Per-Ove Sjöquist

Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide (2008)

Gonon, Adrian T., Widegren, Ulrika, Bulhak, Aliaksandr, Salehzadeh, Firoozeh, Persson, Jonas, Sjöquist, Per-Ove, ...

Aims Cardiovascular disease and type 2 diabetes mellitus are associated with low plasma concentration of adiponectin. The aim of this study was to investigate whether adiponectin exerts...

Pharmacological possibilities for protection against myocardial reperfusion injury (2002)

Wang, Qing-Dong, Pernow, John, Sjöquist, Per-Ove, Rydén, Lars

Reperfusion through thrombolysis or percutananeous coronary angioplasty is standard treatment in impending acute myocardial infarction. Although restoration of blood flow to the jeopardised...

Short-acting calcium antagonist clevidipine protects against reperfusion injury via local nitric oxide-related mechanisms in the jeopardised myocardium (2001)

Gourine, Andrey, Gonon, Adrian, Sjöquist, Per-Ove, Pernow, John

Background: Calcium antagonists may, in addition to their classical actions, release nitric oxide (NO) from coronary arteries. The aim of this study was to elucidate the possible interaction between...

Coronary venous drug infusion in the ischaemic-reperfused isolated rat heart (1996)

Uriuda, Yozo, Wang, Qing-Dong, Li, Xing-San, Sjöquist, Per-Ove, Nordlander, Rolf, Rydén, Lars

Objectives: Coronary venous retroinfusion (CVR) has been used experimentally in large animals for selective drug delivery into ischaemic myocardium. It would be an advantage if CVR could also be used...

Antithrombotic activity of inogatran, a new low-molecular-weight inhibitor of thrombin, in a closed-chest porcine model of coronary artery thrombosis (1996)

Uriuda, Yozo, Wang, Qing-Dong, Grip, Lars, Rydén, Lars, Sjöquist, Per-Ove, Mattsson, Christer

Objective: To characterize the antithrombotic activitiy of inogatran per se in a porcine model of copper-coil-induced coronary artery thrombosis and to compare its effect with that of heparin and...

Endothelium bound extracellular superoxide dismutase type C reduces damage in reperfused ischaemic rat hearts (1992)

Sjöquist, Per-Ove, Marklund, Stefan L

Objective: The aim was to determine if endothelium associated extracellular superoxide dismutase type C (EC-SOD C) exerts any protective effect against cardiac damage induced by ischaemia and...

Recombinant human extracellular superoxide dismutase reduces concentration of oxygen free radicals in the reperfused rat heart (1990)

Johansson, Mats H, Deinum, Johanna, Marklund, Stefan L, Sjöquist, Per-Ove

Study objective – The aim of the study was to determine whether recombinant human extracellular superoxide dismutase type C (rh-EC-SOD C) has antioxidant effects similar to those of the previously...

Endothelin-1 exerts a preconditioning-like cardioprotective effect against ischaemia/reperfusion injury via the ETA receptor and the mitochondrial KATP channel in the rat in vivo

Gourine, Audrey V, Molosh, Audrey I, Poputnikov, Dmitry, Bulhak, Aliaksandr, Sjöquist, Per-Ove, Pernow, John

In vitro studies have demonstrated that endothelin-1 (ET-1) given before myocardial ischaemia may evoke a preconditioning (PC)-like cardioprotective effect. The first aim of this study was to...