A gene signature for post-infectious chronic fatigue syndrome (2009)
Gow, John W, Hagan, Suzanne, Herzyk, Pawel, Cannon, Celia, Behan, Peter O, Chaudhuri, Abhijit
Abstract Background At present, there are no clinically reliable disease markers for chronic fatigue syndrome. DNA chip microarray technology provides a method for examining the differential...
Rainer Breitling, Pawel Herzyk
We review some powerful new algorithms that build on the intuitive biological interpretation techniques for statistical analysis of functional genomics experiments. Although they were originally...
Microarray experiments: New statistical tools facilitate biological interpretation (2008)
Rainer Breitling, Anna Amtmann, Pawel Herzyk, Annotation C, Gene Gene, ...
After data collection, biologists analysing a microarray experiment face three main challenges: 1. Identification of differentially expressed genes. 2. Detecting physiologically relevant patterns...
The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder (2007)
Dalby, Matthew J., Gadegaard, Nikolaj, Tare, Rahul, Andar, Abhay, Riehle, Mathis O., Herzyk, Pawel, ...
A key tenet of bone tissue engineering is the development of scaffold materials that can stimulate stem cell differentiation in the absence of chemical treatment to become osteoblasts without...
Richardson, Andrew, Boscari, Alexandre, Schreiber, Lukas, Kerstiens, Gerhard, Jarvis, Mike, Herzyk, Pawel, ...
The aim of the present study was to isolate clones of genes which are likely to be involved in wax deposition on barley leaves. Of particular interest were those genes which encode proteins that take...
The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder (2007)
Dalby, Matthew J., Gadegaard, Nikolaj, Tare, Rahul, Andar, Abhay, Riehle, Mathis O., Herzyk, Pawel, ...
A key tenet of bone tissue engineering is the development of scaffold materials that can stimulate stem cell differentiation in the absence of chemical treatment to become osteoblasts without...
Automatic generation of 3D motifs for classification of protein binding sites (2007)
Nebel, Jean-Christophe, Herzyk, Pawel, Gilbert, David R
Abstract Background Since many of the new protein structures delivered by high-throughput processes do not have any known function, there is a need for structure-based prediction of protein function....
Breitling, Rainer, Herzyk, Pawel
We review some powerful new algorithms that build on the intuitive biological interpretation techniques for statistical analysis of functional genomics experiments. Although they were originally...
Function-informed transcriptome analysis of Drosophilarenal tubule (2004)
Wang, Jing, Kean, Laura, Yang, Jingli, Allan, Adrian K, Davies, Shireen A, Herzyk, Pawel, ...
Abstract Background Comprehensive, tissue-specific, microarray analysis is a potent tool for the identification of tightly defined expression patterns that might be missed in whole-organism scans. We...
Graph-based iterative Group Analysis enhances microarray interpretation (2004)
Breitling, Rainer, Amtmann, Anna, Herzyk, Pawel
Abstract Background One of the most time-consuming tasks after performing a gene expression experiment is the biological interpretation of the results by identifying physiologically important...
Breitling, Rainer, Amtmann, Anna, Herzyk, Pawel
Abstract Background The biological interpretation of even a simple microarray experiment can be a challenging and highly complex task. Here we present a new method (Iterative Group Analysis) to...
Breitling, Rainer, Amtmann, Anna, Herzyk, Pawel
Background: The biological interpretation of even a simple microarray experiment can be a challenging and highly complex task. Here we present a new method (Iterative Group Analysis) to facilitate,...
Graph-based iterative Group Analysis enhances microarray interpretation (2004)
Breitling, Rainer, Amtmann, Anna, Herzyk, Pawel
Background: One of the most time-consuming tasks after performing a gene expression experiment is the biological interpretation of the results by identifying physiologically important associations...
Breitling, Rainer, Armengaud, Patrick, Amtmann, Anna, Herzyk, Pawel
One of the main objectives in the analysis of microarray experiments is the identification of genes that are differentially expressed under two experimental conditions. This task is complicated by...
Rainer Breitling, Anna Amtmann, Pawel Herzyk, Open Access
Background: The biological interpretation of even a simple microarray experiment can be a challenging and highly complex task. Here we present a new method (Iterative Group Analysis) to facilitate,...
Rainer Breitling, Anna Amtmann, Pawel Herzyk
© 2004 Breitling et al; licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License
Maathuis, Frans J. M., Filatov, Victor, Herzyk, Pawel, Krijger, Gerard C., Axelsen, Kristian B., Chien, Sixue X., ...
Plant nutrition critically depends on the activity of membrane transporters that translocate minerals from the soil into the plant and are responsible for their intra- and intercellular distribution....
Maathuis, Frans J.M., Filatov, Victor, Herzyk, Pawel, Krijger, Gerard C., Axelsen, Kristian B., Chen, Sixue, ...
Plant nutrition critically depends on the activity of membrane transporters that translocate minerals from the soil into the plant and are responsible for their intra- and intercellular distribution....
Cooke, Robert M., Carter, Brian G., Murray-Rust, Peter, Hartshorn, Michael J., Herzyk, Pawel, Hubbard, Roderick E.
The solution structure of the fibrinogen antagonist, echistatin, has been determined by a combination of NMR and simulated annealing methods. While the structure of the disulphidelinked core is...
Function-informed transcriptome analysis of Drosophila renal tubule
Wang, Jing, Kean, Laura, Yang, Jingli, Allan, Adrian K, Davies, Shireen A, Herzyk, Pawel, ...
Analysis of the transcriptome of the Drosophila melanogaster Malpighian (renal) tubule gives a radically new view of the function of the tubule, emphasising solute transport rather than fluid...
A UV-B-specific signaling component orchestrates plant UV protection
Brown, Bobby A., Cloix, Catherine, Jiang, Guang Huai, Kaiserli, Eirini, Herzyk, Pawel, Kliebenstein, Daniel J., ...
UV-B radiation in sunlight has diverse effects on humans, animals, plants, and microorganisms. UV-B can cause damage to molecules and cells, and consequently organisms need to protect against and...
Phenotypic responses to mechanical stress in fibroblasts from tendon, cornea and skin
Mackley, Jennifer R., Ando, Joji, Herzyk, Pawel, Winder, Steven J.
Primary fibroblasts isolated from foetal mouse cornea, skin and tendon were subjected to linear shear stress and analysed for morphological parameters and by microarray, as compared with unstimulated...
Function-informed transcriptome analysis of Drosophila renal tubule
Wang, Jing, Kean, Laura, Yang, Jingli, Allan, Adrian K, Davies, Shireen A, Herzyk, Pawel, ...
Analysis of the transcriptome of the Drosophila melanogaster Malpighian (renal) tubule gives a radically new view of the function of the tubule, emphasising solute transport rather than fluid...
A UV-B-specific signaling component orchestrates plant UV protection
Brown, Bobby A., Cloix, Catherine, Jiang, Guang Huai, Kaiserli, Eirini, Herzyk, Pawel, Kliebenstein, Daniel J., ...
UV-B radiation in sunlight has diverse effects on humans, animals, plants, and microorganisms. UV-B can cause damage to molecules and cells, and consequently organisms need to protect against and...
Phenotypic responses to mechanical stress in fibroblasts from tendon, cornea and skin
Mackley, Jennifer R., Ando, Joji, Herzyk, Pawel, Winder, Steven J.
Primary fibroblasts isolated from foetal mouse cornea, skin and tendon were subjected to linear shear stress and analysed for morphological parameters and by microarray, as compared with unstimulated...
Bolger, Graeme B., Baillie, George S., Li, Xiang, Lynch, Martin J., Herzyk, Pawel, Mohamed, Ahmed, ...
The cAMP-specific phosphodiesterase PDE4D5 can interact with the signalling scaffold proteins RACK (receptors for activated C-kinase) 1 and β-arrestin. Two-hybrid and co-immunoprecipitation analyses...