Paul R. Ingram

Development of Colorimetric Microtiter Plate Assay for Assessment of Antimicrobials against Acanthamoeba

McBride, James, Ingram, Paul R., Henriquez, Fiona L., Roberts, Craig W.

We have developed and optimized a 96-well microtiter plate assay, based on the reduction of alamarBlue, to assess the efficacies of much needed new antimicrobials against Acanthamoeba species. This...

Development of Colorimetric Microtiter Plate Assay for Assessment of Antimicrobials against Acanthamoeba

McBride, James, Ingram, Paul R., Henriquez, Fiona L., Roberts, Craig W.

We have developed and optimized a 96-well microtiter plate assay, based on the reduction of alamarBlue, to assess the efficacies of much needed new antimicrobials against Acanthamoeba species. This...

Molecular Basis for Resistance of Acanthamoeba Tubulins to All Major Classes of Antitubulin Compounds▿ †

Henriquez, Fiona L., Ingram, Paul R., Muench, Stephen P., Rice, David W., Roberts, Craig W.

Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule...