Martin, Charity K., Hoffman, Paul S.
Traditionally, librarians have provided access to journal titles through the library's catalog. With the introduction of full-text databases, which consist of articles from many different journals,...
Thesis (M.F.A.)--Ohio University, June, 1966.
Debets-Ossenkopp, Yvette J., Pot, Raymond G. J., Van Westerloo, David J., Goodwin, Avery, Berg, Douglas E., ...
We found that NCTC11637, the type strain of Helicobacter pylori, the causative agent of peptic ulcer disease and an early risk factor for gastric cancer, is metronidazole resistant. DNA...
Jeong, Jin-Yong, Mukhopadhyay, Asish K., Dailidiene, Daiva, Wang, Yipeng, Velapatiño, Billie, Gilman, Robert H., ...
Helicobacter pylori is a human-pathogenic bacterial species that is subdivided geographically, with different genotypes predominating in different parts of the world. Here we test and extend an...
Sisson, Gary, Jeong, Jin-Yong, Goodwin, Avery, Bryden, Louis, Rossler, Norma, Lim-Morrison, Sabrina, ...
Much of the normal high sensitivity of wild-type Helicobacter pylori to metronidazole (Mtz) depends on rdxA (HP0954), a gene encoding a novel nitroreductase that catalyzes the conversion of Mtz from...
Chalker, Alison F., Minehart, Heather W., Hughes, Nicky J., Koretke, Kristin K., Lonetto, Michael A., Brinkman, Kerry K., ...
A comparative genomic approach was used to identify Helicobacter pylori 26695 open reading frames (ORFs) which are conserved in H. pylori J99 but highly diverged in other eubacteria. A survey of...
Baker, Laura M. S., Raudonikiene, Ausra, Hoffman, Paul S., Poole, Leslie B.
Helicobacter pylori, an oxygen-sensitive microaerophile, contains an alkyl hydroperoxide reductase homologue (AhpC, HP1563) that is more closely related to 2-Cys peroxiredoxins of higher organisms...
Jeong, Jin-Yong, Mukhopadhyay, Asish K., Akada, Junko K., Dailidiene, Daiva, Hoffman, Paul S., Berg, Douglas E.
The relative importance of the frxA and rdxA nitroreductase genes of Helicobacter pylori in metronidazole (MTZ) susceptibility and resistance has been controversial. Jeong et al. (J. Bacteriol....
Immunolocalization of Hsp60 in Legionella pneumophila
Garduño, Rafael A., Faulkner, Gary, Trevors, Mary A., Vats, Neeraj, Hoffman, Paul S.
One of the most abundant proteins synthesized by Legionella pneumophila, particularly during growth in a variety of eukaryotic host cells, is Hsp60, a member of the GroEL family of molecular...
Surface-Associated Hsp60 Chaperonin of Legionella pneumophila Mediates Invasion in a HeLa Cell Model
Garduño, Rafael A., Garduño, Elizabeth, Hoffman, Paul S.
HeLa cells have been previously used to demonstrate that virulent strains of Legionella pneumophila (but not salt-tolerant avirulent strains) efficiently invade nonphagocytic cells. Hsp60, a member...
Sisson, Gary, Goodwin, Avery, Raudonikiene, Ausra, Hughes, Nicky J., Mukhopadhyay, Asish K., Berg, Douglas E., ...
Nitazoxanide (NTZ) is a redox-active nitrothiazolyl-salicylamide prodrug that kills Helicobacter pylori and also many anaerobic bacterial, protozoan, and helminthic species. Here we describe...
Garduño, Rafael A., Garduño, Elizabeth, Hiltz, Margot, Hoffman, Paul S.
When Legionella pneumophila grows in HeLa cells, it alternates between a replicative form and a morphologically distinct “cyst-like” form termed MIF (mature intracellular form). MIFs are also...
Hoffman, Paul S., Vats, Neeraj, Hutchison, Donna, Butler, Jared, Chisholm, Kenneth, Sisson, Gary, ...
The identification of genes associated with colonization and persistence of Helicobacter pylori in the gastric mucosa has been limited by the lack of robust animal models that support infection by...
Mukhopadhyay, Asish K., Jeong, Jin-Yong, Dailidiene, Daiva, Hoffman, Paul S., Berg, Douglas E.
Very few examples of metabolic regulation are known in the gastric pathogen Helicobacter pylori. An unanticipated case was suggested, however, upon finding two types of metronidazole...
A 65-Kilobase Pathogenicity Island Is Unique to Philadelphia-1 Strains of Legionella pneumophila
Brassinga, Ann Karen C., Hiltz, Margot F., Sisson, Gary R., Morash, Michael G., Hill, Nathan, Garduno, Elizabeth, ...
Nucleotide sequence analysis of an ∼80-kb genomic region revealed an ∼65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system,...
Hiltz, Margot F., Sisson, Gary R., Brassinga, Ann Karen C., Garduno, Elizabeth, Garduno, Rafael A., Hoffman, Paul S.
Legionella pneumophila displays a biphasic developmental cycle in which replicating forms (RFs) differentiate postexponentially into highly infectious, cyst-like mature intracellular forms (MIFs)....
Petroni, Alejandro, Melano, Roberto G., Saka, Héctor A., Garutti, Alicia, Mange, Laura, Pasterán, Fernando, ...
The gene blaCARB-9 was located in the Vibrio cholerae super-integron, but in a different location relative to blaCARB-7. CARB-9 (pI 5.2) conferred β-lactam MICs four to eight times lower than those...
Croxen, Matthew A., Sisson, Gary, Melano, Roberto, Hoffman, Paul S.
The location of Helicobacter pylori in the gastric mucosa of mammals is defined by natural pH gradients within the gastric mucus, which are more alkaline proximal to the mucosal epithelial cells and...
Cysteine Metabolism in Legionella pneumophila: Characterization of an l-Cystine-Utilizing Mutant
Ewann, Fanny, Hoffman, Paul S.
Growth of Legionella pneumophila on buffered charcoal-yeast extract (BCYE) medium is dependent on l-cysteine (but not l-cystine), which is added in excess over what is required for nutrition. We...
Debets-Ossenkopp, Yvette J., Pot, Raymond G. J., Van Westerloo, David J., Goodwin, Avery, Berg, Douglas E., ...
We found that NCTC11637, the type strain of Helicobacter pylori, the causative agent of peptic ulcer disease and an early risk factor for gastric cancer, is metronidazole resistant. DNA...
Jeong, Jin-Yong, Mukhopadhyay, Asish K., Dailidiene, Daiva, Wang, Yipeng, Velapatiño, Billie, Gilman, Robert H., ...
Helicobacter pylori is a human-pathogenic bacterial species that is subdivided geographically, with different genotypes predominating in different parts of the world. Here we test and extend an...
Sisson, Gary, Jeong, Jin-Yong, Goodwin, Avery, Bryden, Louis, Rossler, Norma, Lim-Morrison, Sabrina, ...
Much of the normal high sensitivity of wild-type Helicobacter pylori to metronidazole (Mtz) depends on rdxA (HP0954), a gene encoding a novel nitroreductase that catalyzes the conversion of Mtz from...
Chalker, Alison F., Minehart, Heather W., Hughes, Nicky J., Koretke, Kristin K., Lonetto, Michael A., Brinkman, Kerry K., ...
A comparative genomic approach was used to identify Helicobacter pylori 26695 open reading frames (ORFs) which are conserved in H. pylori J99 but highly diverged in other eubacteria. A survey of...
Baker, Laura M. S., Raudonikiene, Ausra, Hoffman, Paul S., Poole, Leslie B.
Helicobacter pylori, an oxygen-sensitive microaerophile, contains an alkyl hydroperoxide reductase homologue (AhpC, HP1563) that is more closely related to 2-Cys peroxiredoxins of higher organisms...
Jeong, Jin-Yong, Mukhopadhyay, Asish K., Akada, Junko K., Dailidiene, Daiva, Hoffman, Paul S., Berg, Douglas E.
The relative importance of the frxA and rdxA nitroreductase genes of Helicobacter pylori in metronidazole (MTZ) susceptibility and resistance has been controversial. Jeong et al. (J. Bacteriol....
Immunolocalization of Hsp60 in Legionella pneumophila
Garduño, Rafael A., Faulkner, Gary, Trevors, Mary A., Vats, Neeraj, Hoffman, Paul S.
One of the most abundant proteins synthesized by Legionella pneumophila, particularly during growth in a variety of eukaryotic host cells, is Hsp60, a member of the GroEL family of molecular...
Surface-Associated Hsp60 Chaperonin of Legionella pneumophila Mediates Invasion in a HeLa Cell Model
Garduño, Rafael A., Garduño, Elizabeth, Hoffman, Paul S.
HeLa cells have been previously used to demonstrate that virulent strains of Legionella pneumophila (but not salt-tolerant avirulent strains) efficiently invade nonphagocytic cells. Hsp60, a member...
Sisson, Gary, Goodwin, Avery, Raudonikiene, Ausra, Hughes, Nicky J., Mukhopadhyay, Asish K., Berg, Douglas E., ...
Nitazoxanide (NTZ) is a redox-active nitrothiazolyl-salicylamide prodrug that kills Helicobacter pylori and also many anaerobic bacterial, protozoan, and helminthic species. Here we describe...
Garduño, Rafael A., Garduño, Elizabeth, Hiltz, Margot, Hoffman, Paul S.
When Legionella pneumophila grows in HeLa cells, it alternates between a replicative form and a morphologically distinct “cyst-like” form termed MIF (mature intracellular form). MIFs are also...
Hoffman, Paul S., Vats, Neeraj, Hutchison, Donna, Butler, Jared, Chisholm, Kenneth, Sisson, Gary, ...
The identification of genes associated with colonization and persistence of Helicobacter pylori in the gastric mucosa has been limited by the lack of robust animal models that support infection by...
Mukhopadhyay, Asish K., Jeong, Jin-Yong, Dailidiene, Daiva, Hoffman, Paul S., Berg, Douglas E.
Very few examples of metabolic regulation are known in the gastric pathogen Helicobacter pylori. An unanticipated case was suggested, however, upon finding two types of metronidazole...
A 65-Kilobase Pathogenicity Island Is Unique to Philadelphia-1 Strains of Legionella pneumophila
Brassinga, Ann Karen C., Hiltz, Margot F., Sisson, Gary R., Morash, Michael G., Hill, Nathan, Garduno, Elizabeth, ...
Nucleotide sequence analysis of an ∼80-kb genomic region revealed an ∼65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system,...
Hiltz, Margot F., Sisson, Gary R., Brassinga, Ann Karen C., Garduno, Elizabeth, Garduno, Rafael A., Hoffman, Paul S.
Legionella pneumophila displays a biphasic developmental cycle in which replicating forms (RFs) differentiate postexponentially into highly infectious, cyst-like mature intracellular forms (MIFs)....
Petroni, Alejandro, Melano, Roberto G., Saka, Héctor A., Garutti, Alicia, Mange, Laura, Pasterán, Fernando, ...
The gene blaCARB-9 was located in the Vibrio cholerae super-integron, but in a different location relative to blaCARB-7. CARB-9 (pI 5.2) conferred β-lactam MICs four to eight times lower than those...
Croxen, Matthew A., Sisson, Gary, Melano, Roberto, Hoffman, Paul S.
The location of Helicobacter pylori in the gastric mucosa of mammals is defined by natural pH gradients within the gastric mucus, which are more alkaline proximal to the mucosal epithelial cells and...
Cysteine Metabolism in Legionella pneumophila: Characterization of an l-Cystine-Utilizing Mutant
Ewann, Fanny, Hoffman, Paul S.
Growth of Legionella pneumophila on buffered charcoal-yeast extract (BCYE) medium is dependent on l-cysteine (but not l-cystine), which is added in excess over what is required for nutrition. We...
LeBlanc, Jason J., Davidson, Ross J., Hoffman, Paul S.
Legionella pneumophila expresses two catalase-peroxidase enzymes that exhibit strong peroxidatic but weak catalatic activities, suggesting that other enzymes participate in decomposition of hydrogen...
Hoffman, Paul S., Sisson, Gary, Croxen, Matthew A., Welch, Kevin, Harman, W. Dean, Cremades, Nunilo, ...
Nitazoxanide (NTZ) exhibits broad-spectrum activity against anaerobic bacteria and parasites and the ulcer-causing pathogen Helicobacter pylori. Here we show that NTZ is a noncompetitive inhibitor...
Croxen, Matthew A., Ernst, Peter B., Hoffman, Paul S.
Much of the gene content of the human gastric pathogen Helicobacter pylori (∼1.7-Mb genome) is considered essential. This view is based on the completeness of metabolic pathways, infrequency of...
St. Maurice, Martin, Cremades, Nunilo, Croxen, Matthew A., Sisson, Gary, Sancho, Javier, Hoffman, Paul S.
Pyruvate-dependent reduction of NADP has been demonstrated in cell extracts of the human gastric pathogen Helicobacter pylori. However, NADP is not a substrate of purified pyruvate:ferredoxin...
LeBlanc, Jason J., Brassinga, Ann Karen C., Ewann, Fanny, Davidson, Ross J., Hoffman, Paul S.
Legionella pneumophila expresses two peroxide-scavenging alkyl hydroperoxide reductase systems (AhpC1 and AhpC2D) that are expressed differentially during the bacterial growth cycle. Functional loss...
Morash, Michael G., Brassinga, Ann Karen C., Warthan, Michelle, Gourabathini, Poornima, Garduño, Rafael A., Goodman, Steven D., ...
Legionella pneumophila is an intracellular parasite of protozoa that differentiates late in infection into metabolically dormant cysts that are highly infectious. Regulation of this process is poorly...