Peili Gu

Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation (2007)

Eimear M. Mullen, Peili Gu, Austin J. Cooney

Embryonic stem (ES) cells have great therapeutic potential because they are capable of indefinite self-renewal and have the potential to differentiate into over 200 different cell types that compose...

Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation (2007)

Eimear M. Mullen, Peili Gu, Austin J. Cooney

Embryonic stem (ES) cells have great therapeutic potential because they are capable of indefinite self-renewal and have the potential to differentiate into over 200 different cell types that compose...

Evolutionary trace-based peptides identify a novel asymmetric interaction that mediates oligomerization in nuclear receptors (2005)

Peili Gu, Daniel H. Morgan, Minawar Sattar, Xueping Xu, Ryan Wagner, Michele Raviscioni, ...

Germ cell nuclear factor (GCNF) is an orphan nuclear receptor that plays important roles in development and reproduction, by repressing the expression of essential genes such as Oct4, GDF9, and...

Expression of the Orphan Nuclear Receptor, Germ Cell Nuclear Factor, in Mouse Gonads and Preimplantation Embryos1 (2003)

Zi-Jian Lan, Peili Gu, Xueping Xu, Austin J. Cooney

Germ cell nuclear factor (GCNF, NR6A1) is an orphan member of the nuclear receptor superfamily and functions as a repressor of gene transcription. GCNF mRNA is expressed in postgastrulation mouse...

GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility

Lan, Zi-Jian, Gu, Peili, Xu, Xueping, Jackson, Kathy J., DeMayo, Francesco J., O’Malley, Bert W., ...

To determine the function of germ cell nuclear factor (GCNF) in female reproduction, we generated an oocyte-specific GCNF knockout mouse model (GCNFfl/flZp3Cre+). These mice displayed hypofertility...

Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development

Gu, Peili, Goodwin, Bryan, Chung, Arthur C.-K., Xu, Xueping, Wheeler, David A., Price, Roger R., ...

Oct4 plays an essential role in maintaining the inner cell mass and pluripotence of embryonic stem (ES) cells. The expression of Oct4 is regulated by the proximal enhancer and promoter in the...

Orphan Nuclear Receptor GCNF Is Required for the Repression of Pluripotency Genes during Retinoic Acid-Induced Embryonic Stem Cell Differentiation

Gu, Peili, LeMenuet, Damien, Chung, Arthur C.-K., Mancini, Michael, Wheeler, David A., Cooney, Austin J.

Embryonic stem (ES) cell pluripotency and differentiation are controlled by a network of transcription factors and signaling molecules. Transcription factors such as Oct4 and Nanog are required for...

GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility

Lan, Zi-Jian, Gu, Peili, Xu, Xueping, Jackson, Kathy J., DeMayo, Francesco J., O’Malley, Bert W., ...

To determine the function of germ cell nuclear factor (GCNF) in female reproduction, we generated an oocyte-specific GCNF knockout mouse model (GCNFfl/flZp3Cre+). These mice displayed hypofertility...

Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development

Gu, Peili, Goodwin, Bryan, Chung, Arthur C.-K., Xu, Xueping, Wheeler, David A., Price, Roger R., ...

Oct4 plays an essential role in maintaining the inner cell mass and pluripotence of embryonic stem (ES) cells. The expression of Oct4 is regulated by the proximal enhancer and promoter in the...

Orphan Nuclear Receptor GCNF Is Required for the Repression of Pluripotency Genes during Retinoic Acid-Induced Embryonic Stem Cell Differentiation

Gu, Peili, LeMenuet, Damien, Chung, Arthur C.-K., Mancini, Michael, Wheeler, David A., Cooney, Austin J.

Embryonic stem (ES) cell pluripotency and differentiation are controlled by a network of transcription factors and signaling molecules. Transcription factors such as Oct4 and Nanog are required for...

Differential Recruitment of Methylated CpG Binding Domains by the Orphan Receptor GCNF Initiates the Repression and Silencing of Oct4 Expression▿

Gu, Peili, Le Menuet, Damien, Chung, Arthur C.-K., Cooney, Austin J.

The pluripotent factor Oct4 is a key transcription factor that maintains embryonic stem (ES) cell self-renewal and is down-regulated upon the differentiation of ES cells and silenced in somatic...

Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation

Mullen, Eimear M., Gu, Peili, Cooney, Austin J.

Embryonic stem (ES) cells have great therapeutic potential because they are capable of indefinite self-renewal and have the potential to differentiate into over 200 different cell types that compose...