimer, Axel, Pfafferot, Katja, Heeg, Malte H.J., Gaudieri, Silvana, Grüner, Norbert, ...
Protection of Hepatocytes from Cytotoxic T Cell Mediated Killing by Interferon-Alpha
Willberg, Christian B., Ward, Scott M., Clayton, Reginald F., Naoumov, Nikolai V., McCormick, Christopher, Proto, Sandra, ...
Northfield, John W., Loo, Christopher P., Barbour, Jason D., Spotts, Gerald, Hecht, Frederick M., Klenerman, Paul, ...
CD8+ T cells are believed to play an important role in the control of human immunodeficiency virus type 1 (HIV-1) infection. However, despite intensive efforts, it has not been possible to...
HCV–HIV Coinfection: Simple Messages from a Complex Disease
The authors discuss our current understanding of the immunopathogenesis of HCV-HIV coinfection.
Kasprowicz, Victoria, Ward, Scott M., Turner, Alison, Grammatikos, Alexandros, Nolan, Brian E., Lewis-Ximenez, Lia, ...
Cross-reactivity of murine and recently human CD8+ T cells between different viral peptides, i.e., heterologous immunity, has been well characterized. However, the directionality and quality of these...
CD8 Epitope Escape and Reversion in Acute HCV Infection
Timm, Joerg, Lauer, Georg M., Kavanagh, Daniel G., Sheridan, Isabelle, Kim, Arthur Y., Lucas, Michaela, ...
In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T lymphocyte (CTL) responses are associated with initial control of viremia. Despite these responses,...
Leslie, Alasdair, Kavanagh, Daniel, Honeyborne, Isobella, Pfafferott, Katja, Edwards, Charles, Pillay, Tilly, ...
Human immunodeficiency virus (HIV)-1 amino acid sequence polymorphisms associated with expression of specific human histocompatibility leukocyte antigen (HLA) class I alleles suggest sites of...
Ciurea, Adrian, Hunziker, Lukas, Klenerman, Paul, Hengartner, Hans, Zinkernagel, Rolf M.
We have shown previously that neutralizing antibodies (nAbs) are important contributors to the long-term immune control of lymphocytic choriomeningitis virus infection, particularly if cytotoxic T...
Antagonist HIV-1 Gag Peptides Induce Structural Changes in HLA B8
Reid, Scott W., McAdam, Steve, Smith, Kathrine J., Klenerman, Paul, O'Callaghan, Chris A., Harlos, Karl, ...
In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend, A.R.M., J....
Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus
Lechner, Franziska, Wong, David K.H., Dunbar, P. Rod, Chapman, Roger, Chung, Raymond T., Dohrenwend, Paul, ...
Although hepatitis C virus (HCV) infection is very common, identification of patients during acute infection is rare. Consequently, little is known about the immune response during this critical...
Kasprowicz, Victoria, Schulze Zur Wiesch, Julian, Kuntzen, Thomas, Nolan, Brian E., Longworth, Steven, Berical, Andrew, ...
We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells from blood and liver during acute and chronic...
Dynamics of killer T cell inflation in viral infections
Wodarz, Dominik, Sierro, Sophie, Klenerman, Paul
Upon acute viral infection, a typical cytotoxic T lymphocyte (CTL) response is characterized by a phase of expansion and contraction after which it settles at a relatively stable memory level....
Neumann-Haefelin, Christoph, Frick, David N., Wang, Jing Jing, Pybus, Oliver G., Salloum, Shadi, Narula, Gagandeep S., ...
Failure of the adaptive immune response to control infection with the hepatitis C virus (HCV) can result from mutational escape in targeted T-cell epitopes. Recent studies suggest that T-cell immune...
Escape from HLA-B*08-Restricted CD8 T Cells by Hepatitis C Virus Is Associated with Fitness Costs ▿
Salloum, Shadi, Oniangue-Ndza, Cesar, Neumann-Haefelin, Christoph, Hudson, Laura, Giugliano, Silvia, Aus Dem Siepen, Marc, ...
The inherent sequence diversity of the hepatitis C virus (HCV) represents a major hurdle for the adaptive immune system to control viral replication. Mutational escape within targeted CD8 epitopes...
Genetic History of Hepatitis C Virus in East Asia ▿
Pybus, Oliver G., Barnes, Eleanor, Taggart, Rachel, Lemey, Philippe, Markov, Peter V., Rasachak, Bouachan, ...
The hepatitis C virus (HCV), which currently infects an estimated 3% of people worldwide, has been present in some human populations for several centuries, notably HCV genotypes 1 and 2 in West...
Matthews, Philippa C., Leslie, Alasdair J., Katzourakis, Aris, Crawford, Hayley, Payne, Rebecca, Prendergast, Andrew, ...
The selection of escape mutations has a major impact on immune control of infections with viruses such as human immunodeficiency virus (HIV). Viral evasion of CD8+ T-cell responses leaves predictable...