Penny Coggill

Generation of a genomic tiling array of the human Major Histocompatibility Complex (MHC) and its application for DNA methylation analysis (2008)

Tomazou, Eleni M, Rakyan, Vardhman K, Lefebvre, Gregory, Andrews, Robert, Ellis, Peter, Jackson, David K, ...

Abstract Background The major histocompatibility complex (MHC) is essential for human immunity and is highly associated with common diseases, including cancer. While the genetics of the MHC has been...

Evolution and comparative analysis of the MHC Class III inflammatory region (2006)

Deakin, Janine E, Papenfuss, Anthony T, Belov, Katherine, Cross, Joseph GR, Coggill, Penny, Palmer, Sophie, ...

Abstract Background The Major Histocompatibility Complex (MHC) is essential for immune function. Historically, it has been subdivided into three regions (Class I, II, and III), but a cluster of...

Identification of the ancestral killer immunoglobulin-like receptor gene in primates (2006)

Sambrook, Jennifer G, Bashirova, Arman, Andersen, Hanne, Piatak, Mike, Vernikos, George S, Coggill, Penny, ...

Abstract Background Killer Immunoglobulin-like Receptors (KIR) are essential immuno-surveillance molecules. They are expressed on natural killer and T cells, and interact with human leukocyte...

The Leukocyte Receptor Complex in Chicken Is Characterized by Massive Expansion and Diversification of Immunoglobulin-Like Loci (2006)

Katja Laun, Penny Coggill, Sophie Palmer, Sarah Sims, Zemin Ning, Jiannis Ragoussis, ...

The innate and adaptive immune systems of vertebrates possess complementary, but intertwined functions within immune responses. Receptors of the mammalian innate immune system play an essential role...

The leukocyte receptor complex in chicken is characterized by massive expansion and diversification of immunoglobulin-like loci (2006)

Katja Laun, Penny Coggill, Sophie Palmer, Sarah Sims, Zemin Ning, Jiannis Ragoussis, ...

The innate and adaptive immune systems of vertebrates possess complementary, but intertwined functions within immune responses. Receptors of the mammalian innate immune system play an essential role...

Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History (2006)

James A. Traherne, Roger Horton, Anne N. Roberts, Marcos M. Miretti, Matthew E. Hurles, C. Andrew Stewart, ...

The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer...

Complete MHC Haplotype Sequencing for Common Disease Gene Mapping

Stewart, C. Andrew, Horton, Roger, Allcock, Richard J.N., Ashurst, Jennifer L., Atrazhev, Alexey M., Coggill, Penny, ...

The future systematic mapping of variants that confer susceptibility to common diseases requires the construction of a fully informative polymorphism map. Ideally, every base pair of the genome would...

Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History

Traherne, James A, Horton, Roger, Roberts, Anne N, Miretti, Marcos M, Hurles, Matthew E, Stewart, C. Andrew, ...

The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer...

The Leukocyte Receptor Complex in Chicken Is Characterized by Massive Expansion and Diversification of Immunoglobulin-Like Loci

Laun, Katja, Coggill, Penny, Palmer, Sophie, Sims, Sarah, Ning, Zemin, Ragoussis, Jiannis, ...

The innate and adaptive immune systems of vertebrates possess complementary, but intertwined functions within immune responses. Receptors of the mammalian innate immune system play an essential role...

Complete MHC Haplotype Sequencing for Common Disease Gene Mapping

Stewart, C. Andrew, Horton, Roger, Allcock, Richard J.N., Ashurst, Jennifer L., Atrazhev, Alexey M., Coggill, Penny, ...

The future systematic mapping of variants that confer susceptibility to common diseases requires the construction of a fully informative polymorphism map. Ideally, every base pair of the genome would...

Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History

Traherne, James A, Horton, Roger, Roberts, Anne N, Miretti, Marcos M, Hurles, Matthew E, Stewart, C. Andrew, ...

The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer...

The Leukocyte Receptor Complex in Chicken Is Characterized by Massive Expansion and Diversification of Immunoglobulin-Like Loci

Laun, Katja, Coggill, Penny, Palmer, Sophie, Sims, Sarah, Ning, Zemin, Ragoussis, Jiannis, ...

The innate and adaptive immune systems of vertebrates possess complementary, but intertwined functions within immune responses. Receptors of the mammalian innate immune system play an essential role...

Variation analysis and gene annotation of eight MHC haplotypes: The MHC Haplotype Project

Horton, Roger, Gibson, Richard, Coggill, Penny, Miretti, Marcos, Allcock, Richard J., Almeida, Jeff, ...

The human major histocompatibility complex (MHC) is contained within about 4 Mb on the short arm of chromosome 6 and is recognised as the most variable region in the human genome. The primary aim of...