Paul L. Carmichael

Different levels of polybrominated diphenyl ethers (PBDEs) and chlorinated compounds in breast milk from two UK regions. (2004)

Kalantzi, Olga I., Martin, Francis L., Thomas, Gareth O., Alcock, Ruth E., Tang, Huiru R., Drury, Suzanne C., ...

Polybrominated diphenyl ether (PBDE) congeners are constituents of flame retardants, and there is growing concern regarding their persistence, bioaccumulation, and toxicity. We collected breast milk...

Correlation of Tumors with DNA Adducts from Methyl Eugenol and Tamoxifen in Rats (2004)

Waddell, William J., Crooks, Neil H., Carmichael, Paul L.

Data on percent tumors in male rats after administration of methyl eugenol, obtained from the National Toxicology Program, or tamoxifen were plotted on a linear scale for percent tumors against the...

Correlation of Tumors with DNA Adducts from Methyl Eugenol and Tamoxifen in Rats (2004)

Waddell, William J., Crooks, Neil H., Carmichael, Paul L.

Data on percent tumors in male rats after administration of methyl eugenol, obtained from the National Toxicology Program (NTP TR 491), or tamoxifen (Greaves et al., 1993) were plotted on a linear...

Electrospray Ionization–Tandem Mass Spectrometry and 32P-Postlabeling Analyses of Tamoxifen–DNA Adducts in Humans (2004)

Beland, Frederick A., Churchwell, Mona I., Doerge, Daniel R., Parkin, Daniel R., Malejka-Giganti, Danuta, Hewer, Alan, ...

Background: Although the nonsteroidal antiestrogen tamoxifen is used as an adjuvant chemotherapeutic agent to treat hormone-dependent breast cancer and as a chemopreventive agent in women with...

Lack of evidence from HPLC 32P-post-labelling for tamoxifen–DNA adducts in the human endometrium (1999)

Carmichael, Paul L., Sardar, Shahida, Crooks, Neil, Neven, Patrick, Van Hoof, Ingrid, Ugwumadu, Austin, ...

Tamoxifen is associated with an increased incidence of endometrial cancer in women. It is also a potent carcinogen in rat liver and forms covalent DNA adducts in this tissue. A previous study...

N-Demethylation accompanies {alpha}-hydroxylation in the metabolic activation of tamoxifen in rat liver cells (1999)

Phillips, David H., Hewer, Alan, Horton, Martin N., Cole, Kathleen J., Carmichael, Paul L., Davis, Warren, ...

Previous work has shown that a major route of activation of tamoxifen to DNA-binding products in rat liver cells is via α-hydroxylation leading to modification of the N2-position of guanine in DNA...

SHORT COMMUNICATION: Metabolic activation and DNA binding of food mutagens and other environmental carcinogens in human mammary epithelial cells (1996)

Carmichael, Paul L., Stone, Elaine M., Grover, Phillip L., Gusterson, Barry A., Phillips, David H.

Cultures of human mammary epithelial cells were treated with one of seven heterocyclic amine food mutagens [2-amino-3-methylimidazo[4, 5-f)quinoline (IQ), 2-amino-3, 4-dimethylimidazo[4,...

Activation of tamoxifen and its metabolite {alpha}-hydroxytamoxifen to DNA-binding products: comparisons between human, rat and mouse hepatocytes (1996)

Phillips, David H., Carmichael, Paul L., Hewer, Alan, Cole, Kathleen J., Hardcastle, Ian R., Poon, Grace K., ...

The metabolic activation of tamoxifen and its metabolite α-hydroxytamoxifen in primary cultures of rat, mouse and human hepatocytes has been compared. The extent of formation of DNA adducts in these...

Tamoxifen does not form detectable DNA adducts in white blood cells of breast cancer patients (1996)

Phillips, David H., Hewer, Alan, Grover, Philip L., Poon, Grace K., Carmichael, Paul L.

DNA from white blood cells of seven women receiving tamoxifen as adjuvant therapy for breast cancer and of three women who served as healthy controls was analysed for the presence of tamoxifen-DNA...

Detection and characterization by 32P-postlabelling of DNA adducts induced by a Fenton-type oxygen radical-generating system (1992)

Carmichael, Paul L., Shé, Meadhbh Ni, Phillips, David H.

Reactive oxygen species can give rise to numerous modifications of DNA. We have investigated the formation of such modifications using the nuclease P1 digestion method of the 32P-postlabelling...

Analysis of the polycyclic aromatic hydrocarbon content of petrol and diesel engine lubricating oils and determination of DNA adducts in topically treated mice by 32P-postlabelling (1990)

Carmichael, Paul L., Jacob, Jürgen, Grimmer, Gernot, Phillips, David H.

Engine lubricating oils are known to accumulate carcinogenic polycyclic aromatic hydrocarbons (PAHs) during engine running. Oils from nine petrol-powered and 11 diesel-powered vehicles, in addition...

Different Levels of Polybrominated Diphenyl Ethers (PBDEs) and Chlorinated Compounds in Breast Milk from Two U.K. Regions

Kalantzi, Olga I., Martin, Francis L., Thomas, Gareth O., Alcock, Ruth E., Tang, Huiru R., Drury, Suzanne C., ...

Polybrominated diphenyl ether (PBDE) congeners are constituents of flame retardants, and there is growing concern regarding their persistence, bioaccumulation, and toxicity. We collected breast milk...

Different Levels of Polybrominated Diphenyl Ethers (PBDEs) and Chlorinated Compounds in Breast Milk from Two U.K. Regions

Kalantzi, Olga I., Martin, Francis L., Thomas, Gareth O., Alcock, Ruth E., Tang, Huiru R., Drury, Suzanne C., ...

Polybrominated diphenyl ether (PBDE) congeners are constituents of flame retardants, and there is growing concern regarding their persistence, bioaccumulation, and toxicity. We collected breast milk...

An In-House Computer System for General Office Ophthalmology

Carmichael, Paul L., Carmichael, Paul L.

Design of an Office Medical Record Module

Carmichael, Paul L., Carmichael, Paul L., Carmichael, Christopher

The Medical Records module allows the physician to use the computer to store, track, and analyze medical records. The computerized record structure is a problem-oriented medical record based on...