Pek Y. Lum

Summary (2009)

Timothy R. Hughes, Matthew J. Marton, Allan R. Jones, Christopher J. Roberts, Christopher D. Armour, Holly A. Bennett, ...

Means have been devised to survey gene functions en masse either computationally (Marcotte et al., 1999) or experimentally; among these, highly parallel assays of thousands of mapped mutants...

Common body mass index-associated variants confer risk of extreme obesity (2009)

Cotsapas, Chris, Speliotes, Elizabeth K., Hatoum, Ida J., Greenawalt, Danielle M., Dobrin, Radu, Lum, Pek Y., ...

To investigate the genetic architecture of severe obesity, we performed a genome-wide association study of 775 cases and 3197 unascertained controls at ∼550 000 markers across the autosomal genome....

Mapping the Genetic Architecture of Gene Expression in Human Liver (2008)

Eric E. Schadt, Cliona Molony, Eugene Chudin, Ke Hao, Xia Yang, Pek Y. Lum, ...

Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order...

Increasing the Power to Detect Causal Associations by Combining Genotypic and Expression Data in Segregating Populations (2007)

Jun Zhu, Matthew C. Wiener, Chunsheng Zhang, Arthur Fridman, Eric Minch, Pek Y. Lum, ...

To dissect common human diseases such as obesity and diabetes, a systematic approach is needed to study how genes interact with one another, and with genetic and environmental factors, to determine...

Increasing the Power to Detect Causal Associations among Genes and between Genes and Complex Traits by Combining Genotypic and Gene Expression Data in Segregating Populations (2007)

Jun Zhu, Matthew C. Wiener, Chunsheng Zhang, Arthur Fridman, Eric Minch, Pek Y. Lum, ...

To dissect common human diseases like obesity and diabetes, a systematic approach is needed to study how genes interact with one another, and how genetic and environmental factors and interactions...

Increasing the Power to Detect Causal Associations by Combining Genotypic and Expression Data in Segregating Populations

Zhu, Jun, Wiener, Matthew C, Zhang, Chunsheng, Fridman, Arthur, Minch, Eric, Lum, Pek Y, ...

To dissect common human diseases such as obesity and diabetes, a systematic approach is needed to study how genes interact with one another, and with genetic and environmental factors, to determine...

Mapping the Genetic Architecture of Gene Expression in Human Liver

Schadt, Eric E, Molony, Cliona, Chudin, Eugene, Hao, Ke, Yang, Xia, Lum, Pek Y, ...

Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order...