THE MULTIVARIATE A/C/E MODEL AND THE GENETICS OF FIBER ARCHITECTURE (2009)
Agatha D. Lee, Natasha Leporé, Caroline C. Brun, Marina Barysheva, Yi-yu Chou, Ming-chang Chiang, ...
We present a new algorithm to compute the voxel-wise genetic contribution to brain fiber microstructure using diffusion tensor imaging (DTI) in a dataset of 25 pairs of monozygotic (MZ) twins and 25...
Can tissue segmentation improve registration? A study of 92 twins (2009)
Yi-yu Chou, Natasha Leporé, Caroline Brun, Marina Barysheva, Katie Mcmahon, ...
Introduction: Robust and automatic non-rigid registration depends on many parameters that have not yet been systematically explored. Here we determined how tissue classification influences non-linear...
Yi-yu Chou, Natasha Leporé, Christina Avedissian, Sarah K. Madsen, Xue Hua, Clifford R. Jack, ...
We developed an automated analysis pipeline to analyze 3D changes in ventricular morphology; it provides a highly sensitive quantitative marker of Alzheimer’s disease (AD) progression for MRI...
Katie L. Mcmahon, Paul M. Thompson, Margaret J. Wright
Introduction: Twin studies can disentangle the genetic and environmental influences on brain function. Here we report the first maps of genetic effects on brain function. We assessed the heritability...
A LAGRANGIAN FORMULATION FOR STATISTICAL FLUID REGISTRATION (2009)
Caroline C. Brun, Natasha Lepore, Xavier Pennec, Yi-yu Chou, Agatha D. Lee, Marina Barysheva, ...
We defined a new statistical fluid registration method with Lagrangian mechanics. Although several authors have suggested that empirical statistics on brain variation should be incorporated into the...
Liang Zhan, Alex D. Leow, Siwei Zhu, Ming-chang Chiang, Marina Barysheva, Arthur W. Toga, ...
High-angular resolution diffusion imaging (HARDI) can reconstruct fiber pathways in the brain with extraordinary detail, identifying anatomical features and connections not seen with conventional...
Alex D. Leow, Liang Zhan, Siwei Zhu, Nathan Hageman, Ming-chang Chiang, Marina Barysheva, ...
Fractional anisotropy (FA), a very widely used measure of fiber integrity based on diffusion tensor imaging (DTI), is a problematic concept as it is influenced by several quantities including the...
SURFACE AND VOLUME REGISTRATION OF BRAIN MAGNETIC RESONANCE IMAGES (2009)
Natasha Leporé, A. Joshi, Richard Leahy, Caroline Brun, Yi-yu Chou, Xavier Pennec, ...
3D volumetric registration of brain images is particularly challenging in cortical regions due to their high complexity and folding. Here we develop a new combined algorithm for surface and volume...
Yalin Wang, Jie Zhang, Tony F. Chan, Arthur W. Toga, Paul M. Thompson
We apply multivariate tensor-based morphometry to study lateral ventricular surface abnormalities associated with HIV/AIDS. We use holomorphic one-forms to obtain a conformal parameterization of...
IMPROVING FLUID REGISTRATION THROUGH WHITE MATTER SEGMENTATION (2009)
Yi-yu Chou, Natasha Leporé, Caroline C. Brun, Agatha D. Lee, Marina Barysheva, ...
Robust and automatic non-rigid registration depends on many parameters that have not yet been systematically explored. Here we determined how tissue classification influences non-linear fluid...
Multi-Atlas Tensor-Based Morphometry and its Application to a Genetic Study of 92 Twins (2009)
Natasha Leporé, Caroline Brun, Yi-yu Chou, Agatha D. Lee, Matthew Meredith, ...
Abstract. Here we develop a multi-template analysis for tensor-based morphometry (TBM) which aims to reduce error from the registration step. In conventional TBM, a single template is nonlinearly...
Yi-yu Chou, Natasha Leporé, Marina Barysheva, Ming-chang Chiang, Katie Mcmahon, Greig De Zubicaray, ...
Despite substantial progress in measuring the 3D profile of anatomical variations in the human brain, their genetic and environmental causes remain enigmatic. We developed an automated system to...
Caroline Brun, Natasha Leporé, Xavier Pennec, Agatha D. Lee, Marina Barysheva, Grieg De Zubicaray, ...
Abstract. We incorporated a new Riemannian fluid registration algorithm into a general MRI analysis method called tensor-based morphometry to map the heritability of brain morphology in MR images...
Natasha Lepore, Caroline Brun, Yi-yu Chou, Ming-chang Chiang, Rebecca A. Dutton, Kiralee M. Hayashi, ...
Abstract—This paper investigates the performance of a new multivariate method for tensor-based morphometry (TBM). Statistics on Riemannian manifolds are developed that exploit the full information...
Yi-yu Chou, Natasha Leporé, Marina Barysheva, Ming-chang Chiang, Katie Mcmahon, Greig De Zubicaray, ...
Imaging genetics is a new field of brain mapping in which genetic influences on brain structure can be quantified and mapped in entire populations. Here we fitted genetic models to computational maps...
Child Psychiatry Branch, and (2009)
Nitin Gogtay, Anna Ordonez, David H. Herman, Kiralee M. Hayashi, Cathy Vaituzis, Marge Lenane, ...
doi:10.1111/j.1469-7610.2007.01747.x Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness
Models of Normal Variation and Local Contrasts in Hippocampal Anatomy ⋆ (2009)
Xinyang Liu, Washington Mio, Yonggang Shi, Ivo Dinov, Xiuwen Liu, Natasha Leporé, ...
Abstract. We develop a model of continuous spherical shapes and use it to analyze the anatomy of the hippocampus. To account for the geometry of bends and folds, the model relies on a geodesic metric...
MAPPING HIPPOCAMPAL DEGENERATION IN 400 SUBJECTS WITH A NOVEL AUTOMATED SEGMENTATION APPROACH (2009)
Jonathan H. Morra, Zhuowen Tu, Liana G. Apostolova, Amity E. Green, Christina Avedissian, Sarah K. Madsen, ...
We automatically segmented the hippocampus in 400 brain MRI scans from the Alzheimer’s Disease Neuroimaging Initiative, using AdaBoost in conjunction with a novel model, the Auto Context Model. Our...
Igor Yanovsky, Paul M. Thompson, Stanley J. Osher, Xue Hua, David W. Shattuck, Arthur W. Toga, ...
This paper examines the power of different nonrigid registration models to detect changes in TBM, and their stability when no real changes are present. Specifically, we investigate an asymmetric...
Ming-chang Chiang, Marina Barysheva, Agatha D. Lee, Sarah Madsen, Andrea D. Klunder, Arthur W. Toga, ...
Abstract. We developed an analysis pipeline enabling population studies of HARDI data, and applied it to map genetic influences on fiber architecture in 90 twin subjects. We applied tensor-driven 3D...
Martina Ballmaier, Virginia Elderkin-thompson, Katherine L Narr, Eileen Luders, Paul M Thompson, Cornelius Hojatkashani, ...
There is some evidence of corpus callosum abnormalities in elderly depression, but it is not known whether these deficits are regionspecific or differ based on age at onset of depression. Twenty-four...
SEGMENTATION-FREE MEASUREMENT OF CORTICAL THICKNESS FROM MRI (2009)
Iman Aganj, Guillermo Sapiro, Neelroop Parikshak, Sarah K. Madsen, Paul M. Thompson
Estimating the thickness of cerebral cortex is a key step in many MR brain imaging studies, revealing valuable information on development or disease progression. In this work we present a new...
How Many Gradients are Sufficient in High-Angular Resolution Diffusion Imaging (HARDI)? (2009)
Liang Zhan, Ming-chang Chiang, Alex D. Leow, Siwei Zhu, Marina Barysheva, Arthur W. Toga, ...
Abstract. We scanned 61 healthy adults with 105-gradient HARDI at 4 Tesla, and examined how the number of diffusion gradients affects the signal-to-noise ratio (SNR) for several common DTI-derived...
Eileen Luders, Katherine L. Narr, Paul M. Thompson, Arthur W. Toga
Contents lists available at ScienceDirect
Caroline Brun, Natasha Lepore, Xavier Pennec, Yi-yu Chou, Oscar L. Lopez, Howard J. Aizenstein, ...
Abstract. Tensor-based morphometry (TBM) is an analysis approach that can be applied to structural brain MRI scans to detect group differences or changes in brain structure. TBM uses nonlinear image...
BEST INDIVIDUAL TEMPLATE SELECTION FROM DEFORMATION TENSOR MINIMIZATION (2009)
Natasha Leporé, Caroline Brun, Yi-yu Chou, Agatha D. Lee, Marina Barysheva, Xavier Pennec, ...
We study the influence of the choice of template in tensorbased morphometry. Using 3D brain MR images from 10 monozygotic twin pairs, we defined a tensor-based distance in the log-Euclidean framework...
3D SURFACE MATCHING WITH MUTUAL INFORMATION AND RIEMANN SURFACE STRUCTURES (2009)
Many medical imaging applications require the computation of dense correspondence vector fields that match one surface with another. Surface-based registration is useful for tracking brain change,...
Agatha D. Lee, Natasha Leporé, Marina Barysheva, Yi-yu Chou, Caroline Brun, Sarah K. Madsen, ...
We used diffusion tensor magnetic resonance imaging (DTI) to reveal the extent of genetic effects on brain fiber microstructure, based on tensor-derived measures, in 22 pairs of monozygotic (MZ)...
Ming-chang Chiang, Marina Barysheva, Agatha D. Lee, Sarah Madsen, Andrea D. Klunder, Arthur W. Toga, ...
We report the first 3D maps of genetic effects on brain fiber complexity. We analyzed HARDI brain imaging data from 90 young adult twins using an information-theoretic measure, the Jensen-Shannon...
Agatha D. Lee, Natasha Leporé, Marina Barysheva, Yiyu Chou, Caroline Brun, Sarah K. Madsen, ...
Abstract. We used tensor-derived measures to map the extent of genetic effects on brain fiber microstructure, in 23 monozygotic and 23 dizygotic twin pairs. All 92 DTI volumes were fluidly registered...
Yalin Wang, Lok Ming Lui, Paul M. Thompson, Tony F. Chan
To compare and integrate brain data, data from multiple subjects are typically mapped into a canonical space. One method to do this is to conformally map cortical surfaces to the sphere. It is well...
HIPPOCAMPAL SURFACE DISCRIMINATION VIA INVARIANT DESCRIPTORS OF SPHERICAL CONFORMAL MAPS (2009)
Boris Gutman, Yalin Wang, Lok Ming Lui, Tony F. Chan, Paul M. Thompson
Weighted spherical harmonic shape descriptors are based on the subspaces of L 2 (S 2) spanned by spherical harmonics of a single degree. Such shape descriptors incorporate both shape and scaling...
A Landmark-Based Brain Conformal Parametrization with Automatic Landmark Tracking Technique (2009)
Lok Ming Lui, Yalin Wang, Tonyf. Chan, Paul M. Thompson
Abstract. In this paper, we present algorithms to automatically detect and match landmark curves on cortical surfaces to get an optimized brain conformal parametrization. First, we propose an...
Bearden, Carrie E., Dutton, Rebecca A., Lee, Agatha D., Simon, Tony J., Cannon, Tyrone D., ...
The 22q11.2 deletion syndrome (velocardiofacial/DiGeorge syndrome) is a neurogenetic condition associated with visuospatial deficits, as well as elevated rates of attentional disturbance, mood...
Time-Lapse Mapping of Cortical Changes in Schizophrenia with Different Treatments (2009)
Thompson, Paul M., Bartzokis, George, Hayashi, Kiralee M., Klunder, Andrea D., Lu, Po H., Edwards, Nancy, ...
Using time-lapse maps, we visualized the dynamics of schizophrenia progression, revealing spreading cortical changes that depend on the type of antipsychotic treatment. Dynamic, 4-dimensional models...
Alex D. Leow, Igor Yanovsky, Neelroop Parikshak, Xue Hua, Suh Lee, Arthur W. Toga, ...
doi:10.1016/j.neuroimage.2009.01.004
Altered hippocampal morphology in unmedicated patients with major depressive illness (2009)
Carrie E Bearden, Paul M Thompson, Christina Avedissian, Andrea D Klunder, Mark Nicoletti, Nicole Dierschke, ...
Despite converging evidence that major depressive illness is associated with both memory impairment and hippocampal pathology, findings vary widely across studies and it is not known whether these...
Katherine L. Narr, Paul M. Thompson, Ph. D, ...
Gender and disease may influence structural brain asymmetries and their functional homologues (1–4). There is evidence, for example, that the pathophysiology of schizophrenia is lateralized such...
Elizabeth R. Sowell, Paul M. Thompson, Christiana M. Leonard, Suzanne E. Welcome, Eric Kan, Arthur W. Toga
Recent advances in magnetic resonance imaging (MRI) technology now allow the tracing of developmental changes in the brains of children. We applied computer-matching algorithms and new techniques for...
Brain Anatomical Structure Segmentation by Hybrid Discriminative/Generative Models (2008)
Zhuowen Tu, Katherine L. Narr, Piotr Dollár, Ivo Dinov, Paul M. Thompson, Arthur W. Toga
Abstract — In this paper, a hybrid discriminative/generative model for brain anatomical structure segmentation is proposed. The learning aspect of the approach is emphasized. In the discriminative...
Lok Ming Lui, Yalin Wang, Tony F. Chan, Paul M. Thompson
Abstract. One important problem in human brain mapping research is to locate the important anatomical features. Anatomical features on the cortical surface are usually represented by landmark curves,...
Lok Ming ~uil, Tony E Chanl, Paul M. Thompson
Using spherical harmonics of an inverse conformal map, we compared hippocampal surfaces of sixteen Alzheimer (AD) and fourteen control subjects. Hippocampal surfaces were conformally mapped to a...
Harris, Peter, Alcantara, Dan A, Amenta, Nina, Lopez, Oscar L, EirÃksdóttir, Guðný, Sigurðsson, Sigurður, ...
Hypertension is highly prevalent in elderly individuals and may be associated with cognitive decline, but the mechanisms by which hypertension may impact brain structure, and thereby modulate the...
Adaptive Reproducing Kernel Particle Method for Extraction of the Cortical Surface (2008)
Meihe Xu, Paul M. Thompson, Arthur W. Toga
Abstract — We propose a novel adaptive approach based on the Reproducing Kernel Particle Method (RKPM) to extract the cortical surfaces of the brain from 3D Magnetic Resonance Images (MRI). To...
Adaptive Reproducing Kernel Particle Method for Extraction of the Cortical Surface (2008)
Meihe Xu, Paul M. Thompson, Arthur W. Toga
Abstract—We propose a novel adaptive approach based on the Reproducing Kernel Particle Method (RKPM) to extract the cortical surfaces of the brain from three–dimensional (3-D) magnetic resonance...
Information-Theoretic Analysis of Brain White Matter Fiber Orientation Distribution Functions (2008)
Ming-chang Chiang, Andrea D. Klunder, Katie Mcmahon, Margaret J. Wright, Arthur W. Toga, ...
Objective: High angular resolution diffusion imaging (HARDI) is a variant of conventional MRI that uses multiple radially-distributed gradients to encode directional profi les and orientations of...
A DEFORMABLE BRODMANN AREA ATLAS (2008)
Paul E. Rasser, Patrick J. Johnston, Philip B. Ward, Paul M. Thompson
Functional MRI studies commonly refer to activation patterns as being localized in specific Brodmann areas, referring to Brodmann’s divisions of the human cortex based on cytoarchitectonic...
Mean Template for Tensor-Based Morphometry using Deformation Tensors (2008)
Natasha Lepore, Caroline Brun, Xavier Pennec, Yi-yu Chou, Oscar L. Lopez, Howard J. Aizenstein, ...
Abstract. Tensor-based morphometry (TBM) studies anatomical differences between brain images statistically, to identify regions that differ between groups, over time, or correlate with cognitive or...
Paul M. Thompson, Kiralee M. Hayashi, Sara L. Simon, Jennifer A. Geaga, Michael S. Hong, Yihong Sui, ...
We visualize, for the first time, the profile of structural deficits in the human brain associated with chronic methamphetamine (MA) abuse. Studies of human subjects who have used MA chronically have...
Correspondence about published article to either author: (2008)
Jeremy R. Gray, Paul M. Thompson, Jeremy R. Gray, Paul M. Thompson
Understanding the neurobiology of intelligence may, in turn, help illuminate the complex relationships between intelligence and health. There is strong evidence that the lateral prefrontal cortex and...
Owen T. Carmichael, Paul M. Thompson, Rebecca A. Dutton, Allen Lu, Sharon E. Lee, Jessica Y. Lee, ...
We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The...
Brain Warping Via Landmark Points and Curves with a Level Set Representation (2008)
Andrew Y. Wang, Alex D. Leow, Hillary D. Protas, Arthur W. Toga, Paul M. Thompson
Abstract. This paper presents and validates a non-linear image registration method driven by points and curved landmarks using implicit representation. This approach produces smooth one-to-one...
Liana G. Apostolova, Paul M. Thompson
Summary: Alzheimer’s disease (AD) is the most common neurodegenerative disorder for those 65 years or older; it currently affects 4.5 million in the United States and is predicted to rise to 13.2...
Paul M. Thompson, Agatha D. Lee, Rebecca A. Dutton, Jennifer A. Geaga, Kiralee M. Hayashi, Mark A. Eckert, ...
We identified and mapped an anatomically localized failure of cortical maturation in Williams syndrome (WS), a genetic condition associated with deletion of �20 contiguous genes on chromosome 7....
Cortical Mapping of Genotype–Phenotype Relationships in Schizophrenia (2008)
Carrie E. Bearden, Paul M. Thompson, Arthur W. Toga, Tyrone D. Cannon
Abstract: Although schizophrenia is highly heritable, the search for susceptibility genes has been challenging. The ‘‘endophenotype’ ’ approach is an alternative method for measuring...
A. Joshi, David W. Shattuck, Paul M. Thompson, Richard M. Leahy
We present a cortical surface registration method that simultaneously aligns sulcal landmarks and parameterizes two cortical surfaces. The approach is based on coregistration of cortical surface...
Surface-Based Analysis of Functional Magnetic Resonance Imaging Data (2008)
Vikas Y. Rao, Helen L. Tran, Kiralee M. Hayashi, Tyrone D. Cannon, Arthur W. Toga, ...
Abstract. Surface-based visualization, atlases, and warping have demonstrated advantages for examining human and non-human brain morphology and the functional specialization of visual, auditory,...
Agatha D. Lee, Natasha Lepore, Franco Lepore, Flamine Alary, Caroline Brun, Yiyu Chou, ...
[Introduce the problem assuming readers will not have knowledge of it. Why worth doing? Take readers from general to specific using succinct explanation.] Detection of systematic patterns of anatomy...
COMMENT Imaging Genomics: Mapping the Influence of Genetics on Brain Structure and Function (2008)
David C. Glahn, Tomás ˇ Paus, Paul M. Thompson
The last two decades have seen tremendous advances in our understanding of human brain structure and function, particularly at the level of systems neuroscience where neuroimaging methods have led to...
Lok Ming Lui, Yalin Wang, Tony F. Chan, Paul M. Thompson
Abstract. One important problem in the human brain mapping research is to locate the important anatomical features. Anatomical features on the cortical surface are usually represented by landmark...
Three-Dimensional Statistical Analysis of Sulcal Variability in the (2008)
Human Brain, Paul M. Thompson, Craig Schwartz, Robert T. Lin, Aelia A. Khan, Arthur W. Toga
Morphometric variance of the human brain is qualitatively observable in surface features of the cortex. Statistical analysis of sulcal geometry will facilitate multisubject atlasing, neurosurgical...
Abstract TEMPORAL DYNAMICS OF BRAIN ANATOMY (2008)
Arthur W. Toga, Paul M. Thompson, W. Toga, Arthur W. Toga, Paul Thompson
The brain changes profoundly in structure and function during development, and as a result of diseases such as the dementias, schizophrenia, multiple sclerosis and tumor growth. Strategies to...
Yi-yu Chou, Natasha Leporé, Stephen E. Rose, Owen T. Carmichael, James T. Becker, ...
We developed and validated a new method to create automated 3D parametric surface models of the lateral ventricles, designed for monitoring degenerative disease effects in clinical neuroscience...
Owen T. Carmichael, Paul M. Thompson, Rebecca A. Dutton, Allen Lu, Sharon E. Lee, Jessica Y. Lee, ...
We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The...
Paul M. Thompson, Kiralee M. Hayashi, Greig De Zubicaray, Andrew L. Janke, Stephen E. Rose, James Semple, ...
We briefly describe a set of algorithms to detect and visualize effects of disease and genetic factors on the brain. Extreme variations in cortical anatomy, even among normal subjects, complicate the...
Conserving and Restoring the Benefits from Bangladesh Wetlands (2008)
"Wetlands in Bangladesh, just as elsewhere, were long regarded as worthless wastelands to be converted to agriculture. This study combines a detailed valuation of uses of Hail Haor, a complex heavily...
Blokland, Gabriella A.M., McMahon, Katie L., Hoffman, Jan, Zhu, Gu, Meredith, Matthew, Martin, Nicholas G., ...
Working memory-related brain activation has been widely studied, and impaired activation patterns have been reported for several psychiatric disorders. We investigated whether variation in N-back...
Schall, Ulrich, Rasser, P. E., Todd, J., Michie, Patricia T., Ward, Philip B., Johnston, Patrick, ...
Abstract not available.
Caroline Brun, Natasha Leporé, Xavier Pennec, Yi-yu Chou, Agatha D. Lee, Grieg De Zubicaray, ...
In structural brain MRI, group differences or changes in brain structures can be detected using Tensor-Based Morphometry (TBM). This method consists of two steps: (1) a non-linear registration step,...
Jonathan H. Morra, Zhuowen Tu, Liana G. Apostolova, Amity E. Green, Christina Avedissian, Sarah K. Madsen, ...
doi:10.1016/j.neuroimage.2008.10.043
Automatic Segmentation of MS Lesions Using a Contextual Model for the MICCAI Grand Challenge (2008)
Jonathan H. Morra, Zhuowen Tu, Arthur W. Toga, Paul M. Thompson
Automatically segmenting subcortical structures in brain images has the potential to greatly accelerate drug trials and population studies of disease. Here we propose an automatic subcortical...
Automatic subcortical segmentation using a contextual model (2008)
Jonathan H. Morra, Zhuowen Tu, Liana G. Apostolova, Amity E, Arthur W. Toga, Paul M. Thompson
Abstract. Automatically segmenting subcortical structures in brain images has the potential to greatly accelerate drug trials and population studies of disease. Here we propose an automatic...
Ming-chang Chiang, Katie L. Mcmahon, David W. Shattuck, Arthur W. Toga, Nicholas G. Martin, ...
genetics gains momentum, extraordinary information will be uncovered on the genetic architecture of the human brain. However, there are significant challenges to be addressed first. Not the least of...
Paul M. Thompson, George Bartzokis, Kiralee M. Hayashi, Andrea D. Klunder, Poh. Lu, Nancy Edwards, ...
Using time-lapse maps, we visualized the dynamics of schizophrenia progression, revealing spreading cortical changes that depend on the type of antipsychotic treatment. Dynamic, 4-dimensional models...
MAPPING GENETIC INFLUENCES ON VENTRICULAR STRUCTURE IN TWINS (2008)
Yi-yu Chou, Natasha Leporé, Ming-chang Chiang, Christina Avedissian, Marina Barysheva, Katie Mcmahon, ...
doi:10.1016/j.neuroimage.2008.10.036
Schall, Ulrich, Rasser, P. E., Todd, J., Michie, Patricia T., Ward, Philip B., Johnston, Patrick, ...
Abstract not available.
Frisoni, Giovanni B., Ganzola, Rossana, Canu, Elisa, Rüb, Udo, Pizzini, Francesca B., Alessandrini, Franco, ...
Histological studies have suggested differing involvement of the hippocampal subfields in ageing and in Alzheimer's disease. The aim of this study was to assess in vivo local hippocampal changes in...
Sowell, Elizabeth R., Mattson, Sarah N., Kan, Eric, Thompson, Paul M., Riley, Edward P., Toga, Arthur W.
Quantitative magnetic resonance imaging (MRI) studies in children with fetal alcohol spectrum disorders (FASDs) have shown regional patterns of dysmorphology, most prominent in parietal and posterior...
BIOINFORMATICS AND BRAIN IMAGING: RECENT ADVANCES AND NEUROSCIENCE APPLICATIONS (2007)
Ph. D, Paul M. Thompson, Paul M. Thompson
This chapter reviews some exciting new techniques for analyzing brain imaging data. We describe computer algorithms that can discover patterns of brain structure and function associated with
I. Challenges in Population-Based Brain Mapping (2007)
John C. Mazziotta, Dr. Paul Thompson, Paul M. Thompson, Paul M. Thompson, Michael S. Mega, Michael S. Mega, ...
invaluable in these investigations. 1 DISEASE-SPECIFIC BRAIN ATLASES
Katherine L. Narr, Paul M. Thompson, Tonmoy Sharma, Jacob Moussai, Rebecca Blanton, Bardia Anvar, ...
Background: Local alterations in morphological parameters are poorly characterized in several brain regions widely implicated in schizophrenia neuropathology. Methods: Surface-based anatomical...
Contents A Framework for Computational Anatomy 1. Diversity of Brain Maps (2007)
Paul M. Thompson, Arthur W. Toga, Chris Johnson, Dr. Paul Thompson, Brain Atlases
Mathematical/Computational Challenges in Creating Deformable and Probabilistic Atlases of (2007)
The Human Brain, Paul M. Thompson, Roger P. Woods, Michael S. Mega, Arthur W. Toga
Abstract: Striking variations in brain structure, especially in the gyral patterns of the human cortex, present fundamental challenges in human brain mapping. Probabilistic brain atlases, which...
Article Reference Code, M. Thompson, Paul M. Thompson, Arthur W. Toga, Arthur W. Toga
Resonance Imaging (fMRI). A brain imaging technique, based on the paramagnetic properties of hemoglobin in the blood, which creates maps of brain activation during cognitive tasks such as language...
Normal and Diseased Populations (2007)
Arthur Toga Paul, Paul M. Thompson, Katherine L. Narr, Elizabeth R. Sowell, Edited Steven, H. Koslow, ...
Morphometric variability of the human brain poses significant challenges for the creation of population-based atlases. The ability to statistically and visually compare and contrast brain image data...
Brain Warping Via Landmark Points and Curves with a Level Set Representation (2007)
Alex D. Leow, Andrew Y. Wang, Hillary D. Protas, Paul M. Thompson
Abstract. This paper presents and validates a non-linear image registration method driven by points and curved landmarks using implicit representation. This approach produces smooth one-to-one...
Automated Piecewise Ane Registration of Biological Images (2007)
Bardinet Paul, M. Thompson, Grgoire Malandain, Unit Inria, Sophia Antipolis, Alain Pitiot, ...
apport de recherche
Lin, Jack J., Salamon, Noriko, Lee, Agatha D., Dutton, Rebecca A., Geaga, Jennifer A., Hayashi, Kiralee M., ...
We mapped the profile of neocortical thickness and complexity in patients with mesial temporal lobe epilepsy (MTLE) and hippocampal sclerosis. Thirty preoperative high-resolution magnetic resonance...
Relationships between IQ and Regional Cortical Gray Matter Thickness in Healthy Adults (2007)
Narr, Katherine L., Woods, Roger P., Thompson, Paul M., Szeszko, Philip, Robinson, Delbert, Dimtcheva, Teodora, ...
Prior studies show positive correlations between full-scale intelligence quotient (FSIQ) and cerebral gray matter measures. Few imaging studies have addressed whether general intelligence is related...
Mapping Cortical Thickness in Children with 22q11.2 Deletions (2007)
Bearden, Carrie E., Dutton, Rebecca A., Tran, Helen, Zimmermann, Lara, Sun, Daqiang, ...
The 22q11.2 deletion syndrome (velocardiofacial/DiGeorge syndrome, 22q11.2DS) involves cardiac and craniofacial anomalies, marked deficits in visuospatial cognition, and elevated rates of psychosis....
Sowell, Elizabeth R., Peterson, Bradley S., Kan, Eric, Woods, Roger P., Yoshii, June, Bansal, Ravi, ...
Findings from previous magnetic resonance imaging studies of sex differences in gray matter have been inconsistent, with some showing proportionally increased gray matter in women and some showing no...
Carmichael, Owen T, Kuller, Lewis H, Lopez, Oscar L, Thompson, Paul M, Dutton, Rebecca A, Lu, Allen, ...
Expansion of the cerebral ventricles may occur at an accelerated rate in subjects with dementia, but the time course of expansion during transitions between normal cognitive function, mild cognitive...
Direct mapping of hippocampal surfaces with intrinsic shape context (2007)
Shi, Yonggang, Thompson, Paul M., De Zubicaray, Greig I., Rose, Stephen E., Tua, Zhuowen, Dinov, Ivo, ...
We propose in this paper a new method for the mapping of hippocampal (HQ surfaces to establish correspondences between points on HC surfaces and enable localized HC shape analysis. A novel geometric...
Tracking Alzheimer's disease (2007)
Thompson, Paul M., Hayashi, Kiralee M., Dutton, Rebecca A., Chiang, Ming-Chang, Leow, Alex D., Sowell, Elizabeth R., ...
Population-based brain mapping provides great insight into the trajectory of aging and dementia, as well as brain changes that normally occur over the human life span. We describe three novel brain...
Direct mapping of hippocampal surfaces with intrinsic shape context (2007)
Shi, Yonggang, Thompson, Paul M., De Zubicaray, Greig I., Rose, Stephen E., Tua, Zhuowen, Dinov, Ivo, ...
We propose in this paper a new method for the mapping of hippocampal (HQ surfaces to establish correspondences between points on HC surfaces and enable localized HC shape analysis. A novel geometric...
Tracking Alzheimer's disease (2007)
Thompson, Paul M., Hayashi, Kiralee M., Dutton, Rebecca A., Chiang, Ming-Chang, Leow, Alex D., Sowell, Elizabeth R., ...
Population-based brain mapping provides great insight into the trajectory of aging and dementia, as well as brain changes that normally occur over the human life span. We describe three novel brain...
Brain surface conformal parameterization using riemann surface structure (2007)
Yalin Wang, Lok Ming Lui, Xianfeng Gu, Kiralee M. Hayashi, Tony F. Chan, Arthur W. Toga, ...
Abstract—In medical imaging, parameterized 3-D surface models are useful for anatomical modeling and visualization, statistical comparisons of anatomy, and surface-based registration and signal...
Local volume change maps in nonrigid registration: When are computed changes real (2007)
Igor Yanovsky, Paul M. Thompson, Andrea D. Klunder, Arthur W. Toga, Alex D. Leow
Abstract. Measures of brain change can be computed from sequential MRI scans, providing valuable information on disease progression. Tensor-based morphometry (TBM) creates maps of these brain...
Topology preserving log-unbiased nonlinear image registration: Theory and implementation (2007)
Igor Yanovsky, Paul M. Thompson, Stanley Osher, Alex D. Leow
In this paper, we present a novel framework for constructing large deformation log-unbiased image registration models that generate theoretically and intuitively correct deformation maps. Such...
Giovanni B. Frisoni, Michela Pievani, Cristina Testa, Francesca Sabattoli, Lorena Bresciani, Matteo Bonetti, ...
Clinical observations have suggested that the neuropsychological profile of early and late onset forms of Alzheimer’s disease (EOAD and LOAD) differ in that neocortical functions are more affected...
Multiphase segmentation of deformation using logarithmic priors (2007)
Igor Yanovsky, Paul M. Thompson, Stanley Osher, Luminita Vese, Alex D. Leow
In [8], the authors proposed the large deformation logunbiased diffeomorphic nonlinear image registration model which has been successfully used to obtain theoretically and intuitively correct...
David C. Glahn, Paul M. Thompson, John Blangero
Abstract: It is vitally important to identify the genetic determinants of complex brain-related disorders such as autism, dementia, mood disorders, and schizophrenia. However, the search for genes...
Ming-chang Chiang, Allan L. Reiss, Agatha D. Lee, Ursula Bellugi, Albert M. Galaburda, Julie R. Korenberg, ...
williams syndrome Visualized using tensor-based morphometry, NeuroImage (2007), doi: 10.1016/j.neuroimage.2007.04.024 This is a PDF file of an unedited manuscript that has been accepted for...
Quantifying deformation using information theory: The log-unbiased nonlinear registration (2007)
Igor Yanovsky, Ming-chang Chiang, Paul M. Thompson, Andrea D. Klunder, James T. Becker, Simon W. Davis, ...
In the past decade, information theory has been studied extensively in medical imaging. In particular, maximization of mutual information has been shown to yield good results in multi-modal image...
Automated Extraction of the Cortical Sulci Based on a Supervised Learning Approach (2007)
Zhuowen Tu, Songfeng Zheng, Alan L. Yuille, Allan L. Reiss, Rebecca A. Dutton, Agatha D. Lee, ...
Abstract—It is important to detect and extract the major cortical sulci from brain images, but manually annotating these sulci is a time-consuming task and requires the labeler to follow complex...
Distinct regional atrophy in the corpus callosum of patients with temporal (2007)
Bernd Weber, Eileen Luders, Jennifer Faber, Sabine Richter, Carlos M. Quesada, Horst Urbach, ...
lobe epilepsy
Carrie E Bearden, Paul M Thompson, Rebecca A Dutton, Benício N Frey, Marco Am Peluso, Mark Nicoletti, ...
Declarative memory impairments are common in patients with bipolar illness, suggesting underlying hippocampal pathology. However, hippocampal volume deficits are rarely observed in bipolar disorder....
Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy (2007)
Weber, Bernd, Luders, Eileen, Faber, Jennifer, Richter, Sabine, Quesada, Carlos M., Urbach, Horst, ...
We analysed the influence of mesial temporal lobe epilepsy on the thickness of the corpus callosum (CC) in a large sample of well-characterized patients (n = 96) and healthy controls (n = 28). In...
The topography of grey matter involvement in early and late onset Alzheimer's disease (2007)
Frisoni, Giovanni B., Pievani, Michela, Testa, Cristina, Sabattoli, Francesca, Bresciani, Lorena, Bonetti, Matteo, ...
Clinical observations have suggested that the neuropsychological profile of early and late onset forms of Alzheimer's disease (EOAD and LOAD) differ in that neocortical functions are more affected in...
Measuring Brain Variability by Extrapolating Sparse Tensor Fields Measured on Sulcal Lines (2006)
Fillard, Pierre, Arsigny, Vincent, Pennec, Xavier, Hayashi, Kiralee M., Thompson, Paul M., Ayache, Nicholas
Modeling and understanding the variability of brain structures is a fundamental problem in the neurosciences. Improved mathematical representations of structural brain variation are needed to help...
Measuring Brain Variability by Extrapolating Sparse Tensor Fields Measured on Sulcal Lines (2006)
Arsigny, Vincent, Pennec, Xavier, Hayashi, Kiralee M., Thompson, Paul M., Ayache, Nicholas, Fillard, Pierre
Modeling and understanding the variability of brain structures is a fundamental problem in the neurosciences. Improved mathematical representations of structural brain variation are needed to help...
Measuring Brain Variability by Extrapolating Sparse Tensor Fields Measured on Sulcal Lines (2006)
Arsigny, Vincent, Pennec, Xavier, Hayashi, Kiralee M., Thompson, Paul M., Ayache, Nicholas, Fillard, Pierre
Modeling and understanding the variability of brain structures is a fundamental problem in the neurosciences. Improved mathematical representations of structural brain variation are needed to help...
learning based algorithm for automatic extraction of the cortical sulci (2006)
Songfeng Zheng, Alan L. Yuille, Allan L. Reiss, Rebecca A. Dutton, Agatha D. Lee, Albert M. Galaburda, ...
Abstract. This paper presents a learning based method for automatic extraction of the major cortical sulci from MRI volumes or extracted surfaces. Instead of using a few pre-defined rules such as the...
learning based algorithm for automatic extraction of the cortical sulci (2006)
Songfeng Zheng, Alan L. Yuille, Allan L. Reiss, Rebecca A. Dutton, Agatha D. Lee, Albert M. Galaburda, ...
Abstract. This paper presents a learning based method for automatic extraction of the major cortical sulci from MRI volumes or extracted surfaces. Instead of using a few pre-defined rules such as the...
Mapping brain maturation (2006)
Arthur W. Toga, Paul M. Thompson, Elizabeth R. Sowell
Human brain maturation is a complex, lifelong process that can now be examined in detail using neuroimaging techniques. Ongoing projects scan subjects longitudinally with structural magnetic...
Brain surface conformal parameterization with algebraic functions (2006)
Yalin Wang, Xianfeng Gu, Tony F. Chan, Paul M. Thompson, Shing-tung Yau
In medical imaging, parameterized 3D surface models are of great interest for anatomical modeling and visualization, statistical comparisons of anatomy, and surface-based registration and signal...
Liana G. Apostolova, Steve Rogers, Rebecca A. Dutton, Kiralee M. Hayashi, ...
Abstract: The Mini-mental State Examination (MMSE) is a brief cognitive screening instrument frequently used to track Alzheimer disease (AD) progression. We investigated the structural neuroimaging...
Pierre Fillard, Vincent Arsigny, A Xavier Pennec, Paul M. Thompson, Nicholas Ayache A
brain variability by extrapolating sparse tensor fields measured on sulcal lines
Brain surface conformal parameterization with algebraic functions (2006)
Yalin Wang, Xianfeng Gu, Tony F. Chan, Paul M. Thompson, Shing-tung Yau
Abstract. In medical imaging, parameterized 3D surface models are of great interest for anatomical modeling and visualization, statistical comparisons of anatomy, and surface-based registration and...
Natasha Lepore, Caroline A. Brun, Ming-chang Chiang, Rebecca A. Dutton, Kiraleem. Hayashi, Oscarl. Lopez, ...
Abstract. Tensor-based morphometry (TBM) is widely used in computational anatomy as a means to understand shape variation between structural brain images. A 3D nonlinear registration technique is...
Boris Gutman, Yalin Wang, Lok Ming Lui, Tony F. Chan, Paul M. Thompson
Using spherical harmonics of an inverse conformal map, we compared hippocampal surfaces of sixteen Alzheimer (AD) and fourteen control subjects. Hippocampal surfaces were conformally mapped to a...
Sowell, Elizabeth R., Peterson, Bradley S., Kan, Eric, Woods, Roger P., Yoshii, June, Bansal, Ravi, ...
Findings from previous magnetic resonance imaging studies of sex differences in gray matter have been inconsistent, with some showing proportionally increased gray matter in women and some showing no...
Mapping Cortical Thickness in Children with 22q11.2 Deletions (2006)
Bearden, Carrie E., Dutton, Rebecca A., Tran, Helen, Zimmermann, Lara, Sun, Daqiang, ...
The 22q11.2 deletion syndrome (velocardiofacial/DiGeorge syndrome, 22q11.2DS) involves cardiac and craniofacial anomalies, marked deficits in visuospatial cognition, and elevated rates of psychosis....
Lin, Jack J., Salamon, Noriko, Lee, Agatha D., Dutton, Rebecca A., Geaga, Jennifer A., Hayashi, Kiralee M., ...
We mapped the profile of neocortical thickness and complexity in patients with mesial temporal lobe epilepsy (MTLE) and hippocampal sclerosis. Thirty preoperative high-resolution magnetic resonance...
Apostolova, Liana G., Dinov, Ivo D., Dutton, Rebecca A., Hayashi, Kiralee M., Toga, Arthur W., Cummings, Jeffrey L., ...
Alzheimer's disease is the most common neurodegenerative disorder in the elderly. Amnestic mild cognitive impairment (MCI) is a relatively newly defined clinical entity that requires memory decline...
Apostolova, Liana G., Dinov, Ivo D., Dutton, Rebecca A., Hayashi, Kiralee M., Toga, Arthur W., Cummings, Jeffrey L., ...
Alzheimer's disease is the most common neurodegenerative disorder in the elderly. Amnestic mild cognitive impairment (MCI) is a relatively newly defined clinical entity that requires memory decline...
Sowell, Elizabeth R., Peterson, Bradley S., Kan, Eric, Woods, Roger P., Yoshii, June, Bansal, Ravi, ...
Findings from previous magnetic resonance imaging studies of sex differences in gray matter have been inconsistent, with some showing proportionally increased gray matter in women and some showing no...
Mapping Cortical Thickness in Children with 22q11.2 Deletions (2006)
Bearden, Carrie E., Dutton, Rebecca A., Tran, Helen, Zimmermann, Lara, Sun, Daqiang, ...
The 22q11.2 deletion syndrome (velocardiofacial/DiGeorge syndrome, 22q11.2DS) involves cardiac and craniofacial anomalies, marked deficits in visuospatial cognition, and elevated rates of psychosis....
Lin, Jack J., Salamon, Noriko, Lee, Agatha D., Dutton, Rebecca A., Geaga, Jennifer A., Hayashi, Kiralee M., ...
We mapped the profile of neocortical thickness and complexity in patients with mesial temporal lobe epilepsy (MTLE) and hippocampal sclerosis. Thirty preoperative high-resolution magnetic resonance...
Atlas-based hippocampus segmentation in Alzheimer's disease and mild cognitive impairment. (2005)
Carmichael, Owen T, Aizenstein, Howard A, Davis, Simon W, Becker, James T, Thompson, Paul M, Meltzer, Carolyn Cidis, ...
This study assesses the performance of public-domain automated methodologies for MRI-based segmentation of the hippocampus in elderly subjects with Alzheimer's disease (AD) and mild cognitive...
Rasser, Paul E., Johnston, Patrick, Lagopoulos, Jim, Ward, Philip B., Schall, Ulrich, Thienel, Renate, ...
Due to its three-dimensional folding pattern, the human neocortex poses a challenge for accurate co-registration of grouped functional brain imaging data. The present study addressed this problem by...
Optimization of brain conformal mapping with landmarks (2005)
Yalin Wang, Tonyf. Chan, Paul M. Thompson
Abstract. To compare and integrate brain data, data from multiple subjects are typically mapped into a canonical space. One method to do this is to conformally map cortical surfaces to the sphere. It...
Automated surface matching using mutual information applied to Riemann surface structures (2005)
Yalin Wang, Ming-chang Chiang, Paul M. Thompson
Abstract. Many medical imaging applications require the computation of dense correspondence vector fields that match one surface with another. To avoid the need for a large set of manually-defined...
Atlas-based hippocampus segmentation in Alzheimer’s disease and mild cognitive impairment (2005)
Owen T. Carmichael, Howard A. Aizenstein, Simon W. Davis, James T. Becker, Paul M. Thompson, Carolyn Cidis Meltzer, ...
Purpose. To assess the performance of standard image registration techniques for automated MRI-based segmentation of the hippocampus in elderly subjects with Alzheimer’s Disease (AD) and mild...
Atlas-based hippocampus segmentation in Alzheimer’s disease and mild cognitive impairment (2005)
Owen T. Carmichael, Howard A. Aizenstein, Paul M. Thompson, ...
This study assesses the performance of public-domain automated methodologies for MRI-based segmentation of the hippocampus in elderly subjects with Alzheimer’s disease (AD) and mild cognitive...
Brain surface parameterization using Riemann Surface structure (2005)
Yalin Wang, Kiraleem. Hayashi, Tonyf. Chan, Paul M. Thompson, Shing-tung Yau
Abstract. We develop a general approach that uses holomorphic 1forms to parameterize anatomical surfaces with complex (possibly branching) topology. Rather than evolve the surface geometry to a plane...
Automated surface matching using mutual information applied to Riemann surface structures (2005)
Yalin Wang, Ming-chang Chiang, Paul M. Thompson
Abstract. Many medical imaging applications require the computation of dense correspondence vector fields that match one surface with another. To avoid the need for a large set of manually-defined...
Surface parameterization using riemann surface structure (2005)
Yalin Wang, Tony F. Chan, Xianfeng Gu, Paul M. Thompson, Kiralee M. Hayashi, Shing-tung Yau
We propose a general method that parameterizes general surfaces with complex (possible branching) topology using Riemann surface structure. Rather than evolve the surface geometry to a plane or...
ARTICLE IN PRESS 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS (2005)
Paul M. Thompson, Rebecca A. Dutton, A Allen Lu, Sharon E. Lee, ...
Objective: 40 million people worldwide are now infected with HIV/ AIDS, an illness that often leads to rapidly progressing dementia and death. Even so, little is known about how AIDS affects the...
Surface parameterization using riemann surface structure (2005)
Yalin Wang, Tony F. Chan, Xianfeng Gu, Paul M. Thompson, Kiralee M. Hayashi, Shing-tung Yau
We propose a general method that parameterizes general surfaces with complex (possible branching) topology using Riemann surface structure. Rather than evolve the surface geometry to a plane or...
Mutual Information-Based 3D Surface Matching with Applications to Face Recognition and (2005)
Face recognition and many medical imaging applications require the computation of dense correspondence vector fields that match one surface with another. In brain imaging, surface-based registration...
Mutual Information-Based 3D Surface Matching with Applications to Face Recognition and (2005)
Face recognition and many medical imaging applications require the computation of dense correspondence vector fields that match one surface with another. In brain imaging, surface-based registration...
Rasser, P. E., Johnston, Patrick, Lagopoulos, Jim, Ward, P. B., Schall, Ulrich, Thienel, Renate, ...
Due to its three-dimensional folding pattern, the human neocortex poses a challenge for accurate co-registration of grouped functional brain imaging data. The present study addressed this problem by...
Rasser, Paul E., Johnston, Patrick, Lagopoulos, Jim, Ward, Philip B., Schall, Ulrich, Thienel, Renate, ...
Due to its three-dimensional folding pattern, the human neocortex poses a challenge for accurate co-registration of grouped functional brain imaging data. The present study addressed this problem by...
Optimization of brain conformal mapping with landmarks (2005)
Yalin Wang, Lok Ming Lui, Tony F. Chan, Paul M. Thompson
Abstract. To compare and integrate brain data, data from multiple subjects are typically mapped into a canonical space. One method to do this is to conformally map cortical surfaces to the sphere. It...
Rasser, P. E., Johnston, Patrick, Lagopoulos, Jim, Ward, P. B., Schall, Ulrich, Thienel, Renate, ...
Due to its three-dimensional folding pattern, the human neocortex poses a challenge for accurate co-registration of grouped functional brain imaging data. The present study addressed this problem by...
Mapping Cortical Thickness and Gray Matter Concentration in First Episode Schizophrenia (2005)
Narr, Katherine L., Bilder, Robert M., Toga, Arthur W., Woods, Roger P., Rex, David E., Szeszko, Philip R., ...
We mapped regional changes in cortical thickness and intensity-based cortical gray matter concentration in first episode schizophrenia. High-resolution magnetic resonance images were obtained from 72...
Gender differences in the left inferior frontal gyrus in normal children (2004)
Blanton, Rebecca E, Levitt, Jennifer G, Peterson, Jeffrey R, Fadale, David, Sporty, Mike L, Lee, Mimi, ...
This study examined frontal lobe subregions in 46 normal children and adolescents (25 females, mean age: 11.08, SD: 3.07; and 21 males, mean age: 10.76, SD: 2.61) to assess the effects of age and...
Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia (2004)
Thompson, Paul M., Hayashi, Kiralee M., Sowell, Elizabeth R., Gogtay, Nitin, Giedd, Jay N., Rapoport, Judith L., ...
This paper describes algorithms that can identify patterns of brain structure and function associated with Alzheimer's disease, schizophrenia, normal aging, and abnormal brain development based on...
Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia (2004)
Thompson, Paul M., Hayashi, Kiralee M., Sowell, Elizabeth R., Gogtay, Nitin, Giedd, Jay N., Rapoport, Judith L., ...
This paper describes algorithms that can identify patterns of brain structure and function associated with Alzheimer's disease, schizophrenia, normal aging, and abnormal brain development based on...
Genus zero surface conformal mapping and its application to brain surface mapping (2004)
Xianfeng Gu, Yalin Wang, Tony F. Chan, Paul M. Thompson, Shing-tung Yau
Abstract—We developed a general method for global conformal parameterizations based on the structure of the cohomology group of holomorphic one-forms for surfaces with or without boundaries (Gu and...
Genus zero surface conformal mapping and its application to brain surface mapping (2004)
Xianfeng Gu, Yalin Wang, Tony F. Chan, Paul M. Thompson, Shing-tung Yau
Abstract. It is well known that any genus zero surface can be mapped conformally onto the sphere and any local portion thereof onto a disk. However, it is not trivial to find a general method which...
Cortical surface parameterization by p-harmonic energy minimization (2004)
Anand A. Joshi, David W. Shattuck, Paul M. Thompson, Richard M. Leahy
Cortical surface parameterization has several applications in visualization and analysis of the brain surface. Here we propose a scheme for parameterizing the surface of the cerebral cortex. The...
Genus zero surface conformal mapping and its application to brain surface mapping (2004)
Xianfeng Gu, Yalin Wang, Tony F. Chan, Paul M. Thompson, Shing-tung Yau
Abstract. It is well known that any genus zero surface can be mapped conformally onto the sphere and any local portion thereof onto a disk. However, it is not trivial to find a general method which...
Intrinsic brain surface conformal mapping using a variational method (2004)
Yalin Wang, Xianfeng Gu, Tony F. Chan, Paul M. Thompson, Shing-tung Yau
Abstract. We propose a new variational method which can find a unique conformal mapping between any two genus zero manifolds by minimizing the harmonic energy of the map and apply it to the cortical...
Genus zero surface conformal mapping and its application to brain surface mapping (2004)
Xianfeng Gu, Yalin Wang, Tony F. Chan, Paul M. Thompson, Shing-tung Yau
It is well known that any genus zero surface can be mapped conformally onto the sphere and any local portion thereof onto a disk. However, it is not trivial to find a general method which finds a...
Genus Zero Surface Conformal Mapping and Its Application to Brain Surface Mapping (2004)
Xianfeng Gu, Yalin Wang, Tony F. Chan, Paul M. Thompson, Shing-tung Yau
It is well known that any genus zero surface can be mapped conformally onto the sphere and any local portion thereof onto a disk. However, it is not trivial to find a general method which computes a...
Genus Zero Surface Conformal Mapping and Its Application to Brain Surface Mapping (2004)
Xianfeng Gu, Yalin Wang, Tony F. Chan, Paul M. Thompson, Shing-tung Yau
We developed a general method for global conformal parameterizations based on the structure of the cohomology group of holomorphic one-forms with or without boundaries [1], [2]. For genus zero...
Volumetric Harmonic Brain Mapping (2004)
Yalin Wang Xianfeng, Yalin Wang, Xianfeng Gu, Tony F. Chan, Paul M. Thompson, Shing-tung Yau
In [1], we developed two different techniques to study volume mapping problem in Computer Graphics. The first one is to find a harmonic map from a 3 manifold to a 3D solid sphere and the second is a...
Yalin Wang, Xianfeng Gu, Paul M. Thompson, Shing-tung Yau
Abstract. We developed two techniques to address 3D volume parameterization and deformation mapping problems that arise in medical imaging [1]. The first algorithm finds a harmonic map from a...
ARTICLE IN PRESS Mapping hippocampal and ventricular change in Alzheimer disease (2004)
Paul M. Thompson, Kiralee M. Hayashi, David M. Doddrell
We developed an anatomical mapping technique to detect hippocampal and ventricular changes in Alzheimer disease (AD). The resulting maps are sensitive to longitudinal changes in brain structure as...
Visualization of anatomic covariance tensor fields (2004)
Gordon L. Kindlmann, David M. Weinstein, Agatha D. Lee, Arthur W. Toga, Paul M. Thompson
of brain variability remains a significant challenge in computational neuroanatomy. Current deformable registration methods can generate, for each vertex of a polygonal mesh modeling the cortical...
A deformable Brodmann area atlas (2004)
Rasser, P. E., Johnston, Patrick J., Ward, Philip B., Thompson, Paul M.
Functional MRI studies commonly refer to activation patterns as being localized in specific Brodmann areas, referring to Brodmann's divisions of the human cortex based on cytoarchitectonic boundaries...
A deformable Brodmann area atlas (2004)
Rasser, P. E., Johnston, Patrick J., Ward, Philip B., Thompson, Paul M.
Functional MRI studies commonly refer to activation patterns as being localized in specific Brodmann areas, referring to Brodmann's divisions of the human cortex based on cytoarchitectonic boundaries...
Mapping Cortical Thickness and Gray Matter Concentration in First Episode Schizophrenia (2004)
Narr, Katherine L., Bilder, Robert M., Toga, Arthur W., Woods, Roger P., Rex, David E., Szeszko, Philip R., ...
We mapped regional changes in cortical thickness and intensity-based cortical gray matter concentration in first episode schizophrenia. High-resolution magnetic resonance images were obtained from 72...
Mapping Cortical Thickness and Gray Matter Concentration in First Episode Schizophrenia (2004)
Narr, Katherine L., Bilder, Robert M., Toga, Arthur W., Woods, Roger P., Rex, David E., Szeszko, Philip R., ...
We mapped regional changes in cortical thickness and intensity-based cortical gray matter concentration in first episode schizophrenia. High-resolution magnetic resonance images were obtained from 72...
Sowell, Elizabeth R, Thompson, Paul M, Welcome, Suzanne E, Henkenius, Amy L, Toga, Arthur W, Peterson, Bradley S
Background Results of structural brain imaging studies of patients with attention-deficit hyperactivity disorder have shown subtle reductions in total brain volume and in volumes of the right frontal...
Automated Piecewise Affine Registration of Biological Images (2003)
Pitiot, Alain, Bardinet, Éric, Thompson, Paul M., Malandain, Grégoire
This report tackles the registration of 2D biological images (histological sections or autoradiographs) to 2D images from the same or different modalities (e.g., histology or MRI). The process of...
Asymmetry of the brain surface from deformation field analysis (2003)
Lancaster, Jack L, Kochunov, Peter V, Thompson, Paul M, Toga, Arthur W, Fox, Peter T
The detection of asymmetry of exposed brain surfaces is examined, and a new method, deformation-based asymmetry (DBA), is introduced. DBA is based on analysis of two high-resolution magnetic...
Mapping cortical change across the human life span (2003)
Sowell, Elizabeth R, Peterson, Bradley S, Thompson, Paul M, Welcome, Suzanne E, Henkenius, Amy L, Toga, Arthur W
We used magnetic resonance imaging and cortical matching algorithms to map gray matter density (GMD) in 176 normal individuals ranging in age from 7 to 87 years. We found a significant, nonlinear...
Dynamics of gray matter loss in Alzheimer's disease (2003)
Thompson, Paul M, Hayashi, Kiralee M, De Zubicaray, Greig, Janke, Andrew L, Rose, Stephen E, Semple, James, ...
We detected and mapped a dynamically spreading wave of gray matter loss in the brains of patients with Alzheimer's disease (AD). The loss pattern was visualized in four dimensions as it spread over...
Automated Piecewise Affine Registration of Biological Images (2003)
Pitiot, Alain, Bardinet, Éric, Thompson, Paul M., Malandain, Grégoire
This report tackles the registration of 2D biological images (histological sections or autoradiographs) to 2D images from the same or different modalities (e.g., histology or MRI). The process of...
Automated Piecewise Affine Registration of Biological Images (2003)
Pitiot, Alain, Bardinet, Éric, Thompson, Paul M., Malandain, Grégoire
This report tackles the registration of 2D biological images (histological sections or autoradiographs) to 2D images from the same or different modalities (e.g., histology or MRI). The process of...
Learning object correspondences with the observed transport shape measure (2003)
Alain Pitiot, Hervé Delingette, Arthur W. Toga, Paul M. Thompson
Abstract. We propose a learning method which introduces explicit knowledge to the object correspondence problem. Our approach uses an a priori learning set to compute a dense correspondence field...
Piecewise Affine Registration of Biological Images (2003)
Alain Pitiot, Grégoire Mal, Eric Bardinet, Paul M Thompson
Abstract. This manuscript tackles the registration of 2D biological images (histological sections or autoradiographs) to 2D images from the same or different modalities (e.g., histology or MRI). The...
Dynamics of Gray Matter Loss in Alzheimer's Disease (2003)
Paul Thompson Kiralee, Paul M. Thompson, Kiralee M. Hayashi, Greig De Zubicaray, Andrew L. Janke, Stephen E. Rose, ...
maps that change over time. Frontal regions, spared early in the disease, showed pervasive deficits later (#15% loss). The maps distinguished different phases of AD and differentiated AD from normal...
Alain Pitiot, Eric Bardinet, Paul M. Thompson, Gregoire Malandain
We propose a fully automated method for locally registering 2-D multi-modal images. We model the images as a number of anatomically separate components, subject to aOEne transformations, and embedded...
Arthur W. Toga and Paul M. Thompson (2003)
Laboratory Of Neuro, W. Toga, Arthur W. Toga, Arthur W. Toga, Paul M. Thompson, ...
Brain asymmetry has been observed in animals and humans structurally, functionally, and behaviorally. This lateralization is thought to originate from evolutionary, hereditary, developmental,...
Structural Mri Data, Paul Thompson Phd, Stephen Lawrie, ...
UCLA School of Medicine Introduction Recent advances in medical imaging have revolutionized our ability to investigate disease. Current brain mapping initiatives are charting brain structure and...
Intrinsic Brain Surface Conformal Mapping (2003)
Using Variational Method, Yalin Wang, Xianfeng Gu, Tony F. Chan, Paul M. Thompson, Shing-tung Yau
We propose a new variational method which can find a unique conformal mapping between any two genus zero manifolds by minimizing the harmonic energy of the map and apply it to the cortical surface...
Dinov, Ivo, Mega, Michael S, Thompson, Paul M., Woods, Roger P., Sumners, De Witt L., Sowell, Elizabeth L., ...
In the field of template-based medical image analysis, image registration and normalization are frequently used to eval- uate and interpret data in a standard template or reference atlas space....
Adaptive Elastic Segmentation of Brain MRI via Shape-Model-Guided Evolutionary Programming (2002)
Alain Pitiot, Arthur W. Toga, Paul M. Thompson
This paper presents a fully automated segmentation method for medical images. The goal is to localize and parameterize a variety of types of structure in these images for subsequent quantitative...
Neuroimaging Alzheimer's Disease (2002)
Margaret M. Esiri, Michael S. Mega, Paul M.Thompson, James H. Morris, Arthur W. Toga, ...
nd time. They detect group-specific features not apparent in individual patients' scans. Once built, these atlases can be stratified into subpopulations to reflect a particular clinical group,...
A Framework For Computational Anatomy (2002)
Paul M. Thompson, Arthur W. Toga
The rapid collection of brain images from healthy and diseased subjects has stimulated the development of powerful mathematical algorithms to compare, pool and average brain data across whole...
Bioinformatics And Brain Imaging: (2002)
Recent Advances And, Paul M. Thompson, Ph. D
This chapter reviews some exciting new techniques for analyzing brain imaging data. We describe computer algorithms that can discover patterns of brain structure and function associated with...
Sowell, Elizabeth R., Thompson, Paul M., Rex, David, Kornsand, David, Tessner, Kevin D., Jernigan, Terry L., ...
Previous in vivo morphometric studies of human brain maturation between childhood and young adulthood have revealed a spatial and temporal pattern of progressive brain changes that is consistent with...
Sowell, Elizabeth R., Thompson, Paul M., Mattson, Sarah N., Tessner, Kevin D., Jernigan, Terry L., Riley, Edward P., ...
We assessed regional brain shape abnormalities and spatial relationships between brain shape and abnormalities observed in the underlying tissue in children and adolescents prenatally exposed to...
Tracking Tumor Growth Rates in Patients with Malignant Gliomas: A Test of Two Algorithms (2001)
Sean M. Haney, Paul M. Thompson, Timothy F. Cloughesy, Jeffry R. Alger, Arthur W. Toga
ghbor tissue segmentation algorithm provides significant power in quantifying tumor volume and in tracking growth rates of contrast-enhancing tissue in patients with GBM. The surface modeling...
Thompson, Paul M., Mega, Michael S., Woods, Roger P., Zoumalan, Chris I., Lindshield, Chris J., Blanton, Rebecca E., ...
We report the first detailed population-based maps of cortical gray matter loss in Alzheimer's disease (AD), revealing prominent features of early structural change. New computational approaches were...
Cooperation, Conflicts and Sustainability in Community-Managed Fisheries in Bangladesh (2000)
Thompson, Paul M., Sultana, Parvin, Islam, Md. Nurul
"Since late 1995 a partnership of Bangladesh Department of Fisheries, five Non-Governmental Orgainzations and ICLARM has worked with fishing communities in 19 waterbodies to establish local user...
Mapping Morphology of the Corpus Callosum in Schizophrenia (2000)
Narr, Katherine L., Thompson, Paul M., Sharma, Tonmoy, Moussai, Jacob, Cannestra, Andrew F., Toga, Arthur W.
The nature and extent of callosal morphological alterations in schizophrenia remain unresolved. A parametric surface modeling approach using magnetic resonance (MR) images was employed. This provided...
Hossain, Md. Mokammel, Rahman, Syed Ataur, Thompson, Paul M.
From the Authors' Paper: "Increasing attention has been focused since the 1980's on common property resources, including fisheries. This has included studies of traditional management systems, and...
Impact of Government-NGO Initiatives in Community Based Fisheries Management in Bangladesh (1998)
Thompson, Paul M., Islam, Md. Nurul, Kadir, Md. Monjur
From the Introduction: "The four million ha of openwaters in Bangladesh are among the world's richest and most complex fisheries. The rivers, beels (lakes), baors (oxbow lakes), haors (large deeply...
Thesis (Ph. D.)--Middlesex Polytechnic, 1989.
The theory of cyclic transfers (1989)
Paul M. Thompson, Paul M. Thompson, James B. Orlin, James B. Orlin
This paper develops the theory of cyclic transfers, a neighborhood search strategy for a broad class of combinatorial problems. The problem class is characterized by a two-phase decision process:...
Thesis (M.S.)--University of Denver, 1987.
Paul M Thompson, Liana G Apostolova
Computational anatomic methods as applied to aging and
Analysis and solution algorithms of sealift routing and scheduling problems : final report (1985)
Psaraftis, Harilaos N., Orlin, James B., Bienstock, Daniel, Thompson, Paul M.
Thompson, Paul M., Vidal, Christine, Giedd, Jay N., Gochman, Peter, Blumenthal, Jonathan, Nicolson, Robert, ...
Neurodevelopmental models for the pathology of schizophrenia propose both polygenetic and environmental risks, as well as early (pre/perinatal) and late (usually adolescent) developmental brain...
Cannon, Tyrone D., Thompson, Paul M., Toga, Arthur W., Poutanen, Veli-Pekka, Huttunen, Matti, ...
The symptoms of schizophrenia imply disruption to brain systems supporting higher-order cognitive activity, but whether these systems are impacted differentially against a background of diffuse...
Dynamic mapping of human cortical development during childhood through early adulthood
Gogtay, Nitin, Giedd, Jay N., Lusk, Leslie, Hayashi, Kiralee M., Greenstein, Deanna, Vaituzis, A. Catherine, ...
We report the dynamic anatomical sequence of human cortical gray matter development between the age of 4–21 years using quantitative four-dimensional maps and time-lapse sequences. Thirteen healthy...
Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline
Thompson, Paul M., Dutton, Rebecca A., Hayashi, Kiralee M., Toga, Arthur W., Lopez, Oscar L., Aizenstein, Howard J., ...
HIV/AIDS infection is the fourth leading cause of death worldwide, and one in every 100 adults aged 15–49 years is HIV-infected. Forty percent of AIDS patients suffer from neurological symptoms,...
Thompson, Paul M., Vidal, Christine, Giedd, Jay N., Gochman, Peter, Blumenthal, Jonathan, Nicolson, Robert, ...
Neurodevelopmental models for the pathology of schizophrenia propose both polygenetic and environmental risks, as well as early (pre/perinatal) and late (usually adolescent) developmental brain...
Cannon, Tyrone D., Thompson, Paul M., Toga, Arthur W., Poutanen, Veli-Pekka, Huttunen, Matti, ...
The symptoms of schizophrenia imply disruption to brain systems supporting higher-order cognitive activity, but whether these systems are impacted differentially against a background of diffuse...
Dynamic mapping of human cortical development during childhood through early adulthood
Gogtay, Nitin, Giedd, Jay N., Lusk, Leslie, Hayashi, Kiralee M., Greenstein, Deanna, Vaituzis, A. Catherine, ...
We report the dynamic anatomical sequence of human cortical gray matter development between the age of 4–21 years using quantitative four-dimensional maps and time-lapse sequences. Thirteen healthy...
Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline
Thompson, Paul M., Dutton, Rebecca A., Hayashi, Kiralee M., Toga, Arthur W., Lopez, Oscar L., Aizenstein, Howard J., ...
HIV/AIDS infection is the fourth leading cause of death worldwide, and one in every 100 adults aged 15–49 years is HIV-infected. Forty percent of AIDS patients suffer from neurological symptoms,...
Functional and aggregative responses of harbour seals to changes in salmonid abundance
Middlemas, Stuart J, Barton, Tim R, Armstrong, John D, Thompson, Paul M
There is intense debate over the potential impact of seal predation on declining salmon stocks in both the Pacific and Atlantic oceans. However, efforts to model such interactions have been...
Baker, Jason D, Thompson, Paul M
Estimates of variability in pinniped survival rates are generally based on observations at single sites, so it is not certain whether observed rates represent the whole population. Here, we provide a...
Gogtay, Nitin, Lu, Allen, Leow, Alex D., Klunder, Andrea D., Lee, Agatha D., Chavez, Alex, ...
Earlier studies revealed progressive cortical gray matter (GM) loss in childhood-onset schizophrenia (COS) across both lateral and medial surfaces of the developing brain. Here, we use tensor-based...
Hippocampal Volume Reduction in Congenital Central Hypoventilation Syndrome
Macey, Paul M., Richard, Christopher A., Kumar, Rajesh, Woo, Mary A., Ogren, Jennifer A., Avedissian, Christina, ...
Children with congenital central hypoventilation syndrome (CCHS), a genetic disorder characterized by diminished drive to breathe during sleep and impaired CO2 sensitivity, show brain structural and...